Determination of free and total vincristine in human plasma after intravenous administration of vincristine sulfate liposome injection using ultra-high performance liquid chromatography tandem mass spectrometry

► An assay for the determination of free and total vincristine (VCR) in plasma. ► The first validated method of separating free VCR from liposomes. ► The SPE method was feasible to separate free VCR without liposomal damage. ► The present method was validated according to FDA guidance. ► The method...

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Bibliographic Details
Published in:	Journal of Chromatography A Vol. 1275; pp. 61 - 69
Main Authors:	Yang, Fen, Wang, Hongyun, Liu, Ming, Hu, Pei, Jiang, Ji
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01.02.2013 Elsevier
Subjects:	Analysis anticarcinogenic activity Antineoplastic Agents - administration & dosage Antineoplastic Agents - blood Biological and medical sciences cholesterol Chromatography, High Pressure Liquid - methods Drug Stability Free vincristine General pharmacology Humans intravenous injection ionization Linear Models Liposomes - administration & dosage Liposomes - blood Liquid-Liquid Extraction Lymphoma Lymphoma - blood Lymphoma - drug therapy Medical sciences monitoring pharmacokinetics Pharmacology. Drug treatments phospholipids Reproducibility of Results Sensitivity and Specificity Solid Phase Extraction SPE Spectrometry, Mass, Electrospray Ionization tandem mass spectrometry Tandem Mass Spectrometry - methods UHPLC–MS/MS ultra-performance liquid chromatography vincristine Vincristine - administration & dosage Vincristine - blood Vincristine - pharmacokinetics Vincristine sulfate liposomes Vincristine sulfate liposomes UHPLC–MS/MS SPE Lymphoma Free vincristine Antineoplastic agent Encapsulation Ultra performance liquid chromatography Solid phase extraction Biological fluid Tandem mass spectrometry Chemical analysis Intravenous administration Free form Solvent extraction Electrospray Blood Chemical enrichment Blood plasma Alkaloid Sample preparation Lymphoproliferative syndrome Antimitotic Quantitative analysis Trace analysis Human Validation Liquid liquid extraction Coupled method Liposome Patient Malignant hemopathy Vincristine UHPLC-MS/MS Pharmacokinetics Cancer
ISSN:	0021-9673, 1873-3778, 1873-3778
Online Access:	Get full text
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