Occurrence and fate of the antidiabetic drug metformin and its metabolite guanylurea in the environment and during drinking water treatment

Metformin, an antidiabetic drug with one of the highest consumption rates of all pharmaceuticals worldwide, is biologically degraded to guanylurea in wastewater treatment plants. Due to high metformin influent concentrations of up to 100 μg/L and its high but incomplete degradation both compounds ar...

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Bibliographic Details
Published in:	Water research (Oxford) Vol. 46; no. 15; pp. 4790 - 4802
Main Authors:	Scheurer, Marco, Michel, Amandine, Brauch, Heinz-Jürgen, Ruck, Wolfgang, Sacher, Frank
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 01.10.2012 Elsevier
Subjects:	activated carbon analogs & derivatives analysis Antidiabetic drugs Applied sciences biodegradation Bioreactors chemistry chlorination chlorine Chlorine - chemistry Disinfection drinking water Drinking water treatment environmental fate Exact sciences and technology filtration Flocculation groundwater recharge Guanylurea Humans Hypoglycemic Agents Hypoglycemic Agents - analysis Metabolite metabolites Metformin Metformin - analysis monitoring Occurrence OECD guideline 106 ozonation ozone Ozone - chemistry Pharmaceuticals Pollution rivers soil sorption streams surface water Urea Urea - analogs & derivatives wastewater wastewater treatment Water Pollutants, Chemical Water Pollutants, Chemical - analysis Water Supply Water treatment and pollution water utilities Guanylurea Drinking water treatment Metabolite Antidiabetic drugs Metformin OECD guideline 106 Occurrence Pharmaceuticals Drinking water Water treatment Chlorination Aquifer recharge Waste water Ozonization Decontamination Batchwise Activated carbon Stream Organic compounds Biodegradation Drug Photochemical oxidants Filtration Chlorine Pollutant behavior Ozone Sewage treatment plant Sorption Surveillance Drinking water treatment plant Flocculation Surface water Physicochemical purification Performance Degradation product Train
ISSN:	0043-1354, 1879-2448, 1879-2448
Online Access:	Get full text
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