Fracture risk following intermission of osteoporosis therapy
Summary Given the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis therapies (bisphosphonates and denosumab). Trial evidence suggests the risk of new clinical fractures, and vertebral fracture increases when osteo...
Uloženo v:
| Vydáno v: | Osteoporosis International Ročník 30; číslo 9; s. 1733 - 1743 |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
Springer Science and Business Media LLC
01.09.2019
Springer London Springer Nature B.V |
| Témata: | |
| ISSN: | 0937-941X, 1433-2965, 1433-2965 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Summary
Given the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis therapies (bisphosphonates and denosumab). Trial evidence suggests the risk of new clinical fractures, and vertebral fracture increases when osteoporosis treatment with bisphosphonates or denosumab is stopped.
Introduction
The aim of this paper was to review the available literature to assess what evidence exists to inform clinical decision-making with regard to drug holidays following treatment with bisphosphonates (BiP) or denosumab.
Methods
Systematic review.
Results
Differing pharmacokinetics lead to varying outcomes on stopping therapy. Prospective and retrospective analyses report that the risk of new clinical fractures was 20–40% higher in subjects who stopped BiP treatment, and vertebral fracture risk was approximately doubled. Rapid bone loss has been well described following denosumab discontinuation with an incidence of multiple vertebral fractures around 5%. Studies have not identified risk factors for fracture after stopping treatment other than those that provide an indication for treatment (e.g. prior fracture and low BMD). Studies that considered long-term continuation did not identify increased fracture risk, and reported only very low rates of adverse skeletal events such as atypical femoral fracture.
Conclusions
The view that patients on long-term treatment with bisphosphonates or denosumab should always be offered a drug holiday is not supported by the existing evidence. Different pharmacokinetic properties for different therapies require different strategies to manage drug intermission. In contrast, long-term treatment with anti-resorptives is not associated with increased risk of fragility fractures and skeletal adverse events remain rare. |
|---|---|
| AbstractList | Given the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis therapies (bisphosphonates and denosumab). Trial evidence suggests the risk of new clinical fractures, and vertebral fracture increases when osteoporosis treatment with bisphosphonates or denosumab is stopped.
The aim of this paper was to review the available literature to assess what evidence exists to inform clinical decision-making with regard to drug holidays following treatment with bisphosphonates (BiP) or denosumab.
Systematic review.
Differing pharmacokinetics lead to varying outcomes on stopping therapy. Prospective and retrospective analyses report that the risk of new clinical fractures was 20-40% higher in subjects who stopped BiP treatment, and vertebral fracture risk was approximately doubled. Rapid bone loss has been well described following denosumab discontinuation with an incidence of multiple vertebral fractures around 5%. Studies have not identified risk factors for fracture after stopping treatment other than those that provide an indication for treatment (e.g. prior fracture and low BMD). Studies that considered long-term continuation did not identify increased fracture risk, and reported only very low rates of adverse skeletal events such as atypical femoral fracture.
The view that patients on long-term treatment with bisphosphonates or denosumab should always be offered a drug holiday is not supported by the existing evidence. Different pharmacokinetic properties for different therapies require different strategies to manage drug intermission. In contrast, long-term treatment with anti-resorptives is not associated with increased risk of fragility fractures and skeletal adverse events remain rare. Given the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis therapies (bisphosphonates and denosumab). Trial evidence suggests the risk of new clinical fractures, and vertebral fracture increases when osteoporosis treatment with bisphosphonates or denosumab is stopped. Introduction: The aim of this paper was to review the available literature to assess what evidence exists to inform clinical decision-making with regard to drug holidays following treatment with bisphosphonates (BiP) or denosumab. Methods: Systematic review. Results: Differing pharmacokinetics lead to varying outcomes on stopping therapy. Prospective and retrospective analyses report that the risk of new clinical fractures was 20–40% higher in subjects who stopped BiP treatment, and vertebral fracture risk was approximately doubled. Rapid bone loss has been well described following denosumab discontinuation with an incidence of multiple vertebral fractures around 5%. Studies have not identified risk factors for fracture after stopping treatment other than those that provide an indication for treatment (e.g. prior fracture and low BMD). Studies that considered long-term continuation did not identify increased fracture risk, and reported only very low rates of adverse skeletal events such as atypical femoral fracture. Conclusions: The view that