Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) and detoxify xenobiotics, which make it a potential target for cancer therapy. Plenty of studies have shown that loss o...

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Vydané v:	Biomaterials Ročník 277; s. 121110
Hlavní autori:	Niu, Boyi, Liao, Kaixin, Zhou, Yixian, Wen, Ting, Quan, Guilan, Pan, Xin, Wu, Chuanbin
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Elsevier Ltd 01.10.2021
Predmet:	biocompatible materials Cancer therapy drug delivery systems Drug resistance Ferroptosis glutathione Glutathione depletion metabolism Nanomaterials oxidative stress photochemotherapy Reactive oxygen species xenobiotics Ferroptosis Nanomaterials Reactive oxygen species Glutathione depletion Drug resistance Cancer therapy
ISSN:	0142-9612, 1878-5905, 1878-5905
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) and detoxify xenobiotics, which make it a potential target for cancer therapy. Plenty of studies have shown that loss of intracellular GSH makes cancer cells more susceptible to oxidative stress and chemotherapeutic agents. GSH depletion has been proved to improve the therapeutic efficacy of ROS-based therapy (photodynamic therapy, sonodynamic therapy, and chemodynamic therapy), ferroptosis, and chemotherapy. In this review, various strategies for GSH depletion used in cancer therapy are comprehensively summarized and discussed. First, the functions of GSH in cancer cells are analyzed to elucidate the necessity of GSH depletion in cancer therapy. Then, the synthesis and metabolism of GSH are briefly introduced to bring up some crucial targets for GSH modulation. Finally, different approaches to GSH depletion in the literature are classified and discussed in detail according to their mechanisms. Particularly, functional materials with GSH-consuming ability based on nanotechnology are elaborated due to their unique advantages and potentials. This review presents the ingenious application of GSH-depleting strategy in cancer therapy for improving the outcomes of various therapeutic regimens, which may provide useful guidance for designing intelligent drug delivery system.
AbstractList	Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) and detoxify xenobiotics, which make it a potential target for cancer therapy. Plenty of studies have shown that loss of intracellular GSH makes cancer cells more susceptible to oxidative stress and chemotherapeutic agents. GSH depletion has been proved to improve the therapeutic efficacy of ROS-based therapy (photodynamic therapy, sonodynamic therapy, and chemodynamic therapy), ferroptosis, and chemotherapy. In this review, various strategies for GSH depletion used in cancer therapy are comprehensively summarized and discussed. First, the functions of GSH in cancer cells are analyzed to elucidate the necessity of GSH depletion in cancer therapy. Then, the synthesis and metabolism of GSH are briefly introduced to bring up some crucial targets for GSH modulation. Finally, different approaches to GSH depletion in the literature are classified and discussed in detail according to their mechanisms. Particularly, functional materials with GSH-consuming ability based on nanotechnology are elaborated due to their unique advantages and potentials. This review presents the ingenious application of GSH-depleting strategy in cancer therapy for improving the outcomes of various therapeutic regimens, which may provide useful guidance for designing intelligent drug delivery system. Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) and detoxify xenobiotics, which make it a potential target for cancer therapy. Plenty of studies have shown that loss of intracellular GSH makes cancer cells more susceptible to oxidative stress and chemotherapeutic agents. GSH depletion has been proved to improve the therapeutic efficacy of ROS-based therapy (photodynamic therapy, sonodynamic therapy, and chemodynamic therapy), ferroptosis, and chemotherapy. In this review, various strategies for GSH depletion used in cancer therapy are comprehensively summarized and discussed. First, the functions of GSH in cancer cells are analyzed to elucidate the necessity of GSH depletion in cancer therapy. Then, the synthesis and metabolism of GSH are briefly introduced to bring up some crucial targets for GSH modulation. Finally, different approaches to GSH depletion in the literature are classified and discussed in detail according to their mechanisms. Particularly, functional materials with GSH-consuming ability based on nanotechnology are elaborated due to their unique advantages and potentials. This review presents the ingenious application of GSH-depleting strategy in cancer therapy for improving the outcomes of various therapeutic regimens, which may provide useful guidance for designing intelligent drug delivery system.Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) and detoxify xenobiotics, which make it a potential target for cancer therapy. Plenty of studies have shown that loss of intracellular GSH makes cancer cells more susceptible to oxidative stress and chemotherapeutic agents. GSH depletion has been proved to improve the therapeutic efficacy of ROS-based therapy (photodynamic therapy, sonodynamic therapy, and chemodynamic therapy), ferroptosis, and chemotherapy. In this review, various strategies for GSH depletion used in cancer therapy are comprehensively summarized and discussed. First, the functions of GSH in cancer cells are analyzed to elucidate the necessity of GSH depletion in cancer therapy. Then, the synthesis and metabolism of GSH are briefly introduced to bring up some crucial targets for GSH modulation. Finally, different approaches to GSH depletion in the literature are classified and discussed in detail according to their mechanisms. Particularly, functional materials with GSH-consuming ability based on nanotechnology are elaborated due to their unique advantages and potentials. This review presents the ingenious application of GSH-depleting strategy in cancer therapy for improving the outcomes of various therapeutic regimens, which may provide useful guidance for designing intelligent drug delivery system.
ArticleNumber	121110
Author	Liao, Kaixin Zhou, Yixian Wu, Chuanbin Wen, Ting Pan, Xin Quan, Guilan Niu, Boyi
Author_xml	– sequence: 1 givenname: Boyi surname: Niu fullname: Niu, Boyi organization: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China – sequence: 2 givenname: Kaixin surname: Liao fullname: Liao, Kaixin organization: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China – sequence: 3 givenname: Yixian surname: Zhou fullname: Zhou, Yixian organization: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China – sequence: 4 givenname: Ting surname: Wen fullname: Wen, Ting organization: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China – sequence: 5 givenname: Guilan surname: Quan fullname: Quan, Guilan organization: College of Pharmacy, Jinan University, Guangzhou, 510632, China – sequence: 6 givenname: Xin surname: Pan fullname: Pan, Xin email: panxin2@mail.sysu.edu.cn organization: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China – sequence: 7 givenname: Chuanbin orcidid: 0000-0003-1661-0201 surname: Wu fullname: Wu, Chuanbin email: wuchuanb@mail.sysu.edu.cn organization: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China
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Cites_doi	10.1038/s41586-019-1426-6 10.1021/acsnano.0c06290 10.1016/j.jphotobiol.2020.111955 10.1021/acsami.0c12756 10.1089/ars.2011.4391 10.1016/j.tiv.2017.04.028 10.1021/acsnano.8b01893 10.1158/1078-0432.CCR-06-2642 10.1002/adfm.202002753 10.1002/biof.1476 10.1016/j.biomaterials.2020.120079 10.1016/j.colsurfb.2018.06.029 10.1097/00132580-200101000-00008 10.1002/anie.201706964 10.1021/acsami.9b16124 10.1096/fj.09-149997 10.1021/jacs.9b12873 10.1016/j.cub.2014.03.034 10.1002/adma.201808200 10.1165/rcmb.2009-0169TR 10.7150/thno.46076 10.1016/j.toxlet.2010.12.010 10.1002/pros.20508 10.1021/acsnano.0c05499 10.1158/0008-5472.CAN-12-3150 10.1016/j.cej.2020.125667 10.1002/mnfr.201300684 10.1002/ppsc.201900018 10.1038/s41420-020-00314-x 10.1007/s11010-005-9098-y 10.1002/anie.201710800 10.1021/acsami.9b09323 10.1073/pnas.0911351106 10.1196/annals.1297.059 10.1016/0014-5793(71)80459-3 10.1073/pnas.67.3.1248 10.1016/j.taap.2011.08.004 10.1016/j.bcp.2007.02.005 10.1006/bbrc.2001.5648 10.1038/s41467-018-03119-w 10.1002/anie.202003653 10.1016/j.bcp.2005.10.005 10.1016/j.ejmech.2017.02.064 10.1016/j.freeradbiomed.2018.07.025 10.1002/advs.201900848 10.1002/adma.202002439 10.1186/s12951-018-0398-2 10.1016/j.bcp.2004.08.010 10.3109/03602532.2015.1105253 10.1021/tx100226n 10.3390/antiox10060967 10.1021/acsnano.0c03781 10.2147/IJN.S249205 10.1021/acsami.8b00207 10.1039/C8NR08141G 10.1021/acsnano.9b00300 10.1016/j.cej.2020.125294 10.1016/j.ccr.2018.12.015 10.1016/j.dyepig.2020.108207 10.1002/adfm.201901417 10.1002/adfm.201907954 10.1074/jbc.R114.609248 10.1021/acsnano.8b06399 10.1039/D0SC02889D 10.1002/adfm.202006216 10.1021/acsnano.0c05541 10.3390/antiox9020133 10.1016/j.toxlet.2008.04.009 10.1080/1061186X.2018.1519029 10.1124/dmd.31.1.11 10.1016/j.ecoenv.2018.10.013 10.1158/0008-5472.CAN-04-0143 10.1016/j.biopha.2017.09.026 10.1016/j.pdpdt.2010.02.001 10.1039/D0TB01357A 10.1002/anie.201907388 10.1016/j.jconrel.2020.03.007 10.1016/j.bmc.2010.07.031 10.1016/j.freeradbiomed.2009.04.022 10.1038/s41598-018-19213-4 10.1016/j.colsurfb.2020.110810 10.1039/C9CC01957J 10.1016/S0304-3835(97)04639-9 10.1021/jacs.8b08714 10.1016/j.bmcl.2015.07.018 10.1016/j.biomaterials.2020.120278 10.1021/acsnano.8b06400 10.1002/adfm.202006098 10.1021/jp712087m 10.1021/acs.nanolett.8b01924 10.1038/sj.cdd.4400959 10.1002/adfm.201905013 10.3390/cells9051161 10.1002/anie.201903981 10.3109/15376516.2013.869783 10.1002/adfm.201903850 10.1083/jcb.201804161 10.1016/j.biomaterials.2020.120140 10.1002/anie.202008868 10.1002/jcp.27497 10.1126/science.aaw9872 10.1016/j.drup.2016.03.001 10.1016/j.nantod.2020.100981 10.1158/1078-0432.CCR-10-1983 10.1016/j.carbpol.2019.03.064 10.3109/1354750X.2012.715672 10.1002/jat.3106 10.1016/j.tips.2006.06.008 10.1016/j.cej.2019.122369 10.1016/j.apsb.2020.07.018 10.1007/s10863-015-9631-y 10.1016/j.biomaterials.2018.09.043 10.1039/C9NJ05427H 10.1016/j.bbagen.2012.09.008 10.1016/j.bcp.2016.10.013 10.1038/s41467-020-15591-4 10.1021/acs.nanolett.9b02904 10.1039/D0DT01742F 10.1039/C9CC06040E 10.1126/sciadv.abc4373 10.1016/j.cej.2020.126305 10.1039/C9NR01306G 10.1039/C9SC01070J 10.1158/0008-5472.CAN-11-0882 10.1002/adfm.201800706 10.1016/0014-5793(70)80063-1 10.1021/acsnano.9b07032 10.1038/s41419-019-1897-2 10.1021/acsami.0c01539 10.1016/j.biomaterials.2020.120456 10.1016/j.ejmech.2018.08.034 10.1089/ars.2017.7134 10.1007/s10863-015-9637-5 10.1016/j.cej.2020.127212 10.1016/j.biopha.2018.06.111 10.2147/JPR.S125045 10.1016/j.cbi.2005.10.044 10.7554/eLife.02523 10.1016/j.ejphar.2010.03.048 10.1351/PAC-REC-12-11-20 10.1038/s41419-018-0635-5 10.1039/C9BM01354G 10.1016/S0016-5085(98)70034-4 10.1016/j.cell.2012.03.042 10.1089/ars.2014.6142 10.1242/jeb.132142 10.1002/anie.201712027 10.1016/j.canlet.2015.07.031 10.1039/D0NR03135F 10.1016/j.ccell.2014.11.019 10.1039/C8BM01042K 10.1007/BF01870891 10.1002/anie.201510748 10.1074/jbc.M504604200 10.1016/j.ijpharm.2019.118782 10.1016/j.celrep.2017.02.054 10.1039/D0NR03661G 10.1111/cbdd.13621 10.1186/s13046-019-1459-6 10.7150/thno.46771 10.1016/j.bbagen.2020.129539 10.1016/j.jconrel.2018.01.034 10.1039/C9BM00797K 10.1016/j.mam.2008.08.004 10.1002/adfm.201904056 10.1021/cr400532z 10.1159/000485089 10.1021/jp2025413 10.1021/acs.nanolett.8b03905 10.1111/cas.14181 10.1038/s41565-019-0499-6 10.1002/smll.201904870 10.1093/jnci/88.3-4.193 10.1007/s00280-003-0609-9 10.1002/adma.201900730 10.3390/nu11081926 10.1039/C9NR03052B 10.3892/ol.2015.3879 10.1016/j.jconrel.2020.04.026 10.3390/antiox7050062 10.1111/cas.13309 10.2174/157340811796575308 10.1074/jbc.M807061200 10.1002/anie.200903924 10.1016/j.biomaterials.2020.120279 10.1016/j.bcp.2008.09.011 10.1093/jn/134.3.489 10.1016/j.ejmech.2019.02.065 10.1089/ars.2007.1901 10.1002/adhm.202000864 10.1016/j.jmb.2008.04.066 10.1016/j.freeradbiomed.2017.01.004 10.1021/bi00813a003 10.1016/j.canlet.2018.04.021 10.1021/acsnano.9b05493 10.1002/anie.201801378 10.1113/expphysiol.1997.sp004024 10.1155/2018/2469486 10.1016/j.bbagen.2019.01.007 10.1371/journal.pone.0054044 10.1016/j.mam.2008.05.005 10.1039/D0NR03138K 10.1039/C9TB02120E 10.1021/acsami.9b10685 10.1021/acsami.7b08347 10.1073/pnas.89.7.3070 10.1038/nature07733 10.1016/j.biopha.2018.05.117 10.18632/oncotarget.4945 10.3892/ijmm.2012.895 10.1016/j.tcb.2020.03.002 10.3389/fonc.2019.01525 10.1002/smll.202001251 10.1155/2012/736837 10.1002/iub.1756 10.1002/anie.201605509 10.7150/thno.28344 10.1021/acsnano.8b09387 10.1002/adfm.201906195 10.1021/acsnano.9b01665 10.1021/acsnano.0c03080 10.15252/embj.201696151 10.1186/s13045-019-0720-y 10.1016/j.pdpdt.2021.102418 10.1016/j.jconrel.2018.01.019 10.1016/j.bcp.2014.05.017 10.1038/s41389-017-0025-3 10.1016/j.freeradbiomed.2018.06.021 10.1038/s41598-019-54065-6 10.1074/jbc.M110.116210 10.1016/j.tiv.2011.12.004 10.1021/acsami.9b23325 10.1021/acs.bioconjchem.0c00209 10.1155/2013/972913 10.1016/j.cej.2021.130094 10.1007/s13402-019-00474-8 10.1016/j.biomaterials.2020.120457 10.1016/j.biomaterials.2019.119498 10.1124/jpet.102.040220 10.1016/j.biomaterials.2020.120329
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References	Ballatori, Krance, Marchan, Hammond (bib168) 2009; 30 Yang, Li, Chen, Zhang, Qiao, Tan, Chen, Pan (bib11) 2020; 15 Zhu, Xiao, Zhang, Che, Shi, Shi, van Hest (bib64) 2020; 14 Liu, Wang, Zhang, Cheng, Yang, Xing, Xu, Dong, Zhang (bib76) 2019; 13 Li, Bey, Dong, Meng, Patra, Yan, Xie, Brekken, Barnett, Bornmann (bib222) 2011; 17 Liu, Zhen, Jin, Zhang, Sun, Zhang, Xu, Song, Wang, Liu, Zhang (bib102) 2018; 12 Ma, Chen, Wang, Lu, Zhu, Song, Yang, Wen, Xu, Hu (bib172) 2015; 368 Batten, Champness, Chen, Garcia-Martinez, Kitagawa, Ohrstrom, O'Keeffe, Suh, Reedijk (bib235) 2013; 85 Majumder, Dutta, Mookerjee, Choudhuri (bib145) 2006; 159 Zhong, Wang, Cheng, Tang, Zhan, Gong, Zhang, Hu, Liu, Yang (bib80) 2020; 30 Hu, Chen, Yang, Huang, Wu, Wu, Li, Yi, Xiao, Li (bib60) 2019; 11 Zhang, Lu, Gao, Li, Zhang, Ma, Wang, Tang (bib33) 2018; 57 Dixon, Lemberg, Lamprecht, Skouta, Zaitsev, Gleason, Patel, Bauer, Cantley, Yang, Morrison, Stockwell (bib150) 2012; 149 Yang, Liu, Ma, Xu, Chen, Wang, Xiao, Li, Liang, Yu, Yu (bib108) 2021; 265 Wu, Chen, Gu, You, Sun (bib67) 2020; 12 Fu, Yang, Zhang, Liu, Du, Cao, Xu, Cui, Kang, Xue (bib70) 2020; 257 Li, Yan, Xu, Liu, Wu, Zhao (bib175) 2019; 19 Wang, Wang, Li, Tong, Wang, Huang, Xu, Huang, Li, Wu, Zhao, Yin (bib142) 2020; 12 Debiton, Madelmont, Legault, Barthomeuf (bib234) 2003; 51 Liu, Song, Zhang, Chan, Guo, Shen (bib251) 2020; 11 Song, Yang, Xu, Lu, Li, Ren, Liu, Wang, Zhu, Tan, Li (bib119) 2020; 254 Cao, Zhong, Wang, Chen, Tian, Zhang (bib58) 2020; 8 De Souza, Schmitz, Silva, De Oliveira, Nedel, Tasca, De Bem, Farina, Dafre (bib224) 2017; 42 Huang, Huang, Chen, Chen, Zeng, Xu, Huang, Luo, Xiao, Ding, Zhao (bib71) 2020; 399 Gu, An, He, Wu, Gao, Li, Chen, Cheng, Zhang, You (bib111) 2020; 189 Xiao, Lu, Feng, Dong, Cao, Zhang, Chen, Liu (bib104) 2020; 396 Zhou, Wu, Yang, Xu, Zhang, Dong, Qian, Sun (bib113) 2020; 6 Henderson, Ritchie, Mclaren, Chakravarty, Wolf (bib48) 2011; 71 Zou, Hu, Xu, Tong, Jing, Xi, Zhou, Lu, Wang, Yang (bib28) 2018; 41 Sun, Deng, Kang, Sun, Ren, Qu (bib31) 2020; 14 Ling, Chen, Riddell, Tao, Wang, Hollett, Lippard, Farokhzad, Shi, Wu (bib30) 2018; 18 Lian, Huang, Zhu, Fang, Zhao, Joseph, Li, Pellois, Zhou (bib122) 2018; 57 Stoner, Morse (bib230) 1997; 114 Pu, Zhou, Xiang, Wu, Yin, Yue, Yin, Li, Chen, Xu (bib121) 2020; 259 Lu (bib156) 2013; 1830 Laskar, Somani, Altwaijry, Mullin, Bowering, Warzecha, Keating, Tate, Leung, Dufes (bib14) 2018; 10 Ritchie, Walsh, Sansom, Henderson, Wolf (bib49) 2009; 106 Li, Wang, Yang, Lei, Yang, Liang, Chen, Xia, Wang, Tang (bib50) 2019; 38 Scire, Cianfruglia, Minnelli, Bartolini, Torquato, Principato, Galli, Armeni (bib39) 2019; 45 Galadari, Rahman, Pallichankandy, Thayyullathil (bib46) 2017; 104 Zhao, Wang, Wu, Wang, Gu, Chen, Jana, Wang, Xu, Guo, Chen, Feng, Liu (bib73) 2021; 60 Liu, Gong, Shen, He, Liang, Shu, Wang, Ma, Li, Zhang, Wu, Gong (bib95) 2021; 403 Doxsee, Gout, Kurita, Lo, Buckley, Wang, Xue, Karp, Cutz, Cunha (bib219) 2007; 67 Fletcher, Williams, Henderson, Norris, Haber (bib241) 2016; 26 Cruz, Mota, Ramos, Pires, Mendes, Silva, Nunes, Bonifacio, Serpa (bib129) 2020; 9 Wang, Liu, Sun, Dong, Kuang, Dong, He, Gai, Yang (bib100) 2020; 12 Deng, Liu, Wang, An, Gao, Wang, Zhao (bib90) 2019; 7 Brechbuhl, Kachadourian, Min, Chan, Day (bib213) 2012; 258 Wei, Huang, Jiang, Shen, Huang, Huang, Sun, Zhao (bib132) 2019; 169 Gong, Cheng, Yang, Betzer, Feng, Zhou, Li, Chen, Popovtzer, Liu (bib21) 2019; 31 Hu, Deng, Jia, Jin, Ji (bib248) 2020; 14 Fazzari, Balenko, Zacal, Singh (bib176) 2017; 10 Guo, Cheng, Zhao, Luo, Chen, Yuan (bib238) 2018; 16 Traverso, Ricciarelli, Nitti, Marengo, Furfaro, Pronzato, Marinari, Domenicotti (bib53) 2013; 2013 Chen, Wang, Zhang, Zhang, Liu, Zhang, Feng, Li, Wu, Gao, Yang (bib68) 2021; 266 Bannai, Tateishi (bib155) 1986; 89 Dixon, Patel, Welsch, Skouta, Lee, Hayano, Thomas, Gleason, Tatonetti, Slusher (bib220) 2014; 3 Gaucher, Boudier, Bonetti, Clarot, Leroy, Parent (bib35) 2018; 7 Zheng, Zhou, Zhu, Wang, Li, Chen, Chen, Che, Xie (bib197) 2018; 106 Wang, Li, Qiao, Hu, Liao, Chen, Wu, Wu, Zhao, Liu (bib135) 2018; 12 Dong, Feng, Hao, Li, Chen, Yang, Zhao, Liu (bib74) 2020; 6 An, Fan, Gu, Gao, Hossain, Sun (bib84) 2020; 321 Wang, Yang, Cho, Chueng, Zhang, Zhang, Lee (bib112) 2019; 224 Li, Dirisala, Ge, Wang, Yin, Ke, Toh, Xie, Matsumoto, Anraku (bib118) 2017; 56 Lin, Song, Song, Ke, Liu, Zhou, Shen, Li, Yang, Tang (bib97) 2018; 57 Larraufie, Yang, Jiang, Thomas, Slusher, Stockwell (bib218) 2015; 25 Zhu, Chen, Yang, Wu, Tian, Hao, Cao, Gao, Zhang (bib83) 2020; 12 Mateo, Morales, Avalos, Haza (bib205) 2014; 24 Kohler, Barrach, Neubert (bib191) 1970; 6 Mukherjee, Oclaonadh, Casey, Chambers (bib184) 2012; 26 Zhang, Gao, Ma, He, Du, Yang, Xie, Xie, Deng (bib249) 2021; 422 Zhang, Forman (bib164) 2009; 41 Poursaitidis, Wang, Crighton, Labuschagne, Mason, Cramer, Triplett, Roy, Pardo, Seckl (bib181) 2017; 18 Otsubo, Nosaki, Imamura, Ogata, Fujita, Sakata, Hirai, Toyokawa, Iwama, Harada (bib174) 2017; 108 Zhao, Wang, Li, Zhang, Yu, Wu, Zhao, Liu, Liu, Yu (bib106) 2019; 29 Catanzaro, Gaude, Orso, Giordano, Guzzo, Rasola, Ragazzi, Caparrotta, Frezza, Montopoli (bib190) 2015; 6 Luo, Zhou, Zhou, Xing, Cui, Sun, Jin, Lu, Jiang (bib130) 2018; 274 Arora, Jain, Rajwade, Paknikar (bib185) 2008; 179 He, Du, Guo, An, Lu, Chen, Wang, Zhong, Shen, Wu, Shuai (bib139) 2020; 16 Shi, Wang, You, Akhtar, Liu, Han, Li, Wang (bib89) 2019; 11 Chen, Zhou, Chen, Luo, Xu, Song (bib20) 2019; 11 Chen, Kuo (bib148) 2010; 2010 Franco, Dehaven, Sifre, Bortner, Cidlowski (bib16) 2008; 283 Hatemelie (bib6) 2017; 27 Lorendeau, Dury, Genouxbastide, Lecerfschmidt, Simoespires, Carrupt, Terreux, Magnard, Pietro, Boumendjel (bib215) 2014; 90 Liu, Wang, Shenvi, Hagen, Liu (bib44) 2004; 1019 Wu, Zhang, Chen, Yu, Ma, Liu (bib131) 2019; 167 Leslie, Deeley, Cole (bib210) 2003; 31 Wan, Cheng, Zeng, Zhang (bib57) 2019; 13 Pathania, Bhatia, Baldi, Singh, Rawal (bib25) 2018; 105 