A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival
The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR signalling interfaces with the circadian clock. UPR a...
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| Vydané v: | Nature cell biology Ročník 20; číslo 1; s. 104 - 115 |
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| Hlavní autori: | , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Nature Publishing Group UK
01.01.2018
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| ISSN: | 1465-7392, 1476-4679, 1476-4679 |
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| Abstract | The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR signalling interfaces with the circadian clock. UPR activation induces a 10 h phase shift in circadian oscillations through induction of miR-211, a PERK-inducible microRNA that transiently suppresses both Bmal1 and Clock, core circadian regulators. Molecular investigation reveals that miR-211 directly regulates Bmal1 and Clock via distinct mechanisms. Suppression of Bmal1 and Clock has the anticipated impact on expression of select circadian genes, but we also find that repression of Bmal1 is essential for UPR-dependent inhibition of protein synthesis and cell adaptation to stresses that disrupt endoplasmic reticulum homeostasis. Our data demonstrate that c-Myc-dependent activation of the UPR inhibits Bmal1 in Burkitt’s lymphoma, thereby suppressing both circadian oscillation and ongoing protein synthesis to facilitate tumour progression.
PERK regulates tumour cell survival. Bu et al. show that the unfolded protein response protein PERK induces miR-211 repression of the circadian factor Bmal1 to regulate protein synthesis and stress responses, contributing to tumour progression. |
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| AbstractList | The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR signalling interfaces with the circadian clock. UPR activation induces a 10 h phase shift in circadian oscillations through induction of miR-211, a PERK-inducible microRNA that transiently suppresses both Bmal1 and Clock, core circadian regulators. Molecular investigation reveals that miR-211 directly regulates Bmal1 and Clock via distinct mechanisms. Suppression of Bmal1 and Clock has the anticipated impact on expression of select circadian genes, but we also find that repression of Bmal1 is essential for UPR-dependent inhibition of protein synthesis and cell adaptation to stresses that disrupt endoplasmic reticulum homeostasis. Our data demonstrate that c-Myc-dependent activation of the UPR inhibits Bmal1 in Burkitt's lymphoma, thereby suppressing both circadian oscillation and ongoing protein synthesis to facilitate tumour progression. PERK regulates tumour cell survival. Bu et al. show that the unfolded protein response protein PERK induces miR-211 repression of the circadian factor Bmal1 to regulate protein synthesis and stress responses, contributing to tumour progression. The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR signalling interfaces with the circadian clock. UPR activation induces a 10 h phase shift in circadian oscillations through induction of miR-211, a PERK-inducible microRNA that transiently suppresses both Bmal1 and Clock, core circadian regulators. Molecular investigation reveals that miR-211 directly regulates Bmal1 and Clock via distinct mechanisms. Suppression of Bmal1 and Clock has the anticipated impact on expression of select circadian genes, but we also find that repression of Bmal1 is essential for UPR-dependent inhibition of protein synthesis and cell adaptation to stresses that disrupt endoplasmic reticulum homeostasis. Our data demonstrate that c-Myc-dependent activation of the UPR inhibits Bmal1 in Burkitt's lymphoma, thereby suppressing