Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity

Hypothesis: Childhood obesity is accompanied by low-grade systemic inflammation, which contributes to the development of insulin resistance and cardiovascular complications later in life. As vitamin D exhibits profound immunomodulatory functions and vitamin D deficiency is highly prevalent in childh...

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Bibliographic Details
Published in:	International Journal of Obesity Vol. 38; no. 1; pp. 46 - 52
Main Authors:	Reyman, M, Verrijn Stuart, A A, van Summeren, M, Rakhshandehroo, M, Nuboer, R, de Boer, F K, van den Ham, H J, Kalkhoven, E, Prakken, B, Schipper, H S
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.01.2014 Nature Publishing Group
Subjects:	631/250/256 631/443/810 692/699/2743/393 692/700/1720 Adhesion Adolescent Alfacalcidol Biological and medical sciences Blood Glucose - metabolism Body Mass Index Calcifediol Chemokines - blood Child Cluster Analysis Coronary Artery Disease - prevention & control Cross-Sectional Studies Dietary Supplements Epidemiology Female Gender General aspects Health aspects Health Promotion and Disease Prevention Hospitals Humans Hypotheses Immunology Inflammation - blood Inflammation - etiology Inflammation - immunology Inflammation Mediators - blood Insulin resistance Insulin Resistance - immunology Internal Medicine Male Medical research Medical sciences Medicine Medicine & Public Health Medicine, Experimental Metabolic Diseases Metabolism Obesity Obesity in children Pediatric Obesity - blood Pediatric Obesity - complications Pediatric Obesity - immunology pediatric-original-article Pediatrics Prevalence Public Health Risk factors Vitamin D Vitamin D - analogs & derivatives Vitamin D - therapeutic use Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D Deficiency - immunology Vitamin deficiency Vitamins - therapeutic use United States > US Netherlands insulin sensitivity adipokines inflammation vitamin D childhood obesity Human Obesity Pancreatic hormone Nutrition Insulin sensitivity Nutrition disorder Metabolic diseases Inflammation Adipokine Insulin Association Vitamin D Mediator Child Nutritional status
ISSN:	0307-0565, 1476-5497, 1476-5497
Online Access:	Get full text
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