patients on long-term treatment with bisphosphonates or denosumab should always be offered a drug holiday is not supported by the existing evidence. Different pharmacokinetic properties for different therapies require different strategies to manage drug intermission. In contrast, long-term treatment with anti-resorptives is not associated with increased risk of fragility fractures and skeletal adverse events remain rare. © 2019, International Osteoporosis Foundation and National Osteoporosis Foundation. SummaryGiven the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis therapies (bisphosphonates and denosumab). Trial evidence suggests the risk of new clinical fractures, and vertebral fracture increases when osteoporosis treatment with bisphosphonates or denosumab is stopped.IntroductionThe aim of this paper was to review the available literature to assess what evidence exists to inform clinical decision-making with regard to drug holidays following treatment with bisphosphonates (BiP) or denosumab.MethodsSystematic review.ResultsDiffering pharmacokinetics lead to varying outcomes on stopping therapy. Prospective and retrospective analyses report that the risk of new clinical fractures was 20–40% higher in subjects who stopped BiP treatment, and vertebral fracture risk was approximately doubled. Rapid bone loss has been well described following denosumab discontinuation with an incidence of multiple vertebral fractures around 5%. Studies have not identified risk factors for fracture after stopping treatment other than those that provide an indication for treatment (e.g. prior fracture and low BMD). Studies that considered long-term continuation did not identify increased fracture risk, and reported only very low rates of adverse skeletal events such as atypical femoral fracture.ConclusionsThe view that patients on long-term treatment with bisphosphonates or denosumab should always be offered a drug holiday is not supported by the existing evidence. Different pharmacokinetic properties for different therapies require different strategies to manage drug intermission. In contrast, long-term treatment with anti-resorptives is not associated with increased risk of fragility fractures and skeletal adverse events remain rare. Given the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis therapies (bisphosphonates and denosumab). Trial evidence suggests the risk of new clinical fractures, and vertebral fracture increases when osteoporosis treatment with bisphosphonates or denosumab is stopped.Given the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis therapies (bisphosphonates and denosumab). Trial evidence suggests the risk of new clinical fractures, and vertebral fracture increases when osteoporosis treatment with bisphosphonates or denosumab is stopped.The aim of this paper was to review the available literature to assess what evidence exists to inform clinical decision-making with regard to drug holidays following treatment with bisphosphonates (BiP) or denosumab.INTRODUCTIONThe aim of this paper was to review the available literature to assess what evidence exists to inform clinical decision-making with regard to drug holidays following treatment with bisphosphonates (BiP) or denosumab.Systematic review.METHODSSystematic review.Differing pharmacokinetics lead to varying outcomes on stopping therapy. Prospective and retrospective analyses report that the risk of new clinical fractures was 20-40% higher in subjects who stopped BiP treatment, and vertebral fracture risk was approximately doubled. Rapid bone loss has been well described following denosumab discontinuation with an incidence of multiple vertebral fractures around 5%. Studies have not identified risk factors for fracture after stopping treatment other than those that provide an indication for treatment (e.g. prior fracture and low BMD). Studies that considered long-term continuation did not identify increased fracture risk, and reported only very low rates of adverse skeletal events such as atypical femoral fracture.RESULTSDiffering pharmacokinetics lead to varying outcomes on stopping therapy. Prospective and retrospective analyses report that the risk of new clinical fractures was 20-40% higher in subjects who stopped BiP treatment, and vertebral fracture risk was approximately doubled. Rapid bone loss has been well described following denosumab discontinuation with an incidence of multiple vertebral fractures around 5%. Studies have not identified risk factors for fracture after stopping treatment other than those that provide an indication for treatment (e.g. prior fracture and low BMD). Studies that considered long-term continuation did not identify increased fracture risk, and reported only very low rates of adverse skeletal events such as atypical femoral fracture.The view that patients on long-term treatment with bisphosphonates or denosumab should always be offered a drug holiday is not supported by the existing evidence. Different pharmacokinetic properties for different therapies require different strategies to manage drug intermission. In contrast, long-term treatment with anti-resorptives is not associated with increased risk of fragility fractures and skeletal adverse events remain rare.CONCLUSIONSThe view that patients on long-term treatment with bisphosphonates or denosumab should always be offered a drug holiday is not supported by the existing evidence. Different pharmacokinetic