MnAl Layered Double Hydroxide Nanoparticles as a Dual‐Functional Platform for Magnetic Resonance Imaging and siRNA Delivery

Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this work, dually functionalised manganese‐based layered double hydroxide nanoparticles (Mn‐LDH) were examined as an effective anticancer drug/gene delivery system and for T1‐...

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Vydáno v:	Chemistry : a European journal Ročník 23; číslo 57; s. 14299 - 14306
Hlavní autoři:	Zuo, Huali, Chen, Weiyu, Li, Bei, Xu, Kewei, Cooper, Helen, Gu, Zi, Xu, Zhi Ping
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Germany Wiley Subscription Services, Inc 12.10.2017
Témata:	Aluminum - chemistry Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biocompatibility Brain Brain cancer Brain Neoplasms - diagnosis Brain Neoplasms - pathology Brain Neoplasms - therapy Cancer Cell death Cell Line, Tumor Cell Survival Chemistry Contrast agents Contrast Media - chemistry Cytotoxicity drug delivery Drug delivery systems Gene transfer Gene Transfer Techniques Genetic Therapy Humans Hydroxides Hydroxides - chemistry layered compounds Magnesium - chemistry Magnetic resonance imaging Magnetic Resonance Imaging - methods Manganese Manganese - chemistry Nanoparticles Nanoparticles - chemistry Neuroimaging Neurons - pathology NMR Nuclear magnetic resonance Particle Size RNA, Small Interfering - administration & dosage RNA, Small Interfering - chemistry siRNA Surface Properties Theranostic Nanomedicine theranostics Therapy Toxicity theranostics layered compounds nanoparticles drug delivery nuclear magnetic resonance
ISSN:	0947-6539, 1521-3765, 1521-3765
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Abstract	Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this work, dually functionalised manganese‐based layered double hydroxide nanoparticles (Mn‐LDH) were examined as an effective anticancer drug/gene delivery system and for T1‐weighted magnetic resonance imaging (MRI) in brain cancer theranostics. Such Mn‐LDH have been shown to accommodate dsDNA/siRNAs and efficiently deliver them to Neuro‐2a cells (N2a). Mn‐LDH have also shown high biocompatibility with low cytotoxicity. Importantly, the cell‐death siRNA (CD‐siRNA) delivered with Mn‐LDH more efficiently kills brain cancer cells than the free CD‐siRNA. Moreover, Mn‐LDH can act as excellent contrast agents for MRI, with an r1 value of 4.47 mm−1 s−1, which is even higher than that of commercial contrast agents based on Gd complexes (r1=3.4 mm−1 s−1). Altogether, the high delivery efficacy and MRI contrast capability make dual‐functional Mn‐LDH potential bimodal agents for simultaneous cancer diagnosis and therapy. Multifunctional nanoparticles: Dual‐functional manganese‐based layered double hydroxide nanoparticles (Mn‐LDH) were fabricated by a co‐precipitation method. Their pH‐sensitive behaviour significantly enhanced T1‐weighted magnetic resonance imaging, which is highly beneficial for the detection of tumour cells and tissues. Anticancer therapeutics carried by Mn‐LDH more efficiently killed cancer cells than their free counterparts (see figure).
AbstractList	Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this work, dually functionalised manganese-based layered double hydroxide nanoparticles (Mn-LDH) were examined as an effective anticancer drug/gene delivery system and for T -weighted magnetic resonance imaging (MRI) in brain cancer theranostics. Such Mn-LDH have been shown to accommodate dsDNA/siRNAs and efficiently deliver them to Neuro-2a cells (N2a). Mn-LDH have also shown high biocompatibility with low cytotoxicity. Importantly, the cell-death siRNA (CD-siRNA) delivered with Mn-LDH more efficiently kills brain cancer cells than the free CD-siRNA. Moreover, Mn-LDH can act as excellent contrast agents for MRI, with an r value of 4.47 mm s , which is even higher than that of commercial contrast agents based on Gd complexes (r =3.4 mm s ). Altogether, the high delivery efficacy and MRI contrast capability make dual-functional Mn-LDH potential bimodal agents for simultaneous cancer diagnosis and therapy. Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this work, dually functionalised manganese‐based layered double hydroxide nanoparticles (Mn‐LDH) were examined as an effective anticancer drug/gene delivery system and for T 1 ‐weighted magnetic resonance imaging (MRI) in brain cancer theranostics. Such Mn‐LDH have been shown to accommodate dsDNA/siRNAs and efficiently deliver them to Neuro‐2a cells (N2a). Mn‐LDH have also shown high biocompatibility with low cytotoxicity. Importantly, the cell‐death siRNA (CD‐siRNA) delivered with Mn‐LDH more efficiently kills brain cancer cells than the free CD‐siRNA. Moreover, Mn‐LDH can act as excellent contrast agents for MRI, with an r 1 value of 4.47 m m −1 s −1 , which is even higher than that of commercial contrast agents based on Gd complexes ( r 1 =3.4 m m −1 s −1 ). Altogether, the high delivery efficacy and MRI contrast capability make dual‐functional Mn‐LDH potential bimodal agents for simultaneous cancer diagnosis and therapy. Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this work, dually functionalised manganese-based layered double hydroxide nanoparticles (Mn-LDH) were examined as an effective anticancer drug/gene delivery system and for T1-weighted magnetic resonance imaging (MRI) in brain cancer theranostics. Such Mn-LDH have been shown to accommodate dsDNA/siRNAs and efficiently deliver them to Neuro-2a cells (N2a). Mn-LDH have also shown high biocompatibility with low cytotoxicity. Importantly, the cell-death siRNA (CD-siRNA) delivered with Mn-LDH more efficiently kills brain cancer cells than the free CD-siRNA. Moreover, Mn-LDH can act as excellent contrast agents for MRI, with an r1 value of 4.47mm-1s-1, which is even higher than that of commercial contrast agents based on Gd complexes (r1=3.4mm-1s-1). Altogether, the high delivery efficacy and MRI contrast capability make dual-functional Mn-LDH potential bimodal agents for simultaneous cancer diagnosis and therapy. Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this work, dually functionalised manganese-based layered double hydroxide nanoparticles (Mn-LDH) were examined as an effective anticancer drug/gene delivery system and for T1 -weighted magnetic resonance imaging (MRI) in brain cancer theranostics. Such Mn-LDH have been shown to accommodate dsDNA/siRNAs and efficiently deliver them to Neuro-2a cells (N2a). Mn-LDH have also shown high biocompatibility with low cytotoxicity. Importantly, the cell-death siRNA (CD-siRNA) delivered with Mn-LDH more efficiently kills brain cancer cells than the free CD-siRNA. Moreover, Mn-LDH can act as excellent contrast agents for MRI, with an r1 value of 4.47 mm-1 s-1 , which is even higher than that of commercial contrast agents based on Gd complexes (r1 =3.4 mm-1 s-1 ). Altogether, the high delivery efficacy and MRI contrast capability make dual-functional Mn-LDH potential bimodal agents for simultaneous cancer diagnosis and therapy.Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this work, dually functionalised manganese-based layered double hydroxide nanoparticles (Mn-LDH) were examined as an effective anticancer drug/gene delivery system and for T1 -weighted magnetic resonance imaging (MRI) in brain cancer theranostics. Such Mn-LDH have been shown to accommodate dsDNA/siRNAs and efficiently deliver them to Neuro-2a cells (N2a). Mn-LDH have also shown high biocompatibility with low cytotoxicity. Importantly, the cell-death siRNA (CD-siRNA) delivered with Mn-LDH more efficiently kills brain cancer cells than the free CD-siRNA. Moreover, Mn-LDH can act as excellent contrast agents for MRI, with an r1 value of 4.47 mm-1 s-1 , which is even higher than that of commercial contrast agents based on Gd complexes (r1 =3.4 mm-1 s-1 ). Altogether, the high delivery efficacy and MRI contrast capability make dual-functional Mn-LDH potential bimodal agents for simultaneous cancer diagnosis and therapy. Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this work, dually functionalised manganese‐based layered double hydroxide nanoparticles (Mn‐LDH) were examined as an effective anticancer drug/gene delivery system and for T1‐weighted magnetic resonance imaging (MRI) in brain cancer theranostics. Such Mn‐LDH have been shown to accommodate dsDNA/siRNAs and efficiently deliver them to Neuro‐2a cells (N2a). Mn‐LDH have also shown high biocompatibility with low cytotoxicity. Importantly, the cell‐death siRNA (CD‐siRNA) delivered with Mn‐LDH more efficiently kills brain cancer cells than the free CD‐siRNA. Moreover, Mn‐LDH can act as excellent contrast agents for MRI, with an r1 value of 4.47 mm−1 s−1, which is even higher than that of commercial contrast agents based on Gd complexes (r1=3.4 mm−1 s−1). Altogether, the high delivery efficacy and MRI contrast capability make dual‐functional Mn‐LDH potential bimodal agents for simultaneous cancer diagnosis and therapy. Multifunctional nanoparticles: Dual‐functional manganese‐based layered double hydroxide nanoparticles (Mn‐LDH) were fabricated by a co‐precipitation method. Their pH‐sensitive behaviour significantly enhanced T1‐weighted magnetic resonance imaging, which is highly beneficial for the detection of tumour cells and tissues. Anticancer therapeutics carried by Mn‐LDH more efficiently killed cancer cells than their free counterparts (see figure).
Author	Xu, Zhi Ping Li, Bei Zuo, Huali Gu, Zi Chen, Weiyu Xu, Kewei Cooper, Helen
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Snippet	Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this work, dually functionalised...
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SubjectTerms	Aluminum - chemistry Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biocompatibility Brain Brain cancer Brain Neoplasms - diagnosis Brain Neoplasms - pathology Brain Neoplasms - therapy Cancer Cell death Cell Line, Tumor Cell Survival Chemistry Contrast agents Contrast Media - chemistry Cytotoxicity drug delivery Drug delivery systems Gene transfer Gene Transfer Techniques Genetic Therapy Humans Hydroxides Hydroxides - chemistry layered compounds Magnesium - chemistry Magnetic resonance imaging Magnetic Resonance Imaging - methods Manganese Manganese - chemistry Nanoparticles Nanoparticles - chemistry Neuroimaging Neurons - pathology NMR Nuclear magnetic resonance Particle Size RNA, Small Interfering - administration & dosage RNA, Small Interfering - chemistry siRNA Surface Properties Theranostic Nanomedicine theranostics Therapy Toxicity
Title	MnAl Layered Double Hydroxide Nanoparticles as a Dual‐Functional Platform for Magnetic Resonance Imaging and siRNA Delivery
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