Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia

Reduced postprandial muscle proteolysis is mainly due to increased insulin availability. Whether rates of proteolysis in response to low physiologic doses of insulin are affected by aging is unknown. We tested the hypothesis that suppression of leg protein breakdown (LPB) by insulin is blunted in ol...

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Bibliographic Details
Published in:	The American journal of clinical nutrition Vol. 90; no. 5; p. 1343
Main Authors:	Wilkes, Emilie A, Selby, Anna L, Atherton, Philip J, Patel, Rekha, Rankin, Debbie, Smith, Ken, Rennie, Michael J
Format:	Journal Article
Language:	English
Published:	United States 01.11.2009
Subjects:	Adult Aged Aging - physiology Amino Acids - blood Amino Acids - metabolism Female Glucose Clamp Technique Humans Insulin - blood Insulin - pharmacology Leg Leucine - metabolism Male Muscle Proteins - drug effects Muscle Proteins - metabolism Muscular Diseases - prevention & control Proteins - metabolism Proto-Oncogene Proteins c-akt - metabolism
ISSN:	1938-3207, 1938-3207
Online Access:	Get more information
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