Shen, Ma, Huang, Chen, Xu, Li, Meng, Fan, Xi, Yan, Koo, Yang, Jiang, Gao (bib250) 2020; 35 Pompella, De Tata, Paolicchi, Zunino (bib228) 2006; 71 Liu, Zhou, Liu, Li, Huang, Qian, Sun (bib59) 2019; 7 Li, Zhao, Gong, Wang, Jiang, Cheng, Liu, Wu, Bu (bib72) 2020; 59 Cheng, Yang, Zhang, Zhang, Cao, Liu, Lu, Dong, Zhang (bib116) 2019; 29 Li, Wu, Zhang, Chen (bib223) 2018; 129 Xu, Han, Li, Min, Zhao, Zhang, Qi, Shi, Qi, Bao (bib29) 2019; 13 Mena, Benlloch, Ortega, Carretero, Obrador, Asensi, Petschen, Brown, Estrela (bib194) 2007; 13 Luo, Han, Zhao, Pan, Tian, Ding, Zhang (bib12) 2019; 215 Kwiatkowska, Wojtala, Gajewska, Soszynski, Bartosz, Sadowskabartosz (bib200) 2016; 48 Liu, Guo, Zeng, Ye, Wang, Li, Sun, Cheng, Zhang (bib87) 2020; 30 Hu, Wang, Zhou, Wei (bib161) 2020; 209 An, Gao, Sun, Gu, Wu, You, Li, Cheng, Zhang, Wang (bib140) 2019; 11 Liu, Liu, Liu, Du, Wang, He (bib153) 2019; 382 He, He, Farrar, Ji, Liu, Ma (bib7) 2017; 44 Xie, Liang, Cai, Ding, Huang, Hou, Ma, Cheng, Lin (bib77) 2019; 11 Badgley, Kremer, Maurer, DelGiorno, Lee, Purohit, Sagalovskiy, Ma, Kapilian, Firl, Decker, Sastra, Palermo, Andrade, Sajjakulnukit, Zhang, Tolstyka, Hirschhorn, Lamb, Liu, Gu, Seeley, Stone, Georgiou, Manor, Iuga, Wahl, Stockwell, Lyssiotis, Olive (bib180) 2020; 368 Shi, Zhao, Li, Pan, Ma, Ding (bib199) 2015; 35 Zhou, Niu, Wu, Luo, Fu, Zhao, Quan, Pan, Wu (bib236) 2020; 10 Farina, Aschner (bib23) 2019; 1863 Lan, Liu, Zeng, Qin, Hou, Xie, Yue, Yang, Ho, Ding, Zhang (bib92) 2020; 407 Bohme, Thaens, Schramm, Paschke, Schuurmann (bib231) 2010; 23 Zhou, Li, Cheng, Zhang, Sun, Du, Cao, Liu, Huang (bib62) 2020; 8 Li, Li, Shi, Ahmed, Liu, Guo, Tang, Guo, Zhang (bib198) 2020; 9 Zhu, Chu, Li, Pang, Zheng, Wang, Shi, Zhang, Cheng, Ren (bib110) 2019; 29 Krejsa, Franklin, White, Ledbetter, Schieven, Kavanagh (bib159) 2010; 285 Shen, Xia, Ma, Zhu, Gao, Han, Liang, Cao, Sun (bib107) 2020; 10 Gao, Liu, Wei, Liu, Xu, Guo, Li, Jiang, Wu (bib196) 2012; 29 Zhang, Pavlova, Thompson (bib157) 2017; 36 Loschen, Flohe, Chance (bib3) 1971; 18 Orlowski, Meister (bib165) 1970; 67 Lu (bib41) 2009; 30 Chen, Shertzer, Schneider, Nebert, Dalton (bib158) 2005; 280 Tao, Ren, Yi, Zhou, Xiong, Ge, Chen, Yang (bib75) 2019; 36 Schieber, Chandel (bib52) 2014; 24 Tang, Li, Zhang, Zheng, Cheng, Zhu, Chen, Zhu, Piao, Li (bib137) 2020; 10 Lewerenz, Hewett, Huang, Lambros, Gout, Kalivas, Massie, Smolders, Methner, Pergande, Smith, Ganapathy, Maher (bib154) 2013; 18 Wu, Guo, Qiu, Lin, Yao, Lian, Lin, Song, Yang (bib114) 2019; 10 Zhang, Chen, Jiang, Ma, Xia, Cheng, Jia, Liu, Gu, Chen (bib204) 2018; 10 Raineri, Levy (bib192) 1970; 9 Zhang, Tan, Daniels, Zandkarimi, Liu, Brown, Uchida, Oconnor, Stockwell (bib171) 2019; 26 del Valle, Yeh, Huang (bib138) 2020; 9 Liao, Xiang, Wang, Wang, Ding (bib189) 2017; 95 Godwin, Meister, Odwyer, Huang, Hamilton, Anderson (bib26) 1992; 89 Li, Yang, Xu (bib13) 2019; 27 Allocati, Masulli, Di Ilio, Federici (bib37) 2018; 7 Wang, Wu, Yang, Qian, Gu, Wang, Zhou, Liu, Wu, Zhang, Guo, Chen, Jana, Zhao (bib63) 2020; 14 Wu, Fang, Yang, Lupton, Turner (bib8) 2004; 134 Ju, Dong, Chen, Liu, Liu, Huang, Wang, Pu, Ren, Qu (bib22) 2016; 55 Fatehihassanabad, Chan, Furman (bib43) 2010; 636 Salerno, Loechariyakul, Saengkhae, Garniersuillerot (bib217) 2004; 68 Jiang, Du, Zheng (bib24) 2019; 14 Jawaid, Rehman, Zhao, Misawa, Ishikawa, Hori, Shimizu, Saitoh, Noguchi, Kondo (bib120) 2020; 6 Zhang, Meng, Yang, Dong, Zhang (bib82) 2020; 258 Mou, Wang, Wu, He, Zhang, Duan, Li (bib151) 2019; 12 Wu, Liu, Ren, Qu (bib141) 2019; 15 Gupta, Kim, Kim, Srivastava (bib229) 2014; 58 Gong, Chen, Yang, Dong, Tian, Hao, Zhuo, Liu, Chen, Cheng (bib99) 2020; 30 Wang, Cao, Ruan, Jia, Zhen, Jiang (bib115) 2019; 58 Hochwald, Harrison, Rose, Anderson, Burt (bib226) 1996; 88 Joycebrady, Hiratake (bib227) 2011; 7 Walters, Cho, Kleeberger (bib45) 2008; 10 Lu, Pokharel, Bebawy (bib240) 2015; 47 Harris, DeNicola (bib47) 2020; 30 Raza, Hayat, Rasheed, Bilal, Iqbal (bib9) 2018; 157 Bachhawat, Yadav (bib166) 2018; 70 Cao, Li, Gao, Li, Li, Cao, Dai, Mao, Wang, Tai (bib69) 2020; 49 Gamcsik, Kasibhatla, Teeter, Colvin (bib147) 2012; 17 Tang, Chen, Li, Zheng, Wu, Zhang, Song, Fei (bib134) 2019; 572 Diehn, Cho, Lobo, Kalisky, Liu (10.1016/j.biomaterials.2021.121110_bib102) 2018; 12 Bannai (10.1016/j.biomaterials.2021.121110_bib155) 1986; 89 Xu (10.1016/j.biomaterials.2021.121110_bib29) 2019; 13 Zou (10.1016/j.biomaterials.2021.121110_bib28) 2018; 41 Prisant (10.1016/j.biomaterials.2021.121110_bib243) 2001; 3 Fu (10.1016/j.biomaterials.2021.121110_bib81) 2019; 29 Armstrong (10.1016/j.biomaterials.2021.121110_bib239) 2002; 9 Dong (10.1016/j.biomaterials.2021.121110_bib96) 2019; 19 Wang (10.1016/j.biomaterials.2021.121110_bib135) 2018; 12 Wang (10.1016/j.biomaterials.2021.121110_bib177) 2018; 428 Sies (10.1016/j.biomaterials.2021.121110_bib5) 1997; 82 Wang (10.1016/j.biomaterials.2021.121110_bib55) 2019; 13 Zhao (10.1016/j.biomaterials.2021.121110_bib225) 2009; 47 Lash (10.1016/j.biomaterials.2021.121110_bib162) 2002; 303 Lin (10.1016/j.biomaterials.2021.121110_bib97) 2018; 57 Stoner (10.1016/j.biomaterials.2021.121110_bib230) 1997; 114 Yu (10.1016/j.biomaterials.2021.121110_bib10) 2018; 9 Leslie (10.1016/j.biomaterials.2021.121110_bib210) 2003; 31 Gaucher (10.1016/j.biomaterials.2021.121110_bib35) 2018; 7 Galadari (10.1016/j.biomaterials.2021.121110_bib46) 2017; 104 Li (10.1016/j.biomaterials.2021.121110_bib118) 2017; 56 Shen (10.1016/j.biomaterials.2021.121110_bib107) 2020; 10 Fan (10.1016/j.biomaterials.2021.121110_bib19) 2016; 55 Walters (10.1016/j.biomaterials.2021.121110_bib45) 2008; 10 Li (10.1016/j.biomaterials.2021.121110_bib223) 2018; 129 Cheng (10.1016/j.biomaterials.2021.121110_bib116) 2019; 29 Gamcsik (10.1016/j.biomaterials.2021.121110_bib147) 2012; 17 Guo (10.1016/j.biomaterials.2021.121110_bib238) 2018; 16 Barrett (10.1016/j.biomaterials.2021.121110_bib51) 2013; 73 Ju (10.1016/j.biomaterials.2021.121110_bib22) 2016; 55 Barattin (10.1016/j.biomaterials.2021.121110_bib209) 2010; 18 Zhou (10.1016/j.biomaterials.2021.121110_bib236) 2020; 10 Ma (10.1016/j.biomaterials.2021.121110_bib172) 2015; 368 Zhou (10.1016/j.biomaterials.2021.121110_bib62) 2020; 8 Li (10.1016/j.biomaterials.2021.121110_bib72) 2020; 59 Bachhawat (10.1016/j.biomaterials.2021.121110_bib166) 2018; 70 De Souza (10.1016/j.biomaterials.2021.121110_bib224) 2017; 42 Schieber (10.1016/j.biomaterials.2021.121110_bib52) 2014; 24 Tang (10.1016/j.biomaterials.2021.121110_bib221) 2015; 22 Hu (10.1016/j.biomaterials.2021.121110_bib60) 2019; 11 Fu (10.1016/j.biomaterials.2021.121110_bib70) 2020; 257 Otsubo (10.1016/j.biomaterials.2021.121110_bib174) 2017; 108 Li (10.1016/j.biomaterials.2021.121110_bib13) 2019; 27 Zhang (10.1016/j.biomaterials.2021.121110_bib91) 2020; 12 Pu (10.1016/j.biomaterials.2021.121110_bib121) 2020; 259 Wu (10.1016/j.biomaterials.2021.121110_bib131) 2019; 167 Gupta (10.1016/j.biomaterials.2021.121110_bib229) 2014; 58 Min (10.1016/j.biomaterials.2021.121110_bib93) 2019; 31 Zhang (10.1016/j.biomaterials.2021.121110_bib249) 2021; 422 Zhu (10.1016/j.biomaterials.2021.121110_bib83) 2020; 12 Wu (10.1016/j.biomaterials.2021.121110_bib114) 2019; 10 Cole (10.1016/j.biomaterials.2021.121110_bib242) 2014; 289 Meng (10.1016/j.biomaterials.2021.121110_bib136) 2019; 19 Wei (10.1016/j.biomaterials.2021.121110_bib246) 2020; 1864 Zhang (10.1016/j.biomaterials.2021.121110_bib82) 2020; 258 Hochwald (10.1016/j.biomaterials.2021.121110_bib226) 1996; 88 Salerno (10.1016/j.biomaterials.2021.121110_bib217) 2004; 68 Hu (10.1016/j.biomaterials.2021.121110_bib161) 2020; 209 Lewerenz (10.1016/j.biomaterials.2021.121110_bib154) 2013; 18 Mukherjee (10.1016/j.biomaterials.2021.121110_bib184) 2012; 26 Majumder (10.1016/j.biomaterials.2021.121110_bib145) 2006; 159 Jawaid (10.1016/j.biomaterials.2021.121110_bib120) 2020; 6 Piao (10.1016/j.biomaterials.2021.121110_bib187) 2011; 201 Liao (10.1016/j.biomaterials.2021.121110_bib189) 2017; 95 Gu (10.1016/j.biomaterials.2021.121110_bib111) 2020; 189 Jiang (10.1016/j.biomaterials.2021.121110_bib24) 2019; 14 Wang (10.1016/j.biomaterials.2021.121110_bib115) 2019; 58 Lan (10.1016/j.biomaterials.2021.121110_bib92) 2020; 407 Deng (10.1016/j.biomaterials.2021.121110_bib90) 2019; 7 Desideri (10.1016/j.biomaterials.2021.121110_bib167) 2019; 11 Zheng (10.1016/j.biomaterials.2021.121110_bib197) 2018; 106 Lee (10.1016/j.biomaterials.2021.121110_bib15) 2010; 24 Dixon (10.1016/j.biomaterials.2021.121110_bib220) 2014; 3 Zhang (10.1016/j.biomaterials.2021.121110_bib157) 2017; 36 Shi (10.1016/j.biomaterials.2021.121110_bib199) 2015; 35 Zhao (10.1016/j.biomaterials.2021.121110_bib73) 2021; 60 Wu (10.1016/j.biomaterials.2021.121110_bib152) 2019; 572 Scire (10.1016/j.biomaterials.2021.121110_bib39) 2019; 45 Sun (10.1016/j.biomaterials.2021.121110_bib31) 2020; 14 Hu (10.1016/j.biomaterials.2021.121110_bib248) 2020; 14 Fatehihassanabad (10.1016/j.biomaterials.2021.121110_bib43) 2010; 636 Lu (10.1016/j.biomaterials.2021.121110_bib41) 2009; 30 Xie (10.1016/j.biomaterials.2021.121110_bib77) 2019; 11 Catanzaro (10.1016/j.biomaterials.2021.121110_bib190) 2015; 6 Dong (10.1016/j.biomaterials.2021.121110_bib85) 2020; 32 Zhu (10.1016/j.biomaterials.2021.121110_bib178) 2020; 27 Chen (10.1016/j.biomaterials.2021.121110_bib158) 2005; 280 Loschen (10.1016/j.biomaterials.2021.121110_bib3) 1971; 18 Wu (10.1016/j.biomaterials.2021.121110_bib67) 2020; 12 Badgley (10.1016/j.biomaterials.2021.121110_bib180) 2020; 368 He (10.1016/j.biomaterials.2021.121110_bib139) 2020; 16 Wu (10.1016/j.biomaterials.2021.121110_bib141) 2019; 15 Wan (10.1016/j.biomaterials.2021.121110_bib57) 2019; 13 Dong (10.1016/j.biomaterials.2021.121110_bib74) 2020; 6 Wu (10.1016/j.biomaterials.2021.121110_bib8) 2004; 134 Cheng (10.1016/j.biomaterials.2021.121110_bib143) 2014; 114 Hatemelie (10.1016/j.biomaterials.2021.121110_bib6) 2017; 27 Gao (10.1016/j.biomaterials.2021.121110_bib196) 2012; 29 Han (10.1016/j.biomaterials.2021.121110_bib126) 2018; 273 Raineri (10.1016/j.biomaterials.2021.121110_bib192) 1970; 9 Harris (10.1016/j.biomaterials.2021.121110_bib47) 2020; 30 Zhang (10.1016/j.biomaterials.2021.121110_bib204) 2018; 10 Yin (10.1016/j.biomaterials.2021.121110_bib195) 2017; 9 Munro (10.1016/j.biomaterials.2021.121110_bib2) 2017; 220 Csala (10.1016/j.biomaterials.2021.121110_bib163) 2001; 287 Tao (10.1016/j.biomaterials.2021.121110_bib75) 2019; 36 Arora (10.1016/j.biomaterials.2021.121110_bib185) 2008; 179 Lian (10.1016/j.biomaterials.2021.121110_bib122) 2018; 57 Debiton (10.1016/j.biomaterials.2021.121110_bib234) 2003; 51 Gong (10.1016/j.biomaterials.2021.121110_bib99) 2020; 30 Zhu (10.1016/j.biomaterials.2021.121110_bib64) 2020; 14 Tang (10.1016/j.biomaterials.2021.121110_bib134) 2019; 572 An (10.1016/j.biomaterials.2021.121110_bib140) 2019; 11 Dixon (10.1016/j.biomaterials.2021.121110_bib150) 2012; 149 Allison (10.1016/j.biomaterials.2021.121110_bib18) 2010; 7 Yang (10.1016/j.biomaterials.2021.121110_bib117) 2018; 28 Tenório (10.1016/j.biomaterials.2021.121110_bib244) 2021; 10 Mele (10.1016/j.biomaterials.2021.121110_bib188) 2018; 9 Wang (10.1016/j.biomaterials.2021.121110_bib100) 2020; 12 Wang (10.1016/j.biomaterials.2021.121110_bib63) 2020; 14 Yu (10.1016/j.biomaterials.2021.121110_bib170) 2019; 110 Hoyle (10.1016/j.biomaterials.2021.121110_bib233) 2010; 49 Wang (10.1016/j.biomaterials.2021.121110_bib112) 2019; 224 Ballatori (10.1016/j.biomaterials.2021.121110_bib168) 2009; 30 Liu (10.1016/j.biomaterials.2021.121110_bib79) 2020; 11 del Valle (10.1016/j.biomaterials.2021.121110_bib138) 2020; 9 Liu (10.1016/j.biomaterials.2021.121110_bib87) 2020; 30 Luo (10.1016/j.biomaterials.2021.121110_bib12) 2019; 215 Liu (10.1016/j.biomaterials.2021.121110_bib59) 2019; 7 Bao (10.1016/j.biomaterials.2021.121110_bib206) 2020; 152 Sang (10.1016/j.biomaterials.2021.121110_bib32) 2020; 142 Carlson (10.1016/j.biomaterials.2021.121110_bib186) 2008; 112 Zheng (10.1016/j.biomaterials.2021.121110_bib86) 2020; 12 Joycebrady (10.1016/j.biomaterials.2021.121110_bib227) 2011; 7 Li (10.1016/j.biomaterials.2021.121110_bib193) 2019; 234 Zheng (10.1016/j.biomaterials.2021.121110_bib173) 2020; 43 Hu (10.1016/j.biomaterials.2021.121110_bib109) 2020; 31 Harris (10.1016/j.biomaterials.2021.121110_bib54) 2015; 27 Mena (10.1016/j.biomaterials.2021.121110_bib194) 2007; 13 Li (10.1016/j.biomaterials.2021.121110_bib198) 2020; 9 Bi (10.1016/j.biomaterials.2021.121110_bib179) 2019; 10 Orlowski (10.1016/j.biomaterials.2021.121110_bib165) 1970; 67 Brechbuhl (10.1016/j.biomaterials.2021.121110_bib213) 2012; 258 Cruz (10.1016/j.biomaterials.2021.121110_bib129) 2020; 9 Pathania (10.1016/j.biomaterials.2021.121110_bib25) 2018; 105 Kohler (10.1016/j.biomaterials.2021.121110_bib191) 1970; 6 Lu (10.1016/j.biomaterials.2021.121110_bib240) 2015; 47 Cao (10.1016/j.biomaterials.2021.121110_bib69) 2020; 49 Laskar (10.1016/j.biomaterials.2021.121110_bib14) 2018; 10 Sies (10.1016/j.biomaterials.2021.121110_bib4) 1985 Lv (10.1016/j.biomaterials.2021.121110_bib17) 2019 Li (10.1016/j.biomaterials.2021.121110_bib50) 2019; 38 Mou (10.1016/j.biomaterials.2021.121110_bib151) 2019; 12 Ling (10.1016/j.biomaterials.2021.121110_bib30) 2018; 18 Sarkhoshinanlou (10.1016/j.biomaterials.2021.121110_bib123) 2020; 95 Bansal (10.1016/j.biomaterials.2021.121110_bib40) 2018; 217 Li (10.1016/j.biomaterials.2021.121110_bib175) 2019; 19 Huang (10.1016/j.biomaterials.2021.121110_bib71) 2020; 399 Bohme (10.1016/j.biomaterials.2021.121110_bib231) 2010; 23 Lu (10.1016/j.biomaterials.2021.121110_bib156) 2013; 1830 Ling (10.1016/j.biomaterials.2021.121110_bib125) 2019; 13 Tian (10.1016/j.biomaterials.2021.121110_bib88) 2019; 55 Wan (10.1016/j.biomaterials.2021.121110_bib105) 2019; 58 Chen (10.1016/j.biomaterials.2021.121110_bib20) 2019; 11 Cole (10.1016/j.biomaterials.2021.121110_bib38) 2006; 27 Shi (10.1016/j.biomaterials.2021.121110_bib89) 2019; 11 Zhong (10.1016/j.biomaterials.2021.121110_bib80) 2020; 30 Li (10.1016/j.biomaterials.2021.121110_bib222) 2011; 17 Poursaitidis (10.1016/j.biomaterials.2021.121110_bib181) 2017; 18 Zhou (10.1016/j.biomaterials.2021.121110_bib113) 2020; 6 Chen (10.1016/j.biomaterials.2021.121110_bib148) 2010; 2010 Zhao (10.1016/j.biomaterials.2021.121110_bib106) 2019; 29 Huang (10.1016/j.biomaterials.2021.121110_bib78) 2020; 380 Wang (10.1016/j.biomaterials.2021.121110_bib142) 2020; 12 Liu (10.1016/j.biomaterials.2021.12111
References_xml	– volume: 14 start-page: 11225 year: 2020 end-page: 11237 ident: bib64 article-title: Surface-charge-switchable nanoclusters for magnetic resonance imaging-guided and glutathione depletion-enhanced photodynamic therapy publication-title: ACS Nano – volume: 57 start-page: 4902 year: 2018 end-page: 4906 ident: bib97 article-title: Simultaneous fenton‐like ion delivery and glutathione depletion by MnO2‐based nanoagent to enhance chemodynamic therapy publication-title: Angew. Chem. Int. Ed. – volume: 31 start-page: 1808200 year: 2019 ident: bib93 article-title: Biomimetic metal–organic framework nanoparticles for cooperative combination of antiangiogenesis and photodynamic therapy for enhanced efficacy publication-title: Adv. Mater. – volume: 380 start-page: 122369 year: 2020 ident: bib78 article-title: Three birds with one stone: a ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/chemodynamic therapy with glutathione depletion publication-title: Chem. Eng. J. – volume: 382 start-page: 160 year: 2019 end-page: 180 ident: bib153 article-title: Nanomaterial-induced ferroptosis for cancer specific therapy publication-title: Coord. Chem. Rev. – volume: 29 start-page: 649 year: 2012 end-page: 655 ident: bib196 article-title: Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells publication-title: Int. J. Mol. Med. – volume: 18 start-page: 6265 year: 2010 end-page: 6274 ident: bib209 article-title: Iodination of verapamil for a stronger induction of death, through GSH efflux, of cancer cells overexpressing MRP1 publication-title: Bioorg. Med. Chem. – volume: 283 start-page: 36071 year: 2008 end-page: 36087 ident: bib16 article-title: Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis publication-title: J. Biol. Chem. – volume: 8 year: 2013 ident: bib183 article-title: Purine nucleoside analog-sulfinosine modulates diverse mechanisms of cancer progression in multi-drug resistant cancer cell lines publication-title: PloS One – volume: 12 start-page: 15767 year: 2020 end-page: 15774 ident: bib142 article-title: Histone methyltransferase G9a inhibitor-loaded redox-responsive nanoparticles for pancreatic ductal adenocarcinoma therapy publication-title: Nanoscale – volume: 10 start-page: 321 year: 2008 end-page: 332 ident: bib45 article-title: Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2 publication-title: Antioxidants Redox Signal. – volume: 19 start-page: 323 year: 2019 end-page: 333 ident: bib175 article-title: Erastin/sorafenib induces cisplatin-resistant non-small cell lung cancer cell ferroptosis through inhibition of the Nrf2/xCT pathway publication-title: Oncol. Lett. – volume: 73 start-page: 1245 year: 2013 end-page: 1255 ident: bib51 article-title: Tumor suppressor function of the plasma glutathione peroxidase Gpx 3 in colitis-associated carcinoma publication-title: Canc. Res. – volume: 11 start-page: 8495 year: 2020 end-page: 8501 ident: bib251 article-title: A ratiometric fluorescent probe for real-time monitoring of intracellular glutathione fluctuations in response to cisplatin publication-title: Chem. Sci. – volume: 396 start-page: 125294 year: 2020 ident: bib104 article-title: Multifunctional FeS2 theranostic nanoparticles for photothermal-enhanced chemodynamic/photodynamic cancer therapy and photoacoustic imaging publication-title: Chem. Eng. J. – volume: 17 start-page: 671 year: 2012 end-page: 691 ident: bib147 article-title: Glutathione levels in human tumors publication-title: Biomarkers – volume: 368 start-page: 85 year: 2020 end-page: + ident: bib180 article-title: Cysteine depletion induces pancreatic tumor ferroptosis in mice publication-title: Science – volume: 50 start-page: 2424 year: 2007 end-page: 2431 ident: bib232 article-title: Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin publication-title: J. Mater. Chem. – volume: 35 start-page: 102418 year: 2021 ident: bib247 article-title: Synthesis and characterization of lysozyme-conjugated Ag.ZnO@HA nanocomposite: a redox and pH-responsive antimicrobial agent with photocatalytic activity publication-title: Photodiagn. Photodyn. – volume: 41 start-page: 989 year: 2018 end-page: 998 ident: bib28 article-title: Glutathione S-transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer publication-title: Oncol. Rep. – volume: 73 start-page: 1727 year: 2007 end-page: 1737 ident: bib211 article-title: Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress publication-title: Biochem. Pharmacol. – volume: 10 start-page: 967 year: 2021 ident: bib244 article-title: N-acetylcysteine (NAC): impacts on human health publication-title: Antioxidants – volume: 368 start-page: 88 year: 2015 end-page: 96 ident: bib172 article-title: Xc - inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism publication-title: Canc. Lett. – volume: 57 start-page: 5725 year: 2018 end-page: 5730 ident: bib122 article-title: Enzyme-MOF nanoreactor activates nontoxic paracetamol for cancer therapy publication-title: Angew. Chem. Int. Ed. – volume: 572 start-page: 402 year: 2019 end-page: 406 