Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) and detoxify xenobiotics, which make it a potential target for cancer therapy. Plenty of studies have shown that loss o...

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Bibliographic Details
Published in:	Biomaterials Vol. 277; p. 121110
Main Authors:	Niu, Boyi, Liao, Kaixin, Zhou, Yixian, Wen, Ting, Quan, Guilan, Pan, Xin, Wu, Chuanbin
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01.10.2021
Subjects:	biocompatible materials Cancer therapy drug delivery systems Drug resistance Ferroptosis glutathione Glutathione depletion metabolism Nanomaterials oxidative stress photochemotherapy Reactive oxygen species xenobiotics Ferroptosis Nanomaterials Reactive oxygen species Glutathione depletion Drug resistance Cancer therapy
ISSN:	0142-9612, 1878-5905, 1878-5905
Online Access:	Get full text
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