properties for different therapies require different strategies to manage drug intermission. In contrast, long-term treatment with anti-resorptives is not associated with increased risk of fragility fractures and skeletal adverse events remain rare. Summary Given the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis therapies (bisphosphonates and denosumab). Trial evidence suggests the risk of new clinical fractures, and vertebral fracture increases when osteoporosis treatment with bisphosphonates or denosumab is stopped. Introduction The aim of this paper was to review the available literature to assess what evidence exists to inform clinical decision-making with regard to drug holidays following treatment with bisphosphonates (BiP) or denosumab. Methods Systematic review. Results Differing pharmacokinetics lead to varying outcomes on stopping therapy. Prospective and retrospective analyses report that the risk of new clinical fractures was 20–40% higher in subjects who stopped BiP treatment, and vertebral fracture risk was approximately doubled. Rapid bone loss has been well described following denosumab discontinuation with an incidence of multiple vertebral fractures around 5%. Studies have not identified risk factors for fracture after stopping treatment other than those that provide an indication for treatment (e.g. prior fracture and low BMD). Studies that considered long-term continuation did not identify increased fracture risk, and reported only very low rates of adverse skeletal events such as atypical femoral fracture. Conclusions The view that patients on long-term treatment with bisphosphonates or denosumab should always be offered a drug holiday is not supported by the existing evidence. Different pharmacokinetic properties for different therapies require different strategies to manage drug intermission. In contrast, long-term treatment with anti-resorptives is not associated with increased risk of fragility fractures and skeletal adverse events remain rare. |
| Author | Serge Ferrari John A. Kanis Cyrus Cooper Stuart L. Silverman Olivier Bruyère Daniel Prieto-Alhambra Elaine M. Dennison Bo Abrahamsen Eugene V. McCloskey |
| Author_xml | – sequence: 1 givenname: E.M. surname: Dennison fullname: Dennison, E.M. organization: MRC Lifecourse Epidemiology Unit, University of Southampton – sequence: 2 givenname: C. surname: Cooper fullname: Cooper, C. email: cc@mrc.soton.ac.uk organization: MRC Lifecourse Epidemiology Unit, University of Southampton, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford – sequence: 3 givenname: J.A. surname: Kanis fullname: Kanis, J.A. organization: Centre for Metabolic Bone Diseases, University of Sheffield Medical School, University of Sheffield, Mary McKillop Health Institute, Australian Catholic University – sequence: 4 givenname: O. surname: Bruyère fullname: Bruyère, O. organization: World Health Organization Collaborating Center for Public Health Aspects of Musculoskeletal Health and Ageing, Department of Public Health, Epidemiology and Health Economics, University of Liège – sequence: 5 givenname: S. surname: Silverman fullname: Silverman, S. organization: Cedars-Sinai/UCLA Medical Center and OMC Clinical Research Center – sequence: 6 givenname: E. surname: McCloskey fullname: McCloskey, E. organization: Academic Unit of Bone Metabolism, Department of Oncology and Metabolism, The Mellanby Centre For Bone Research, University of Sheffield – sequence: 7 givenname: B. surname: Abrahamsen fullname: Abrahamsen, B. organization: Department of Medicine, Holbaek Hospital, OPEN, Institute of Clinical Research, University of Southern Denmark – sequence: 8 givenname: D. surname: Prieto-Alhambra fullname: Prieto-Alhambra, D. organization: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, GREMPAL Research Group, Idiap Jordi Gol and CIBERFes, Universitat Autonoma de Barcelona and Instituto de Salud Carlos III – sequence: 9 givenname: S. surname: Ferrari fullname: Ferrari, S. organization: Division of Bone Disease, Faculty of Medicine, Geneva University Hospital |
| BackLink | https://cir.nii.ac.jp/crid/1872555065574545408$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/31175404$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kUtrFTEUgINU7LX2D7iQAbtwMzbPSQJupPQhFNxUcBcyc0-u0bnJNZnx0n_vqXOL0EUJnITwfYfzeE2OUk5AyFtGPzJK9XmllFnTYmipopS3-xdkxaQQLbedOiIraoVurWTfj8lprbGnnGqhO2FekWPBmFaSyhX5dFX8MM0FmhLrrybkccz7mDZNTBOUbUQzpyaHJtcJ8i6XXGNtph9Q_O7-DXkZ_Fjh9HCfkG9Xl3cXN-3t1-svF59v20ExObVGwZrzntnBcCHXwXJjesONZTyYjjGOX17qXgQhegPSAP6vodfediFoKU6IWPKOETbgcumj-8Nd9nF5z-PG-cH14DjvjOMSuxRofVisXcm_Z6iTw3YGGEefIM8VWSMYtYZRRN8_QX_muSTsCSnRCd5xZZB6d6Dmfgtrtytx68u9e5wmAmYBBhxTLRDcECc_4QSn4uPoGHUPu3PL7hwG9293bo8qf6I-Zn9WOsylIpw2UP6X_ax1tlgpRizwITKjuVKKdkppqfBQI_4C_n20sQ |