ident: bib152 article-title: Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling publication-title: Nature – volume: 176 start-page: 108207 year: 2020 ident: bib182 article-title: Lowering glutathione level by buthionine sulfoximine enhances in vivo photodynamic therapy using chlorin e6-loaded nanoparticles publication-title: Dyes Pigments – volume: 24 start-page: 2533 year: 2010 end-page: 2545 ident: bib15 article-title: Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases publication-title: Faseb. J. – volume: 49 start-page: 1540 year: 2010 end-page: 1573 ident: bib233 article-title: Thiol–ene click chemistry publication-title: Angew. Chem. Int. Ed. – volume: 14 start-page: 347 year: 2020 end-page: 359 ident: bib248 article-title: Surface charge switchable supramolecular nanocarriers for nitric oxide synergistic photodynamic eradication of biofilms publication-title: ACS Nano – volume: 12 start-page: 12380 year: 2018 end-page: 12392 ident: bib135 article-title: Arginine-rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics publication-title: ACS Nano – volume: 30 start-page: 42 year: 2009 end-page: 59 ident: bib41 article-title: Regulation of glutathione synthesis publication-title: Mol. Aspect. Med. – volume: 8 start-page: 9251 year: 2020 end-page: 9257 ident: bib62 article-title: A Janus upconverting nanoplatform with biodegradability for glutathione depletion, near-infrared light induced photodynamic therapy and accelerated excretion publication-title: J. Mater. Chem. B – volume: 18 start-page: 522 year: 2013 end-page: 555 ident: bib154 article-title: The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities publication-title: Antioxidants Redox Signal. – volume: 7 start-page: 5359 year: 2019 end-page: 5368 ident: bib59 article-title: H2O2-activated oxidative stress amplifier capable of GSH scavenging for enhancing tumor photodynamic therapy publication-title: Biomater. Sci. – volume: 14 start-page: 13500 year: 2020 end-page: 13511 ident: bib63 article-title: Metal–organic framework derived multicomponent nanoagent as a reactive oxygen species amplifier for enhanced photodynamic therapy publication-title: ACS Nano – volume: 12 start-page: 17319 year: 2020 end-page: 17331 ident: bib67 article-title: A pH-activated autocatalytic nanoreactor for self-boosting Fenton-like chemodynamic therapy publication-title: Nanoscale – volume: 29 start-page: 1905013 year: 2019 ident: bib106 article-title: Reactive oxygen species–activatable liposomes regulating hypoxic tumor microenvironment for synergistic photo/chemodynamic therapies publication-title: Adv. Funct. Mater. – volume: 114 start-page: 113 year: 1997 end-page: 119 ident: bib230 article-title: Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer publication-title: Canc. Lett. – volume: 24 start-page: R453 year: 2014 end-page: R462 ident: bib52 article-title: ROS function in redox signaling and oxidative stress publication-title: Curr. Biol. – volume: 179 start-page: 93 year: 2008 end-page: 100 ident: bib185 article-title: Cellular responses induced by silver nanoparticles: in vitro studies publication-title: Toxicol. Lett. – volume: 55 start-page: 12956 year: 2019 end-page: 12959 ident: bib66 article-title: A novel Mn–Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion publication-title: Chem. Commun. – volume: 273 start-page: 30 year: 2018 end-page: 39 ident: bib126 article-title: Intracellular glutathione-depleting polymeric micelles for cisplatin prodrug delivery to overcome cisplatin resistance of cancers publication-title: J. Contr. Release – volume: 130 start-page: 346 year: 2017 end-page: 353 ident: bib214 article-title: Ferrocene-embedded flavonoids targeting the Achilles heel of multidrug-resistant cancer cells through collateral sensitivity publication-title: Eur. J. Med. Chem. – volume: 12 start-page: 5680 year: 2020 end-page: 5694 ident: bib91 article-title: Self-delivered and self-monitored chemo-photodynamic nanoparticles with light-triggered synergistic antitumor therapies by downregulation of HIF-1α and depletion of GSH publication-title: ACS Appl. Mater. Interfaces – volume: 266 start-page: 120457 year: 2021 ident: bib68 article-title: A redox-triggered C-centered free radicals nanogenerator for self-enhanced magnetic resonance imaging and chemodynamic therapy publication-title: Biomaterials – volume: 10 start-page: 9865 year: 2020 end-page: 9887 ident: bib137 article-title: Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis publication-title: Theranostics – volume: 47 start-page: 493 year: 2015 end-page: 506 ident: bib201 article-title: 3-Bromopyruvate induces rapid human prostate cancer cell death by affecting cell energy metabolism, GSH pool and the glyoxalase system publication-title: J. Bioenerg. Biomembr. – volume: 31 start-page: 1900730 year: 2019 ident: bib21 article-title: Ultrasmall oxygen‐deficient bimetallic oxide MnWOX nanoparticles for depletion of endogenous GSH and enhanced sonodynamic cancer therapy publication-title: Adv. Mater. – volume: 31 start-page: 2006216 year: 2021 ident: bib103 article-title: An ultrasmall SnFe2O4 nanozyme with endogenous oxygen generation and glutathione depletion for synergistic cancer therapy publication-title: Adv. Funct. Mater. – volume: 9 start-page: 1525 year: 2020 ident: bib198 article-title: Involvement of glutathione depletion in selective cytotoxicity of oridonin to p53-mutant esophageal squamous carcinoma cells publication-title: Front. Oncol. – volume: 189 start-page: 110810 year: 2020 ident: bib111 article-title: A novel versatile yolk-shell nanosystem based on NIR-elevated drug release and GSH depletion-enhanced Fenton-like reaction for synergistic cancer therapy publication-title: Colloids Surf., B – volume: 18 start-page: 4618 year: 2018 end-page: 4625 ident: bib30 article-title: Glutathione-scavenging poly(disulfide amide) nanoparticles for the effective delivery of Pt(IV) prodrugs and reversal of cisplatin resistance publication-title: Nano Lett. – volume: 58 start-page: 1685 year: 2014 end-page: 1707 ident: bib229 article-title: Molecular targets of isothiocyanates in cancer: recent advances publication-title: Mol. Nutr. Food Res. – volume: 251 start-page: 120079 year: 2020 ident: bib101 article-title: A mitochondria-targeting magnetothermogenic nanozyme for magnet-induced synergistic cancer therapy publication-title: Biomaterials – volume: 12 start-page: 4886 year: 2018 end-page: 4893 ident: bib102 article-title: All-in-One theranostic nanoagent with enhanced reactive oxygen species generation and modulating tumor microenvironment ability for effective tumor eradication publication-title: ACS Nano – volume: 7 start-page: 429 year: 2019 end-page: 441 ident: bib90 article-title: Hypoxia- and singlet oxygen-responsive chemo-photodynamic Micelles featured with glutathione depletion and aldehyde production publication-title: Biomater. Sci. – volume: 85 start-page: 1715 year: 2013 end-page: 1724 ident: bib235 article-title: Terminology of metal-organic frameworks and coordination polymers (IUPAC Recommendations 2013) publication-title: Pure Appl. Chem. – volume: 43 start-page: 95 year: 2020 end-page: 106 ident: bib173 article-title: The Xc− inhibitor sulfasalazine improves the anti-cancer effect of pharmacological vitamin C in prostate cancer cells via a glutathione-dependent mechanism publication-title: Cell. Oncol. – volume: 9 start-page: 2233 year: 1970 end-page: 2243 ident: bib192 article-title: On the specificity of steroid interaction with mammary glucose 6-phosphate dehydrogenase publication-title: Biochemistry – volume: 170 start-page: 293 year: 2018 end-page: 302 ident: bib133 article-title: Redox-responsive chemosensitive polyspermine delivers ursolic acid targeting to human breast tumor cells: the depletion of intracellular GSH contents arouses chemosensitizing effects publication-title: Colloids Surf., B – volume: 56 start-page: 14025 year: 2017 end-page: 14030 ident: bib118 article-title: Therapeutic vesicular nanoreactors with tumor-specific activation and self-destruction for synergistic tumor ablation publication-title: Angew. Chem. Int. Ed. – volume: 157 start-page: 705 year: 2018 end-page: 715 ident: bib9 article-title: Redox-responsive nano-carriers as tumor-targeted drug delivery systems publication-title: Eur. J. Med. Chem. – volume: 27 start-page: 423 year: 2019 end-page: 433 ident: bib13 article-title: Stimuli-responsive nanoscale drug delivery systems for cancer therapy publication-title: J. Drug Target. – volume: 10 start-page: 9132 year: 2020 end-page: 9152 ident: bib107 article-title: Tumor microenvironment-triggered nanosystems as dual-relief tumor hypoxia immunomodulators for enhanced phototherapy publication-title: Theranostics – volume: 234 start-page: 7384 year: 2019 end-page: 7394 ident: bib193 article-title: Exogenous glutathione improves intracellular glutathione synthesis via the gamma-glutamyl cycle in bovine zygotes and cleavage embryos publication-title: J. Cell. Physiol. – volume: 67 start-page: 1248 year: 1970 end-page: 1255 ident: bib165 article-title: The gamma-glutamyl cycle: a possible transport system for amino acids publication-title: P. Natl. Acad. Sci. USA – volume: 16 start-page: 2001251 year: 2020 ident: bib139 article-title: Redox responsive metal organic framework nanoparticles induces ferroptosis for cancer therapy publication-title: Small – volume: 30 start-page: 1907954 year: 2020 ident: bib80 article-title: GSH‐Depleted PtCu3 nanocages for chemodynamic‐ enhanced sonodynamic cancer therapy publication-title: Adv. Funct. Mater. – volume: 26 start-page: 1 year: 2016 end-page: 9 ident: bib241 article-title: ABC transporters as mediators of drug resistance and contributors to cancer cell biology publication-title: Drug Resist. Updates – volume: 258 start-page: 1 year: 2012 end-page: 9 ident: bib213 article-title: Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: the role of glutathione publication-title: Toxicol. Appl. Pharmacol. – volume: 13 start-page: 6879 year: 2019 end-page: 6890 ident: bib55 article-title: Cancer-cell-activated photodynamic therapy assisted by Cu(II)-Based metal–organic framework publication-title: ACS Nano – volume: 124 start-page: 10 year: 2017 end-page: 18 ident: bib212 article-title: Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1 publication-title: Biochem. Pharmacol. – volume: 141 start-page: 849 year: 2019 end-page: 857 ident: bib34 article-title: Self-assembled copper–amino acid nanoparticles for in situ glutathione “AND” H2O2 sequentially triggered chemodynamic therapy publication-title: J. Am. Chem. Soc. – volume: 422 start-page: 130094 year: 2021 ident: bib249 article-title: Copper ferrite heterojunction coatings empower polyetheretherketone implant with multi-modal bactericidal functions and boosted osteogenicity through synergistic photo/Fenton-therapy publication-title: Chem. Eng. J. – volume: 10 start-page: 22830 year: 2018 end-page: 22847 ident: bib14 article-title: Redox-sensitive, cholesterol-bearing PEGylated poly(propylene imine)-based dendrimersomes for drug and gene delivery to cancer cells publication-title: Nanoscale – volume: 38 start-page: 438 year: 2019 ident: bib50 article-title: GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway publication-title: J. Exp. Clin. Canc. Res. – volume: 380 start-page: 131 year: 2008 end-page: 144 ident: bib146 article-title: The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants publication-title: J. Mol. Biol. – volume: 70 start-page: 585 year: 2018 end-page: 592 ident: bib166 article-title: The glutathione cycle: glutathione metabolism beyond the γ-glutamyl cycle publication-title: IUBMB Life – volume: 115 start-page: 1541 year: 1998 end-page: 1551 ident: bib42 article-title: Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor publication-title: Gastroenterology – volume: 9 start-page: 133 year: 2020 ident: bib129 article-title: Polyurea dendrimer folate-targeted nanodelivery of l-buthionine sulfoximine as a tool to tackle ovarian cancer chemoresistance publication-title: Antioxidants – volume: 303 start-page: 476 year: 2002 end-page: 486 ident: bib162 article-title: Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter publication-title: J. Pharmacol. Exp. Therapeut. – volume: 399 start-page: 125667 year: 2020 ident: bib71 article-title: Bone-targeted oxidative stress nanoamplifier for synergetic chemo/chemodynamic therapy of bone metastases through increasing generation and reducing elimination of ROS publication-title: Chem. Eng. J. – volume: 42 start-page: 273 year: 2017 end-page: 280 ident: bib224 article-title: Inhibition of reductase systems by 2-AAPA modulates peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells publication-title: Toxicol. Vitro – volume: 19 start-page: 805 year: 2019 end-page: 815 ident: bib96 article-title: Amplification of tumor oxidative stresses with liposomal Fenton catalyst and glutathione inhibitor for enhanced cancer chemotherapy and radiotherapy publication-title: Nano Lett. – volume: 58 start-page: 9846 year: 2019 end-page: 9850 ident: bib115 article-title: Specific generation of singlet oxygen through the russell mechanism in hypoxic tumors and GSH depletion by Cu‐TCPP nanosheets for cancer therapy publication-title: Angew. Chem. Int. Ed. – volume: 10 start-page: 2404 year: 2020 end-page: 2416 ident: bib236 article-title: A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility publication-title: Acta Pharm. Sin. B – volume: 8 start-page: 478 year: 2020 end-page: 483 ident: bib58 article-title: Enhanced photodynamic therapy based on an amphiphilic branched copolymer with pendant vinyl groups for simultaneous GSH depletion and Ce6 release publication-title: J. Mater. Chem. B – volume: 13 start-page: 2658 year: 2007 end-page: 2666 ident: bib194 article-title: Bcl-2 and glutathione depletion sensitizes B16 melanoma to combination therapy and eliminates metastatic disease publication-title: Clin. Canc. Res. – volume: 7 start-page: 61 year: 2010 end-page: 75 ident: bib18 article-title: Oncologic photodynamic therapy photosensitizers: a clinical review publication-title: Photodiagn. Photodyn. – volume: 17 start-page: 275 year: 2011 end-page: 285 ident: bib222 article-title: Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy publication-title: Clin. Canc. Res. – volume: 6 start-page: 30102 year: 2015 end-page: 30114 ident: bib190 article-title: Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death publication-title: Oncotarget – volume: 1830 start-page: 3143 year: 2013 end-page: 3153 ident: bib156 article-title: Glutathione synthesis publication-title: BBA-Gen. Subjects – volume: 47 start-page: 176 year: 2009 end-page: 183 ident: bib225 article-title: Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation publication-title: Free Radic. Biol. Med. – volume: 13 start-page: 357 year: 2019 end-page: 370 ident: bib125 article-title: Glutathione-responsive prodrug nanoparticles for effective drug delivery and cancer therapy publication-title: ACS Nano – volume: 26 start-page: 623 year: 2019 ident: bib171 article-title: Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model publication-title: Chem. Biol. – volume: 36 start-page: 1900018 year: 2019 ident: bib75 article-title: Self-assemble polymeric nanoparticle with GSH exhaustion for SPECT imaging–guided enhanced radioisotope therapy publication-title: Part. Part. Syst. Char. – volume: 35 start-page: 1372 year: 2015 end-page: 1380 ident: bib199 article-title: Cytotoxicity of luteolin in primary rat hepatocytes: the role of CYP3A‐mediated ortho‐benzoquinone metabolite formation and glutathione depletion publication-title: J. Appl. Toxicol. – volume: 77 start-page: 76 year: 2009 end-page: 85 ident: bib216 article-title: The role OF GSH efflux IN staurosporine-induced apoptosis IN colonic epithelial cells publication-title: Biochem. Pharmacol. – volume: 13 start-page: 6561 year: 2019 end-page: 6571 ident: bib57 article-title: A Mn(III)-Sealed metal–organic framework nanosystem for redox-unlocked tumor theranostics publication-title: ACS Nano – volume: 44 start-page: 2578 year: 2020 end-page: 2586 ident: bib98 article-title: Tumor microenvironment responsive mesoporous silica nanoparticles for dual delivery of doxorubicin and chemodynamic therapy (CDT) agent publication-title: New J. Chem. – volume: 10 start-page: 7068 year: 2019 end-page: 7075 ident: bib114 article-title: An inorganic prodrug, tellurium nanowires with enhanced ROS generation and GSH depletion for selective cancer therapy publication-title: Chem. Sci. – volume: 9 start-page: 252 year: 2002 end-page: 263 ident: bib239 article-title: Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line publication-title: Cell Death Differ. – volume: 289 start-page: 30880 year: 2014 end-page: 30888 ident: bib242 article-title: Multidrug resistance protein 1 (MRP1, ABCC1), a “multitasking” ATP-binding cassette (ABC) transporter publication-title: J. Biol. Chem. – volume: 12 start-page: 44523 year: 2020 end-page: 44533 ident: bib83 article-title: Inhibiting radiative transition-mediated multifunctional polymeric nanoplatforms for highly efficient tumor phototherapeutics publication-title: ACS Appl. Mater. Interfaces – volume: 95 start-page: 1177 year: 2017 end-page: 1186 ident: bib189 article-title: Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress publication-title: Biomed. Pharmacother. – volume: 19 start-page: 7866 year: 2019 end-page: 7876 ident: bib136 article-title: Triggered all-active metal organic framework: ferroptosis machinery contributes to the apoptotic photodynamic antitumor therapy publication-title: Nano Lett. – volume: 18 start-page: 261 year: 1971 end-page: 264 ident: bib3 article-title: Respiratory chain linked H(2)O(2) production in pigeon heart mitochondria publication-title: FEBS Lett. – volume: 36 start-page: 1302 year: 2017 end-page: 1315 ident: bib157 article-title: Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine publication-title: EMBO J. – volume: 286 start-page: 95 year: 2006 end-page: 101 ident: bib160 article-title: Consumption of redox energy by glutathione metabolism contributes to hypoxia/reoxygenation-induced injury in astrocytes publication-title: Mol. Cell. Biochem. – volume: 57 start-page: 4891 year: 2018 end-page: 4896 ident: bib33 article-title: Enhanced photodynamic therapy by reduced levels of intracellular glutathione obtained by employing a nano-MOF with CuII as the active center publication-title: Angew. Chem. Int. Ed. – volume: 285 start-page: 16116 year: 2010 end-page: 16124 ident: bib159 article-title: Rapid activation of glutamate cysteine ligase following oxidative stress publication-title: J. Biol. Chem. – volume: 9 start-page: 17639 year: 2019 ident: bib27 article-title: The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells publication-title: Sci. Rep. – volume: 129 start-page: 256 year: 2018 end-page: 267 ident: bib223 article-title: Glutathione reductase-mediated thiol oxidative stress suppresses metastasis of murine melanoma cells publication-title: Free Radic. Biol. Med. – volume: 12 start-page: 1 year: 2019 end-page: 16 ident: bib151 article-title: Ferroptosis, a new form of cell death: opportunities and challenges in cancer publication-title: J. Hematol. Oncol. – volume: 32 start-page: 2002439 year: 2020 ident: bib85 article-title: GSH-depleted