Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community
Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality. We examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion...
Uloženo v:
| Vydáno v: | Arteriosclerosis, thrombosis, and vascular biology Ročník 33; číslo 7; s. 1728 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
01.07.2013
|
| Témata: | |
| ISSN: | 1524-4636, 1524-4636 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality.
We examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, P-selectin, and tumor necrosis factor receptor II [TNFRII]) in relation to incident major CVD and mortality in the community. We studied 3035 participants (mean age, 61 ± 9 years; 53% women). During follow-up (median, 8.9 years), 253 participants experienced a CVD event and 343 died. C-reactive protein (hazard ratio [HR] reported per SD ln-transformed biomarker, 1.18; 95% confidence interval [CI], 1.02-1.35; nominal P=0.02) and TNFRII (HR, 1.15; 95% CI, 1.01-1.32; nominal P=0.04) were retained in multivariable-adjusted models for major CVD, but were not significant after adjustment for multiple testing. The biomarkers related to mortality were TNFRII (HR, 1.33; 95% CI, 1.19-1.49; P<0.0001), ICAM-1 (HR, 1.24; 95% CI, 1.12-1.37; P<0.0001), and interleukin-6 (HR, 1.25; 95% CI, 1.12-1.39; P<0.0001). The addition of these markers to the model, including traditional risk factors, increased discrimination and reclassification for risk of death (P<0.0001), but not for CVD.
Of 11 inflammatory biomarkers tumor necrosis factor receptor II was related to cardiovascular disease and mortality in the Framingham Heart Study. The combination of TNFRII with C-reactive protein in relation to CVD and with interleukin-6 to mortality increased the predictive ability in addition to CVD risk factors for total mortality but not for incident CVD. |
|---|---|
| AbstractList | Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality.
We examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, P-selectin, and tumor necrosis factor receptor II [TNFRII]) in relation to incident major CVD and mortality in the community. We studied 3035 participants (mean age, 61 ± 9 years; 53% women). During follow-up (median, 8.9 years), 253 participants experienced a CVD event and 343 died. C-reactive protein (hazard ratio [HR] reported per SD ln-transformed biomarker, 1.18; 95% confidence interval [CI], 1.02-1.35; nominal P=0.02) and TNFRII (HR, 1.15; 95% CI, 1.01-1.32; nominal P=0.04) were retained in multivariable-adjusted models for major CVD, but were not significant after adjustment for multiple testing. The biomarkers related to mortality were TNFRII (HR, 1.33; 95% CI, 1.19-1.49; P<0.0001), ICAM-1 (HR, 1.24; 95% CI, 1.12-1.37; P<0.0001), and interleukin-6 (HR, 1.25; 95% CI, 1.12-1.39; P<0.0001). The addition of these markers to the model, including traditional risk factors, increased discrimination and reclassification for risk of death (P<0.0001), but not for CVD.