| CitedBy_id | crossref_primary_10_1002_jbm4_10629 crossref_primary_10_1007_s00784_023_05462_9 crossref_primary_10_1080_14656566_2025_2489122 crossref_primary_10_1007_s00198_020_05413_0 crossref_primary_10_1093_ckj_sfac230 crossref_primary_10_3390_ijerph192315866 crossref_primary_10_1007_s11657_022_01061_5 crossref_primary_10_1016_j_ceramint_2024_08_437 crossref_primary_10_3390_nu13020561 crossref_primary_10_1080_14656566_2025_2451741 crossref_primary_10_1007_s11657_020_00869_3 crossref_primary_10_1007_s11657_025_01588_3 crossref_primary_10_1007_s00198_021_05951_1 crossref_primary_10_1007_s11657_024_01389_0 crossref_primary_10_1136_pn_2024_004257 crossref_primary_10_1007_s11657_022_01192_9 crossref_primary_10_1093_ageing_afac044 crossref_primary_10_1016_j_kint_2021_04_043 crossref_primary_10_7861_clinmed_2020_0131 crossref_primary_10_1016_j_bone_2024_117325 crossref_primary_10_1002_jbm4_10476 crossref_primary_10_1038_s41584_023_00935_3 crossref_primary_10_1016_S2665_9913_19_30136_5 crossref_primary_10_1007_s00508_024_02441_2 crossref_primary_10_1016_j_berh_2022_101754 crossref_primary_10_1007_s00198_021_05961_z crossref_primary_10_1016_j_bone_2021_116297 crossref_primary_10_1007_s40674_022_00191_8 crossref_primary_10_1210_clinem_dgaa756 crossref_primary_10_3389_fbioe_2022_827626 crossref_primary_10_1016_j_jocd_2019_09_006 crossref_primary_10_1080_17512433_2020_1839416 crossref_primary_10_1007_s11657_024_01447_7 crossref_primary_10_1007_s00198_022_06667_6 crossref_primary_10_1080_14728222_2020_1726889 crossref_primary_10_1093_ndt_gfaa192 crossref_primary_10_1007_s11914_020_00566_7 crossref_primary_10_1016_j_bone_2020_115833 |
| Cites_doi | 10.1007/s00198-017-4144-7 10.1007/s00198-018-4460-6 10.1007/s00198-014-2900-5 10.1007/s00198-017-4242-6 10.1007/s00198-008-0604-4 10.1007/s00198-017-4132-y 10.1097/AOG.0b013e318291718c 10.1007/s00198-012-2052-4 10.1056/NEJMoa1001086 10.1007/s00198-006-0172-4 10.4158/EP.16.6.1016 10.1210/jc.2010-1502 10.1002/jbmr.11 10.1186/s12891-017-1520-6 10.1056/NEJMp1202619 10.1007/s00198-007-0460-7 10.1210/jc.2014-1971 10.1002/jbmr.1864 10.1002/jbmr.1719 10.1002/jbmr.3110 10.1002/jbmr.3337 10.1002/jbmr.1494 10.1016/j.joms.2005.07.010 10.1210/jc.2013-1597 10.1002/jbmr.3420 10.1002/jbmr.2236 10.1016/S2213-8587(17)30138-9 10.1002/jbmr.2361 10.1002/jbmr.2405 10.1136/bmj.i3365 10.1002/jbmr.2442 10.1002/jbmr.1808 10.1007/s00198-011-1773-0 10.1002/jbmr.3359 10.7326/0003-4819-144-10-200605160-00009 10.1001/jama.296.24.2927 10.1359/jbmr.090711 10.1007/s00198-014-2929-5 10.1007/s00198-014-2619-3 10.1056/NEJMoa1010650 10.1016/j.joms.2009.03.050 10.1016/S0140-6736(15)61120-5 10.1007/s00198-015-3234-7 10.1007/s00198-015-3179-x 10.1002/jbmr.253 10.1002/jbmr.2708 10.1210/jc.2014-1193 10.1016/S0278-2391(03)00720-1 10.1002/jbmr.1479 10.1007/s11657-017-0324-5 10.1186/s40902-016-0099-4 10.1210/jc.2010-1805 10.1016/j.maturitas.2017.04.008 10.1359/JBMR.040326 10.1016/j.bone.2017.08.003 10.1007/s00198-008-0651-x 10.1007/s00198-015-3453-y 10.1007/s00198-011-1793-9 10.1007/s00198-006-0274-z 10.1007/s12603-015-0652-3 10.1002/jbmr.2767 10.1210/jc.2011-0412 10.1007/s00198-017-3919-1 10.1359/jbmr.090702 10.1007/s00223-018-0394-4 10.3109/17453674.2015.1004149 10.1056/NEJMoa067312 10.1007/s00198-015-3447-9 10.1001/jamainternmed.2014.1232 10.1007/s00198-017-4215-9 10.1136/bmj.e3698 10.1136/annrheumdis-2018-eular.4953 |
| ContentType | Journal Article |
| Copyright | International Osteoporosis Foundation and National Osteoporosis Foundation 2019 Osteoporosis International is a copyright of Springer, (2019). All Rights Reserved. |
| Copyright_xml | – notice: International Osteoporosis Foundation and National Osteoporosis Foundation 2019 – notice: Osteoporosis International is a copyright of Springer, (2019). All Rights Reserved. |
| CorporateAuthor | On behalf of the IOF Epidemiology/Quality of Life Working Group IOF Epidemiology/Quality of Life Working Group |
| CorporateAuthor_xml | – name: On behalf of the IOF Epidemiology/Quality of Life Working Group – name: IOF Epidemiology/Quality of Life Working Group |
| DBID | RYH AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QP 7RV 7TS 7X7 7XB 88E 8AO 8C1 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH K9. KB0 M0S M1P NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 Q33 |
| DOI | 10.1007/s00198-019-05002-w |
| DatabaseName | CiNii Complete CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Nursing & Allied Health Database Physical Education Index Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central ProQuest One Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Health & Medical Collection PML(ProQuest Medical Library) Nursing & Allied Health Premium ProQuest Databases ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic Université de Liège - Open Repository and Bibliography (ORBI) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection ProQuest Central China Physical Education Index ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE ProQuest One Academic Middle East (New) MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1433-2965 |
| EndPage | 1743 |
| ExternalDocumentID | oai_orbi_ulg_ac_be_2268_246383 31175404 10_1007_s00198_019_05002_w |
| Genre | Systematic Review Journal Article |
| GrantInformation_xml | – fundername: Medical Research Council grantid: G0400491 – fundername: Medical Research Council grantid: MC_UU_12011/1 – fundername: Medical Research Council grantid: MC_U147585824 – fundername: Medical Research Council grantid: MC_UP_A620_1014 – fundername: Medical Research Council grantid: MC_U147585819 – fundername: Versus Arthritis grantid: 19583 |
