Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia

Reduced postprandial muscle proteolysis is mainly due to increased insulin availability. Whether rates of proteolysis in response to low physiologic doses of insulin are affected by aging is unknown. We tested the hypothesis that suppression of leg protein breakdown (LPB) by insulin is blunted in ol...

Ausführliche Beschreibung