both circadian oscillation and ongoing protein synthesis to facilitate tumour progression. The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR signalling interfaces with the circadian clock. UPR activation induces a 10 h phase shift in circadian oscillations through induction of miR-211, a PERK-inducible microRNA that transiently suppresses both Bmal1 and Clock, core circadian regulators. Molecular investigation reveals that miR-211 directly regulates Bmal1 and Clock via distinct mechanisms. Suppression of Bmal1 and Clock has the anticipated impact on expression of select circadian genes, but we also find that repression of Bmal1 is essential for UPR-dependent inhibition of protein synthesis and cell adaptation to stresses that disrupt endoplasmic reticulum homeostasis. Our data demonstrate that c-Myc-dependent activation of the UPR inhibits Bmal1 in Burkitt's lymphoma, thereby suppressing both circadian oscillation and ongoing protein synthesis to facilitate tumour progression.The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR signalling interfaces with the circadian clock. UPR activation induces a 10 h phase shift in circadian oscillations through induction of miR-211, a PERK-inducible microRNA that transiently suppresses both Bmal1 and Clock, core circadian regulators. Molecular investigation reveals that miR-211 directly regulates Bmal1 and Clock via distinct mechanisms. Suppression of Bmal1 and Clock has the anticipated impact on expression of select circadian genes, but we also find that repression of Bmal1 is essential for UPR-dependent inhibition of protein synthesis and cell adaptation to stresses that disrupt endoplasmic reticulum homeostasis. Our data demonstrate that c-Myc-dependent activation of the UPR inhibits Bmal1 in Burkitt's lymphoma, thereby suppressing both circadian oscillation and ongoing protein synthesis to facilitate tumour progression. The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR signalling interfaces with the circadian clock. UPR activation induces a 10 h phase shift in circadian oscillations through induction of miR-211, a PERK-inducible microRNA that transiently suppresses both Bmal1 and Clock, core circadian regulators. Molecular investigation reveals that miR-211 directly regulates Bmal1 and Clock via distinct mechanisms. Suppression of Bmal1 and Clock has the anticipated impact on expression of select circadian genes, but we also find that repression of Bmal1 is essential for UPR-dependent inhibition of protein synthesis and cell adaptation to stresses that disrupt endoplasmic reticulum homeostasis. Our data demonstrate that c-Myc-dependent activation of the UPR inhibits Bmal1 in Burkitt’s lymphoma, thereby suppressing both circadian oscillation and ongoing protein synthesis to facilitate tumour progression. PERK regulates tumour cell survival. Bu et al. show that the unfolded protein response protein PERK induces miR-211 repression of the circadian factor Bmal1 to regulate protein synthesis and stress responses, contributing to tumour progression. |
| Audience | Academic |
| Author | Ruggero, Davide Oran, Amanda Koumenis, Constantinos Diehl, J. Alan Tameire, Feven Yoshida, Akihiro Altman, Brian J. Wertheim, Gerald B. Chitnis, Nilesh Armeson, Kent E. Dang, Chi V. Bu, Yiwen McMahon, Steven B. Gennaro, Victoria Fuchs, Serge Y. |