Of 11 inflammatory biomarkers tumor necrosis factor receptor II was related to cardiovascular disease and mortality in the Framingham Heart Study. The combination of TNFRII with C-reactive protein in relation to CVD and with interleukin-6 to mortality increased the predictive ability in addition to CVD risk factors for total mortality but not for incident CVD. Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality.OBJECTIVEEvidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality.We examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, P-selectin, and tumor necrosis factor receptor II [TNFRII]) in relation to incident major CVD and mortality in the community. We studied 3035 participants (mean age, 61 ± 9 years; 53% women). During follow-up (median, 8.9 years), 253 participants experienced a CVD event and 343 died. C-reactive protein (hazard ratio [HR] reported per SD ln-transformed biomarker, 1.18; 95% confidence interval [CI], 1.02-1.35; nominal P=0.02) and TNFRII (HR, 1.15; 95% CI, 1.01-1.32; nominal P=0.04) were retained in multivariable-adjusted models for major CVD, but were not significant after adjustment for multiple testing. The biomarkers related to mortality were TNFRII (HR, 1.33; 95% CI, 1.19-1.49; P<0.0001), ICAM-1 (HR, 1.24; 95% CI, 1.12-1.37; P<0.0001), and interleukin-6 (HR, 1.25; 95% CI, 1.12-1.39; P<0.0001). The addition of these markers to the model, including traditional risk factors, increased discrimination and reclassification for risk of death (P<0.0001), but not for CVD.APPROACH AND RESULTSWe examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, P-selectin, and tumor necrosis factor receptor II [TNFRII]) in relation to incident major CVD and mortality in the community. We studied 3035 participants (mean age, 61 ± 9 years; 53% women). During follow-up (median, 8.9 years), 253 participants experienced a CVD event and 343 died. C-reactive protein (hazard ratio [HR] reported per SD ln-transformed biomarker, 1.18; 95% confidence interval [CI], 1.02-1.35; nominal P=0.02) and TNFRII (HR, 1.15; 95% CI, 1.01-1.32; nominal P=0.04) were retained in multivariable-adjusted models for major CVD, but were not significant after adjustment for multiple testing. The biomarkers related to mortality were TNFRII (HR, 1.33; 95% CI, 1.19-1.49; P<0.0001), ICAM-1 (HR, 1.24; 95% CI, 1.12-1.37; P<0.0001), and interleukin-6 (HR, 1.25; 95% CI, 1.12-1.39; P<0.0001). The addition of these markers to the model, including traditional risk factors, increased discrimination and reclassification for risk of death (P<0.0001), but not for CVD.Of 11 inflammatory biomarkers tumor necrosis factor receptor II was related to cardiovascular disease and mortality in the Framingham Heart Study. The combination of TNFRII with C-reactive protein in relation to CVD and with interleukin-6 to mortality increased the predictive ability in addition to CVD risk factors for total mortality but not for incident CVD.CONCLUSIONSOf 11 inflammatory biomarkers tumor necrosis factor receptor II was related to cardiovascular disease and mortality in the Framingham Heart Study. The combination of TNFRII with C-reactive protein in relation to CVD and with interleukin-6 to mortality increased the predictive ability in addition to CVD risk factors for total mortality but not for incident CVD. |
| Author | Keaney, Jr, John F Schnabel, Renate B Yamamoto, Jennifer F Vasan, Ramachandran S Rong, Jian Wang, Thomas J Benjamin, Emelia J Murabito, Joanne M Fontes, João D Yin, Xiaoyan Larson, Martin G Kathiresan, Sekar Levy, Daniel |
