HACD1 , a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth

The reduced diameter of skeletal myofibres is a hallmark of several congenital myopathies, yet the underlying cellular and molecular mechanisms remain elusive. In this study, we investigate the role of HACD1/PTPLA, which is involved in the elongation of the very long chain fatty acids, in muscle fib...

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Veröffentlicht in:	Journal of molecular cell biology Jg. 7; H. 5; S. 429 - 440
Hauptverfasser:	Blondelle, Jordan, Ohno, Yusuke, Gache, Vincent, Guyot, Stéphane, Storck, Sébastien, Blanchard-Gutton, Nicolas, Barthélémy, Inès, Walmsley, Gemma, Rahier, Anaëlle, Gadin, Stéphanie, Maurer, Marie, Guillaud, Laurent, Prola, Alexandre, Ferry, Arnaud, Aubin-Houzelstein, Geneviève, Demarquoy, Jean, Relaix, Frédéric, Piercy, Richard J., Blot, Stéphane, Kihara, Akio, Tiret, Laurent, Pilot-Storck, Fanny
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Oxford UP 01.10.2015 Oxford University Press
Schlagworte:	Animals Cell Differentiation - genetics Cell Differentiation - physiology Cell Line Cell Membrane - genetics Cell Membrane - metabolism Chemical and Process Engineering Dogs Engineering Sciences Female Food engineering Humans Life Sciences Male Mice Mice, Knockout Muscle Development - genetics Muscle Development - physiology Muscle, Skeletal - metabolism Myoblasts - cytology Myoblasts - metabolism Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism centronuclear myopathy LPC MUFA VLCFA PTPLA Centronuclear myopathy
ISSN:	1674-2788, 1759-4685, 1759-4685
Online-Zugang:	Volltext
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