nanozymes with hyperthermia-enhanced dual enzyme-mimic activities for tumor nanocatalytic therapy publication-title: Adv. Mater. – volume: 12 start-page: 17254 year: 2020 end-page: 17267 ident: bib100 article-title: Fusiform-like copper(II)-Based metal-organic framework through relief hypoxia and GSH-depletion Co-enhanced starvation and chemodynamic synergetic cancer therapy publication-title: ACS Appl. Mater. Interfaces – volume: 10 start-page: 682 year: 2019 ident: bib179 article-title: Metadherin enhances vulnerability of cancer cells to ferroptosis publication-title: Cell Death Dis. – volume: 18 start-page: 2547 year: 2017 end-page: 2556 ident: bib181 article-title: Oncogene-Selective sensitivity to synchronous cell death following modulation of the amino acid nutrient cystine publication-title: Cell Rep. – volume: 71 start-page: 231 year: 2006 end-page: 238 ident: bib228 article-title: Expression of γ-glutamyltransferase in cancer cells and its significance in drug resistance publication-title: Biochem. Pharmacol. – volume: 259 start-page: 120329 year: 2020 ident: bib121 article-title: Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment publication-title: Biomaterials – volume: 55 start-page: 11467 year: 2016 end-page: 11471 ident: bib22 article-title: Copper(II)–Graphitic carbon nitride triggered synergy: improved ROS generation and reduced glutathione levels for enhanced photodynamic therapy publication-title: Angew. Chem. Int. Ed. – volume: 254 start-page: 120140 year: 2020 ident: bib119 article-title: Boosted photocatalytic activity induced NAMPT-Regulating therapy based on elemental bismuth-humic acids heterojunction for inhibiting tumor proliferation/migration/inflammation publication-title: Biomaterials – volume: 7 start-page: 62 year: 2018 ident: bib35 article-title: Glutathione: antioxidant properties dedicated to nanotechnologies publication-title: Antioxidants – volume: 257 start-page: 120279 year: 2020 ident: bib70 article-title: Biomimetic CoO@AuPt nanozyme responsive to multiple tumor microenvironmental clues for augmenting chemodynamic therapy publication-title: Biomaterials – volume: 6 year: 2020 ident: bib113 article-title: GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer publication-title: Sci. Adv. – volume: 280 start-page: 33766 year: 2005 end-page: 33774 ident: bib158 article-title: Glutamate cysteine ligase catalysis dependence ON ATP and modifier subunit for regulation OF tissue glutathione levels publication-title: J. Biol. Chem. – start-page: 3150145 year: 2019 ident: bib17 article-title: Unraveling the potential role of glutathione in multiple forms of cell death in cancer therapy publication-title: Oxid. Med. Cell. Longev. – volume: 95 start-page: 215 year: 2020 end-page: 223 ident: bib123 article-title: Sanguinarine enhances cisplatin sensitivity via glutathione depletion in cisplatin‐resistant ovarian cancer (A2780) cells publication-title: Chem. Biol. Drug Des. – volume: 8 start-page: 968 year: 2018 ident: bib169 article-title: The ferroptosis inducer erastin irreversibly inhibits system x(c)- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells publication-title: Sci. Rep. – volume: 169 start-page: 53 year: 2019 end-page: 64 ident: bib132 article-title: Lenvatinib-zinc phthalocyanine conjugates as potential agents for enhancing synergistic therapy of multidrug-resistant cancer by glutathione depletion publication-title: Eur. J. Med. Chem. – volume: 10 start-page: 915 year: 2017 end-page: 925 ident: bib176 article-title: Identification of capsazepine as a novel inhibitor of system x(c)(-) and cancer-induced bone pain publication-title: J. Pain Res. – volume: 45 start-page: 152 year: 2019 end-page: 168 ident: bib39 article-title: Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways publication-title: Biofactors – volume: 152 start-page: ‏597 year: 2020 end-page: 608 ident: bib206 article-title: A hydrogen peroxide-activated Cu(II) pro-ionophore strategy for modifying naphthazarin as a promising anticancer agent with high selectivity for generating ROS in HepG2 cells over in L02 cells, Free Radical Bio publication-title: Med – volume: 10 start-page: 10601 year: 2018 end-page: 10606 ident: bib204 article-title: Glutathione-depleting gold nanoclusters for enhanced cancer radiotherapy through synergistic external and internal regulations publication-title: ACS Appl. Mater. Interfaces – volume: 48 start-page: 23 year: 2016 end-page: 32 ident: bib200 article-title: Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells publication-title: J. Bioenerg. Biomembr. – volume: 105 start-page: 53 year: 2018 end-page: 65 ident: bib25 article-title: Drug metabolizing enzymes and their inhibitors' role in cancer resistance, Biomed publication-title: Pharmacother – volume: 11 start-page: 1735 year: 2020 ident: bib79 article-title: An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy publication-title: Nat. Commun. – volume: 30 start-page: 440 year: 2020 end-page: 451 ident: bib47 article-title: The complex interplay between antioxidants and ROS in cancer publication-title: Trends Cell Biol. – volume: 30 start-page: 13 year: 2009 end-page: 28 ident: bib168 article-title: Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology publication-title: Mol. Aspect. Med. – volume: 1019 start-page: 346 year: 2004 end-page: 349 ident: bib44 article-title: Glutathione metabolism during aging and in alzheimer disease publication-title: Ann. NY Acad. Sci. – volume: 3 year: 2014 ident: bib220 article-title: Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis publication-title: eLife – volume: 29 start-page: 1904056 year: 2019 ident: bib110 article-title: Fe(III)‐Porphyrin sonotheranostics: a green triple‐regulated ROS generation nanoplatform for enhanced cancer imaging and therapy publication-title: Adv. Funct. Mater. – volume: 11 start-page: 30551 year: 2019 end-page: 30565 ident: bib20 article-title: Tumor-specific expansion of oxidative stress by glutathione depletion and use of a Fenton nanoagent for enhanced chemodynamic therapy publication-title: ACS Appl. Mater. Interfaces – volume: 27 year: 2020 ident: bib178 article-title: Ferroptosis: a novel mechanism of artemisinin and its derivatives in cancer therapy publication-title: Curr. Med. Chem. – volume: 201 start-page: 92 year: 2011 end-page: 100 ident: bib187 article-title: Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis publication-title: Toxicol. Lett. – volume: 8 start-page: 5059 year: 2018 end-page: 5071 ident: bib61 article-title: Tumor-specific activated photodynamic therapy with an oxidation-regulated strategy for enhancing anti-tumor efficacy publication-title: Theranostics – volume: 29 start-page: 1903850 year: 2019 ident: bib116 article-title: Non-fenton-type hydroxyl radical generation and photothermal effect by mitochondria-targeted WSSe/MnO2 nanocomposite loaded with isoniazid for synergistic anticancer treatment publication-title: Adv. Funct. Mater. – volume: 2018 start-page: 2469486 year: 2018 ident: bib245 article-title: N-acetylcysteine for the treatment of psychiatric disorders: a review of current evidence publication-title: BioMed Res. Int. – volume: 14 start-page: 13894 year: 2020 end-page: 13904 ident: bib31 article-title: A smart nanoparticle-laden and remote-controlled self-destructive macrophage for enhanced chemo/chemodynamic synergistic therapy publication-title: ACS Nano – volume: 82 start-page: 291 year: 1997 end-page: 295 ident: bib5 article-title: Oxidative stress: oxidants and antioxidants publication-title: Exp. Physiol. – volume: 30 start-page: 2002753 year: 2020 ident: bib99 article-title: Bimetallic oxide FeWOX nanosheets as multifunctional cascade bioreactors for tumor microenvironment-modulation and enhanced multimodal cancer therapy publication-title: Adv. Funct. Mater. – volume: 287 start-page: 696 year: 2001 end-page: 700 ident: bib163 article-title: Ryanodine receptor channel-dependent glutathione transport in the sarcoplasmic reticulum of skeletal muscle publication-title: Biochem. Bioph. Res. Co. – volume: 321 start-page: 734 year: 2020 end-page: 743 ident: bib84 article-title: Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy publication-title: J. Contr. Release – volume: 187 start-page: 55 year: 2018 end-page: 65 ident: bib94 article-title: Nitric oxide as an all-rounder for enhanced photodynamic therapy: hypoxia relief, glutathione depletion and reactive nitrogen species generation publication-title: Biomaterials – volume: 13 start-page: 4267 year: 2019 end-page: 4277 ident: bib76 article-title: Biodegradable biomimic copper/manganese silicate nanospheres for chemodynamic/photodynamic synergistic therapy with simultaneous glutathione depletion and hypoxia relief publication-title: ACS Nano – volume: 124 start-page: 342 year: 2018 end-page: 352 ident: bib207 article-title: Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: hitting three birds with one stone publication-title: Free Radic. Biol. Med. – volume: 68 start-page: 2159 year: 2004 end-page: 2165 ident: bib217 article-title: Relation between the ability of some compounds to modulate the MRP1-mediated efflux of glutathione and to inhibit the MRPl-mediated efflux of daunorubicin publication-title: Biochem. Pharmacol. – volume: 6 start-page: 1391 year: 2020 end-page: 1407 ident: bib74 article-title: Synthesis of CaCO3-based nanomedicine for enhanced sonodynamic therapy via amplification of tumor oxidative stress publication-title: Inside Chem. – volume: 110 start-page: 3173 year: 2019 end-page: 3182 ident: bib170 article-title: Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells publication-title: Canc. Sci. – volume: 41 start-page: 509 year: 2009 end-page: 515 ident: bib164 article-title: Redox regulation of gamma-glutamyl transpeptidase publication-title: Am. J. Resp. Cell Mol. – volume: 24 start-page: 161 year: 2014 end-page: 172 ident: bib205 article-title: Oxidative stress contributes to gold nanoparticle-induced cytotoxicity in human tumor cells publication-title: Toxicol. Mech. Methods – volume: 1864 start-page: 129539 year: 2020 ident: bib246 article-title: Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy publication-title: BBA-Gen. Subjects – volume: 7 start-page: 8 year: 2018 ident: bib37 article-title: Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases publication-title: Oncogenesis – volume: 11 start-page: 1926 year: 2019 ident: bib167 article-title: Targeting glutathione metabolism: partner in crime in anticancer therapy publication-title: Nutrients – volume: 108 start-page: 1843 year: 2017 end-page: 1849 ident: bib174 article-title: Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non‐small‐cell lung cancer publication-title: Canc. Sci. – volume: 114 start-page: 10869 year: 2014 end-page: 10939 ident: bib143 article-title: Functional nanomaterials for phototherapies of cancer publication-title: Chem. Rev. – volume: 265 start-page: 120456 year: 2021 ident: bib108 article-title: Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy publication-title: Biomaterials – volume: 13 start-page: 13445 year: 2019 end-page: 13455 ident: bib29 article-title: Sulforaphane mediates glutathione depletion via polymeric nanoparticles to restore cisplatin chemosensitivity publication-title: ACS Nano – volume: 159 start-page: 90 year: 2006 end-page: 103 ident: bib145 article-title: The role of a novel copper complex in overcoming doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo publication-title: Chem. Biol. Interact. – volume: 22 start-page: 744 year: 2015 end-page: 759 ident: bib221 article-title: Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance publication-title: Antioxidants Redox Signal. – volume: 64 start-page: 4950 year: 2004 end-page: 4956 ident: bib208 article-title: Verapamil and its derivative trigger apoptosis through glutathione extrusion by multidrug resistance protein MRP1 publication-title: Canc. Res. – volume: 209 start-page: 111955 year: 2020 ident: bib161 article-title: A ROS responsive nanomedicine with enhanced photodynamic therapy via dual mechanisms: GSH depletion and biosynthesis inhibition publication-title: J. Photochem. Photobiol., B – volume: 2012 start-page: 736837 year: 2012 ident: bib36 article-title: Glutathione homeostasis and functions: potential targets for medical interventions publication-title: J. Amino Acids – volume: 6 start-page: 1900848 year: 2019 ident: bib65 article-title: Monodispersed copper(I)‐Based nano metal–organic framework as a biodegradable drug carrier with enhanced photodynamic therapy efficacy publication-title: Adv. Sci. – volume: 55 start-page: 5477 year: 2016 end-page: 5482 ident: bib19 article-title: A smart photosensitizer–manganese dioxide nanosystem for enhanced photodynamic therapy by reducing glutathione levels in cancer cells publication-title: Angew. Chem. Int. Ed. – volume: 28 start-page: 1800706 year: 2018 ident: bib117 article-title: Stepwise degradable nanocarriers enabled cascade delivery for synergistic cancer therapy publication-title: Adv. Funct. Mater. – volume: 9 start-page: 766 year: 2018 ident: bib10 article-title: Polyrotaxane-based supramolecular theranostics publication-title: Nat. Commun. – volume: 2013 start-page: 972913 year: 2013 ident: bib53 article-title: Role of glutathione in cancer progression and chemoresistance publication-title: Oxid. Med. Cell. Longev. – volume: 142 start-page: 5177 year: 2020 end-page: 5183 ident: bib32 article-title: Bioinspired construction of a nanozyme-based H2O2 homeostasis disruptor for intensive chemodynamic therapy publication-title: J. Am. Chem. Soc. – volume: 106 start-page: 175 year: 2018 end-page: 182 ident: bib197 article-title: Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death, Biomed publication-title: Pharmacother – volume: 220 start-page: 1170 year: 2017 end-page: 1180 ident: bib2 article-title: A radical shift in perspective: mitochondria as regulators of reactive oxygen species publication-title: J. Exp. Biol. – volume: 149 start-page: 1060 year: 2012 end-page: 1072 ident: bib150 article-title: Ferroptosis: an iron-dependent form of nonapoptotic cell death publication-title: Cell – volume: 403 start-page: 126305 year: 2021 ident: bib95 article-title: A glutathione-activatable nanoplatform for enhanced photodynamic therapy with simultaneous hypoxia relief and glutathione depletion publication-title: Chem. Eng. J. – volume: 27 start-page: 211 year: 2015 end-page: 222 ident: bib54 article-title: Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression publication-title: Canc. Cell – volume: 167 start-page: 301 year: 2019 end-page: 308 ident: bib131 article-title: Chemosensitization effect of cerium oxide nanosheets by suppressing drug detoxification and efflux, Ecotox publication-title: Environ. Safe. – volume: 26 start-page: 238 year: 2012 end-page: 251 ident: bib184 article-title: Comparative in vitro cytotoxicity study of silver nanoparticle on two mammalian cell lines publication-title: Toxicol. Vitro – volume: 30 start-page: 2006098 year: 2020 ident: bib87 article-title: Yolk-shell structured nanoflowers induced intracellular oxidative/thermal stress damage for cancer treatment publication-title: Adv. Funct. Mater. – volume: 112 start-page: 13608 year: 2008 end-page: 13619 ident: bib186 article-title: Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species publication-title: J. Phys. Chem. B – volume: 47 start-page: 406 year: 2015 end-page: 419 ident: bib240 article-title: MRP1 and its role in anticancer drug resistance publication-title: Drug Metab. Rev. – volume: 29 year: 2019 ident: bib56 article-title: Persistent regulation of tumor microenvironment via circulating catalysis of MnFe2O4@Metal-organic frameworks for enhanced photodynamic therapy publication-title: Adv. Funct. Mater. – volume: 35 start-page: 100981 year: 2020 ident: bib250 article-title: Nano-decocted ferrous polysulfide coordinates ferroptosis-like death in bacteria for anti-infection therapy publication-title: Nano Today – volume: 407 start-page: 127212 year: 2020 ident: bib92 article-title: Tumor-specific carrier-free nanodrugs with GSH depletion and enhanced ROS generation for endogenous synergistic anti-tumor by a chemotherapy-photodynamic therapy publication-title: Chem. Eng. J. – volume: 12 start-page: 15845 year: 2020 end-page: 15856 ident: bib86 article-title: Two-stage activated nano-truck enhanced specific aggregation and deep delivery for synergistic tumor ablation publication-title: Nanoscale – volume: 428 start-page: 21 year: 2018 end-page: 33 ident: bib177 article-title: Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox 4 and inhibition of xCT publication-title: Canc. Lett. – volume: 115 start-page: 12797 year: 2011 end-page: 12802 ident: bib203 article-title: Association of glutathione level and cytotoxicity of gold nanoparticles in lung cancer cells publication-title: J. Phys. Chem. C – volume: 15 start-page: 2885 year: 2020 end-page: 2902 ident: bib11 article-title: Dual receptor-targeted and redox-sensitive polymeric micelles self-assembled from a folic acid-hyaluronic acid-SS-vitamin E succinate polymer for precise cancer therapy publication-title: Int. J. Nanomed. – volume: 7 start-page: 4260 year: 2019 end-page: 4272 ident: bib124 article-title: Enhancement of cisplatin efficacy by lipid-CaO2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment publication-title: Biomater. Sci. – volume: 6 start-page: 83 year: 2020 ident: bib120 article-title: Small size gold nanoparticles enhance apoptosis-induced by cold atmospheric plasma via depletion of intracellular GSH and modification of oxidative stress publication-title: Cell Death Dis. – volume: 1863 start-page: 129285 year: 2019 ident: bib23 article-title: Glutathione antioxidant system and methylmercury-induced neurotoxicity: an intriguing interplay publication-title: BBA-Gen. Subjects – volume: 25 start-page: 4787 year: 2015 end-page: 4792 ident: bib218 article-title: Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility publication-title: Bioorg. Med. Chem. Lett – volume: 7 start-page: 71 year: 2011 end-page: 78 ident: bib227 article-title: Inhibiting glutathione metabolism in lung lining fluid as a strategy to augment antioxidant defense publication-title: Curr. Enzym. Inhib. – volume: 274 start-page: 56 year: 2018 end-page: 68 ident: bib130 article-title: Reactive oxygen species-responsive nanoprodrug with quinone methides-mediated GSH depletion for improved chlorambucil breast cancers therapy publication-title: J. Contr. Release – volume: 58 start-page: 14134 year: 2019 end-page: 14139 ident: bib105 article-title: Programmed release of dihydroartemisinin for synergistic cancer therapy using a CaCO3 mineralized metal–organic framework publication-title: Angew. Chem. Int. Ed. – volume: 89 start-page: 3070 year: 1992 end-page: 3074 ident: bib26 article-title: High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis publication-title: P. Natl. Acad. Sci. USA – volume: 31 start-page: 11 year: 2003 end-page: 15 ident: bib210 article-title: Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1) publication-title: Drug Metab. Dispos. – volume: 458 start-page: 780 year: 2009 end-page: 783 ident: bib144 article-title: Association of reactive oxygen species levels and radioresistance in cancer stem cells publication-title: Nature – volume: 90 start-page: 235 