Tissue and serum biomarkers as prognostic variables in endometrioid-type endometrial cancer

FIGO stage, tumor grade, depth of myometrial invasion, lymph-vascular space status and lymph node status are the most important clinical-pathological prognostic variables for endometrioid-type endometrial carcinoma. In the last years, several investigations have assessed different biological variabl...

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Bibliographic Details
Published in:	Critical reviews in oncology/hematology Vol. 80; no. 2; pp. 181 - 192
Main Authors:	Gadducci, Angiolo, Cosio, Stefania, Genazzani, Andrea Riccardo
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 01.11.2011 Elsevier
Subjects:	Animals Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - blood Biomarkers, Tumor - genetics CA 125 Carcinoma, Endometrioid - blood Carcinoma, Endometrioid - diagnosis Carcinoma, Endometrioid - genetics DNA aneuploidy Endometrial Neoplasms - blood Endometrial Neoplasms - diagnosis Endometrial Neoplasms - genetics Endometriod endometrial carcinoma Female Female genital diseases Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Hematologic and hematopoietic diseases Hematology, Oncology and Palliative Medicine Humans K-ras Medical sciences Microsatellite instability mTOR Mutation p53 Prognosis PTEN Tumors Vascular endothelial growth factor β-Catenin K-ras CA 125 DNA aneuploidy PTEN mTOR β-Catenin Microsatellite instability Vascular endothelial growth factor Endometriod endometrial carcinoma p53 Chromosomal aberration Carbohydrate antigen Endometrium cancer Prognosis Biological marker Aneuploidy Tumoral marker K ras Gene Cancerology TP53 Gene Microsatellite DNA Uterine diseases Serum PTEN Gene Endometrium carcinoma Protooncogene Tumor suppressor gene Tumor associated antigen Malignant tumor Female genital diseases Vascular endothelium growth factor C-Onc gene β Catenin Mammalian target of rapamycin Cytogenetics CA 125 antigen Instability Cancer
ISSN:	1040-8428, 1879-0461, 1879-0461
Online Access:	Get full text
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Summary:	FIGO stage, tumor grade, depth of myometrial invasion, lymph-vascular space status and lymph node status are the most important clinical-pathological prognostic variables for endometrioid-type endometrial carcinoma. In the last years, several investigations have assessed different biological variables in tissue and serum samples from patients with this malignancy in order to detect biomarkers able to predict the clinical outcome. The present paper reviewed the literature data about the prognostic relevance of mutational status and/or immunohistochemical expression of p53, PTEN, PIK3, mTOR, β-catenin, k-ras and RASSF1A, microsatellite instability, vascular endothelial growth factor expression, DNA aneuploidy, and serum assay of CA125 and other tumor associated antigens. Tissue and serum biomarkers could be used, in addition to the conventional clinical-pathological variables, for the stratification of patients into categories with different risk of recurrence to better tailor adjuvant treatment.
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ISSN:	1040-8428 1879-0461 1879-0461
DOI:	10.1016/j.critrevonc.2010.11.005