| Author_xml | – sequence: 1 givenname: Yiwen surname: Bu fullname: Bu, Yiwen organization: Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina – sequence: 2 givenname: Akihiro surname: Yoshida fullname: Yoshida, Akihiro organization: Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina – sequence: 3 givenname: Nilesh surname: Chitnis fullname: Chitnis, Nilesh organization: Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina – sequence: 4 givenname: Brian J. orcidid: 0000-0002-3954-4916 surname: Altman fullname: Altman, Brian J. organization: Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania – sequence: 5 givenname: Feven surname: Tameire fullname: Tameire, Feven organization: Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania – sequence: 6 givenname: Amanda surname: Oran fullname: Oran, Amanda organization: Department of Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University – sequence: 7 givenname: Victoria surname: Gennaro fullname: Gennaro, Victoria organization: Department of Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University – sequence: 8 givenname: Kent E. surname: Armeson fullname: Armeson, Kent E. organization: Department of Public Health Sciences and Hollings Cancer Center, Medical University of South Carolina – sequence: 9 givenname: Steven B. surname: McMahon fullname: McMahon, Steven B. organization: Department of Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University – sequence: 10 givenname: Gerald B. surname: Wertheim fullname: Wertheim, Gerald B. organization: Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia – sequence: 11 givenname: Chi V. surname: Dang fullname: Dang, Chi V. organization: Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania – sequence: 12 givenname: Davide surname: Ruggero fullname: Ruggero, Davide organization: Departments of Urology and Cellular and Molecular Pharmacology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco – sequence: 13 givenname: Constantinos surname: Koumenis fullname: Koumenis, Constantinos organization: Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania – sequence: 14 givenname: Serge Y. surname: Fuchs fullname: Fuchs, Serge Y. organization: Department of Biomedical Sciences, School of Veterinary Medicine – sequence: 15 givenname: J. Alan orcidid: 0000-0001-9854-5049 surname: Diehl fullname: Diehl, J. Alan email: diehl@musc.edu organization: Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29230015$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/sj.onc.1211017 10.1016/j.ccr.2010.08.012 10.1038/onc.2010.153 10.1371/journal.pbio.1000052 10.1002/jcp.25336 10.1016/S0092-8674(01)00611-0 10.1016/j.cell.2011.08.017 10.1038/ng1532 10.1126/science.1093686 10.1158/0008-5472.CAN-04-2469 10.1371/journal.pone.0082241 10.1101/gad.12.12.1812 10.1128/MCB.22.11.3864-3874.2002 10.1038/onc.2015.178 10.1038/16729 10.1128/MCB.01009-12 10.1016/j.molcel.2012.08.025 10.1128/MCB.18.12.7499 10.1128/MCB.23.21.7448-7459.2003 10.1038/nature07449 10.1053/j.gastro.2011.05.018 10.1016/j.cell.2013.11.034 10.1016/j.cmet.2015.09.003 10.1073/pnas.1115753108 10.1038/onc.2012.512 10.1371/journal.pgen.1006518 10.1158/0008-5472.CAN-15-2931 10.1038/415092a 10.1073/pnas.0504834102 10.1158/0008-5472.CAN-09-1970 10.1038/onc.2012.439 10.1016/j.cell.2015.04.002 10.1126/science.1195027 10.1021/jm300713s 10.1074/jbc.273.50.33741 10.1016/S1097-2765(00)80330-5 10.1172/JCI62973 10.1038/ncomms11422 10.1158/2159-8290.CD-14-0625 10.1016/j.ymeth.2007.04.007 10.1038/nrendo.2015.117 |
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| References | Baggs (CR20) 2009; 7 Lee, Iwakoshi, Glimcher (CR4) 2003; 23 Pytel, Majsterek, Diehl (CR9) 2015; 35 Avivar-Valderas (CR34) 2012; 32 Diehl, Fuchs, Koumenis (CR1) 2011; 141 Belinsky, Chen, Shchaveleva, Zeng, Kruh (CR37) 2002; 62 Aggarwal (CR42) 2010; 18 Barna (CR26) 2008; 456 Orom, Lund (CR25) 2007; 43 Delmore (CR36) 2011; 146 Gao (CR16) 2012; 32 Bu, Diehl (CR19) 2016; 231 Chitnis (CR22) 2012; 48 Altman (CR28) 2015; 22 Ushmorov (CR39) 2008; 27 Li (CR32) 2015; 5 Axten (CR21) 2012; 55 Pytel (CR12) 2016; 12 Bhattacharya (CR13) 2013; 32 Ruggero (CR27) 2009; 69 Garten (CR29) 2015; 11 Verdel (CR24) 2004; 303 Hart (CR11) 2012; 122 Gyorffy, Surowiak, Budczies, Lanczky (CR35) 2013; 8 Yoshida, Lee, Diehl (CR40) 2016; 76 Yoshida, Matsui, Yamamoto, Okada, Mori (CR6) 2001; 107 Harfe, McManus, Mansfield, Hornstein, Tabin (CR23) 2005; 102 Yoshida, Haze, Yanagi, Yura, Mori (CR3) 1998; 273 Harding, Zhang, Bertolotti, Zeng, Ron (CR14) 2000; 5 Lipton (CR17) 2015; 161 Calfon (CR5) 2002; 415 Bobrovnikova-Marjon (CR10) 2010; 29 Bass, Takahashi (CR18) 2010; 330 Harding, Zhang, Ron (CR8) 1999; 397 Valentijn (CR38) 2005; 65 Basso (CR33) 2005; 37 Atwood (CR30) 2011; 108 Xu (CR41) 2016; 7 Zhang (CR15) 2002; 22 Tirasophon, Welihinda, Kaufman (CR2) 1998; 12 Shi (CR7) 1998; 18 Eckel-Mahan (CR31) 2013; 155 W Tirasophon (6_CR2) 1998; 12 Y Shi (6_CR7) 1998; 18 B Gyorffy (6_CR35) 2013; 8 D Pytel (6_CR12) 2016; 12 A Ushmorov (6_CR39) 2008; 27 BJ Altman (6_CR28) 2015; 22 Z Xu (6_CR41) 2016; 7 K Basso (6_CR33) 2005; 37 BD Harfe (6_CR23) 2005; 102 JM Axten (6_CR21) 2012; 55 KL Eckel-Mahan (6_CR31) 2013; 155 JE Delmore (6_CR36) 2011; 146 E Bobrovnikova-Marjon (6_CR10) 2010; 29 JA Diehl (6_CR1) 2011; 141 Y Li (6_CR32) 2015; 5 M Calfon (6_CR5) 2002; 415 LJ Valentijn (6_CR38) 2005; 65 A Atwood (6_CR30) 2011; 108 LS Hart (6_CR11) 2012; 122 S Bhattacharya (6_CR13) 2013; 32 H Yoshida (6_CR3) 1998; 273 D Pytel (6_CR9) 2015; 35 Y Bu (6_CR19) 2016; 231 HP Harding (6_CR8) 1999; 397 A Yoshida (6_CR40) 2016; 76 M Barna (6_CR26) 2008; 456 NS Chitnis (6_CR22) 2012; 48 AH Lee (6_CR4) 2003; 23 D Ruggero (6_CR27) 2009; 69 J Bass (6_CR18) 2010; 330 A Avivar-Valderas (6_CR34) 2012; 32 Y Gao (6_CR16) 2012; 32 H Yoshida (6_CR6) 2001; 107 P Aggarwal (6_CR42) 2010; 18 P Zhang (6_CR15) 2002; 22 JE Baggs (6_CR20) 2009; 7 A Garten (6_CR29) 2015; 11 A Verdel (6_CR24) 2004; 303 MG Belinsky (6_CR37) 2002; 62 JO Lipton (6_CR17) 2015; 161 UA Orom (6_CR25) 2007; 43 HP Harding (6_CR14) 2000; 5 29316442 - Dev Cell. 2018 Jan 8;44(1):7-9 29269949 - Nat Cell Biol. 2018 Jan;20(1):4-5 30198016 - Noncoding RNA Investig. 2018 May;2 29259333 - Nat Rev Mol Cell Biol. 2018 Feb;19(2):74-75 |
| References_xml | – volume: 27 start-page: 3424 year: 2008 end-page: 3434 ident: CR39 article-title: N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells publication-title: Oncogene doi: 10.1038/sj.onc.1211017 – volume: 18 start-page: 329 year: 2010 end-page: 340 ident: CR42 article-title: Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase publication-title: Cancer Cell doi: 10.1016/j.ccr.2010.08.012 – volume: 29 start-page: 3881 year: 2010 end-page: 3895 ident: CR10 article-title: PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage publication-title: Oncogene doi: 10.1038/onc.2010.153 – volume: 7 year: 2009 ident: CR20 article-title: Network features of the mammalian circadian clock publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1000052 – volume: 231 start-page: 2088 year: 2016 end-page: 2096 ident: CR19 article-title: PERK integrates oncogenic signaling and cell survival during cancer development publication-title: J. Cell. Physiol. doi: 10.1002/jcp.25336 – volume: 62 start-page: 6172 year: 2002 end-page: 6177 ident: CR37 article-title: Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6) publication-title: Cancer Res. – volume: 107 start-page: 881 year: 2001 end-page: 891 ident: CR6 article-title: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor publication-title: Cell doi: 10.1016/S0092-8674(01)00611-0 – volume: 146 start-page: 904 year: 2011 end-page: 917 ident: CR36 article-title: BET bromodomain inhibition as a therapeutic strategy to target c-Myc publication-title: Cell doi: 10.1016/j.cell.2011.08.017 – volume: 37 start-page: 382 year: 2005 end-page: 390 ident: CR33 article-title: Reverse engineering of regulatory networks in human B cells publication-title: Nat. Genet. doi: 10.1038/ng1532 – volume: 303 start-page: 672 year: 2004 end-page: 676 ident: CR24 article-title: RNAi-mediated targeting of