year: 2014 end-page: 245 ident: bib215 article-title: Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux publication-title: Biochem. Pharmacol. – volume: 23 start-page: 1905 year: 2010 end-page: 1912 ident: bib231 article-title: Thiol reactivity and its impact on the ciliate toxicity of α,β-unsaturated aldehydes, ketones, and esters publication-title: Chem. Res. Toxicol. – volume: 89 start-page: 1 year: 1986 end-page: 8 ident: bib155 article-title: Role of membrane transport in metabolism and function of glutathione in mammals publication-title: J. Membr. Biol. – volume: 51 start-page: 474 year: 2003 end-page: 482 ident: bib234 article-title: Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion publication-title: Canc. Chemother. Pharmacol. – volume: 11 start-page: 13078 year: 2019 end-page: 13088 ident: bib89 article-title: Enhancement of ultralow-intensity NIR light-triggered photodynamic therapy based on exo- and endogenous synergistic effects through combined glutathione-depletion chemotherapy publication-title: Nanoscale – volume: 27 start-page: 438 year: 2006 end-page: 446 ident: bib38 article-title: Transport of glutathione and glutathione conjugates by MRP1 publication-title: Trends Pharmacol. Sci. – volume: 16 start-page: 74 year: 2018 ident: bib238 article-title: Advances in redox-responsive drug delivery systems of tumor microenvironment publication-title: J. Nanobiotechnol. – volume: 2010 start-page: 430939 year: 2010 ident: bib148 article-title: Role of glutathione in the regulation of cisplatin resistance in cancer chemotherapy publication-title: Met. Base. Drugs – volume: 217 start-page: 2291 year: 2018 end-page: 2298 ident: bib40 article-title: Glutathione metabolism in cancer progression and treatment resistance publication-title: J. Cell Biol. – volume: 55 start-page: 6241 year: 2019 end-page: 6244 ident: bib88 article-title: GSH-activated MRI-guided enhanced photodynamic- and chemo-combination therapy with a MnO2-coated porphyrin metal organic framework publication-title: Chem. Commun. – start-page: 1 year: 1985 end-page: 8 ident: bib4 article-title: 1 - oxidative stress: introductory remarks publication-title: Oxidative Stress – volume: 11 start-page: 474 year: 2016 end-page: 480 ident: bib149 article-title: The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine publication-title: Oncol. Lett. – volume: 6 start-page: 225 year: 1970 end-page: 228 ident: bib191 article-title: Inhibition of NADP dependent oxidoreductases by the 6-aminonicotinamide analogue of NADP publication-title: FEBS Lett. – volume: 60 start-page: 3001 year: 2021 end-page: 3007 ident: bib73 article-title: Self-assembled single-site nanozyme for tumor-specific amplified cascade enzymatic therapy publication-title: Angew. Chem. Int. Ed. – volume: 31 start-page: 1661 year: 2020 end-page: 1670 ident: bib109 article-title: Copper-doped nanoscale covalent organic polymer for augmented photo/chemodynamic synergistic therapy and immunotherapy publication-title: Bioconjugate Chem. – volume: 88 start-page: 193 year: 1996 end-page: 197 ident: bib226 article-title: Gamma-Glutamyl transpeptidase mediation of tumor glutathione utilization in vivo publication-title: J. Natl. Cancer Inst. – volume: 11 start-page: 6384 year: 2019 end-page: 6393 ident: bib60 article-title: Potentiating photodynamic therapy of ICG-loaded nanoparticles by depleting GSH with PEITC publication-title: Nanoscale – volume: 104 start-page: 144 year: 2017 end-page: 164 ident: bib46 article-title: Reactive oxygen species and cancer paradox: to promote or to suppress? publication-title: Free Radic. Biol. Med. – volume: 9 start-page: 1161 year: 2020 ident: bib202 article-title: The anticancer drug 3-bromopyruvate induces DNA damage potentially through reactive oxygen species in yeast and in human cancer cells publication-title: Cells – volume: 3 start-page: 55 year: 2001 end-page: 62 ident: bib243 article-title: Verapamil revisited: a transition in novel drug delivery systems and outcomes publication-title: Heart Dis. – volume: 49 start-page: 11851 year: 2020 end-page: 11858 ident: bib69 article-title: A simultaneously GSH-depleted bimetallic Cu(ii) complex for enhanced chemodynamic cancer therapy publication-title: Dalton Trans. – volume: 215 start-page: 8 year: 2019 end-page: 19 ident: bib12 article-title: Redox-sensitive micelles based on retinoic acid modified chitosan conjugate for intracellular drug delivery and smart drug release in cancer therapy publication-title: Carbohydr. Polym. – volume: 9 start-page: 572 year: 2018 ident: bib188 article-title: A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo publication-title: Cell Death Dis. – volume: 636 start-page: 8 year: 2010 end-page: 17 ident: bib43 article-title: Reactive oxygen species and endothelial function in diabetes publication-title: Eur. J. Pharmacol. – volume: 11 start-page: 42988 year: 2019 end-page: 42997 ident: bib140 article-title: Photothermal-enhanced inactivation of glutathione peroxidase for ferroptosis sensitized by an autophagy promotor publication-title: ACS Appl. Mater. Interfaces – start-page: 1 year: 2018 end-page: 18 ident: bib237 article-title: Current developments in Pt(IV) prodrugs conjugated with bioactive ligands publication-title: Bioinorgan. Chem. Appl. – volume: 323 start-page: 203 year: 2020 end-page: 224 ident: bib1 article-title: Tumor microenvironment-induced structure changing drug/gene delivery system for overcoming delivery-associated challenges publication-title: J. Contr. Release – volume: 9 start-page: 29538 year: 2017 end-page: 29546 ident: bib195 article-title: Integrated nanoparticles to synergistically elevate tumor oxidative stress and suppress antioxidative capability for amplified oxidation therapy publication-title: ACS Appl. Mater. Interfaces – volume: 134 start-page: 489 year: 2004 end-page: 492 ident: bib8 article-title: Glutathione metabolism and its implications for health publication-title: J. Nutr. – volume: 71 start-page: 7048 year: 2011 end-page: 7060 ident: bib48 article-title: Increased skin papilloma formation in mice lacking glutathione transferase GSTP publication-title: Canc. Res. – volume: 11 start-page: 31671 year: 2019 end-page: 31680 ident: bib77 article-title: O-2-Cu/ZIF-8@Ce6/ZIF-8@F127 composite as a tumor microenvironment-responsive nanoplatform with enhanced photo-/chemodynamic antitumor efficacy publication-title: ACS Appl. Mater. Interfaces – volume: 67 start-page: 162 year: 2007 end-page: 171 ident: bib219 article-title: Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy publication-title: Prostate – volume: 14 start-page: 874 year: 2019 end-page: 882 ident: bib24 article-title: Glutathione-mediated biotransformation in the liver modulates nanoparticle transport publication-title: Nat. Nanotechnol. – volume: 14 start-page: 14831 year: 2020 end-page: 14845 ident: bib128 article-title: Near-infrared light irradiation induced mild hyperthermia enhances glutathione depletion and DNA interstrand cross-link formation for efficient chemotherapy publication-title: ACS Nano – volume: 9 start-page: 2000864 year: 2020 ident: bib138 article-title: Near infrared-activatable platinum-decorated gold nanostars for synergistic photothermal/ferroptotic therapy in combating cancer drug resistance publication-title: Adv. Healthc. Mater. – volume: 44 start-page: 532 year: 2017 end-page: 553 ident: bib7 article-title: Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species publication-title: Cell. Physiol. Biochem. – volume: 572 start-page: 118782 year: 2019 ident: bib134 article-title: Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells publication-title: Int. J. Pharm. – volume: 106 start-page: 20859 year: 2009 end-page: 20864 ident: bib49 article-title: Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi publication-title: P. Natl. Acad. Sci. USA – volume: 59 start-page: 22537 year: 2020 end-page: 22543 ident: bib72 article-title: Redox dyshomeostasis strategy for hypoxic tumor therapy based on DNAzyme-loaded electrophilic ZIFs publication-title: Angew. Chem. Int. Ed. – volume: 29 start-page: 1906195 year: 2019 ident: bib81 article-title: Ultrasound-activated oxygen and ROS generation nanosystem systematically modulates tumor microenvironment and sensitizes sonodynamic therapy for hypoxic solid tumors publication-title: Adv. Funct. Mater. – volume: 14 start-page: 13536 year: 2020 end-page: 13547 ident: bib127 article-title: Illuminating platinum transportation while maximizing therapeutic efficacy by gold nanoclusters via simultaneous near-infrared-I/II imaging and glutathione scavenging publication-title: ACS Nano – volume: 258 start-page: 120278 year: 2020 ident: bib82 article-title: Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem publication-title: Biomaterials – volume: 15 start-page: 1904870 year: 2019 ident: bib141 article-title: Glutathione depletion in a benign manner by MoS2‐based nanoflowers for enhanced hypoxia‐irrelevant free‐radical‐based cancer therapy publication-title: Small – volume: 27 start-page: 1217 year: 2017 end-page: 1234 ident: bib6 article-title: Huangmenger, multifaceted roles of glutathione and glutathione-based systems in carcinogenesis and anticancer drug resistance publication-title: Antioxidants Redox Signal. – volume: 224 start-page: 119498 year: 2019 ident: bib112 article-title: Programmed degradation of a hierarchical nanoparticle with redox and light responsivity for self-activated photo-chemical enhanced chemodynamic therapy publication-title: Biomaterials – volume: 572 start-page: 402 issue: 7769 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib152 article-title: Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling publication-title: Nature doi: 10.1038/s41586-019-1426-6 – volume: 41 start-page: 989 issue: 2 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib28 article-title: Glutathione S-transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer publication-title: Oncol. Rep. – volume: 14 start-page: 13894 issue: 10 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib31 article-title: A smart nanoparticle-laden and remote-controlled self-destructive macrophage for enhanced chemo/chemodynamic synergistic therapy publication-title: ACS Nano doi: 10.1021/acsnano.0c06290 – volume: 209 start-page: 111955 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib161 article-title: A ROS responsive nanomedicine with enhanced photodynamic therapy via dual mechanisms: GSH depletion and biosynthesis inhibition publication-title: J. Photochem. Photobiol., B doi: 10.1016/j.jphotobiol.2020.111955 – volume: 12 start-page: 44523 issue: 40 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib83 article-title: Inhibiting radiative transition-mediated multifunctional polymeric nanoplatforms for highly efficient tumor phototherapeutics publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.0c12756 – volume: 18 start-page: 522 issue: 5 year: 2013 ident: 10.1016/j.biomaterials.2021.121110_bib154 article-title: The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities publication-title: Antioxidants Redox Signal. doi: 10.1089/ars.2011.4391 – volume: 42 start-page: 273 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib224 article-title: Inhibition of reductase systems by 2-AAPA modulates peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells publication-title: Toxicol. Vitro doi: 10.1016/j.tiv.2017.04.028 – volume: 12 start-page: 4886 issue: 5 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib102 article-title: All-in-One theranostic nanoagent with enhanced reactive oxygen species generation and modulating tumor microenvironment ability for effective tumor eradication publication-title: ACS Nano doi: 10.1021/acsnano.8b01893 – volume: 13 start-page: 2658 issue: 9 year: 2007 ident: 10.1016/j.biomaterials.2021.121110_bib194 article-title: Bcl-2 and glutathione depletion sensitizes B16 melanoma to combination therapy and eliminates metastatic disease publication-title: Clin. Canc. Res. doi: 10.1158/1078-0432.CCR-06-2642 – volume: 30 start-page: 2002753 issue: 49 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib99 article-title: Bimetallic oxide FeWOX nanosheets as multifunctional cascade bioreactors for tumor microenvironment-modulation and enhanced multimodal cancer therapy publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.202002753 – volume: 45 start-page: 152 issue: 2 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib39 article-title: Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways publication-title: Biofactors doi: 10.1002/biof.1476 – volume: 26 start-page: 623 issue: 5 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib171 article-title: Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model publication-title: Chem. Biol. – volume: 251 start-page: 120079 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib101 article-title: A mitochondria-targeting magnetothermogenic nanozyme for magnet-induced synergistic cancer therapy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2020.120079 – volume: 170 start-page: 293 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib133 article-title: Redox-responsive chemosensitive polyspermine delivers ursolic acid targeting to human breast tumor cells: the depletion of intracellular GSH contents arouses chemosensitizing effects publication-title: Colloids Surf., B doi: 10.1016/j.colsurfb.2018.06.029 – volume: 3 start-page: 55 issue: 1 year: 2001 ident: 10.1016/j.biomaterials.2021.121110_bib243 article-title: Verapamil revisited: a transition in novel drug delivery systems and outcomes publication-title: Heart Dis. doi: 10.1097/00132580-200101000-00008 – volume: 56 start-page: 14025 issue: 45 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib118 article-title: Therapeutic vesicular nanoreactors with tumor-specific activation and self-destruction for synergistic tumor ablation publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201706964 – volume: 11 start-page: 42988 issue: 46 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib140 article-title: Photothermal-enhanced inactivation of glutathione peroxidase for ferroptosis sensitized by an autophagy promotor publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.9b16124 – volume: 24 start-page: 2533 issue: 7 year: 2010 ident: 10.1016/j.biomaterials.2021.121110_bib15 article-title: Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases publication-title: Faseb. J. doi: 10.1096/fj.09-149997 – volume: 19 start-page: 323 issue: 1 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib175 article-title: Erastin/sorafenib induces cisplatin-resistant non-small cell lung cancer cell ferroptosis through inhibition of the Nrf2/xCT pathway publication-title: Oncol. Lett. – volume: 142 start-page: 5177 issue: 11 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib32 article-title: Bioinspired construction of a nanozyme-based H2O2 homeostasis disruptor for intensive chemodynamic therapy publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.9b12873 – volume: 24 start-page: R453 issue: 10 year: 2014 ident: 10.1016/j.biomaterials.2021.121110_bib52 article-title: ROS function in redox signaling and oxidative stress publication-title: Curr. Biol. doi: 10.1016/j.cub.2014.03.034 – volume: 31 start-page: 1808200 issue: 15 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib93 article-title: Biomimetic metal–organic framework nanoparticles for cooperative combination of antiangiogenesis and photodynamic therapy for enhanced efficacy publication-title: Adv. Mater. doi: 10.1002/adma.201808200 – volume: 41 start-page: 509 issue: 5 year: 2009 ident: 10.1016/j.biomaterials.2021.121110_bib164 article-title: Redox regulation of gamma-glutamyl transpeptidase publication-title: Am. J. Resp. Cell Mol. doi: 10.1165/rcmb.2009-0169TR – volume: 10 start-page: 9132 issue: 20 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib107 article-title: Tumor microenvironment-triggered nanosystems as dual-relief tumor hypoxia immunomodulators for enhanced phototherapy publication-title: Theranostics doi: 10.7150/thno.46076 – volume: 201 start-page: 92 issue: 1 year: 2011 ident: 10.1016/j.biomaterials.2021.121110_bib187 article-title: Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2010.12.010 – volume: 67 start-page: 162 issue: 2 year: 2007 ident: 10.1016/j.biomaterials.2021.121110_bib219 article-title: Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy publication-title: Prostate doi: 10.1002/pros.20508 – volume: 14 start-page: 13500 issue: 10 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib63 article-title: Metal–organic framework derived multicomponent nanoagent as a reactive oxygen species amplifier for enhanced photodynamic therapy publication-title: ACS Nano doi: 10.1021/acsnano.0c05499 – volume: 73 start-page: 1245 issue: 3 year: 2013 ident: 10.1016/j.biomaterials.2021.121110_bib51 article-title: Tumor suppressor function of the plasma glutathione peroxidase Gpx 3 in colitis-associated carcinoma publication-title: Canc. Res. doi: 10.1158/0008-5472.CAN-12-3150 – volume: 399 start-page: 125667 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib71 article-title: Bone-targeted oxidative stress nanoamplifier for synergetic chemo/chemodynamic therapy of bone metastases through increasing generation and reducing elimination of ROS publication-title: Chem. Eng. J. doi: 10.1016/j.cej.2020.125667 – volume: 58 start-page: 1685 issue: 8 year: 2014 ident: 10.1016/j.biomaterials.2021.121110_bib229 article-title: Molecular targets of isothiocyanates in cancer: recent advances publication-title: Mol. Nutr. Food Res. doi: 10.1002/mnfr.201300684 – volume: 36 start-page: 1900018 issue: 6 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib75 article-title: Self-assemble polymeric nanoparticle with GSH exhaustion for SPECT imaging–guided enhanced radioisotope therapy publication-title: Part. Part. Syst. Char. doi: 10.1002/ppsc.201900018 – volume: 6 start-page: 83 issue: 1 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib120 article-title: Small size gold nanoparticles enhance apoptosis-induced by cold atmospheric plasma via depletion of intracellular GSH and modification of oxidative stress publication-title: Cell Death Dis. doi: 10.1038/s41420-020-00314-x – volume: 286 start-page: 95 issue: 1 year: 2006 ident: 10.1016/j.biomaterials.2021.121110_bib160 article-title: Consumption of redox energy by glutathione metabolism contributes to hypoxia/reoxygenation-induced injury in astrocytes publication-title: Mol. Cell. Biochem. doi: 10.1007/s11010-005-9098-y – volume: 57 start-page: 4891 issue: 18 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib33 article-title: Enhanced photodynamic therapy by reduced levels of intracellular glutathione obtained by employing a nano-MOF with CuII as the active center publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201710800 – volume: 11 start-page: 30551 issue: 34 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib20 article-title: Tumor-specific expansion of oxidative stress by glutathione depletion and use of a Fenton nanoagent for enhanced chemodynamic therapy publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.9b09323 – volume: 106 start-page: 20859 issue: 49 year: 2009 ident: 10.1016/j.biomaterials.2021.121110_bib49 