Removal of metronidazole from aqueous media by C. vulgaris

Schematic diagram of MDZ removal in Chlorella vulgaris culture. [Display omitted] •Metronidazole is efficiently removed during algal treatment.•Metronidazole is removed via sorption onto the biomass.•Metronidazole showed toxicity to C. vulgaris at stationary phase of life cycle.•The removal efficien...

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Published in:	Journal of hazardous materials Vol. 384; p. 121400
Main Authors:	Hena, Sufia, Gutierrez, Leo, Croué, Jean-Philippe
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15.02.2020 Elsevier
Subjects:	acute toxicity Adsorption antibiotics Biomass biomass production C. vulgaris Chlorella vulgaris - drug effects Chlorella vulgaris - growth & development Chlorella vulgaris - metabolism Dose-Response Relationship, Drug EC50 Environmental Sciences inoculum Metronidazole Metronidazole - analysis Metronidazole - metabolism Metronidazole - toxicity Microalgae - growth & development Microalgae - metabolism Models, Theoretical Surface Properties Toxicity Tests Water Pollutants, Chemical - analysis Water Pollutants, Chemical - metabolism Water Pollutants, Chemical - toxicity Water Purification - methods zeta potential C. vulgaris EC50 Metronidazole Adsorption
ISSN:	0304-3894, 1873-3336, 1873-3336
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Abstract	Schematic diagram of MDZ removal in Chlorella vulgaris culture. [Display omitted] •Metronidazole is efficiently removed during algal treatment.•Metronidazole is removed via sorption onto the biomass.•Metronidazole showed toxicity to C. vulgaris at stationary phase of life cycle.•The removal efficiency of C. vulgaris decreased with increase of antibiotic. This current study investigated the removal of metronidazole from aqueous media by C. vulgaris. Two different initial sizes of inoculum (0.05 and 0.5 g L−1) were tested for a wide concentration range of metronidazole (1–50 μM). The effect of metronidazole concentrations on biomass production was studied for 20 days. The exopolymeric substances (EPS) were quantified and correlated with the removal of antibiotics from aqueous media. Specifically, MDZ stimulated the production of EPS in C. vulgaris, which played the major role in the adsorption of this antibiotic. Also, metronidazole significantly influenced the zeta potential of C. vulgaris in the test cultures, indicating a change in surface characteristics. This decrease in surface negative charge caused auto-flocculation phenomena at a stationary phase. Chronic and acute toxicity experiments showed that metronidazole was harmful to C. vulgaris at stationary phase. Results from this study would advance our knowledge on the treatment of metronidazole-contaminated waters with C. vulgaris as a green technology-oriented process.
AbstractList	This current study investigated the removal of metronidazole from aqueous media by C. vulgaris. Two different initial sizes of inoculum (0.05 and 0.5 g L⁻¹) were tested for a wide concentration range of metronidazole (1–50 μM). The effect of metronidazole concentrations on biomass production was studied for 20 days. The exopolymeric substances (EPS) were quantified and correlated with the removal of antibiotics from aqueous media. Specifically, MDZ stimulated the production of EPS in C. vulgaris, which played the major role in the adsorption of this antibiotic. Also, metronidazole significantly influenced the zeta potential of C. vulgaris in the test cultures, indicating a change in surface characteristics. This decrease in surface negative charge caused auto-flocculation phenomena at a stationary phase. Chronic and acute toxicity experiments showed that metronidazole was harmful to C. vulgaris at stationary phase. Results from this study would advance our knowledge on the treatment of metronidazole-contaminated waters with C. vulgaris as a green technology-oriented process. This current study investigated the removal of metronidazole from aqueous media by C. vulgaris. Two different initial sizes of inoculum (0.05 and 0.5 g L ) were tested for a wide concentration range of metronidazole (1-50 μM). The effect of metronidazole concentrations on biomass production was studied for 20 days. The exopolymeric substances (EPS) were quantified and correlated with the removal of antibiotics from aqueous media. Specifically, MDZ stimulated the production of EPS in C. vulgaris, which played the major role in the adsorption of this antibiotic. Also, metronidazole significantly influenced the zeta potential of C. vulgaris in the test cultures, indicating a change in surface characteristics. This decrease in surface negative charge caused auto-flocculation phenomena at a stationary phase. Chronic and acute toxicity experiments showed that metronidazole was harmful to C. vulgaris at stationary phase. Results from this study would advance our knowledge on the treatment of metronidazole-contaminated waters with C. vulgaris as a green technology-oriented process. Schematic diagram of MDZ removal in Chlorella vulgaris culture. [Display omitted] •Metronidazole is efficiently removed during algal treatment.•Metronidazole is removed via sorption onto the biomass.•Metronidazole showed toxicity to C. vulgaris at stationary phase of life cycle.