Fracture risk following intermission of osteoporosis therapy

Summary Given the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis therapies (bisphosphonates and denosumab). Trial evidence suggests the risk of new clinical fractures, and vertebral fracture increases when osteo...

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Bibliographic Details
Published in:	Osteoporosis International Vol. 30; no. 9; pp. 1733 - 1743
Main Authors:	Dennison, E.M., Cooper, C., Kanis, J.A., Bruyère, O., Silverman, S., McCloskey, E., Abrahamsen, B., Prieto-Alhambra, D., Ferrari, S.
Format:	Journal Article
Language:	English
Published:	London Springer Science and Business Media LLC 01.09.2019 Springer London Springer Nature B.V
Subjects:	Age Factors Atypical fracture Bisphosphonate-Associated Osteonecrosis of the Jaw Bisphosphonate-Associated Osteonecrosis of the Jaw - epidemiology Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology Bisphosphonates Bone Density Bone Density - physiology Bone Density Conservation Agents Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - therapeutic use Bone loss Bone mineral density Bone strength Clinical Decision-Making Clinical Decision-Making - methods Decision making Denosumab Denosumab - administration & dosage Denosumab - therapeutic use Diphosphonates Diphosphonates - administration & dosage Diphosphonates - therapeutic use Drug Administration Schedule Drug holiday Endocrinology Femur Fractures Geriatrics Gériatrie Human health sciences Humans Immunotherapy info:eu-repo/classification/ddc/616 Medicine Medicine & Public Health Monoclonal antibodies Original Article Orthopedics Osteoporosis Osteoporosis, Postmenopausal Osteoporosis, Postmenopausal - drug therapy Osteoporosis, Postmenopausal - physiopathology Osteoporotic Fractures Osteoporotic Fractures - epidemiology Osteoporotic Fractures - prevention & control Pharmacokinetics Postmenopausal/drug therapy Public health, health care sciences & services Rheumatology Rhumatologie Risk Assessment Risk Assessment - methods Risk Factors Santé publique, services médicaux & soins de santé Sciences de la santé humaine Vertebrae Withholding Treatment Drug holiday Atypical fracture Denosumab Bisphosphonates
ISSN:	0937-941X, 1433-2965, 1433-2965
Online Access:	Get full text
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