article-title: Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi publication-title: P. Natl. Acad. Sci. USA doi: 10.1073/pnas.0911351106 – volume: 1019 start-page: 346 issue: 1 year: 2004 ident: 10.1016/j.biomaterials.2021.121110_bib44 article-title: Glutathione metabolism during aging and in alzheimer disease publication-title: Ann. NY Acad. Sci. doi: 10.1196/annals.1297.059 – volume: 18 start-page: 261 issue: 2 year: 1971 ident: 10.1016/j.biomaterials.2021.121110_bib3 article-title: Respiratory chain linked H(2)O(2) production in pigeon heart mitochondria publication-title: FEBS Lett. doi: 10.1016/0014-5793(71)80459-3 – volume: 67 start-page: 1248 issue: 3 year: 1970 ident: 10.1016/j.biomaterials.2021.121110_bib165 article-title: The gamma-glutamyl cycle: a possible transport system for amino acids publication-title: P. Natl. Acad. Sci. USA doi: 10.1073/pnas.67.3.1248 – volume: 258 start-page: 1 issue: 1 year: 2012 ident: 10.1016/j.biomaterials.2021.121110_bib213 article-title: Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: the role of glutathione publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2011.08.004 – volume: 73 start-page: 1727 issue: 11 year: 2007 ident: 10.1016/j.biomaterials.2021.121110_bib211 article-title: Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2007.02.005 – volume: 287 start-page: 696 issue: 3 year: 2001 ident: 10.1016/j.biomaterials.2021.121110_bib163 article-title: Ryanodine receptor channel-dependent glutathione transport in the sarcoplasmic reticulum of skeletal muscle publication-title: Biochem. Bioph. Res. Co. doi: 10.1006/bbrc.2001.5648 – volume: 9 start-page: 766 issue: 1 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib10 article-title: Polyrotaxane-based supramolecular theranostics publication-title: Nat. Commun. doi: 10.1038/s41467-018-03119-w – volume: 59 start-page: 22537 issue: 50 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib72 article-title: Redox dyshomeostasis strategy for hypoxic tumor therapy based on DNAzyme-loaded electrophilic ZIFs publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202003653 – volume: 71 start-page: 231 issue: 3 year: 2006 ident: 10.1016/j.biomaterials.2021.121110_bib228 article-title: Expression of γ-glutamyltransferase in cancer cells and its significance in drug resistance publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2005.10.005 – volume: 130 start-page: 346 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib214 article-title: Ferrocene-embedded flavonoids targeting the Achilles heel of multidrug-resistant cancer cells through collateral sensitivity publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2017.02.064 – volume: 129 start-page: 256 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib223 article-title: Glutathione reductase-mediated thiol oxidative stress suppresses metastasis of murine melanoma cells publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2018.07.025 – volume: 6 start-page: 1900848 issue: 15 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib65 article-title: Monodispersed copper(I)‐Based nano metal–organic framework as a biodegradable drug carrier with enhanced photodynamic therapy efficacy publication-title: Adv. Sci. doi: 10.1002/advs.201900848 – volume: 32 start-page: 2002439 issue: 42 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib85 article-title: GSH-depleted nanozymes with hyperthermia-enhanced dual enzyme-mimic activities for tumor nanocatalytic therapy publication-title: Adv. Mater. doi: 10.1002/adma.202002439 – volume: 16 start-page: 74 issue: 1 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib238 article-title: Advances in redox-responsive drug delivery systems of tumor microenvironment publication-title: J. Nanobiotechnol. doi: 10.1186/s12951-018-0398-2 – volume: 68 start-page: 2159 issue: 11 year: 2004 ident: 10.1016/j.biomaterials.2021.121110_bib217 article-title: Relation between the ability of some compounds to modulate the MRP1-mediated efflux of glutathione and to inhibit the MRPl-mediated efflux of daunorubicin publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2004.08.010 – volume: 47 start-page: 406 issue: 4 year: 2015 ident: 10.1016/j.biomaterials.2021.121110_bib240 article-title: MRP1 and its role in anticancer drug resistance publication-title: Drug Metab. Rev. doi: 10.3109/03602532.2015.1105253 – volume: 23 start-page: 1905 issue: 12 year: 2010 ident: 10.1016/j.biomaterials.2021.121110_bib231 article-title: Thiol reactivity and its impact on the ciliate toxicity of α,β-unsaturated aldehydes, ketones, and esters publication-title: Chem. Res. Toxicol. doi: 10.1021/tx100226n – volume: 10 start-page: 967 issue: 6 year: 2021 ident: 10.1016/j.biomaterials.2021.121110_bib244 article-title: N-acetylcysteine (NAC): impacts on human health publication-title: Antioxidants doi: 10.3390/antiox10060967 – volume: 14 start-page: 14831 issue: 11 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib128 article-title: Near-infrared light irradiation induced mild hyperthermia enhances glutathione depletion and DNA interstrand cross-link formation for efficient chemotherapy publication-title: ACS Nano doi: 10.1021/acsnano.0c03781 – volume: 15 start-page: 2885 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib11 article-title: Dual receptor-targeted and redox-sensitive polymeric micelles self-assembled from a folic acid-hyaluronic acid-SS-vitamin E succinate polymer for precise cancer therapy publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S249205 – volume: 10 start-page: 10601 issue: 13 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib204 article-title: Glutathione-depleting gold nanoclusters for enhanced cancer radiotherapy through synergistic external and internal regulations publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.8b00207 – volume: 10 start-page: 22830 issue: 48 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib14 article-title: Redox-sensitive, cholesterol-bearing PEGylated poly(propylene imine)-based dendrimersomes for drug and gene delivery to cancer cells publication-title: Nanoscale doi: 10.1039/C8NR08141G – volume: 13 start-page: 6561 issue: 6 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib57 article-title: A Mn(III)-Sealed metal–organic framework nanosystem for redox-unlocked tumor theranostics publication-title: ACS Nano doi: 10.1021/acsnano.9b00300 – volume: 396 start-page: 125294 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib104 article-title: Multifunctional FeS2 theranostic nanoparticles for photothermal-enhanced chemodynamic/photodynamic cancer therapy and photoacoustic imaging publication-title: Chem. Eng. J. doi: 10.1016/j.cej.2020.125294 – volume: 382 start-page: 160 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib153 article-title: Nanomaterial-induced ferroptosis for cancer specific therapy publication-title: Coord. Chem. Rev. doi: 10.1016/j.ccr.2018.12.015 – volume: 176 start-page: 108207 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib182 article-title: Lowering glutathione level by buthionine sulfoximine enhances in vivo photodynamic therapy using chlorin e6-loaded nanoparticles publication-title: Dyes Pigments doi: 10.1016/j.dyepig.2020.108207 – volume: 29 issue: 25 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib56 article-title: Persistent regulation of tumor microenvironment via circulating catalysis of MnFe2O4@Metal-organic frameworks for enhanced photodynamic therapy publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201901417 – volume: 30 start-page: 1907954 issue: 4 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib80 article-title: GSH‐Depleted PtCu3 nanocages for chemodynamic‐ enhanced sonodynamic cancer therapy publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201907954 – volume: 289 start-page: 30880 issue: 45 year: 2014 ident: 10.1016/j.biomaterials.2021.121110_bib242 article-title: Multidrug resistance protein 1 (MRP1, ABCC1), a “multitasking” ATP-binding cassette (ABC) transporter publication-title: J. Biol. Chem. doi: 10.1074/jbc.R114.609248 – volume: 12 start-page: 12380 issue: 12 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib135 article-title: Arginine-rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics publication-title: ACS Nano doi: 10.1021/acsnano.8b06399 – volume: 11 start-page: 8495 issue: 32 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib251 article-title: A ratiometric fluorescent probe for real-time monitoring of intracellular glutathione fluctuations in response to cisplatin publication-title: Chem. Sci. doi: 10.1039/D0SC02889D – volume: 31 start-page: 2006216 issue: 5 year: 2021 ident: 10.1016/j.biomaterials.2021.121110_bib103 article-title: An ultrasmall SnFe2O4 nanozyme with endogenous oxygen generation and glutathione depletion for synergistic cancer therapy publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.202006216 – volume: 14 start-page: 13536 issue: 10 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib127 article-title: Illuminating platinum transportation while maximizing therapeutic efficacy by gold nanoclusters via simultaneous near-infrared-I/II imaging and glutathione scavenging publication-title: ACS Nano doi: 10.1021/acsnano.0c05541 – volume: 9 start-page: 133 issue: 2 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib129 article-title: Polyurea dendrimer folate-targeted nanodelivery of l-buthionine sulfoximine as a tool to tackle ovarian cancer chemoresistance publication-title: Antioxidants doi: 10.3390/antiox9020133 – volume: 50 start-page: 2424 issue: 10 year: 2007 ident: 10.1016/j.biomaterials.2021.121110_bib232 article-title: Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin publication-title: J. Mater. Chem. – volume: 179 start-page: 93 issue: 2 year: 2008 ident: 10.1016/j.biomaterials.2021.121110_bib185 article-title: Cellular responses induced by silver nanoparticles: in vitro studies publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2008.04.009 – volume: 27 start-page: 423 issue: 4 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib13 article-title: Stimuli-responsive nanoscale drug delivery systems for cancer therapy publication-title: J. Drug Target. doi: 10.1080/1061186X.2018.1519029 – volume: 31 start-page: 11 issue: 1 year: 2003 ident: 10.1016/j.biomaterials.2021.121110_bib210 article-title: Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1) publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.31.1.11 – volume: 167 start-page: 301 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib131 article-title: Chemosensitization effect of cerium oxide nanosheets by suppressing drug detoxification and efflux, Ecotox publication-title: Environ. Safe. doi: 10.1016/j.ecoenv.2018.10.013 – volume: 64 start-page: 4950 issue: 14 year: 2004 ident: 10.1016/j.biomaterials.2021.121110_bib208 article-title: Verapamil and its derivative trigger apoptosis through glutathione extrusion by multidrug resistance protein MRP1 publication-title: Canc. Res. doi: 10.1158/0008-5472.CAN-04-0143 – volume: 95 start-page: 1177 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib189 article-title: Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2017.09.026 – volume: 7 start-page: 61 issue: 2 year: 2010 ident: 10.1016/j.biomaterials.2021.121110_bib18 article-title: Oncologic photodynamic therapy photosensitizers: a clinical review publication-title: Photodiagn. Photodyn. doi: 10.1016/j.pdpdt.2010.02.001 – volume: 8 start-page: 9251 issue: 40 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib62 article-title: A Janus upconverting nanoplatform with biodegradability for glutathione depletion, near-infrared light induced photodynamic therapy and accelerated excretion publication-title: J. Mater. Chem. B doi: 10.1039/D0TB01357A – volume: 58 start-page: 14134 issue: 40 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib105 article-title: Programmed release of dihydroartemisinin for synergistic cancer therapy using a CaCO3 mineralized metal–organic framework publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201907388 – volume: 321 start-page: 734 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib84 article-title: Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy publication-title: J. Contr. Release doi: 10.1016/j.jconrel.2020.03.007 – volume: 18 start-page: 6265 issue: 17 year: 2010 ident: 10.1016/j.biomaterials.2021.121110_bib209 article-title: Iodination of verapamil for a stronger induction of death, through GSH efflux, of cancer cells overexpressing MRP1 publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2010.07.031 – volume: 47 start-page: 176 issue: 2 year: 2009 ident: 10.1016/j.biomaterials.2021.121110_bib225 article-title: Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2009.04.022 – volume: 8 start-page: 968 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib169 article-title: The ferroptosis inducer erastin irreversibly inhibits system x(c)- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells publication-title: Sci. Rep. doi: 10.1038/s41598-018-19213-4 – volume: 189 start-page: 110810 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib111 article-title: A novel versatile yolk-shell nanosystem based on NIR-elevated drug release and GSH depletion-enhanced Fenton-like reaction for synergistic cancer therapy publication-title: Colloids Surf., B doi: 10.1016/j.colsurfb.2020.110810 – volume: 2010 start-page: 430939 year: 2010 ident: 10.1016/j.biomaterials.2021.121110_bib148 article-title: Role of glutathione in the regulation of cisplatin resistance in cancer chemotherapy publication-title: Met. Base. Drugs – volume: 55 start-page: 6241 issue: 44 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib88 article-title: GSH-activated MRI-guided enhanced photodynamic- and chemo-combination therapy with a MnO2-coated porphyrin metal organic framework publication-title: Chem. Commun. doi: 10.1039/C9CC01957J – volume: 114 start-page: 113 issue: 1 year: 1997 ident: 10.1016/j.biomaterials.2021.121110_bib230 article-title: Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer publication-title: Canc. Lett. doi: 10.1016/S0304-3835(97)04639-9 – volume: 141 start-page: 849 issue: 2 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib34 article-title: Self-assembled copper–amino acid nanoparticles for in situ glutathione “AND” H2O2 sequentially triggered chemodynamic therapy publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.8b08714 – volume: 25 start-page: 4787 issue: 21 year: 2015 ident: 10.1016/j.biomaterials.2021.121110_bib218 article-title: Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility publication-title: Bioorg. Med. Chem. Lett doi: 10.1016/j.bmcl.2015.07.018 – volume: 258 start-page: 120278 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib82 article-title: Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem publication-title: Biomaterials doi: 10.1016/j.biomaterials.2020.120278 – volume: 13 start-page: 357 issue: 1 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib125 article-title: Glutathione-responsive prodrug nanoparticles for effective drug delivery and cancer therapy publication-title: ACS Nano doi: 10.1021/acsnano.8b06400 – volume: 30 start-page: 2006098 issue: 51 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib87 article-title: Yolk-shell structured nanoflowers induced intracellular oxidative/thermal stress damage for cancer treatment publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.202006098 – volume: 112 start-page: 13608 issue: 43 year: 2008 ident: 10.1016/j.biomaterials.2021.121110_bib186 article-title: Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species publication-title: J. Phys. Chem. B doi: 10.1021/jp712087m – volume: 18 start-page: 4618 issue: 7 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib30 article-title: Glutathione-scavenging poly(disulfide amide) nanoparticles for the effective delivery of Pt(IV) prodrugs and reversal of cisplatin resistance publication-title: Nano Lett. doi: 10.1021/acs.nanolett.8b01924 – volume: 6 start-page: 1391 issue: 6 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib74 article-title: Synthesis of CaCO3-based nanomedicine for enhanced sonodynamic therapy via amplification of tumor oxidative stress publication-title: Inside Chem. – volume: 9 start-page: 252 issue: 3 year: 2002 ident: 10.1016/j.biomaterials.2021.121110_bib239 article-title: Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4400959 – start-page: 1 year: 1985 ident: 10.1016/j.biomaterials.2021.121110_bib4 article-title: 1 - oxidative stress: introductory remarks – volume: 29 start-page: 1905013 issue: 44 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib106 article-title: Reactive oxygen species–activatable liposomes regulating hypoxic tumor microenvironment for synergistic photo/chemodynamic therapies publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201905013 – volume: 9 start-page: 1161 issue: 5 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib202 article-title: The anticancer drug 3-bromopyruvate induces DNA damage potentially through reactive oxygen species in yeast and in human cancer cells publication-title: Cells doi: 10.3390/cells9051161 – volume: 58 start-page: 9846 issue: 29 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib115 article-title: Specific generation of singlet oxygen through the russell mechanism in hypoxic tumors and GSH depletion by Cu‐TCPP nanosheets for cancer therapy publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201903981 – volume: 24 start-page: 161 issue: 3 year: 2014 ident: 10.1016/j.biomaterials.2021.121110_bib205 article-title: Oxidative stress contributes to gold nanoparticle-induced cytotoxicity in human tumor cells publication-title: Toxicol. Mech. Methods doi: 10.3109/15376516.2013.869783 – volume: 29 start-page: 1903850 issue: 45 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib116 article-title: Non-fenton-type hydroxyl radical generation and photothermal effect by mitochondria-targeted WSSe/MnO2 nanocomposite loaded with isoniazid for synergistic anticancer treatment publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201903850 – volume: 217 start-page: 2291 issue: 7 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib40 article-title: Glutathione metabolism in cancer progression and treatment resistance publication-title: J. Cell Biol. doi: 10.1083/jcb.201804161 – volume: 254 start-page: 120140 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib119 article-title: Boosted photocatalytic activity induced NAMPT-Regulating therapy based on elemental bismuth-humic acids heterojunction for inhibiting tumor proliferation/migration/inflammation publication-title: Biomaterials doi: 10.1016/j.biomaterials.2020.120140 – volume: 60 start-page: 3001 issue: 6 year: 2021 ident: 10.1016/j.biomaterials.2021.121110_bib73 article-title: Self-assembled single-site nanozyme for tumor-specific amplified cascade enzymatic therapy publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202008868 – volume: 234 start-page: 7384 issue: 5 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib193 article-title: Exogenous glutathione improves intracellular glutathione synthesis via the gamma-glutamyl cycle in bovine zygotes and cleavage embryos publication-title: J. Cell. Physiol. doi: 10.1002/jcp.27497 – volume: 368 