MnAl Layered Double Hydroxide Nanoparticles as a Dual‐Functional Platform for Magnetic Resonance Imaging and siRNA Delivery

Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this work, dually functionalised manganese‐based layered double hydroxide nanoparticles (Mn‐LDH) were examined as an effective anticancer drug/gene delivery system and for T1‐...

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Veröffentlicht in:Chemistry : a European journal Jg. 23; H. 57; S. 14299 - 14306
Hauptverfasser: Zuo, Huali, Chen, Weiyu, Li, Bei, Xu, Kewei, Cooper, Helen, Gu, Zi, Xu, Zhi Ping
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Germany Wiley Subscription Services, Inc 12.10.2017
Schlagworte:
Aluminum - chemistry
Anticancer properties
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biocompatibility
Brain
Brain cancer
Brain Neoplasms - diagnosis
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Cancer
Cell death
Cell Line, Tumor
Cell Survival
Chemistry
Contrast agents
Contrast Media - chemistry
Cytotoxicity
drug delivery
Drug delivery systems
Gene transfer
Gene Transfer Techniques
Genetic Therapy
Humans
Hydroxides
Hydroxides - chemistry
layered compounds
Magnesium - chemistry
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Manganese
Manganese - chemistry
Nanoparticles
Nanoparticles - chemistry
Neuroimaging
Neurons - pathology
NMR
Nuclear magnetic resonance
Particle Size
RNA, Small Interfering - administration & dosage
RNA, Small Interfering - chemistry
siRNA
Surface Properties
Theranostic Nanomedicine
theranostics
Therapy
Toxicity
theranostics
layered compounds
nanoparticles
drug delivery
nuclear magnetic resonance
ISSN:0947-6539, 1521-3765, 1521-3765
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Zusammenfassung:Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this work, dually functionalised manganese‐based layered double hydroxide nanoparticles (Mn‐LDH) were examined as an effective anticancer drug/gene delivery system and for T1‐weighted magnetic resonance imaging (MRI) in brain cancer theranostics. Such Mn‐LDH have been shown to accommodate dsDNA/siRNAs and efficiently deliver them to Neuro‐2a cells (N2a). Mn‐LDH have also shown high biocompatibility with low cytotoxicity. Importantly, the cell‐death siRNA (CD‐siRNA) delivered with Mn‐LDH more efficiently kills brain cancer cells than the free CD‐siRNA. Moreover, Mn‐LDH can act as excellent contrast agents for MRI, with an r1 value of 4.47 mm−1 s−1, which is even higher than that of commercial contrast agents based on Gd complexes (r1=3.4 mm−1 s−1). Altogether, the high delivery efficacy and MRI contrast capability make dual‐functional Mn‐LDH potential bimodal agents for simultaneous cancer diagnosis and therapy. Multifunctional nanoparticles: Dual‐functional manganese‐based layered double hydroxide nanoparticles (Mn‐LDH) were fabricated by a co‐precipitation method. Their pH‐sensitive behaviour significantly enhanced T1‐weighted magnetic resonance imaging, which is highly beneficial for the detection of tumour cells and tissues. Anticancer therapeutics carried by Mn‐LDH more efficiently killed cancer cells than their free counterparts (see figure).
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0947-6539
1521-3765
1521-3765
DOI:10.1002/chem.201702835