| Author_xml | – sequence: 1 givenname: Renate B surname: Schnabel fullname: Schnabel, Renate B organization: Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA – sequence: 2 givenname: Xiaoyan surname: Yin fullname: Yin, Xiaoyan – sequence: 3 givenname: Martin G surname: Larson fullname: Larson, Martin G – sequence: 4 givenname: Jennifer F surname: Yamamoto fullname: Yamamoto, Jennifer F – sequence: 5 givenname: João D surname: Fontes fullname: Fontes, João D – sequence: 6 givenname: Sekar surname: Kathiresan fullname: Kathiresan, Sekar – sequence: 7 givenname: Jian surname: Rong fullname: Rong, Jian – sequence: 8 givenname: Daniel surname: Levy fullname: Levy, Daniel – sequence: 9 givenname: John F surname: Keaney, Jr fullname: Keaney, Jr, John F – sequence: 10 givenname: Thomas J surname: Wang fullname: Wang, Thomas J – sequence: 11 givenname: Joanne M surname: Murabito fullname: Murabito, Joanne M – sequence: 12 givenname: Ramachandran S surname: Vasan fullname: Vasan, Ramachandran S – sequence: 13 givenname: Emelia J surname: Benjamin fullname: Benjamin, Emelia J |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23640499$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkEtPwzAQhC0Eog_4AxyQj1xS_EyTY6iAIhVxKVwjx3aEwY9iO5X67wmiSJx2dvTtSjMzcOqD1wBcYbTAuMS3zfbtrlk340IWFGG8ZCdgijlhBStpefpPT8AspQ-EECMEnYMJoSVDrK6nQD0PNpud1dD43grnRA7xADsTnIifOqbRh1FbkU3wMAcoRVQm7EWSgxUR6r32OUHhFXQhZmFNPvyc5HcNZXBu8KNxAc56YZO-PM45eH24367Wxebl8WnVbArJMWdF1SuKu1JqhbjqMFE91pxz3eNaiFrwsusIl7hWctkRKqlUVMlKLUlFFWJckTm4-f27i-Fr0Cm3ziSprRVehyG1mOFqTF5xMqLXR3TonFbtLpox8KH9a4Z8A-waarc |
| CitedBy_id | crossref_primary_10_1177_00033197231198688 crossref_primary_10_1093_cvr_cvw022 crossref_primary_10_1016_j_neubiorev_2023_105186 crossref_primary_10_1111_ajt_17047 crossref_primary_10_3390_children9010042 crossref_primary_10_1155_2019_8563845 crossref_primary_10_1007_s11357_025_01855_8 crossref_primary_10_1016_j_ygeno_2014_10_003 crossref_primary_10_1002_ctm2_1412 crossref_primary_10_26508_lsa_202000817 crossref_primary_10_1007_s00011_021_01462_1 crossref_primary_10_3389_fonc_2024_1375362 crossref_primary_10_1016_j_atherosclerosis_2020_11_008 crossref_primary_10_1016_j_ebiom_2015_07_029 crossref_primary_10_1007_s11904_013_0190_8 crossref_primary_10_1016_j_phanu_2022_100297 crossref_primary_10_1038_s42003_022_03304_0 crossref_primary_10_1080_03014460_2021_1998619 crossref_primary_10_1002_dev_70052 crossref_primary_10_1161_ATVBAHA_116_308531 crossref_primary_10_1016_j_ijcard_2015_07_106 crossref_primary_10_1093_ije_dyv337 crossref_primary_10_1007_s00038_016_0939_0 crossref_primary_10_1017_S0007114523001903 crossref_primary_10_1093_ajcn_nqaa082 crossref_primary_10_1111_acel_12717 crossref_primary_10_1177_0898264319862419 crossref_primary_10_1186_s12979_024_00431_6 crossref_primary_10_3390_ijms232112947 crossref_primary_10_1007_s00408_017_0029_y crossref_primary_10_1007_s00392_019_01475_1 crossref_primary_10_1016_j_psychres_2014_01_046 crossref_primary_10_1161_CIRCRESAHA_116_309955 crossref_primary_10_1016_S2213_8587_14_70134_2 crossref_primary_10_1007_s10522_023_10047_w crossref_primary_10_2215_CJN_07360715 crossref_primary_10_1016_j_atherosclerosis_2014_09_005 crossref_primary_10_1681_ASN_2013080860 crossref_primary_10_3390_biom11101464 crossref_primary_10_1067_j_cpsurg_2016_06_001 crossref_primary_10_1016_j_avsg_2025_09_003 crossref_primary_10_1016_j_ebiom_2022_103824 crossref_primary_10_1186_s12967_020_02600_9 crossref_primary_10_1016_j_cca_2017_10_004 crossref_primary_10_3389_fphys_2020_587013 crossref_primary_10_7555_JBR_38_20240432 crossref_primary_10_1007_s13668_013_0054_2 crossref_primary_10_1038_s41598_022_21786_0 crossref_primary_10_1111_obr_12551 crossref_primary_10_1016_j_advms_2019_02_003 crossref_primary_10_1016_j_hjc_2024_03_010 crossref_primary_10_1016_j_exger_2024_112590 crossref_primary_10_1038_bjc_2016_85 crossref_primary_10_1371_journal_pone_0122073 crossref_primary_10_3389_fimmu_2024_1352440 crossref_primary_10_1016_j_clnu_2015_03_022 crossref_primary_10_1016_j_bbi_2018_02_013 