Pairing structural reconstruction with catalytic competence to evaluate the mechanisms of key enzymes in the folate‐mediated one‐carbon pathway

Mammalian metabolism comprises a series of interlinking pathways that include two major cycles: the folate and methionine cycles. The folate‐mediated metabolic cycle uses several oxidation states of tetrahydrofolate to carry activated one‐carbon units to be readily used and interconverted within the...

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Bibliographic Details
Published in:	The FEBS journal Vol. 290; no. 9; pp. 2279 - 2291
Main Authors:	Zhao, Li Na, Kaldis, Philipp
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.05.2023
Subjects:	Activated carbon Animals Antineoplastic Agents Cancer Cancer and Oncology Cancer och onkologi Carbon Cell proliferation Clinical Medicine CRISPR DHFR Drug development enzyme catalysis enzyme reaction mechanism Enzymes folate folate metabolism folate‐mediated one‐carbon pathway Folic acid Folic Acid - metabolism Genomes Homology Humans Klinisk medicin loss-of-function mutation mammals Mammals - metabolism Medical and Health Sciences Medicin och hälsovetenskap Metabolism Methionine Methylation Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism MTHFD1 MTHFD2 MTHFD2L Neoplasms - genetics Nucleotides Oxidation Reaction mechanisms SHMT2 Tetrahydrofolic acid TYMS viability Vitamin B DHFR folate MTHFD1 MTHFD2 SHMT2 MTHFD2L enzyme catalysis TYMS enzyme reaction mechanism folate metabolism folate-mediated one-carbon pathway
ISSN:	1742-464X, 1742-4658, 1742-4658
Online Access:	Get full text
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