heterochromatin by the RITS complex publication-title: Science doi: 10.1126/science.1093686 – volume: 65 start-page: 3136 year: 2005 end-page: 3145 ident: CR38 article-title: Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-04-2469 – volume: 8 year: 2013 ident: CR35 article-title: Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer publication-title: PLoS ONE doi: 10.1371/journal.pone.0082241 – volume: 12 start-page: 1812 year: 1998 end-page: 1824 ident: CR2 article-title: A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells publication-title: Genes Dev. doi: 10.1101/gad.12.12.1812 – volume: 22 start-page: 3864 year: 2002 end-page: 3874 ident: CR15 article-title: The PERK eukaryotic initiation factor 2α kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.22.11.3864-3874.2002 – volume: 35 start-page: 1207 year: 2015 end-page: 1215 ident: CR9 article-title: Tumor progression and the different faces of the PERK kinase publication-title: Oncogene doi: 10.1038/onc.2015.178 – volume: 397 start-page: 271 year: 1999 end-page: 274 ident: CR8 article-title: Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase publication-title: Nature doi: 10.1038/16729 – volume: 32 start-page: 5129 year: 2012 end-page: 5139 ident: CR16 article-title: PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01009-12 – volume: 48 start-page: 353 year: 2012 end-page: 364 ident: CR22 article-title: miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner publication-title: Mol. Cell doi: 10.1016/j.molcel.2012.08.025 – volume: 18 start-page: 7499 year: 1998 end-page: 7509 ident: CR7 article-title: Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control publication-title: Mol. Cell Biol. doi: 10.1128/MCB.18.12.7499 – volume: 23 start-page: 7448 year: 2003 end-page: 7459 ident: CR4 article-title: XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response publication-title: Mol. Cell Biol. doi: 10.1128/MCB.23.21.7448-7459.2003 – volume: 456 start-page: 971 year: 2008 end-page: 975 ident: CR26 article-title: Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency publication-title: Nature doi: 10.1038/nature07449 – volume: 141 start-page: 38 year: 2011 end-page: 41 ident: CR1 article-title: The cell biology of the unfolded protein response publication-title: Gastroenterology doi: 10.1053/j.gastro.2011.05.018 – volume: 155 start-page: 1464 year: 2013 end-page: 1478 ident: CR31 article-title: Reprogramming of the circadian clock by nutritional challenge publication-title: Cell doi: 10.1016/j.cell.2013.11.034 – volume: 22 start-page: 1009 year: 2015 end-page: 1019 ident: CR28 article-title: MYC disrupts the circadian clock and metabolism in cancer cells publication-title: Cell Metab. doi: 10.1016/j.cmet.2015.09.003 – volume: 108 start-page: 18560 year: 2011 end-page: 18565 ident: CR30 article-title: Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1115753108 – volume: 32 start-page: 4932 year: 2012 end-page: 4940 ident: CR34 article-title: Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK publication-title: Oncogene doi: 10.1038/onc.2012.512 – volume: 12 year: 2016 ident: CR12 article-title: PERK is a haploinsufficient tumor suppressor: gene dose determines tumor-suppressive versus tumor promoting properties of PERK in melanoma publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1006518 – volume: 76 start-page: 2990 year: 2016 end-page: 3002 ident: CR40 article-title: Induction of therapeutic senescence in vemurafenib-resistant melanoma by extended inhibition of CDK4/6 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-15-2931 – volume: 415 start-page: 92 year: 2002 end-page: 96 ident: CR5 article-title: IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA publication-title: Nature doi: 10.1038/415092a – volume: 102 start-page: 10898 year: 2005 