Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019

Background Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with allergic rhinitis and food allergy and cause high morbidity and mortality both in children and adults. This study aims to evaluate the global, regional, national, and temporal trends of the burden of asthma and...

Full description

Saved in:
Bibliographic Details
Published in:Allergy (Copenhagen) Vol. 78; no. 8; pp. 2232 - 2254
Main Authors: Shin, Youn Ho, Hwang, Jimin, Lee, Seung Won, Abate, Yohannes Habtegiorgis, Abbasi‐Kangevari, Mohsen, Aboagye, Richard Gyan, Adane, Tigist Demssew, Adha, Rishan, Adnani, Qorinah Estiningtyas Sakilah, Ahmadi, Ali, Ahmed, Ali, Ahmed, Ayman, Al‐Azzam, Sayer, Alhalaiqa, Fadwa Alhalaiqa Naji, Alipour, Vahid, Altirkawi, Khalid A., Ansar, Adnan, Azadnajafabad, Sina, Babaei, Mahsa, Badawi, Alaa, Baghcheghi, Nayereh, Bagherieh, Sara, Bajbouj, Khuloud, Barone‐Adesi, Francesco, Barrow, Amadou, Bhat, Ajay Nagesh, Carr, Sinclair, Carugno, Andrea, Chakraborty, Promit Ananyo, Dai, Xiaochen, Foroutan, Masoud, Gela, Yibeltal Yismaw, Obsa, Abera Getachew, Gillum, Richard F., Goldust, Mohamad, Golechha, Mahaveer, Heibati, Behzad, Horita, Nobuyuki, Hossain, Md Shakhaoat, Ilic, Milena D., Irilouzadian, Rana, Ismail, Nahlah Elkudssiah, Kaambwa, Billingsley, Kabir, Zubair, Kandel, Himal, Kaur, Harkiran, Keikavoosi‐Arani, Leila, Keykhaei, Mohammad, Khan, Maseer, Kisa, Adnan, Lám, Judit, Maharaj, Sandeep B., Mahmoud, Mansour Adam, Malik, Ahmad Azam, Mamun, Abdullah A., Medina, John Robert Carabeo, Menezes, Ritesh G., Mensah, George A., Minh, Le Huu Nhat, Mulugeta, Temesgen, Murillo‐Zamora, Efrén, Swamy, Sreenivas Narasimha, Natto, Zuhair S., Nazari, Javad, Nguyen, Dang H., Oancea, Bogdan, Obaidur, Rahman Md, Okati‐Aliabad, Hassan, Pandey, Anamika, Park, Eun‐Kee, Patthipati, Venkata Suresh, Rahimi, Mehran, Rahmani, Shayan, Rajput, Prashant, Ramasubramani, Premkumar, Ratan, Zubair Ahmed, Redwan, Elrashdy Moustafa Mohamed, Rezaei, Saeid, Roever, Leonardo, Saad, Aly M. A., Sahebkar, Amirhossein, Samy, Abdallah M., Senthilkumaran, Subramanian, Shaikh, Masood Ali, Shigematsu, Mika, Singh, Jasvinder A., Soyiri, Ireneous N., Thangaraju, Pugazhenthan, Tusa, Biruk Shalmeno, Ullah, Irfan, Ullah, Sana, Verras, Georgios‐Ioannis, Wickramasinghe, Nuwan Darshana, Yada, Dereje Y., Zeineddine, Mohammad A., Zenebe, Getachew Assefa, Zoladl, Mohammad, Shin, Jae Il, Yon, Dong Keon
Format: Journal Article
Language:English
Published: Denmark Blackwell Publishing Ltd 01.08.2023
Subjects:
Adult
adulthood
Age
Allergic rhinitis
Asthma
Asthma - epidemiology
Atopic dermatitis
Body mass index
burden of disease
Child
Child, Preschool
Demography
disability‐adjusted life years
Disease
Eczema
epidemiology
Food allergies
global burden
Global Burden of Disease
Global Health
Humans
Incidence
Morbidity
Mortality
Prevalence
Quality-Adjusted Life Years
risk
Risk Factors
Trends
uncertainty
epidemiology
disability-adjusted life years
eczema
mortality
atopic dermatitis
asthma
global burden
ISSN:0105-4538, 1398-9995, 1398-9995
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with allergic rhinitis and food allergy and cause high morbidity and mortality both in children and adults. This study aims to evaluate the global, regional, national, and temporal trends of the burden of asthma and AD from 1990 to 2019 and analyze their associations with geographic, demographic, social, and clinical factors. Methods Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2019, we assessed the age‐standardized prevalence, incidence, mortality, and disability‐adjusted life years (DALYs) of both asthma and AD from 1990 to 2019, stratified by geographic region, age, sex, and socio‐demographic index (SDI). DALYs were calculated as the sum of years lived with disability and years of life lost to premature mortality. Additionally, the disease burden