Data- and knowledge-derived functional landscape of human solute carriers

The human solute carrier (SLC) superfamily of ~460 membrane transporters remains the largest understudied protein family despite its therapeutic potential. To advance SLC research, we developed a comprehensive knowledgebase that integrates systematic multi-omics data sets with selected curated infor...

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Veröffentlicht in:	Molecular systems biology Jg. 21; H. 6; S. 599 - 631
Hauptverfasser:	Goldmann, Ulrich, Wiedmer, Tabea, Garofoli, Andrea, Sedlyarov, Vitaly, Bichler, Manuel, Haladik, Ben, Wolf, Gernot, Christodoulaki, Eirini, Ingles-Prieto, Alvaro, Ferrada, Evandro, Frommelt, Fabian, Teoh, Shao Thing, Leippe, Philipp, Onea, Gabriel, Pfeifer, Martin, Kohlbrenner, Mariah, Chang, Lena, Selzer, Paul, Reinhardt, Jürgen, Digles, Daniela, Ecker, Gerhard F, Osthushenrich, Tanja, MacNamara, Aidan, Malarstig, Anders, Hepworth, David, Superti-Furga, Giulio
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 02.06.2025 Springer Nature
Schlagworte:	Biomedical and Life Sciences Computational Biology - methods Data Mining Databases, Protein EMBO20 EMBO22 Human Gene Function Humans Knowledge Bases Knowledgebase Life Sciences Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Membrane Transporters Molecular Sequence Annotation Multimodal Data Integration Solute Carrier Proteins - genetics Solute Carrier Proteins - metabolism Solute Carriers Systems Biology Human Gene Function Solute Carriers Knowledgebase Membrane Transporters Multimodal Data Integration
ISSN:	1744-4292, 1744-4292
Online-Zugang:	Volltext
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