crossref_primary_10_1177_2047487317725017 crossref_primary_10_3945_jn_115_220103 crossref_primary_10_1007_s00392_014_0674_6 crossref_primary_10_3389_fcvm_2023_1175174 crossref_primary_10_1016_j_bbr_2022_113959 crossref_primary_10_1111_jgs_13133 crossref_primary_10_1161_STROKEAHA_114_007624 crossref_primary_10_1161_JAHA_117_008299 crossref_primary_10_1186_s12865_015_0106_z crossref_primary_10_3389_fcvm_2025_1538466 crossref_primary_10_1016_j_envres_2017_07_009 crossref_primary_10_1186_s12967_024_05679_6 crossref_primary_10_1161_ATVBAHA_118_311999 crossref_primary_10_1016_j_jacl_2014_07_001 crossref_primary_10_1371_journal_pone_0175909 crossref_primary_10_1371_journal_pone_0127550 crossref_primary_10_1128_cmr_00098_22 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1161/ATVBAHA.112.301174 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1524-4636 |
| ExternalDocumentID | 23640499 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | Massachusetts |
| GeographicLocations_xml | – name: Massachusetts |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: R01 HL076784 – fundername: NHLBI NIH HHS grantid: K23 HL083102 – fundername: NHLBI NIH HHS grantid: N01 HC025195 – fundername: NINDS NIH HHS grantid: R01 NS017950 – fundername: NHLBI NIH HHS grantid: K24 HL004334 – fundername: NHLBI NIH HHS grantid: R01 HL064753 – fundername: NHLBI NIH HHS grantid: R01 HL071039 – fundername: NIA NIH HHS grantid: R01 AG028321 |
| GroupedDBID | --- .3C .55 .GJ .Z2 01R 0R~ 1J1 23N 2WC 3O- 40H 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS 71W 77Y 7O~ AAAAV AAAXR AAGIX AAHPQ AAIQE AAMOA AAMTA AAQKA AARTV AASCR AASOK AAXQO ABASU ABBUW ABDIG ABJNI ABPXF ABQRW ABVCZ ABXVJ ABZAD ABZZY ACCJW ACDDN ACEWG ACGFS ACGOD ACILI ACLDA ACPRK ACWDW ACWRI ACXJB ACXNZ ACZKN ADBBV ADFPA ADGGA ADGHP ADHPY ADNKB AE3 AE6 AEETU AENEX AFBFQ AFDTB AFFNX AFUWQ AGINI AHJKT AHMBA AHOMT AHQNM AHRYX AHVBC AIJEX AINUH AJCLO AJIOK AJNWD AJNYG AJZMW AKCTQ AKULP ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOQMC AYCSE BAWUL BOYCO BQLVK BS7 C1A C45 CGR CS3 CUY CVF DIK DIWNM DUNZO E.X E3Z EBS ECM EEVPB EIF EJD ERAAH EX3 F2K F2L F2M F2N F5P FCALG FL- FRP FW0 GNXGY GQDEL GX1 H0~ H13 HLJTE HZ~ IKREB IKYAY IN~ IPNFZ J5H JF9 JG8 JK3 JK8 K8S KD2 KMI KQ8 L-C L7B N9A NPM N~7 N~B N~M O9- OAG OAH OB2 OCUKA ODA OL1 OLG OLH OLU OLV OLY OLZ OPUJH ORVUJ OUVQU OVD OVDNE OVIDH OVLEI OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P PQQKQ PZZ RAH RIG RLZ S4R S4S T8P TEORI TR2 TSPGW V2I VVN W3M W8F WOQ WOW X3V X3W X7M XXN XYM YFH ZGI ZZMQN 7X8 ADKSD |
| ID | FETCH-LOGICAL-c5154-8fd31b6ced05db12df1e555ef19aa9a56bb25c19dc7b23c3cd3dc8d7283d045d2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 84 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000320671800040&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1524-4636 |
| IngestDate | Sun Sep 28 02:34:02 EDT 2025 Mon Jul 21 06:05:04 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Keywords | mortality cardiovascular disease epidemiology cohort inflammation |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5154-8fd31b6ced05db12df1e555ef19aa9a56bb25c19dc7b23c3cd3dc8d7283d045d2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.112.301174 |
| PMID | 23640499 |
| PQID | 1418364852 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1418364852 pubmed_primary_23640499 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-July |
| PublicationDateYYYYMMDD | 2013-07-01 |
| PublicationDate_xml | – month: 07 year: 2013 text: 2013-July |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Arteriosclerosis, thrombosis, and vascular biology |
| PublicationTitleAlternate | Arterioscler Thromb Vasc Biol |
| PublicationYear | 2013 |
| SSID | ssj0004220 |
| Score | 2.4161208 |
| Snippet | Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality.
