Induction of FoxP3 Pre-mRNA Alternative Splicing to Enhance the Suppressive Activity of Regulatory T Cells from Amyotrophic Lateral Sclerosis Patients

Forkhead box protein 3 (FoxP3) is a key transcription factor responsible for the development, maturation, and function of regulatory T cells (Tregs). The FoxP3 pre-mRNA is subject to alternative splicing, resulting in the translation of multiple splice variants. We have shown that Tregs from patient...

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Bibliographic Details
Published in:	Biomedicines Vol. 12; no. 5; p. 1022
Main Authors:	Zhdanov, Dmitry D., Gladilina, Yulia A., Blinova, Varvara G., Abramova, Anna A., Shishparenok, Anastasia N., Eliseeva, Daria D.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01.05.2024
Subjects:	Alternative splicing Amyotrophic lateral sclerosis Antibodies Apoptosis Autoimmune diseases CD25 antigen CD4 antigen Cell therapy CTLA-4 protein Development and progression Disease Endopeptidases Ethylenediaminetetraacetic acid Exons Flow cytometry Forkhead protein FoxP3 Foxp3 protein Gene expression Immunoregulation Lymphocytes Lymphocytes T Medical prognosis Messenger RNA Oligonucleotides Perforin Peripheral blood Proteins regulatory T cells Serine proteinase splicing-switching oligonucleotides suppressive activity T cells Telomerase Transcription factors Germany Russia United States > US regulatory T cells splicing-switching oligonucleotides alternative splicing FoxP3 amyotrophic lateral sclerosis suppressive activity
ISSN:	2227-9059, 2227-9059
Online Access:	Get full text
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