end-page: 10903 ident: CR23 article-title: The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0504834102 – volume: 69 start-page: 8839 year: 2009 end-page: 8843 ident: CR27 article-title: The role of Myc-induced protein synthesis in cancer publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-09-1970 – volume: 32 start-page: 4214 year: 2013 end-page: 4221 ident: CR13 article-title: Anti-tumorigenic effects of type 1 interferon are subdued by integrated stress responses publication-title: Oncogene doi: 10.1038/onc.2012.439 – volume: 161 start-page: 1138 year: 2015 end-page: 1151 ident: CR17 article-title: The circadian protein BMAL1 regulates translation in response to S6K1-mediated phosphorylation publication-title: Cell doi: 10.1016/j.cell.2015.04.002 – volume: 330 start-page: 1349 year: 2010 end-page: 1354 ident: CR18 article-title: Circadian integration of metabolism and energetics publication-title: Science doi: 10.1126/science.1195027 – volume: 55 start-page: 7193 year: 2012 end-page: 7207 ident: CR21 article-title: Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1 -indol-5-yl)-7 -pyrrolo[2,3- ]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) publication-title: J. Med. Chem. doi: 10.1021/jm300713s – volume: 273 start-page: 33741 year: 1998 end-page: 33749 ident: CR3 article-title: Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.50.33741 – volume: 5 start-page: 897 year: 2000 end-page: 904 ident: CR14 article-title: PERK is essential for translational regulation and cell survival during the unfolded protein response publication-title: Mol. Cell doi: 10.1016/S1097-2765(00)80330-5 – volume: 122 start-page: 4621 year: 2012 end-page: 4634 ident: CR11 article-title: ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth publication-title: J. Clin. Invest. doi: 10.1172/JCI62973 – volume: 7 year: 2016 ident: CR41 article-title: miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis publication-title: Nat. Commun. doi: 10.1038/ncomms11422 – volume: 11 start-page: 535 year: 2015 end-page: 546 ident: CR29 article-title: Physiological and pathophysiological roles of NAMPT and NAD metabolism publication-title: Nat. Rev. Endocrinol. – volume: 5 start-page: 288 year: 2015 end-page: 303 ident: CR32 article-title: PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-14-0625 – volume: 43 start-page: 162 year: 2007 end-page: 165 ident: CR25 article-title: Isolation of microRNA targets using biotinylated synthetic microRNAs publication-title: Methods doi: 10.1016/j.ymeth.2007.04.007 – volume: 29 start-page: 3881 year: 2010 ident: 6_CR10 publication-title: Oncogene doi: 10.1038/onc.2010.153 – volume: 155 start-page: 1464 year: 2013 ident: 6_CR31 publication-title: Cell doi: 10.1016/j.cell.2013.11.034 – volume: 12 start-page: 1812 year: 1998 ident: 6_CR2 publication-title: Genes Dev. doi: 10.1101/gad.12.12.1812 – volume: 5 start-page: 897 year: 2000 ident: 6_CR14 publication-title: Mol. Cell doi: 10.1016/S1097-2765(00)80330-5 – volume: 231 start-page: 2088 year: 2016 ident: 6_CR19 publication-title: J. Cell. Physiol. doi: 10.1002/jcp.25336 – volume: 76 start-page: 2990 year: 2016 ident: 6_CR40 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-15-2931 – volume: 23 start-page: 7448 year: 2003 ident: 6_CR4 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.23.21.7448-7459.2003 – volume: 102 start-page: 10898 year: 2005 ident: 6_CR23 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0504834102 – volume: 69 start-page: 8839 year: 2009 ident: 6_CR27 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-09-1970 – volume: 7 year: 2016 ident: 6_CR41 publication-title: Nat. Commun. – volume: 273 start-page: 33741 year: 1998 ident: 6_CR3 publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.50.33741 – volume: 43 start-page: 162 year: 2007 