Tissue and serum biomarkers as prognostic variables in endometrioid-type endometrial cancer
FIGO stage, tumor grade, depth of myometrial invasion, lymph-vascular space status and lymph node status are the most important clinical-pathological prognostic variables for endometrioid-type endometrial carcinoma. In the last years, several investigations have assessed different biological variabl...
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| Vydáno v: | Critical reviews in oncology/hematology Ročník 80; číslo 2; s. 181 - 192 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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Shannon
Elsevier Ireland Ltd
01.11.2011
Elsevier |
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| ISSN: | 1040-8428, 1879-0461, 1879-0461 |
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| Abstract | FIGO stage, tumor grade, depth of myometrial invasion, lymph-vascular space status and lymph node status are the most important clinical-pathological prognostic variables for endometrioid-type endometrial carcinoma. In the last years, several investigations have assessed different biological variables in tissue and serum samples from patients with this malignancy in order to detect biomarkers able to predict the clinical outcome.
The present paper reviewed the literature data about the prognostic relevance of mutational status and/or immunohistochemical expression of p53, PTEN, PIK3, mTOR, β-catenin, k-ras and RASSF1A, microsatellite instability, vascular endothelial growth factor expression, DNA aneuploidy, and serum assay of CA125 and other tumor associated antigens. Tissue and serum biomarkers could be used, in addition to the conventional clinical-pathological variables, for the stratification of patients into categories with different risk of recurrence to better tailor adjuvant treatment. |
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| AbstractList | FIGO stage, tumor grade, depth of myometrial invasion, lymph-vascular space status and lymph node status are the most important clinical-pathological prognostic variables for endometrioid-type endometrial carcinoma. In the last years, several investigations have assessed different biological variables in tissue and serum samples from patients with this malignancy in order to detect biomarkers able to predict the clinical outcome.
The present paper reviewed the literature data about the prognostic relevance of mutational status and/or immunohistochemical expression of p53, PTEN, PIK3, mTOR, β-catenin, k-ras and RASSF1A, microsatellite instability, vascular endothelial growth factor expression, DNA aneuploidy, and serum assay of CA125 and other tumor associated antigens. Tissue and serum biomarkers could be used, in addition to the conventional clinical-pathological variables, for the stratification of patients into categories with different risk of recurrence to better tailor adjuvant treatment. Abstract FIGO stage, tumor grade, depth of myometrial invasion, lymph-vascular space status and lymph node status are the most important clinical-pathological prognostic variables for endometrioid-type endometrial carcinoma. In the last years, several investigations have assessed different biological variables in tissue and serum samples from patients with this malignancy in order to detect biomarkers able to predict the clinical outcome. The present paper reviewed the literature data about the prognostic relevance of mutational status and/or immunohistochemical expression of p53, PTEN, PIK3, mTOR, β-catenin, k-ras and RASSF1A, microsatellite instability, vascular endothelial growth factor expression, DNA aneuploidy, and serum assay of CA125 and other tumor associated antigens. Tissue and serum biomarkers could be used, in addition to the conventional clinical-pathological variables, for the stratification of patients into categories with different risk of recurrence to better tailor adjuvant treatment. FIGO stage, tumor grade, depth of myometrial invasion, lymph-vascular space status and lymph node status are the most important clinical-pathological prognostic variables for endometrioid-type endometrial carcinoma. In the last years, several investigations have assessed different biological variables in tissue and serum samples from patients with this malignancy in order to detect biomarkers able to predict the clinical outcome. The present paper reviewed the literature data about the prognostic relevance of mutational status and/or immunohistochemical expression of p53, PTEN, PIK3, mTOR, β-catenin, k-ras and RASSF1A, microsatellite instability, vascular endothelial growth factor expression, DNA aneuploidy, and serum assay of CA125 and other tumor associated