A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival

The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR signalling interfaces with the circadian clock. UPR a...

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Vydané v:	Nature cell biology Ročník 20; číslo 1; s. 104 - 115
Hlavní autori:	Bu, Yiwen, Yoshida, Akihiro, Chitnis, Nilesh, Altman, Brian J., Tameire, Feven, Oran, Amanda, Gennaro, Victoria, Armeson, Kent E., McMahon, Steven B., Wertheim, Gerald B., Dang, Chi V., Ruggero, Davide, Koumenis, Constantinos, Fuchs, Serge Y., Diehl, J. Alan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.01.2018 Nature Publishing Group
Predmet:	631/337/384/331 631/67/395 631/80/105 631/80/474/1768 Activation Animals ARNTL Transcription Factors - antagonists & inhibitors ARNTL Transcription Factors - genetics ARNTL Transcription Factors - metabolism B-Lymphocytes - metabolism B-Lymphocytes - pathology Biomedical and Life Sciences BMAL1 protein Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology c-Myc protein Cancer Cancer cells Cancer Research Cell Biology Cell Line, Tumor Cell proliferation Cell Survival Cellular signal transduction Circadian Clocks - genetics Circadian rhythm Circadian rhythms CLOCK Proteins - antagonists & inhibitors CLOCK Proteins - genetics CLOCK Proteins - metabolism Developmental Biology eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Endoplasmic reticulum Gene expression Gene Expression Regulation, Neoplastic Genes Heterografts Homeostasis Humans Interfaces Life Sciences Light Signal Transduction Lymphoma Lymphomas Male Metabolism Mice Mice, Inbred C57BL Mice, Transgenic MicroRNA MicroRNAs - genetics MicroRNAs - metabolism miRNA Myc protein Oscillations Osteoblasts - metabolism Osteoblasts - pathology Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Photoperiod Protein biosynthesis Protein folding Protein synthesis Proteins Regulators Ribonucleic acid RNA RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal transduction Signaling Stem Cells Survival Tumors Unfolded Protein Response
ISSN:	1465-7392, 1476-4679, 1476-4679
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