Single Nucleoprotein Residue Modulates Arenavirus Replication Complex Formation

The Arenaviridae are enveloped, negative-sense RNA viruses with several family members that cause hemorrhagic fevers. This work provides immunofluorescence evidence that, unlike those of New World arenaviruses, the replication and transcription complexes (RTC) of lymphocytic choriomeningitis virus (...

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Veröffentlicht in:	mBio Jg. 6; H. 3; S. e00524 - e00515
Hauptverfasser:	Knopp, Kristeene A., Ngo, Tuan, Gershon, Paul D., Buchmeier, Michael J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Society for Microbiology 01.07.2015 American Society of Microbiology
Schlagworte:	Arenaviridae Cell cycle Conserved Sequence Eukaryotic Initiation Factor-4E - metabolism fluorescent antibody technique Genomes glycoproteins Hemorrhage Host-Pathogen Interactions Immunofluorescence Initiation factor eIF-4E Kinases Liquid chromatography Lymphocytic choriomeningitis mammarenavirus Lymphocytic choriomeningitis virus - genetics Lymphocytic choriomeningitis virus - physiology mammals Mass spectroscopy Matrix protein messenger RNA Microscopy, Fluorescence mutants Mutation Northern blotting nucleoproteins Nucleoproteins - genetics Nucleoproteins - metabolism pathogens Phosphorylation Protein Binding Protein Biosynthesis Protein Processing, Post-Translational Proteins Replication RNA polymerase RNA viruses Signal transduction tandem mass spectrometry translation (genetics) viability Viral Proteins - genetics Viral Proteins - metabolism Virus Replication Viruses
ISSN:	2161-2129, 2150-7511, 2150-7511
Online-Zugang:	Volltext
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