Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers

Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression clustered with the expression of 10 well-known hypoxia-regulated genes (e.g., CA9, GLUT1, and VEGF). To minimize random aggregatio...

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Vydáno v:	Cancer research (Chicago, Ill.) Ročník 67; číslo 7; s. 3441
Hlavní autoři:	Winter, Stuart C, Buffa, Francesca M, Silva, Priyamal, Miller, Crispin, Valentine, Helen R, Turley, Helen, Shah, Ketan A, Cox, Graham J, Corbridge, Rogan J, Homer, Jarrod J, Musgrove, Brian, Slevin, Nick, Sloan, Philip, Price, Pat, West, Catharine M L, Harris, Adrian L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.04.2007
Témata:	Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Cell Hypoxia - genetics Female Gene Expression Regulation, Neoplastic Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Humans Male Middle Aged Multigene Family Oligonucleotide Array Sequence Analysis Prognosis RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics Up-Regulation
ISSN:	0008-5472
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