start-page: 85 issue: 6486 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib180 article-title: Cysteine depletion induces pancreatic tumor ferroptosis in mice publication-title: Science doi: 10.1126/science.aaw9872 – volume: 26 start-page: 1 year: 2016 ident: 10.1016/j.biomaterials.2021.121110_bib241 article-title: ABC transporters as mediators of drug resistance and contributors to cancer cell biology publication-title: Drug Resist. Updates doi: 10.1016/j.drup.2016.03.001 – volume: 35 start-page: 100981 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib250 article-title: Nano-decocted ferrous polysulfide coordinates ferroptosis-like death in bacteria for anti-infection therapy publication-title: Nano Today doi: 10.1016/j.nantod.2020.100981 – volume: 17 start-page: 275 issue: 2 year: 2011 ident: 10.1016/j.biomaterials.2021.121110_bib222 article-title: Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy publication-title: Clin. Canc. Res. doi: 10.1158/1078-0432.CCR-10-1983 – volume: 215 start-page: 8 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib12 article-title: Redox-sensitive micelles based on retinoic acid modified chitosan conjugate for intracellular drug delivery and smart drug release in cancer therapy publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2019.03.064 – volume: 17 start-page: 671 issue: 8 year: 2012 ident: 10.1016/j.biomaterials.2021.121110_bib147 article-title: Glutathione levels in human tumors publication-title: Biomarkers doi: 10.3109/1354750X.2012.715672 – volume: 35 start-page: 1372 issue: 11 year: 2015 ident: 10.1016/j.biomaterials.2021.121110_bib199 article-title: Cytotoxicity of luteolin in primary rat hepatocytes: the role of CYP3A‐mediated ortho‐benzoquinone metabolite formation and glutathione depletion publication-title: J. Appl. Toxicol. doi: 10.1002/jat.3106 – volume: 27 start-page: 438 issue: 8 year: 2006 ident: 10.1016/j.biomaterials.2021.121110_bib38 article-title: Transport of glutathione and glutathione conjugates by MRP1 publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2006.06.008 – volume: 380 start-page: 122369 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib78 article-title: Three birds with one stone: a ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/chemodynamic therapy with glutathione depletion publication-title: Chem. Eng. J. doi: 10.1016/j.cej.2019.122369 – volume: 10 start-page: 2404 issue: 12 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib236 article-title: A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility publication-title: Acta Pharm. Sin. B doi: 10.1016/j.apsb.2020.07.018 – volume: 47 start-page: 493 issue: 6 year: 2015 ident: 10.1016/j.biomaterials.2021.121110_bib201 article-title: 3-Bromopyruvate induces rapid human prostate cancer cell death by affecting cell energy metabolism, GSH pool and the glyoxalase system publication-title: J. Bioenerg. Biomembr. doi: 10.1007/s10863-015-9631-y – volume: 187 start-page: 55 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib94 article-title: Nitric oxide as an all-rounder for enhanced photodynamic therapy: hypoxia relief, glutathione depletion and reactive nitrogen species generation publication-title: Biomaterials doi: 10.1016/j.biomaterials.2018.09.043 – volume: 44 start-page: 2578 issue: 6 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib98 article-title: Tumor microenvironment responsive mesoporous silica nanoparticles for dual delivery of doxorubicin and chemodynamic therapy (CDT) agent publication-title: New J. Chem. doi: 10.1039/C9NJ05427H – volume: 1830 start-page: 3143 issue: 5 year: 2013 ident: 10.1016/j.biomaterials.2021.121110_bib156 article-title: Glutathione synthesis publication-title: BBA-Gen. Subjects doi: 10.1016/j.bbagen.2012.09.008 – volume: 124 start-page: 10 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib212 article-title: Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2016.10.013 – volume: 11 start-page: 1735 issue: 1 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib79 article-title: An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy publication-title: Nat. Commun. doi: 10.1038/s41467-020-15591-4 – volume: 19 start-page: 7866 issue: 11 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib136 article-title: Triggered all-active metal organic framework: ferroptosis machinery contributes to the apoptotic photodynamic antitumor therapy publication-title: Nano Lett. doi: 10.1021/acs.nanolett.9b02904 – volume: 49 start-page: 11851 issue: 34 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib69 article-title: A simultaneously GSH-depleted bimetallic Cu(ii) complex for enhanced chemodynamic cancer therapy publication-title: Dalton Trans. doi: 10.1039/D0DT01742F – volume: 55 start-page: 12956 issue: 86 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib66 article-title: A novel Mn–Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion publication-title: Chem. Commun. doi: 10.1039/C9CC06040E – volume: 6 issue: 36 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib113 article-title: GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer publication-title: Sci. Adv. doi: 10.1126/sciadv.abc4373 – volume: 403 start-page: 126305 year: 2021 ident: 10.1016/j.biomaterials.2021.121110_bib95 article-title: A glutathione-activatable nanoplatform for enhanced photodynamic therapy with simultaneous hypoxia relief and glutathione depletion publication-title: Chem. Eng. J. doi: 10.1016/j.cej.2020.126305 – volume: 11 start-page: 6384 issue: 13 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib60 article-title: Potentiating photodynamic therapy of ICG-loaded nanoparticles by depleting GSH with PEITC publication-title: Nanoscale doi: 10.1039/C9NR01306G – volume: 10 start-page: 7068 issue: 29 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib114 article-title: An inorganic prodrug, tellurium nanowires with enhanced ROS generation and GSH depletion for selective cancer therapy publication-title: Chem. Sci. doi: 10.1039/C9SC01070J – volume: 71 start-page: 7048 issue: 22 year: 2011 ident: 10.1016/j.biomaterials.2021.121110_bib48 article-title: Increased skin papilloma formation in mice lacking glutathione transferase GSTP publication-title: Canc. Res. doi: 10.1158/0008-5472.CAN-11-0882 – volume: 28 start-page: 1800706 issue: 28 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib117 article-title: Stepwise degradable nanocarriers enabled cascade delivery for synergistic cancer therapy publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201800706 – volume: 6 start-page: 225 issue: 3 year: 1970 ident: 10.1016/j.biomaterials.2021.121110_bib191 article-title: Inhibition of NADP dependent oxidoreductases by the 6-aminonicotinamide analogue of NADP publication-title: FEBS Lett. doi: 10.1016/0014-5793(70)80063-1 – volume: 13 start-page: 13445 issue: 11 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib29 article-title: Sulforaphane mediates glutathione depletion via polymeric nanoparticles to restore cisplatin chemosensitivity publication-title: ACS Nano doi: 10.1021/acsnano.9b07032 – volume: 10 start-page: 682 issue: 10 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib179 article-title: Metadherin enhances vulnerability of cancer cells to ferroptosis publication-title: Cell Death Dis. doi: 10.1038/s41419-019-1897-2 – volume: 12 start-page: 17254 issue: 15 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib100 article-title: Fusiform-like copper(II)-Based metal-organic framework through relief hypoxia and GSH-depletion Co-enhanced starvation and chemodynamic synergetic cancer therapy publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.0c01539 – volume: 265 start-page: 120456 year: 2021 ident: 10.1016/j.biomaterials.2021.121110_bib108 article-title: Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2020.120456 – volume: 157 start-page: 705 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib9 article-title: Redox-responsive nano-carriers as tumor-targeted drug delivery systems publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2018.08.034 – volume: 27 start-page: 1217 issue: 15 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib6 article-title: Huangmenger, multifaceted roles of glutathione and glutathione-based systems in carcinogenesis and anticancer drug resistance publication-title: Antioxidants Redox Signal. doi: 10.1089/ars.2017.7134 – volume: 48 start-page: 23 issue: 1 year: 2016 ident: 10.1016/j.biomaterials.2021.121110_bib200 article-title: Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells publication-title: J. Bioenerg. Biomembr. doi: 10.1007/s10863-015-9637-5 – volume: 407 start-page: 127212 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib92 article-title: Tumor-specific carrier-free nanodrugs with GSH depletion and enhanced ROS generation for endogenous synergistic anti-tumor by a chemotherapy-photodynamic therapy publication-title: Chem. Eng. J. doi: 10.1016/j.cej.2020.127212 – volume: 106 start-page: 175 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib197 article-title: Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death, Biomed publication-title: Pharmacother doi: 10.1016/j.biopha.2018.06.111 – volume: 10 start-page: 915 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib176 article-title: Identification of capsazepine as a novel inhibitor of system x(c)(-) and cancer-induced bone pain publication-title: J. Pain Res. doi: 10.2147/JPR.S125045 – volume: 159 start-page: 90 issue: 2 year: 2006 ident: 10.1016/j.biomaterials.2021.121110_bib145 article-title: The role of a novel copper complex in overcoming doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo publication-title: Chem. Biol. Interact. doi: 10.1016/j.cbi.2005.10.044 – volume: 3 year: 2014 ident: 10.1016/j.biomaterials.2021.121110_bib220 article-title: Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis publication-title: eLife doi: 10.7554/eLife.02523 – volume: 636 start-page: 8 issue: 1 year: 2010 ident: 10.1016/j.biomaterials.2021.121110_bib43 article-title: Reactive oxygen species and endothelial function in diabetes publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2010.03.048 – volume: 85 start-page: 1715 issue: 8 year: 2013 ident: 10.1016/j.biomaterials.2021.121110_bib235 article-title: Terminology of metal-organic frameworks and coordination polymers (IUPAC Recommendations 2013) publication-title: Pure Appl. Chem. doi: 10.1351/PAC-REC-12-11-20 – volume: 9 start-page: 572 issue: 5 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib188 article-title: A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo publication-title: Cell Death Dis. doi: 10.1038/s41419-018-0635-5 – volume: 7 start-page: 5359 issue: 12 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib59 article-title: H2O2-activated oxidative stress amplifier capable of GSH scavenging for enhancing tumor photodynamic therapy publication-title: Biomater. Sci. doi: 10.1039/C9BM01354G – volume: 115 start-page: 1541 issue: 6 year: 1998 ident: 10.1016/j.biomaterials.2021.121110_bib42 article-title: Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor publication-title: Gastroenterology doi: 10.1016/S0016-5085(98)70034-4 – volume: 149 start-page: 1060 issue: 5 year: 2012 ident: 10.1016/j.biomaterials.2021.121110_bib150 article-title: Ferroptosis: an iron-dependent form of nonapoptotic cell death publication-title: Cell doi: 10.1016/j.cell.2012.03.042 – volume: 22 start-page: 744 issue: 9 year: 2015 ident: 10.1016/j.biomaterials.2021.121110_bib221 article-title: Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance publication-title: Antioxidants Redox Signal. doi: 10.1089/ars.2014.6142 – volume: 220 start-page: 1170 issue: 7 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib2 article-title: A radical shift in perspective: mitochondria as regulators of reactive oxygen species publication-title: J. Exp. Biol. doi: 10.1242/jeb.132142 – volume: 57 start-page: 4902 issue: 18 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib97 article-title: Simultaneous fenton‐like ion delivery and glutathione depletion by MnO2‐based nanoagent to enhance chemodynamic therapy publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201712027 – volume: 368 start-page: 88 issue: 1 year: 2015 ident: 10.1016/j.biomaterials.2021.121110_bib172 article-title: Xc - inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism publication-title: Canc. Lett. doi: 10.1016/j.canlet.2015.07.031 – volume: 12 start-page: 17319 issue: 33 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib67 article-title: A pH-activated autocatalytic nanoreactor for self-boosting Fenton-like chemodynamic therapy publication-title: Nanoscale doi: 10.1039/D0NR03135F – volume: 27 start-page: 211 issue: 2 year: 2015 ident: 10.1016/j.biomaterials.2021.121110_bib54 article-title: Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression publication-title: Canc. Cell doi: 10.1016/j.ccell.2014.11.019 – volume: 7 start-page: 429 issue: 1 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib90 article-title: Hypoxia- and singlet oxygen-responsive chemo-photodynamic Micelles featured with glutathione depletion and aldehyde production publication-title: Biomater. Sci. doi: 10.1039/C8BM01042K – volume: 89 start-page: 1 issue: 1 year: 1986 ident: 10.1016/j.biomaterials.2021.121110_bib155 article-title: Role of membrane transport in metabolism and function of glutathione in mammals publication-title: J. Membr. Biol. doi: 10.1007/BF01870891 – start-page: 3150145 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib17 article-title: Unraveling the potential role of glutathione in multiple forms of cell death in cancer therapy publication-title: Oxid. Med. Cell. Longev. – volume: 55 start-page: 5477 issue: 18 year: 2016 ident: 10.1016/j.biomaterials.2021.121110_bib19 article-title: A smart photosensitizer–manganese dioxide nanosystem for enhanced photodynamic therapy by reducing glutathione levels in cancer cells publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201510748 – volume: 280 start-page: 33766 issue: 40 year: 2005 ident: 10.1016/j.biomaterials.2021.121110_bib158 article-title: Glutamate cysteine ligase catalysis dependence ON ATP and modifier subunit for regulation OF tissue glutathione levels publication-title: J. Biol. Chem. doi: 10.1074/jbc.M504604200 – volume: 572 start-page: 118782 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib134 article-title: Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2019.118782 – volume: 18 start-page: 2547 issue: 11 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib181 article-title: Oncogene-Selective sensitivity to synchronous cell death following modulation of the amino acid nutrient cystine publication-title: Cell Rep. doi: 10.1016/j.celrep.2017.02.054 – volume: 12 start-page: 15845 issue: 29 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib86 article-title: Two-stage activated nano-truck enhanced specific aggregation and deep delivery for synergistic tumor ablation publication-title: Nanoscale doi: 10.1039/D0NR03661G – volume: 95 start-page: 215 issue: 2 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib123 article-title: Sanguinarine enhances cisplatin sensitivity via glutathione depletion in cisplatin‐resistant ovarian cancer (A2780) cells publication-title: Chem. Biol. Drug Des. doi: 10.1111/cbdd.13621 – volume: 38 start-page: 438 issue: 1 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib50 article-title: GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway publication-title: J. Exp. Clin. Canc. Res. doi: 10.1186/s13046-019-1459-6 – volume: 10 start-page: 9865 issue: 21 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib137 article-title: Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis publication-title: Theranostics doi: 10.7150/thno.46771 – volume: 1864 start-page: 129539 issue: 4 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib246 article-title: Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy publication-title: BBA-Gen. Subjects doi: 10.1016/j.bbagen.2020.129539 – volume: 274 start-page: 56 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib130 article-title: Reactive oxygen species-responsive nanoprodrug with quinone methides-mediated GSH depletion for improved chlorambucil breast cancers therapy publication-title: J. Contr. Release doi: 10.1016/j.jconrel.2018.01.034 – volume: 7 start-page: 4260 issue: 10 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib124 article-title: Enhancement of cisplatin efficacy by lipid-CaO2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment publication-title: Biomater. Sci. doi: 10.1039/C9BM00797K – volume: 30 start-page: 13 issue: 1 year: 2009 ident: 10.1016/j.biomaterials.2021.121110_bib168 article-title: Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology publication-title: Mol. Aspect. Med. doi: 10.1016/j.mam.2008.08.004 – volume: 29 start-page: 1904056 issue: 36 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib110 article-title: Fe(III)‐Porphyrin sonotheranostics: a green triple‐regulated ROS generation nanoplatform for enhanced cancer imaging and therapy publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201904056 – volume: 114 start-page: 10869 issue: 21 year: 2014 ident: 10.1016/j.biomaterials.2021.121110_bib143 article-title: Functional nanomaterials for phototherapies of cancer publication-title: Chem. Rev. doi: 10.1021/cr400532z – volume: 44 start-page: 532 issue: 2 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib7 article-title: Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species publication-title: Cell. Physiol. Biochem. doi: 10.1159/000485089 – volume: 115 start-page: 12797 issue: 26 year: 2011 ident: 10.1016/j.biomaterials.2021.121110_bib203 article-title: Association of glutathione level and cytotoxicity of gold nanoparticles in lung cancer cells publication-title: J. Phys. Chem. C doi: 10.1021/jp2025413 – volume: 19 start-page: 805 issue: 2 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib96 article-title: Amplification of tumor oxidative stresses with liposomal Fenton catalyst and glutathione inhibitor for enhanced cancer chemotherapy and radiotherapy publication-title: Nano Lett. doi: 10.1021/acs.nanolett.8b03905 – volume: 110 start-page: 3173 issue: 10 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib170 article-title: Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells publication-title: Canc. Sci. doi: 10.1111/cas.14181 – volume: 14 start-page: 874 issue: 9 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib24 article-title: Glutathione-mediated biotransformation in the liver modulates nanoparticle transport publication-title: Nat. Nanotechnol. doi: 10.1038/s41565-019-0499-6 – volume: 15 start-page: 1904870 issue: 51 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib141 article-title: Glutathione depletion in a benign manner by MoS2‐based nanoflowers for enhanced hypoxia‐irrelevant free‐radical‐based cancer therapy publication-title: Small doi: 10.1002/smll.201904870 – volume: 88 start-page: 193 issue: 3–4 year: 1996 ident: 10.1016/j.biomaterials.2021.121110_bib226 article-title: Gamma-Glutamyl transpeptidase mediation of tumor glutathione utilization in vivo publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/88.3-4.193 – volume: 51 start-page: 