We examined 11... Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality.OBJECTIVEEvidence suggests... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1728 |
| SubjectTerms | Aged Biomarkers - blood C-Reactive Protein - metabolism Cardiovascular Diseases - blood Cardiovascular Diseases - mortality Disease-Free Survival Female Health Surveys Humans Incidence Inflammation - blood Inflammation - mortality Inflammation Mediators - blood Intercellular Adhesion Molecule-1 - blood Interleukin-6 - blood Male Massachusetts - epidemiology Middle Aged Multivariate Analysis Principal Component Analysis Prognosis Proportional Hazards Models Receptors, Tumor Necrosis Factor, Type II - blood Risk Assessment Risk Factors Time Factors |
| Title | Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23640499 https://www.proquest.com/docview/1418364852 |
| Volume | 33 |
| WOSCitedRecordID | wos000320671800040&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1NS8MwGA7qRLz4_TG_iOC1zqRp056kimOXjR2m7FbyCR5s5zoF_71v0gz1IAheegikhPRp8iTv8z4vQleWUcYzFUfWSlfCzJIoV5RFxipuhLR5lihfbIKPRtl0mo_DhVsTZJXLNdEv1LpW7o68RxiAL2VZQm9nr5GrGuWiq6GExirqxEBlnKSLT7-5hVNvywhbFIucMdYyaSYlvWLydFcMCpdBc-0w7gR_v1FMv9X0t_87yB20FUgmLlpU7KIVU-2hjWEIo-8jPQwyQgz4Aki8-FA7dqn4Tq0zb6Adz4NMDi9qrH6oVrF3fWqwqDR-8fQdqLzrAmQSqzbjZPFxgB77D5P7QRTKLUQKSA2LMqtjIlNl9E2iJaHaEpMkibEkFyIXSSolTRTJteKSxipWOtYq0xwIigZiqOkhWqvqyhwjnAIvpHlmBVOcCThlM3gHk4YTYXIpbRddLuevBDi7GIWoTP3WlF8z2EVH7UcoZ63vRum87t0J7eQPvU_RJvWFK5yw9gx1LPzM5hytq_fFczO_8DiB52g8_AR2rMqN |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Multiple+inflammatory+biomarkers+in+relation+to+cardiovascular+events+and+mortality+in+the+community&rft.jtitle=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.au=Schnabel%2C+Renate+B&rft.au=Yin%2C+Xiaoyan&rft.au=Larson%2C+Martin+G&rft.au=Yamamoto%2C+Jennifer+F&rft.date=2013-07-01&rft.issn=1524-4636&rft.eissn=1524-4636&rft.volume=33&rft.issue=7&rft.spage=1728&rft_id=info:doi/10.1161%2FATVBAHA.112.301174&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1524-4636&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1524-4636&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1524-4636&client=summon |