Single‐extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron‐derived EVs

Isolation of neuron‐derived extracellular vesicles (NDEVs) with L1 Cell Adhesion Molecule (L1CAM)‐specific antibodies has been widely used to identify blood biomarkers of CNS disorders. However, full methodological validation requires demonstration of L1CAM in individual NDEVs and lower levels or ab...

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Bibliographic Details
Published in:	Journal of extracellular vesicles Vol. 13; no. 6; pp. e12459 - n/a
Main Authors:	Nogueras‐Ortiz, Carlos J, Eren, Erden, Yao, Pamela, Calzada, Elizabeth, Dunn, Christopher, Volpert, Olga, Delgado‐Peraza, Francheska, Mustapic, Maja, Lyashkov, Alexey, Rubio, F Javier, Vreones, Michael, Cheng, Lesley, You, Yang, Hill, Andrew F, Ikezu, Tsuneya, Eitan, Erez, Goetzl, Edward J, Kapogiannis, Dimitrios
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01.06.2024 John Wiley and Sons Inc Wiley
Subjects:	Alzheimer's disease Biomarkers Biomarkers - blood Biomarkers - metabolism blood biomarkers Brain diseases Cell adhesion & migration Cell adhesion molecules Cerebrospinal fluid Epitopes Extracellular vesicles Extracellular Vesicles - metabolism Humans L1CAM Ligands Microscopy Molecules Neural Cell Adhesion Molecule L1 - metabolism Neurons Neurons - metabolism neuron‐derived extracellular vesicles Pathology Plasma Proteins Tubulin Tubulin - metabolism Vesicle-Associated Membrane Protein 2 - metabolism blood biomarkers extracellular vesicles neuron‐derived extracellular vesicles L1CAM Alzheimer's disease
ISSN:	2001-3078, 2001-3078
Online Access:	Get full text
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