| GroupedDBID | --- -~C .86 .VR 06C 06D 0R~ 0VY 123 199 1N0 203 29O 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2~H 30V 36B 4.4 406 408 409 40D 40E 5RE 5VS 67Z 6NX 78A 7RV 7X7 8AO 8C1 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AANZL AAPKM AARTL AASML AATNV AATVU AAUYE AAWCG AAWTL AAYIU AAYQN ABAKF ABBBX ABBRH ABBXA ABDBE ABDZT ABECU ABFSG ABFTV ABHLI ABHQN ABIPD ABJNI ABJOX ABKCH ABKTR ABLJU ABMNI ABMQK ABNWP ABOCM ABPLI ABQBU ABRTQ ABSXP ABTEG ABTKH ABTMW ABUWG ABWNU ABXPI ACAOD ACDTI ACGFS ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACSTC ACZOJ ADBBV ADHHG ADHIR ADIMF ADJJI ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADZKW AEFQL AEGAL AEGNC AEJHL AEJRE AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AEZWR AFBBN AFDZB AFHIU AFKRA AFLOW AFOHR AFQWF AFWTZ AFZKB AGAYW AGDGC AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHIZS AHKAY AHMBA AHPBZ AHSBF AHWEU AHYZX AIAKS AIGIU AIIXL AILAN AITGF AIXLP AJRNO AKMHD ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG ATHPR AVWKF AXYYD AYFIA AZFZN B-. BA0 BDATZ BENPR BGNMA BKEYQ BPHCQ BSONS BVXVI CS3 CSCUP DDRTE DL5 DNIVK DPUIP EBD EBLON EBS EIHBH EIOEI EJD EMB EMOBN ESBYG EX3 F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ7 GQ8 GXS HF~ HG5 HG6 HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ IMOTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KPH L7B LAS LLZTM M1P M4Y MA- N9A NAPCQ NB0 NPVJJ NQJWS NU0 O93 O9G O9I O9J OAM P19 P2P P9S PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R89 R9I RHV RNS ROL RPX RRX RSV RYH S16 S27 S37 S3B SAP SDH SDM SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UOJIU UTJUX VC2 W23 W48 WJK WK8 WOW YLTOR Z45 ZMTXR ZOVNA ~A9 ~EX ~KM -53 -5E -5G -BR -EM 88E 8FI 8FJ AAYZH ADINQ ALIPV CCPQU GQ6 HMCUK Z7U Z7W Z82 Z83 Z87 Z8O Z8Q Z8V Z8W Z91 -Y2 1SB 28- 2P1 2VQ 53G 5QI AANXM AARHV AAYTO AAYXX ABQSL ABULA ACBXY ACUDM ADHKG AEBTG AEFIE AEKMD AFEXP AFFHD AGGDS AGQPQ AJBLW BBWZM CAG CITATION COF EN4 GRRUI H13 KOW N2Q NDZJH O9- OVD PHGZM PHGZT PJZUB PPXIY R4E RNI RZK S1Z S26 S28 SCLPG SDE T16 TEORI UZXMN VFIZW ZXP CGR CUY CVF ECM EIF NPM RIG 3V. 7QP 7TS 7XB 8FK K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO Q33 |
| ID | FETCH-LOGICAL-c514t-85ed22b19c8234df9288b828912f86112df9a47b3f33b8e48e2f8deb7a96ff743 |
| IEDL.DBID | RSV |
| ISICitedReferencesCount | 46 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000483690500003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0937-941X 1433-2965 |
| IngestDate | Sat Nov 29 01:26:54 EST 2025 Fri Sep 05 10:09:45 EDT 2025 Tue Nov 04 22:09:40 EST 2025 Mon Jul 21 06:02:53 EDT 2025 Sat Nov 29 05:07:45 EST 2025 Tue Nov 18 22:03:12 EST 2025 Fri Feb 21 02:34:02 EST 2025 Mon Nov 10 09:10:40 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Keywords | Drug holiday Atypical fracture Denosumab Bisphosphonates |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c514t-85ed22b19c8234df9288b828912f86112df9a47b3f33b8e48e2f8deb7a96ff743 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 scopus-id:2-s2.0-85067304661 |
| ORCID | 0000-0003-3510-0709 0000-0002-1372-4417 0000-0002-2730-6080 0000-0002-3048-4961 0000-0003-4269-9393 |
| OpenAccessLink | https://cir.nii.ac.jp/crid/1872555065574545408 |
| PMID | 31175404 |
| PQID | 2236326258 |
| PQPubID | 33762 |
| PageCount | 11 |
| ParticipantIDs | liege_orbi_v2_oai_orbi_ulg_ac_be_2268_246383 proquest_miscellaneous_2283109810 proquest_journals_2236326258 pubmed_primary_31175404 crossref_citationtrail_10_1007_s00198_019_05002_w crossref_primary_10_1007_s00198_019_05002_w springer_journals_10_1007_s00198_019_05002_w nii_cinii_1872555065574545408 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-09-01 |
| PublicationDateYYYYMMDD | 2019-09-01 |
| PublicationDate_xml | – month: 09 year: 2019 text: 2019-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationSubtitle | With other metabolic bone diseases |
| PublicationTitle | Osteoporosis International |
| PublicationTitleAbbrev | Osteoporos Int |
| PublicationTitleAlternate | Osteoporos Int |
| PublicationYear | 2019 |
| Publisher | Springer Science and Business Media LLC Springer London Springer Nature B.V |
| Publisher_xml | – name: Springer Science and Business Media LLC – name: Springer London – name: Springer Nature B.V |
| References | Anastasilakis, Polyzos, Makras, Aubry-Rozier, Kaouri, Lamy (CR42) 2017; 32 Schwarz, Bauer, Cummings, Cauley, Ensrud, Palermo, Wallace, Hochberg, Feldstein, Lombardi, Black (CR48) 2010; 25 McNabb, Vittinghoff, Eastell, Schwartz, Bauer, Ensrud, Barrett-Connor, Black (CR30) 2014; 99 Adler, El-Hajj Fuleihan, Bauer, Camacho, Clarke, Clines, Compston, Drake, Edwards, Favus, Greenspan, McKinney, Pignolo, Sellmeyer (CR10) 2016; 31 McNabb, Vittinghoff, Schwartz, Eastell, Bauer, Ensrud, Rosenberg, Santora, Barrett-Connor, Black (CR31) 2013; 28 Bauer, Schwartz, Palermo, Cauley, Hochberg, Santora, Cummings, Black (CR49) 2014; 174 Khow, Shibu, Yu, Chehade, Visvanathan (CR63) 2017; 21 Anagnostis, Paschou, Mintziori, Ceausu, Depypere, Lambrinoudaki, Mueck, Perez-Lopez, Rees, Senturk, Simoncini, Stevenson, Stute, Tremollieres, Goulis (CR7) 2017; 101 Popp, Varathan, Buffat, Senn, Perrelet, Lippuner (CR44) 2018; 103 Mignot, Taisne, Legroux, Cortet, Paccou (CR56) 2017; 28 Adams, Adams, Raebel, Tang, Kuntz, Vi jayadeva, McGlynn, Gozansky (CR52) 2018; 33 Schilcher, Michaëlsson, Aspenberg (CR59) 2011; 364 Dell, Adams, Greene, Funahashi, Silverman, Eisman, Zhou, Burchetter, Ott (CR62) 2012; 27 Kharazmi, Hallberg, Schilcher, Aspenberg, Michaëlsson (CR64) 2016; 31 Black, Kelly, Genant, Palermo, Eastell, Bucci-Rechtweg, Cauley, Leung, Booen, Santora, de Papp, Bauer (CR58) 2010; 362 Zanchetta, Boailchuk, Massari, Silveira, Bogado, Zanchetta (CR45) 2018; 29 Black, Reid, Cauley, Cosman, Leung, Lakatos, Lippuner, Cummings, Hue, Mukhopadhyay, Tan, Aftring, Eastell (CR17) 2015; 30 Strom, Landfeldt, Garellick (CR54) 2015; 26 