A mouse model of the most aggressive subgroup of human medulloblastoma

Medulloblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called MYC-subgroup differs in its histopathology, gene expression profile, and clinical behavior from other forms of medulloblastom...

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Bibliographic Details
Published in:	Cancer cell Vol. 21; no. 2; p. 168
Main Authors:	Kawauchi, Daisuke, Robinson, Giles, Uziel, Tamar, Gibson, Paul, Rehg, Jerold, Gao, Cuilan, Finkelstein, David, Qu, Chunxu, Pounds, Stanley, Ellison, David W, Gilbertson, Richard J, Roussel, Martine F
Format:	Journal Article
Language:	English
Published:	United States 14.02.2012
Subjects:	Animals Cell Proliferation - drug effects Cell Transformation, Neoplastic - drug effects Cerebellar Neoplasms - genetics Cerebellar Neoplasms - pathology Disease Models, Animal Gene Expression Regulation, Neoplastic Hedgehog Proteins - antagonists & inhibitors Humans Medulloblastoma - genetics Medulloblastoma - pathology Mice Salivary alpha-Amylases - genetics Salivary alpha-Amylases - metabolism Salivary alpha-Amylases - physiology Transcriptome Tumor Suppressor Protein p53 - genetics Veratrum Alkaloids - pharmacology
ISSN:	1878-3686, 1878-3686
Online Access:	Get more information
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