•The removal efficiency of C. vulgaris decreased with increase of antibiotic. This current study investigated the removal of metronidazole from aqueous media by C. vulgaris. Two different initial sizes of inoculum (0.05 and 0.5 g L−1) were tested for a wide concentration range of metronidazole (1–50 μM). The effect of metronidazole concentrations on biomass production was studied for 20 days. The exopolymeric substances (EPS) were quantified and correlated with the removal of antibiotics from aqueous media. Specifically, MDZ stimulated the production of EPS in C. vulgaris, which played the major role in the adsorption of this antibiotic. Also, metronidazole significantly influenced the zeta potential of C. vulgaris in the test cultures, indicating a change in surface characteristics. This decrease in surface negative charge caused auto-flocculation phenomena at a stationary phase. Chronic and acute toxicity experiments showed that metronidazole was harmful to C. vulgaris at stationary phase. Results from this study would advance our knowledge on the treatment of metronidazole-contaminated waters with C. vulgaris as a green technology-oriented process. his current study investigated the removal of metronidazole from aqueous media by C. vulgaris. Two different initial sizes of inoculum (0.05 and 0.5 g L−1) were tested for a wide concentration range of metronidazole (1–50 μM). The effect of metronidazole concentrations on biomass production was studied for 20 days. The exopolymeric substances (EPS) were quantified and correlated with the removal of antibiotics from aqueous media. Specifically, MDZ stimulated the production of EPS in C. vulgaris, which played the major role in the adsorption of this antibiotic. Also, metronidazole significantly influenced the zeta potential of C. vulgaris in the test cultures, indicating a change in surface characteristics. This decrease in surface negative charge caused auto-flocculation phenomena at a stationary phase. Chronic and acute toxicity experiments showed that metronidazole was harmful to C. vulgaris at stationary phase. Results from this study would advance our knowledge on the treatment of metronidazole-contaminated waters with C. vulgaris as a green technology-oriented process. This current study investigated the removal of metronidazole from aqueous media by C. vulgaris. Two different initial sizes of inoculum (0.05 and 0.5 g L-1) were tested for a wide concentration range of metronidazole (1-50 μM). The effect of metronidazole concentrations on biomass production was studied for 20 days. The exopolymeric substances (EPS) were quantified and correlated with the removal of antibiotics from aqueous media. Specifically, MDZ stimulated the production of EPS in C. vulgaris, which played the major role in the adsorption of this antibiotic. Also, metronidazole significantly influenced the zeta potential of C. vulgaris in the test cultures, indicating a change in surface characteristics. This decrease in surface negative charge caused auto-flocculation phenomena at a stationary phase. Chronic and acute toxicity experiments showed that metronidazole was harmful to C. vulgaris at stationary phase. Results from this study would advance our knowledge on the treatment of metronidazole-contaminated waters with C. vulgaris as a green technology-oriented process.This current study investigated the removal of metronidazole from aqueous media by C. vulgaris. Two different initial sizes of inoculum (0.05 and 0.5 g L-1) were tested for a wide concentration range of metronidazole (1-50 μM). The effect of metronidazole concentrations on biomass production was studied for 20 days. The exopolymeric substances (EPS) were quantified and correlated with the removal of antibiotics from aqueous media. Specifically, MDZ stimulated the production of EPS in C. vulgaris, which played the major role in the adsorption of this antibiotic. Also, metronidazole significantly influenced the zeta potential of C. vulgaris in the test cultures, indicating a change in surface characteristics. This decrease in surface negative charge caused auto-flocculation phenomena at a stationary phase. Chronic and acute toxicity experiments showed that metronidazole was harmful to C. vulgaris at stationary phase. Results from this study would advance our knowledge on the treatment of metronidazole-contaminated waters with C. vulgaris as a green technology-oriented process.
ArticleNumber	121400
Author	Gutierrez, Leo Croué, Jean-Philippe Hena, Sufia
Author_xml	– sequence: 1 givenname: Sufia surname: Hena fullname: Hena, Sufia organization: Curtin Water Quality Research Centre, Department of Chemistry, Curtin University, Australia – sequence: 2 givenname: Leo orcidid: 0000-0001-7573-6635 surname: Gutierrez fullname: Gutierrez, Leo organization: Facultad del Mar y Medio Ambiente, Universidad del Pacifico, Ecuador – sequence: 3 givenname: Jean-Philippe surname: Croué fullname: Croué, Jean-Philippe email: jean-philippe.croue@curtin.edu.au organization: Curtin Water Quality Research Centre, Department of Chemistry, Curtin University, Australia
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Keywords	C. vulgaris EC50 Metronidazole Adsorption
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Snippet	Schematic diagram of MDZ removal in Chlorella vulgaris culture. [Display omitted] •Metronidazole is efficiently removed during algal treatment.•Metronidazole... This current study investigated the removal of metronidazole from aqueous media by C. vulgaris. Two different initial sizes of inoculum (0.05 and 0.5 g L )... This current study investigated the removal of metronidazole from aqueous media by C. vulgaris. Two different initial sizes of inoculum (0.05 and 0.5 g L-1)... This current study investigated the removal of metronidazole from aqueous media by C. vulgaris. Two different initial sizes of inoculum (0.05 and 0.5 g L⁻¹)... his current study investigated the removal of metronidazole from aqueous media by C. vulgaris. Two different initial sizes of inoculum (0.05 and 0.5 g L−1)...
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SubjectTerms	acute toxicity Adsorption antibiotics Biomass biomass production C. vulgaris Chlorella vulgaris - drug effects Chlorella vulgaris - growth & development Chlorella vulgaris - metabolism Dose-Response Relationship, Drug EC50 Environmental Sciences inoculum Metronidazole Metronidazole - analysis Metronidazole - metabolism Metronidazole - toxicity Microalgae - growth & development Microalgae - metabolism Models, Theoretical Surface Properties Toxicity Tests Water Pollutants, Chemical - analysis Water Pollutants, Chemical - metabolism Water Pollutants, Chemical - toxicity Water Purification - methods zeta potential
Title	Removal of metronidazole from aqueous media by C. vulgaris
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