Bone, Chapurlat, Brandi, Brown, Czerwinski, Krieg, Mellstrom, Radominski, Reginster, Resch, Roman Ivorra, Roux, Vittinghoff, Daizadeh, Wang, Bradley, Franchimont, Geller, Wagman, Cummings, Papapoulos (CR19) 2013; 98 Masoodi (CR70) 2009; 2 Bone, Wagman, Brandi, Brown, Chapurlat, Cummings, Czerwiński, Fahrleitner-Pammer, Kendler, Lippuner, Reginster, Roux, Malouf, Bradley, Daizadeh, Wang, Dakin, Pannacciulli, Dempster, Papapoulos (CR47) 2017; 5 Marx, Sawatari, Fortin, Bromand (CR69) 2005; 63 Black, Reid, Boonen, Bucci-Rechtweg, Cauley, Cosman, Cummings, Hue, Lippuner, Lakatos, Leung, Man, Martinez, Tan, Ruzycky, Su, Eastell (CR16) 2012; 27 Lo, O’Ryan, Gordon, Yang, Hui, Martin, Hutchinson, Lathon, Sanchez, Silver, Chandra, McCloskey, Staffa, Willy, Selby, Go (CR66) 2010; 68 McClung, Lewiecki, Geller, Bolognese, Peacock, Weinstein, Ding, Rockabrand, Wagman, Miller (CR29) 2013; 24 Hassler, Gamsjaeger, Hofstetter, Brozek, Klaushofer, Paschalis (CR27) 2015; 26 Black, Schwartz, Ensrud, Cauley, Levis, Quandt, Satterfield, Wallace, Bauer, Palermo, Wehren, Lombardi, Santora, Cummings (CR39) 2006; 296 Johnell, Kanis (CR1) 2006; 17 Curtis, Westfall, Cheng, Delzell, Saag (CR57) 2008; 19 Compston, Cooper, Cooper, Gittoes, Gregson, Harvey, Hope, Kanis, McCloskey, Poole, Reid, Selby, Thompson, Thurston, Vine (CR11) 2017; 12 Eastell, Boonen, Cosman, Reid, Palermo, Cummings, Black (CR24) 2015; 30 Borah, Dufresne, Nurre, Phipps, Chmielewski, Wagner, Lundy, Bouxsein, Zebaze, Seeman (CR20) 2010; 25 Cairoli, Eller-Vainicher, Ulivieri, Zhukouskaya, Palmieri, Morelli, Beck-Peccoz, Chiodini (CR75) 2014; 25 Xu, Adams-Huet, Poindexter, Maalouf (CR55) 2016; 27 Miller, Wagman, Peacock, Lewiecki, Bolognese, Weinstein, Ding, San Martin, McClung (CR33) 2011; 96 Eiken, Prieto-Alhambra, Eastell, Abrahamsen (CR73) 2017; 28 Papapoulos, Chapurlat, Libanati, Brandi, Brown, Czerwinski, Krieg, Man, Mellstrom, Radominski, Reginster, Resch, Ivorra, Roux, Vittinghoff, Austin, Daizadeh, Bradley, Grauer, Cummings, Bone (CR34) 2012; 27 Ensrud, Barrett-Connor, Schwartz, Santora, Bauer, Suryawanshi, Feldstein, Haskell, Hochberg, Torner, Lombardi, Black (CR38) 2004; 19 Khan, Morrison, Hanley, Felsenberg, McCauley, O’Ryan, Reid, Ruggiero, Taguchi, Tetradis, Watts, Brandi, Peters, Guise, Eastell, Cheung, Morin, Masri, Cooper, Morgan, Obermayer-Pietsch, Langdahl, Al Dabagh, Davison, Kendler, Sándor, Josse, Bhandari, El Rabbany, Pierroz, Sulimani, Saunders, Brown, Compston (CR67) 2015; 30 Lindsay, Watts, Lange, Delmas, Silverman (CR2) 2013; 24 Roerholt, Eiken, Abrahamsen (CR4) 2009; 20 Cosman, Cauley, Eastell, Boonen, Palermo, Reid, Cummings, Black (CR23) 2014; 99 Roschger, Lombardi, Misof, Maier, Fratzl-Zelman, Fratzl, Klaushofer (CR37) 2010; 25 Ferrari, Adachi, Lippuner, Zapalowski, Miller, Reginster, Torring, Kendler, Daizadeh, Wang, O’Malley, Wagman, Libanati, Lewiecki (CR26) 2015; 26 Tsourdi, Langdahl, Cohen-Solal, Aubry-Rozier, Eriksen, Guañabens, Obermayer-Pietsch, Ralston, Eastell, Zillikens (CR40) 2017; 105 CR12 Abrahamsen, Eiken, Prieto-Alhambra, Eastell (CR74) 2016; 353 Recknor, Czerwinski, Bone, Bonnick, Binkley, Palacios, Moffett, Siddhanti, Ferreira, Ghelani, Wagman, Hall, Bolognese, Benhamou (CR36) 2013; 121 Silverman, Adachi, Dennison (CR5) 2016; 27 Bianchi, Czerwinski, Kenwright, Burdeska, Recker, Felsenberg (CR14) 2012; 23 Cummings, Ferrari, Eastell, Gilchrist, Jensen, McClung, Roux, Törring, Valter, Wang, Brown (CR50) 2018; 33 CR53 Adachi, Bone, Daizadeh, Dakin, Papapoulos, Hadji, Recknor, Bolognese, wang, Lin, Wagman, Ferrari (CR46) 2017; 18 Whittaker, Guo, Kehoe (CR6) 2012; 366 Schilcher, Koeppen, Aspenberg, Michaëlsson (CR60) 2015; 86 Reyes, Tebe, Martinez-Laguna, Ali, Soria-Castro, Carbonell, Prieto-Alhambra (CR3) 2017; 28 Watts, Chines, Olszynski, McKeever, McClung, Zhao, Grauer (CR13) 2008; 19 Black, Delmas, Eastell, Reid, Boonen, Cauley, Cosman, Lakatos, Leung, Man, Mautalen, Mesenbrink, Hu, Caminis, Tong, Rosario-Jansen, Krasnow, Hue, Sellmeyer, Eriksen, Cummings (CR71) 2007; 356 Choi, Lee, Yoon, Min, Lee (CR72) 2017; 39 Shane, Burr, Ebeling, Abrahamsen, Adler, Brown (CR9) 2010; 25 Naylor, Bradburn, Paggiosi, Gossiel, Peel, McCloskey, Walsh, Eastell (CR51) 2018; 29 Cummings, Ferrari, Eastell, Gilchrist, Jensen, McClung, Roux, Torring, Valter, Wang, Brown (CR41) 2017; 33 McClung, Wagman, Miller, Wang, Lewiecki (CR43) 2017; 28 Brown, Roux, Torring, Ho, Beck Jensen, Gilchrist, Recknor, Austin, Wang, Grauer, Wagman (CR22) 2013; 28 Brown, Reid, Wagman, Kendler, Miller, Jensen, Bolognese, Daizadeh, Valter, Zerbini, Dempster (CR21) 2014; 29 Papapoulos, Lippuner, Roux, Lin, Kendler, Lewiecki, Brandi, Czerwinski, Franek, Lakatos, Mautalen, Minisola, Reginster, Jensen, Daizadeh, Wang, Gavin, Libanati, Wagman, Bone (CR35) 2015; 26 Miller, Recker, Reginster, Riis, Czerwinski, Masanauskaite, Kenwright, Lorenc, Stakkestad, Lakatos (CR32) 2012; 23 CR61 Eastell, Hannon, Wenderoth, Rodriguez-Moreno, Sawicki (CR25) 2011; 96 Bone, Bolognese, Yuenn, Kendler, Miller, Yang, Grazette, Martin, Gallagher (CR18) 2011; 96 Watts, Bilezikian, Camacho, Greenspan, Harris, Hodgson, Kleerekoper, Luckey, McClung, Pollack, Petak (CR8) 2010; 16 Black, Boonen, Cauley, Cummings, Lippuner, Leung, Martinez, Ruzycky, Eastell (CR15) 2012; 27 Leder, Tsai, Uihlein, Wallace, Lee, Neer, Burnett-Bowie (CR28) 2015; 386 Marx (CR65) 2003; 61 Woo, Hellstein, Kalmar (CR68) 2006; 144 O Johnell (5002_CR1) 2006; 17 DM Black (5002_CR15) 2012; 27 S Ferrari (5002_CR26) 2015; 26 JR Curtis (5002_CR57) 2008; 19 DM Black (5002_CR71) 2007; 356 O Strom (5002_CR54) 2015; 26 J Compston (5002_CR11) 2017; 12 NB Watts (5002_CR8) 2010; 16 JP Brown (5002_CR21) 2014; 29 KE Ensrud (5002_CR38) 2004; 19 C Roerholt (5002_CR4) 2009; 20 B Borah (5002_CR20) 2010; 25 S Papapoulos (5002_CR35) 2015; 26 AV Schwarz (5002_CR48) 2010; 25 N Masoodi (5002_CR70) 2009; 2 E Tsourdi (5002_CR40) 2017; 105 AW Popp (5002_CR44) 2018; 103 AD Anastasilakis (5002_CR42) 2017; 32 HG Bone (5002_CR18) 2011; 96 BZ Leder (5002_CR28) 2015; 386 PD Miller (5002_CR32) 2012; 23 SR Cummings (5002_CR50) 2018; 33 PD Miller (5002_CR33) 2011; 96 P Roschger (5002_CR37) 2010; 25 SL Silverman (5002_CR5) 2016; 27 R Eastell (5002_CR24) 2015; 30 SR Cummings (5002_CR41) 2017; 33 RM Dell (5002_CR62) 2012; 27 MB Zanchetta (5002_CR45) 2018; 29 C Recknor (5002_CR36) 2013; 121 5002_CR61 RE Marx (5002_CR69) 2005; 63 B McNabb (5002_CR30) 2014; 99 KS Khow (5002_CR63) 2017; 21 R Lindsay (5002_CR2) 2013; 24 JP Brown (5002_CR22) 2013; 28 HG Bone (5002_CR47) 2017; 5 F Cosman (5002_CR23) 2014; 99 M Kharazmi (5002_CR64) 2016; 31 MA Mignot (5002_CR56) 2017; 28 R Eastell (5002_CR25) 2011; 96 S Papapoulos (5002_CR34) 2012; 27 KE Naylor (5002_CR51) 2018; 29 5002_CR12 NB Watts (5002_CR13) 2008; 19 N Hassler (5002_CR27) 2015; 26 5002_CR53 PA Eiken (5002_CR73) 2017; 28 BL McNabb (5002_CR31) 2013; 28 JD Adachi (5002_CR46) 2017; 18 HG Bone (5002_CR19) 2013; 98 AA Khan (5002_CR67) 2015; 30 RA Adler (5002_CR10) 2016; 31 DM Black (5002_CR17) 2015; 30 LH Xu (5002_CR55) 2016; 27 JC Lo (5002_CR66) 2010; 68 C Reyes (5002_CR3) 2017; 28 DM Black (5002_CR58) 2010; 362 SB Woo (5002_CR68) 2006; 144 J Schilcher (5002_CR59) 2011; 364 M Whittaker (5002_CR6) 2012; 366 DM Black (5002_CR16) 2012; 27 AL Adams (5002_CR52) 2018; 33 P Anagnostis (5002_CR7) 2017; 101 DC Bauer (5002_CR49) 2014; 174 E Shane (5002_CR9) 2010; 25 MR McClung (5002_CR29) 2013; 24 J Schilcher (5002_CR60) 2015; 86 MR McClung (5002_CR43) 2017; 28 B Abrahamsen (5002_CR74) 2016; 353 DM Black (5002_CR39) 2006; 296 E Cairoli (5002_CR75) 2014; 25 G Bianchi (5002_CR14) 2012; 23 RE Marx (5002_CR65) 2003; 61 WS Choi (5002_CR72) 2017; 39 |
| References_xml | – volume: 28 start-page: 2997 issue: 10 year: 2017 end-page: 3004 ident: CR3 article-title: One and two year persistence with different anti-osteoporosis medications: a retrospective cohort study publication-title: Osteoporos Int doi: 10.1007/s00198-017-4144-7 – volume: 29 start-page: 1407 issue: 6 year: 2018 end-page: 1417 ident: CR51 article-title: Effects of discontinuing oral bisphosphonate treatments for postmenopausal osteoporosis on bone turnover markers and bone density publication-title: Osteoporos Int doi: 10.1007/s00198-018-4460-6 – volume: 26 start-page: 315 issue: 1 year: 2015 end-page: 325 ident: CR54 article-title: Residual effect after oral bisphosphonate treatment and healthy adhere effects – the Swedish Adherence Register Analysis (SARA) publication-title: Osteoporos Int doi: 10.1007/s00198-014-2900-5 – volume: 29 start-page: 41 issue: 1 year: 2018 end-page: 47 ident: CR45 article-title: Significant bone loss after stopping long-term denosumab treatment: a post FREEDOM study publication-title: Osteoporos Int doi: 10.1007/s00198-017-4242-6 – volume: 19 start-page: 1613 year: 2008 end-page: 1620 ident: CR57 article-title: Risk of hip fracture after bisphosphonate discontinuation: implications for a drug holiday publication-title: Osteoporos Int doi: 10.1007/s00198-008-0604-4 – volume: 28 start-page: 2921 issue: 10 year: 2017 end-page: 2928 ident: CR73 article-title: Surgically treated osteonecrosis and osteomyelitis of the jaw and oral cavity in patients highly adherent to alendronate treatment: a nationwide user-only cohort study including over 60,000 alendronate users publication-title: Osteporosis Int doi: 10.1007/s00198-017-4132-y – volume: 121 start-page: 1291 issue: 6 year: 2013 end-page: 1299 ident: CR36 article-title: Denosumab compared with ibandronate in postmenopausal women previously treated with bisphosphonate therapy: a randomized open-label trial publication-title: Obstet Gynecol doi: 10.1097/AOG.0b013e318291718c – ident: CR12 – volume: 24 start-page: 227 issue: 1 year: 2013 end-page: 235 ident: CR29 article-title: Effect of denosumab on bone mineral density and biochemical markers of bone turnover: 8-year results of a phase 2 clinical trial publication-title: Osteoporos Int doi: 10.1007/s00198-012-2052-4 – volume: 362 start-page: 1761 issue: 19 year: 2010 end-page: 1771 ident: CR58 article-title: Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur publication-title: N Engl J Med doi: 10.1056/NEJMoa1001086 – volume: 17 start-page: 1726 issue: 12 year: 2006 end-page: 1733 ident: CR1 article-title: An estimate of the worldwide prevalence and disability associated with osteoporotic fractures publication-title: Osteoporos Int doi: 10.1007/s00198-006-0172-4 – volume: 16 start-page: 1016 year: 2010 end-page: 1019 ident: CR8 article-title: American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis: executive summary of recommendations publication-title: Endocr Pract doi: 10.4158/EP.16.6.1016 – ident: CR61 – volume: 96 start-page: 972 issue: 4 year: 2011 end-page: 980 ident: CR18 article-title: Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2010-1502 – volume: 25 start-page: 976 issue: 5 year: 2010 end-page: 982 ident: CR48 article-title: Efficacy of continued alendronate for fractures in women with