of asthma attributable to high body mass index, occupational asthmagens, and smoking was described. Results In 2019, there were a total of 262 million [95% uncertainty interval (UI): 224–309 million] cases of asthma and 171 million [95% UI: 165–178 million] total cases of AD globally; age‐standardized prevalence rates were 3416 [95% UI: 2899–4066] and 2277 [95% UI: 2192–2369] per 100,000 population for asthma and AD, respectively, a 24.1% [95% UI: −27.2 to −20.8] decrease for asthma and a 4.3% [95% UI: 3.8–4.8] decrease for AD compared to baseline in 1990. Both asthma and AD had similar trends according to age, with age‐specific prevalence rates peaking at age 5–9 years and rising again in adulthood. The prevalence and incidence of asthma and AD were both higher for individuals with higher SDI; however, mortality and DALYs rates of individuals with asthma had a reverse trend, with higher mortality and DALYs rates in those in the lower SDI quintiles. Of the three risk factors, high body mass index contributed to the highest DALYs and deaths due to asthma, accounting for a total of 3.65 million [95% UI: 2.14–5.60 million] asthma DALYs and 75,377 [95% UI: 40,615–122,841] asthma deaths. Conclusions Asthma and AD continue to cause significant morbidity worldwide, having increased in total prevalence and incidence cases worldwide, but having decreased in age‐standardized prevalence rates from 1990 to 2019. Although both are more frequent at younger ages and more prevalent in high‐SDI countries, each condition has distinct temporal and regional characteristics. Understanding the temporospatial trends in the disease burden of asthma and AD could guide future policies and interventions to better manage these diseases worldwide and achieve equity in prevention, diagnosis, and treatment. Using data from the Global Burden Disease 2019 study, we assessed the total cases and age‐standardized prevalence of both asthma and atopic dermatitis in 204 countries and territories from 1990 to 2019. In 2019, there were a total of 262 million [95% uncertainty interval (UI): 224–309 million] cases of asthma and 171 million [95% UI: 165–178 million] cases of AD globally; age‐standardized prevalence rates were 3416 [95% UI: 2899–4066] and 2277 [95% UI: 2192–2369] per 100,000 population for asthma and atopic dermatitis, respectively, a 24.1% [95% UI: −27.2 to −20.8] decrease for asthma and a 4.3% [95% UI: 3.8–4.8] decrease for atopic dermatitis compared to baseline in 1990. Asthma and atopic dermatitis continue to cause significant morbidity worldwide, having increased in total prevalence and incidence cases worldwide, but having decreased in age‐standardized prevalence rates from 1990 to 2019. Abbreviations: GBD, Global Burden Disease; UI, uncertainty interval
Bibliography:Jae Il Shin and Dong Keon Yon contributed equally to this work as corresponding authors.
Youn Ho Shin, Jimin Hwang, Rosie Kwon, Seung Won Lee, and Min Seo Kim contributed equally to this work as first authors.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Jae II Shin and Dong Keon Yon contributed equally to this work as corresponding authors
Please see appendix for more detailed information about individual author contributions to the research, divided into the following categories: providing data or critical feedback on data sources; developing methods or computational machinery; providing critical feedback on methods or results; drafting the manuscript or revising it critically for important intellectual content; and managing the estimation or publications process. Youn Ho Shin, Jimin Hwang, Rosie Kwon, Seung Won Lee, and Min Seo Kim contributed equally to this work as first authors. Jae II Shin and Dong Keon Yon contributed equally to this work as corresponding authors. Dong Keon Yon is a senior author.
Contributors
ISSN:0105-4538
1398-9995
1398-9995
DOI:10.1111/all.15807