ident: 6_CR25 publication-title: Methods doi: 10.1016/j.ymeth.2007.04.007 – volume: 22 start-page: 1009 year: 2015 ident: 6_CR28 publication-title: Cell Metab. doi: 10.1016/j.cmet.2015.09.003 – volume: 330 start-page: 1349 year: 2010 ident: 6_CR18 publication-title: Science doi: 10.1126/science.1195027 – volume: 5 start-page: 288 year: 2015 ident: 6_CR32 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-14-0625 – volume: 146 start-page: 904 year: 2011 ident: 6_CR36 publication-title: Cell doi: 10.1016/j.cell.2011.08.017 – volume: 32 start-page: 5129 year: 2012 ident: 6_CR16 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01009-12 – volume: 161 start-page: 1138 year: 2015 ident: 6_CR17 publication-title: Cell doi: 10.1016/j.cell.2015.04.002 – volume: 27 start-page: 3424 year: 2008 ident: 6_CR39 publication-title: Oncogene doi: 10.1038/sj.onc.1211017 – volume: 141 start-page: 38 year: 2011 ident: 6_CR1 publication-title: Gastroenterology doi: 10.1053/j.gastro.2011.05.018 – volume: 55 start-page: 7193 year: 2012 ident: 6_CR21 publication-title: J. Med. Chem. doi: 10.1021/jm300713s – volume: 62 start-page: 6172 year: 2002 ident: 6_CR37 publication-title: Cancer Res. – volume: 397 start-page: 271 year: 1999 ident: 6_CR8 publication-title: Nature doi: 10.1038/16729 – volume: 11 start-page: 535 year: 2015 ident: 6_CR29 publication-title: Nat. Rev. Endocrinol. doi: 10.1038/nrendo.2015.117 – volume: 12 year: 2016 ident: 6_CR12 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1006518 – volume: 37 start-page: 382 year: 2005 ident: 6_CR33 publication-title: Nat. Genet. doi: 10.1038/ng1532 – volume: 32 start-page: 4932 year: 2012 ident: 6_CR34 publication-title: Oncogene doi: 10.1038/onc.2012.512 – volume: 18 start-page: 7499 year: 1998 ident: 6_CR7 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.18.12.7499 – volume: 48 start-page: 353 year: 2012 ident: 6_CR22 publication-title: Mol. Cell doi: 10.1016/j.molcel.2012.08.025 – volume: 107 start-page: 881 year: 2001 ident: 6_CR6 publication-title: Cell doi: 10.1016/S0092-8674(01)00611-0 – volume: 32 start-page: 4214 year: 2013 ident: 6_CR13 publication-title: Oncogene doi: 10.1038/onc.2012.439 – volume: 456 start-page: 971 year: 2008 ident: 6_CR26 publication-title: Nature doi: 10.1038/nature07449 – volume: 303 start-page: 672 year: 2004 ident: 6_CR24 publication-title: Science doi: 10.1126/science.1093686 – volume: 65 start-page: 3136 year: 2005 ident: 6_CR38 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-04-2469 – volume: 35 start-page: 1207 year: 2015 ident: 6_CR9 publication-title: Oncogene doi: 10.1038/onc.2015.178 – volume: 18 start-page: 329 year: 2010 ident: 6_CR42 publication-title: Cancer Cell doi: 10.1016/j.ccr.2010.08.012 – volume: 8 year: 2013 ident: 6_CR35 publication-title: PLoS ONE doi: 10.1371/journal.pone.0082241 – volume: 122 start-page: 4621 year: 2012 ident: 6_CR11 publication-title: J. Clin. Invest. doi: 10.1172/JCI62973 – volume: 108 start-page: 18560 year: 2011 ident: 6_CR30 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1115753108 – volume: 22 start-page: 3864 year: 2002 ident: 6_CR15 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.22.11.3864-3874.2002 – volume: 415 start-page: 92 year: 2002 ident: 6_CR5 publication-title: Nature doi: 10.1038/415092a – volume: 7 year: 2009 ident: 6_CR20 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1000052 – reference: 29259333 - Nat Rev Mol Cell Biol. 2018 Feb;19(2):74-75 – reference: 29316442 - Dev Cell. 2018 Jan 8;44(1):7-9 – reference: 29269949 - Nat Cell Biol. 2018 Jan;20(1):4-5 – reference: 30198016 - Noncoding RNA Investig. 2018 May;2: |
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| Title | A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival |
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