474 issue: 6 year: 2003 ident: 10.1016/j.biomaterials.2021.121110_bib234 article-title: Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion publication-title: Canc. Chemother. Pharmacol. doi: 10.1007/s00280-003-0609-9 – volume: 31 start-page: 1900730 issue: 23 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib21 article-title: Ultrasmall oxygen‐deficient bimetallic oxide MnWOX nanoparticles for depletion of endogenous GSH and enhanced sonodynamic cancer therapy publication-title: Adv. Mater. doi: 10.1002/adma.201900730 – volume: 11 start-page: 1926 issue: 8 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib167 article-title: Targeting glutathione metabolism: partner in crime in anticancer therapy publication-title: Nutrients doi: 10.3390/nu11081926 – volume: 11 start-page: 13078 issue: 27 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib89 article-title: Enhancement of ultralow-intensity NIR light-triggered photodynamic therapy based on exo- and endogenous synergistic effects through combined glutathione-depletion chemotherapy publication-title: Nanoscale doi: 10.1039/C9NR03052B – volume: 11 start-page: 474 issue: 1 year: 2016 ident: 10.1016/j.biomaterials.2021.121110_bib149 article-title: The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine publication-title: Oncol. Lett. doi: 10.3892/ol.2015.3879 – volume: 323 start-page: 203 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib1 article-title: Tumor microenvironment-induced structure changing drug/gene delivery system for overcoming delivery-associated challenges publication-title: J. Contr. Release doi: 10.1016/j.jconrel.2020.04.026 – volume: 7 start-page: 62 issue: 5 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib35 article-title: Glutathione: antioxidant properties dedicated to nanotechnologies publication-title: Antioxidants doi: 10.3390/antiox7050062 – volume: 108 start-page: 1843 issue: 9 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib174 article-title: Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non‐small‐cell lung cancer publication-title: Canc. Sci. doi: 10.1111/cas.13309 – volume: 7 start-page: 71 issue: 2 year: 2011 ident: 10.1016/j.biomaterials.2021.121110_bib227 article-title: Inhibiting glutathione metabolism in lung lining fluid as a strategy to augment antioxidant defense publication-title: Curr. Enzym. Inhib. doi: 10.2174/157340811796575308 – volume: 152 start-page: ‏597 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib206 article-title: A hydrogen peroxide-activated Cu(II) pro-ionophore strategy for modifying naphthazarin as a promising anticancer agent with high selectivity for generating ROS in HepG2 cells over in L02 cells, Free Radical Bio publication-title: Med – volume: 283 start-page: 36071 issue: 52 year: 2008 ident: 10.1016/j.biomaterials.2021.121110_bib16 article-title: Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis publication-title: J. Biol. Chem. doi: 10.1074/jbc.M807061200 – volume: 49 start-page: 1540 issue: 9 year: 2010 ident: 10.1016/j.biomaterials.2021.121110_bib233 article-title: Thiol–ene click chemistry publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.200903924 – volume: 257 start-page: 120279 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib70 article-title: Biomimetic CoO@AuPt nanozyme responsive to multiple tumor microenvironmental clues for augmenting chemodynamic therapy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2020.120279 – volume: 77 start-page: 76 issue: 1 year: 2009 ident: 10.1016/j.biomaterials.2021.121110_bib216 article-title: The role OF GSH efflux IN staurosporine-induced apoptosis IN colonic epithelial cells publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2008.09.011 – volume: 134 start-page: 489 issue: 3 year: 2004 ident: 10.1016/j.biomaterials.2021.121110_bib8 article-title: Glutathione metabolism and its implications for health publication-title: J. Nutr. doi: 10.1093/jn/134.3.489 – volume: 169 start-page: 53 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib132 article-title: Lenvatinib-zinc phthalocyanine conjugates as potential agents for enhancing synergistic therapy of multidrug-resistant cancer by glutathione depletion publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2019.02.065 – volume: 10 start-page: 321 issue: 2 year: 2008 ident: 10.1016/j.biomaterials.2021.121110_bib45 article-title: Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2 publication-title: Antioxidants Redox Signal. doi: 10.1089/ars.2007.1901 – volume: 9 start-page: 2000864 issue: 20 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib138 article-title: Near infrared-activatable platinum-decorated gold nanostars for synergistic photothermal/ferroptotic therapy in combating cancer drug resistance publication-title: Adv. Healthc. Mater. doi: 10.1002/adhm.202000864 – volume: 380 start-page: 131 issue: 1 year: 2008 ident: 10.1016/j.biomaterials.2021.121110_bib146 article-title: The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2008.04.066 – volume: 104 start-page: 144 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib46 article-title: Reactive oxygen species and cancer paradox: to promote or to suppress? publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2017.01.004 – volume: 9 start-page: 2233 issue: 11 year: 1970 ident: 10.1016/j.biomaterials.2021.121110_bib192 article-title: On the specificity of steroid interaction with mammary glucose 6-phosphate dehydrogenase publication-title: Biochemistry doi: 10.1021/bi00813a003 – volume: 428 start-page: 21 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib177 article-title: Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox 4 and inhibition of xCT publication-title: Canc. Lett. doi: 10.1016/j.canlet.2018.04.021 – volume: 14 start-page: 347 issue: 1 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib248 article-title: Surface charge switchable supramolecular nanocarriers for nitric oxide synergistic photodynamic eradication of biofilms publication-title: ACS Nano doi: 10.1021/acsnano.9b05493 – volume: 27 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib178 article-title: Ferroptosis: a novel mechanism of artemisinin and its derivatives in cancer therapy publication-title: Curr. Med. Chem. – volume: 57 start-page: 5725 issue: 20 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib122 article-title: Enzyme-MOF nanoreactor activates nontoxic paracetamol for cancer therapy publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201801378 – volume: 82 start-page: 291 issue: 2 year: 1997 ident: 10.1016/j.biomaterials.2021.121110_bib5 article-title: Oxidative stress: oxidants and antioxidants publication-title: Exp. Physiol. doi: 10.1113/expphysiol.1997.sp004024 – volume: 2018 start-page: 2469486 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib245 article-title: N-acetylcysteine for the treatment of psychiatric disorders: a review of current evidence publication-title: BioMed Res. Int. doi: 10.1155/2018/2469486 – volume: 1863 start-page: 129285 issue: 12 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib23 article-title: Glutathione antioxidant system and methylmercury-induced neurotoxicity: an intriguing interplay publication-title: BBA-Gen. Subjects doi: 10.1016/j.bbagen.2019.01.007 – volume: 8 issue: 1 year: 2013 ident: 10.1016/j.biomaterials.2021.121110_bib183 article-title: Purine nucleoside analog-sulfinosine modulates diverse mechanisms of cancer progression in multi-drug resistant cancer cell lines publication-title: PloS One doi: 10.1371/journal.pone.0054044 – volume: 30 start-page: 42 issue: 1 year: 2009 ident: 10.1016/j.biomaterials.2021.121110_bib41 article-title: Regulation of glutathione synthesis publication-title: Mol. Aspect. Med. doi: 10.1016/j.mam.2008.05.005 – volume: 12 start-page: 15767 issue: 29 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib142 article-title: Histone methyltransferase G9a inhibitor-loaded redox-responsive nanoparticles for pancreatic ductal adenocarcinoma therapy publication-title: Nanoscale doi: 10.1039/D0NR03138K – volume: 8 start-page: 478 issue: 3 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib58 article-title: Enhanced photodynamic therapy based on an amphiphilic branched copolymer with pendant vinyl groups for simultaneous GSH depletion and Ce6 release publication-title: J. Mater. Chem. B doi: 10.1039/C9TB02120E – volume: 11 start-page: 31671 issue: 35 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib77 article-title: O-2-Cu/ZIF-8@Ce6/ZIF-8@F127 composite as a tumor microenvironment-responsive nanoplatform with enhanced photo-/chemodynamic antitumor efficacy publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.9b10685 – volume: 9 start-page: 29538 issue: 35 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib195 article-title: Integrated nanoparticles to synergistically elevate tumor oxidative stress and suppress antioxidative capability for amplified oxidation therapy publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.7b08347 – volume: 89 start-page: 3070 issue: 7 year: 1992 ident: 10.1016/j.biomaterials.2021.121110_bib26 article-title: High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis publication-title: P. Natl. Acad. Sci. USA doi: 10.1073/pnas.89.7.3070 – volume: 458 start-page: 780 issue: 7239 year: 2009 ident: 10.1016/j.biomaterials.2021.121110_bib144 article-title: Association of reactive oxygen species levels and radioresistance in cancer stem cells publication-title: Nature doi: 10.1038/nature07733 – volume: 105 start-page: 53 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib25 article-title: Drug metabolizing enzymes and their inhibitors' role in cancer resistance, Biomed publication-title: Pharmacother doi: 10.1016/j.biopha.2018.05.117 – volume: 6 start-page: 30102 issue: 30 year: 2015 ident: 10.1016/j.biomaterials.2021.121110_bib190 article-title: Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death publication-title: Oncotarget doi: 10.18632/oncotarget.4945 – volume: 29 start-page: 649 issue: 4 year: 2012 ident: 10.1016/j.biomaterials.2021.121110_bib196 article-title: Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells publication-title: Int. J. Mol. Med. doi: 10.3892/ijmm.2012.895 – volume: 30 start-page: 440 issue: 6 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib47 article-title: The complex interplay between antioxidants and ROS in cancer publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2020.03.002 – volume: 9 start-page: 1525 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib198 article-title: Involvement of glutathione depletion in selective cytotoxicity of oridonin to p53-mutant esophageal squamous carcinoma cells publication-title: Front. Oncol. doi: 10.3389/fonc.2019.01525 – volume: 16 start-page: 2001251 issue: 33 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib139 article-title: Redox responsive metal organic framework nanoparticles induces ferroptosis for cancer therapy publication-title: Small doi: 10.1002/smll.202001251 – volume: 2012 start-page: 736837 year: 2012 ident: 10.1016/j.biomaterials.2021.121110_bib36 article-title: Glutathione homeostasis and functions: potential targets for medical interventions publication-title: J. Amino Acids doi: 10.1155/2012/736837 – volume: 70 start-page: 585 issue: 7 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib166 article-title: The glutathione cycle: glutathione metabolism beyond the γ-glutamyl cycle publication-title: IUBMB Life doi: 10.1002/iub.1756 – volume: 55 start-page: 11467 issue: 38 year: 2016 ident: 10.1016/j.biomaterials.2021.121110_bib22 article-title: Copper(II)–Graphitic carbon nitride triggered synergy: improved ROS generation and reduced glutathione levels for enhanced photodynamic therapy publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201605509 – volume: 8 start-page: 5059 issue: 18 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib61 article-title: Tumor-specific activated photodynamic therapy with an oxidation-regulated strategy for enhancing anti-tumor efficacy publication-title: Theranostics doi: 10.7150/thno.28344 – volume: 13 start-page: 4267 issue: 4 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib76 article-title: Biodegradable biomimic copper/manganese silicate nanospheres for chemodynamic/photodynamic synergistic therapy with simultaneous glutathione depletion and hypoxia relief publication-title: ACS Nano doi: 10.1021/acsnano.8b09387 – volume: 29 start-page: 1906195 issue: 51 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib81 article-title: Ultrasound-activated oxygen and ROS generation nanosystem systematically modulates tumor microenvironment and sensitizes sonodynamic therapy for hypoxic solid tumors publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201906195 – start-page: 1 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib237 article-title: Current developments in Pt(IV) prodrugs conjugated with bioactive ligands publication-title: Bioinorgan. Chem. Appl. – volume: 13 start-page: 6879 issue: 6 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib55 article-title: Cancer-cell-activated photodynamic therapy assisted by Cu(II)-Based metal–organic framework publication-title: ACS Nano doi: 10.1021/acsnano.9b01665 – volume: 14 start-page: 11225 issue: 9 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib64 article-title: Surface-charge-switchable nanoclusters for magnetic resonance imaging-guided and glutathione depletion-enhanced photodynamic therapy publication-title: ACS Nano doi: 10.1021/acsnano.0c03080 – volume: 36 start-page: 1302 issue: 10 year: 2017 ident: 10.1016/j.biomaterials.2021.121110_bib157 article-title: Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine publication-title: EMBO J. doi: 10.15252/embj.201696151 – volume: 12 start-page: 1 issue: 1 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib151 article-title: Ferroptosis, a new form of cell death: opportunities and challenges in cancer publication-title: J. Hematol. Oncol. doi: 10.1186/s13045-019-0720-y – volume: 35 start-page: 102418 year: 2021 ident: 10.1016/j.biomaterials.2021.121110_bib247 article-title: Synthesis and characterization of lysozyme-conjugated Ag.ZnO@HA nanocomposite: a redox and pH-responsive antimicrobial agent with photocatalytic activity publication-title: Photodiagn. Photodyn. doi: 10.1016/j.pdpdt.2021.102418 – volume: 273 start-page: 30 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib126 article-title: Intracellular glutathione-depleting polymeric micelles for cisplatin prodrug delivery to overcome cisplatin resistance of cancers publication-title: J. Contr. Release doi: 10.1016/j.jconrel.2018.01.019 – volume: 90 start-page: 235 issue: 3 year: 2014 ident: 10.1016/j.biomaterials.2021.121110_bib215 article-title: Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2014.05.017 – volume: 7 start-page: 8 issue: 1 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib37 article-title: Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases publication-title: Oncogenesis doi: 10.1038/s41389-017-0025-3 – volume: 124 start-page: 342 year: 2018 ident: 10.1016/j.biomaterials.2021.121110_bib207 article-title: Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: hitting three birds with one stone publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2018.06.021 – volume: 9 start-page: 17639 issue: 1 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib27 article-title: The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells publication-title: Sci. Rep. doi: 10.1038/s41598-019-54065-6 – volume: 285 start-page: 16116 issue: 21 year: 2010 ident: 10.1016/j.biomaterials.2021.121110_bib159 article-title: Rapid activation of glutamate cysteine ligase following oxidative stress publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.116210 – volume: 26 start-page: 238 issue: 2 year: 2012 ident: 10.1016/j.biomaterials.2021.121110_bib184 article-title: Comparative in vitro cytotoxicity study of silver nanoparticle on two mammalian cell lines publication-title: Toxicol. Vitro doi: 10.1016/j.tiv.2011.12.004 – volume: 12 start-page: 5680 issue: 5 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib91 article-title: Self-delivered and self-monitored chemo-photodynamic nanoparticles with light-triggered synergistic antitumor therapies by downregulation of HIF-1α and depletion of GSH publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.9b23325 – volume: 31 start-page: 1661 issue: 6 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib109 article-title: Copper-doped nanoscale covalent organic polymer for augmented photo/chemodynamic synergistic therapy and immunotherapy publication-title: Bioconjugate Chem. doi: 10.1021/acs.bioconjchem.0c00209 – volume: 2013 start-page: 972913 year: 2013 ident: 10.1016/j.biomaterials.2021.121110_bib53 article-title: Role of glutathione in cancer progression and chemoresistance publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2013/972913 – volume: 422 start-page: 130094 year: 2021 ident: 10.1016/j.biomaterials.2021.121110_bib249 article-title: Copper ferrite heterojunction coatings empower polyetheretherketone implant with multi-modal bactericidal functions and boosted osteogenicity through synergistic photo/Fenton-therapy publication-title: Chem. Eng. J. doi: 10.1016/j.cej.2021.130094 – volume: 43 start-page: 95 issue: 1 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib173 article-title: The Xc− inhibitor sulfasalazine improves the anti-cancer effect of pharmacological vitamin C in prostate cancer cells via a glutathione-dependent mechanism publication-title: Cell. Oncol. doi: 10.1007/s13402-019-00474-8 – volume: 266 start-page: 120457 year: 2021 ident: 10.1016/j.biomaterials.2021.121110_bib68 article-title: A redox-triggered C-centered free radicals nanogenerator for self-enhanced magnetic resonance imaging and chemodynamic therapy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2020.120457 – volume: 224 start-page: 119498 year: 2019 ident: 10.1016/j.biomaterials.2021.121110_bib112 article-title: Programmed degradation of a hierarchical nanoparticle with redox and light responsivity for self-activated photo-chemical enhanced chemodynamic therapy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2019.119498 – volume: 303 start-page: 476 issue: 2 year: 2002 ident: 10.1016/j.biomaterials.2021.121110_bib162 article-title: Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter publication-title: J. Pharmacol. Exp. Therapeut. doi: 10.1124/jpet.102.040220 – volume: 259 start-page: 120329 year: 2020 ident: 10.1016/j.biomaterials.2021.121110_bib121 article-title: Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment publication-title: Biomaterials doi: 10.1016/j.biomaterials.2020.120329
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Snippet	Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a high level of GSH is indispensable to scavenge excessive reactive...
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SubjectTerms	biocompatible materials Cancer therapy drug delivery systems Drug resistance Ferroptosis glutathione Glutathione depletion metabolism Nanomaterials oxidative stress photochemotherapy Reactive oxygen species xenobiotics
Title	Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy
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