antigens. Tissue and serum biomarkers could be used, in addition to the conventional clinical-pathological variables, for the stratification of patients into categories with different risk of recurrence to better tailor adjuvant treatment. FIGO stage, tumor grade, depth of myometrial invasion, lymph-vascular space status and lymph node status are the most important clinical-pathological prognostic variables for endometrioid-type endometrial carcinoma. In the last years, several investigations have assessed different biological variables in tissue and serum samples from patients with this malignancy in order to detect biomarkers able to predict the clinical outcome. The present paper reviewed the literature data about the prognostic relevance of mutational status and/or immunohistochemical expression of p53, PTEN, PIK3, mTOR, β-catenin, k-ras and RASSF1A, microsatellite instability, vascular endothelial growth factor expression, DNA aneuploidy, and serum assay of CA125 and other tumor associated antigens. Tissue and serum biomarkers could be used, in addition to the conventional clinical-pathological variables, for the stratification of patients into categories with different risk of recurrence to better tailor adjuvant treatment.FIGO stage, tumor grade, depth of myometrial invasion, lymph-vascular space status and lymph node status are the most important clinical-pathological prognostic variables for endometrioid-type endometrial carcinoma. In the last years, several investigations have assessed different biological variables in tissue and serum samples from patients with this malignancy in order to detect biomarkers able to predict the clinical outcome. The present paper reviewed the literature data about the prognostic relevance of mutational status and/or immunohistochemical expression of p53, PTEN, PIK3, mTOR, β-catenin, k-ras and RASSF1A, microsatellite instability, vascular endothelial growth factor expression, DNA aneuploidy, and serum assay of CA125 and other tumor associated antigens. Tissue and serum biomarkers could be used, in addition to the conventional clinical-pathological variables, for the stratification of patients into categories with different risk of recurrence to better tailor adjuvant treatment. |
| Author | Genazzani, Andrea Riccardo Gadducci, Angiolo Cosio, Stefania |
| Author_xml | – sequence: 1 givenname: Angiolo surname: Gadducci fullname: Gadducci, Angiolo email: a.gadducci@obgyn.med.unipi.it – sequence: 2 givenname: Stefania surname: Cosio fullname: Cosio, Stefania – sequence: 3 givenname: Andrea Riccardo surname: Genazzani fullname: Genazzani, Andrea Riccardo |
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| CitedBy_id | crossref_primary_10_3892_ol_2018_7909 crossref_primary_10_3390_ijms140612123 crossref_primary_10_1007_s13277_014_2676_4 crossref_primary_10_1155_2022_1442441 crossref_primary_10_1016_j_cca_2013_07_017 crossref_primary_10_1177_03936155221132292 crossref_primary_10_3390_cancers13235953 crossref_primary_10_3109_09513590_2013_801446 crossref_primary_10_1016_j_critrevonc_2016_06_006 crossref_primary_10_1016_j_humpath_2012_09_007 crossref_primary_10_1016_j_ygyno_2017_06_017 |
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| Keywords | K-ras CA 125 DNA aneuploidy PTEN mTOR β-Catenin Microsatellite instability Vascular endothelial growth factor Endometriod endometrial carcinoma p53 Chromosomal aberration Carbohydrate antigen Endometrium cancer Prognosis Biological marker Aneuploidy Tumoral marker K ras Gene Cancerology TP53 Gene Microsatellite DNA Uterine diseases Serum PTEN Gene Endometrium carcinoma Protooncogene Tumor suppressor gene Tumor associated antigen Malignant tumor Female genital diseases Vascular endothelium growth factor C-Onc gene β Catenin Mammalian target of rapamycin Cytogenetics CA 125 antigen Instability Cancer |
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| SubjectTerms | Animals Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - blood Biomarkers, Tumor - genetics CA 125 Carcinoma, Endometrioid - blood Carcinoma, Endometrioid - diagnosis Carcinoma, Endometrioid - genetics DNA aneuploidy Endometrial Neoplasms - blood Endometrial Neoplasms - diagnosis Endometrial Neoplasms - genetics Endometriod endometrial carcinoma Female Female genital diseases Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Hematologic and hematopoietic diseases Hematology, Oncology and Palliative Medicine Humans K-ras Medical sciences Microsatellite instability mTOR Mutation p53 Prognosis PTEN Tumors Vascular endothelial growth factor β-Catenin |
| Title | Tissue and serum biomarkers as prognostic variables in endometrioid-type endometrial cancer |
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