Impact of hepatitis B virus surface protein mutations on the diagnosis of occult hepatitis B virus infection

Genotype D occult hepatitis B virus (HBV) infections (OBIs) have a high frequency of amino acid substitutions in the major hydrophilic region of the small surface protein (S protein). This possibly reflects an escape mutation mechanism to evade detection by the host immune system. Mutations may also...

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Bibliographic Details
Published in:	Hepatology (Baltimore, Md.) Vol. 52; no. 5; pp. 1600 - 1610
Main Authors:	El Chaar, Mira, Candotti, Daniel, Crowther, R. Anthony, Allain, Jean Pierre
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2010 Wiley Wolters Kluwer Health, Inc
Subjects:	Amino Acid Substitution Antigens Base Sequence Biological and medical sciences Blood Donors Cloning, Molecular DNA Primers Enzyme-Linked Immunosorbent Assay Gastroenterology. Liver. Pancreas. Abdomen Genetic Variation Genotype Hepatitis Hepatitis B Hepatitis B - blood Hepatitis B - diagnosis Hepatitis B - genetics Hepatitis B - immunology Hepatitis B Core Antigens - genetics Hepatitis B Surface Antigens - genetics Hepatitis B Surface Antigens - immunology Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B virus - pathogenicity Hepatology Human viral diseases Humans Infectious diseases Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Molecular Sequence Data Mutagenesis, Site-Directed Mutation Polymerase Chain Reaction Proteins Viral diseases Viral hepatitis Orthohepadnavirus Hepatic disease Protein Infection Virus Viral hepatitis B Hepadnaviridae Viral disease Gastroenterology Digestive diseases Diagnosis Mutation Hepatitis B virus
ISSN:	0270-9139, 1527-3350, 1527-3350
Online Access:	Get full text
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