Longevity‐related molecular pathways are subject to midlife “switch” in humans

Emerging evidence indicates that molecular aging may follow nonlinear or discontinuous trajectories. Whether this occurs in human neuromuscular tissue, particularly for the noncoding transcriptome, and independent of metabolic and aerobic capacities, is unknown. Applying our novel RNA method to quan...

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Bibliographic Details
Published in:	Aging cell Vol. 18; no. 4; pp. e12970 - n/a
Main Authors:	Timmons, James A., Volmar, Claude‐Henry, Crossland, Hannah, Phillips, Bethan E., Sood, Sanjana, Janczura, Karolina J., Törmäkangas, Timo, Kujala, Urho M., Kraus, William E., Atherton, Philip J., Wahlestedt, Claes
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.08.2019 John Wiley and Sons Inc
Subjects:	1-Phosphatidylinositol 3-kinase Adult Age Aging Aging - genetics Aging - metabolism Alzheimer's Analysis Antisense RNA Apoptosis Brain Cerebral Cortex - metabolism ECSIT Electron transport chain Gene expression Gene Regulatory Networks Genes Genomes Health aspects Heritability Humans Insulin-like growth factors Life span long noncoding RNA Longevity Longevity - genetics Mitochondria mitochondrial complex 1 mTOR Muscle Fibers, Skeletal - metabolism Myotubes NADH-ubiquinone oxidoreductase Neurons - metabolism Non-coding RNA Original Proteins Rapamycin Reactive oxygen species Reactive Oxygen Species - metabolism Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA-Seq Signal Transduction - drug effects Signal Transduction - genetics Sirolimus - pharmacology skeletal muscle skin TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Transcription Transcriptional Activation - drug effects Transcriptome Twins, Monozygotic - genetics Brain reactive oxygen species long noncoding RNA mTOR skin aging ECSIT mitochondrial complex 1 skeletal muscle Alzheimer's
ISSN:	1474-9718, 1474-9726, 1474-9726
Online Access:	Get full text
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