and without prevalent vertebral fracture: the FLEX trial publication-title: J Bone Miner Res doi: 10.1002/jbmr.11 – volume: 18 start-page: 174 year: 2017 ident: CR46 article-title: Influence of subject discontinuation on long-term nonvertebral fracture rate in the denosumab FREEDOM extension study publication-title: BMC Musculoskelet Disord doi: 10.1186/s12891-017-1520-6 – volume: 366 start-page: 2048 year: 2012 end-page: 2051 ident: CR6 article-title: Bisphosphonates for osteoporosis – where do we go from here? publication-title: N Engl J Med doi: 10.1056/NEJMp1202619 – volume: 19 start-page: 365 issue: 3 year: 2008 end-page: 372 ident: CR13 article-title: Fracture risk remains reduced one year after discontinuation of risedronate publication-title: Osteoporos Int doi: 10.1007/s00198-007-0460-7 – volume: 99 start-page: 4546 issue: 12 year: 2014 end-page: 4554 ident: CR23 article-title: Reassessment of fracture risk in women after 3 years of treatment with zoledronic acid: when is it reasonable to discontinue treatment? publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2014-1971 – volume: 28 start-page: 1319 issue: 6 year: 2013 end-page: 1327 ident: CR31 article-title: BMD changes and predictors of increased bone loss in postmenopausal women after a 5-year course of alendronate publication-title: J Bone Miner Res doi: 10.1002/jbmr.1864 – volume: 27 start-page: 2544 issue: 12 year: 2012 end-page: 2550 ident: CR62 article-title: Incidence of atypical nontraumatic diaphyseal fractures of the femur publication-title: J Bone Miner Res doi: 10.1002/jbmr.1719 – volume: 32 start-page: 1291 issue: 6 year: 2017 end-page: 1704 ident: CR42 article-title: Clinical features of 24 patients with rebound associated vertebral fractures after denosumab discontinuation: systematic review and additional cases publication-title: J Bone Miner Res doi: 10.1002/jbmr.3110 – volume: 33 start-page: 190 issue: 2 year: 2018 end-page: 198 ident: CR50 article-title: Vertebral fractures after discontinuation of denosumab: a post hoc analysis of the randomized placebo-controlled FREEDOM trial and its extension publication-title: J Bone Miner Res doi: 10.1002/jbmr.3337 – volume: 27 start-page: 2612 issue: 12 year: 2012 end-page: 2254 ident: CR15 article-title: Erratum: the effect of 3 versus 6 years of Zoledronic acid treatment of osteoporosis: a randomized extension to the horizon-pivotal fracture trial (PFT) publication-title: J Bone Miner Res doi: 10.1002/jbmr.1494 – volume: 63 start-page: 1567 issue: 11 year: 2005 end-page: 1575 ident: CR69 article-title: Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention and treatment publication-title: J Oral Maxillofac Surg doi: 10.1016/j.joms.2005.07.010 – volume: 98 start-page: 4483 issue: 11 year: 2013 end-page: 4919 ident: CR19 article-title: The effect of three or six years of denosumab exposure in women with postmenopausal osteoporosis: results from the FREEDOM extension publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2013-1597 – volume: 33 start-page: 1252 issue: 7 year: 2018 end-page: 1259 ident: CR52 article-title: Bisphosphonate drug holiday and fracture risk: a population-based cohort study publication-title: J Bone Miner Res doi: 10.1002/jbmr.3420 – volume: 29 start-page: 2051 issue: 9 year: 2014 end-page: 2056 ident: CR21 article-title: Effects of up to 5 years of denosumab treatment on bone histology and histomorphometry: the FREEDOM study extension publication-title: J Bone Miner Res doi: 10.1002/jbmr.2236 – volume: 5 start-page: 513 issue: 7 year: 2017 end-page: 523 ident: CR47 article-title: 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(17)30138-9 – volume: 30 start-page: 483 issue: 3 year: 2015 end-page: 758 ident: CR24 article-title: Relationship between pretreatment rate of bone loss and bone density response to once-yearly ZOL: HORIZON-PFT extension study publication-title: J Bone Miner Res doi: 10.1002/jbmr.2361 – volume: 30 start-page: 3 issue: 1 year: 2015 end-page: 23 ident: CR67 article-title: Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus publication-title: J Bone Miner Res doi: 10.1002/jbmr.2405 – volume: 353 year: 2016 ident: CR74 article-title: Risk of hip, subtrochanteric, and femoral shaft fractures among mid and long term users of alendronate: nationwide cohort and nested case-control study publication-title: BMJ doi: 10.1136/bmj.i3365 – volume: 30 start-page: 934 issue: 5 year: 2015 end-page: 944 ident: CR17 article-title: The effect of 6 versus 9 years of zoledronic acid treatment in osteoporosis: a randomized second extension to the HORIZON-pivotal fracture trial (PFT) publication-title: J Bone Miner Res doi: 10.1002/jbmr.2442 – volume: 28 start-page: 746 issue: 4 year: 2013 end-page: 752 ident: CR22 article-title: Discontinuation of denosumab and associated fracture incidence: analysis from the fracture reduction evaluation of denosumab in osteoporosis every 6 months (FREEDOM) trial publication-title: J Bone Miner Res doi: 10.1002/jbmr.1808 – volume: 23 start-page: 1747 issue: 6 year: 2012 end-page: 1756 ident: CR32 article-title: Efficacy of monthly oral ibandronate is sustained over 5 years: the MOBILE long-term extension study publication-title: Osteoporos Int doi: 10.1007/s00198-011-1773-0 – volume: 33 start-page: 190 issue: 2 year: 2017 end-page: 198 ident: CR41 article-title: Vertebral fractures after discontinuation of denosumab: a post hoc analysis of the randomized placebo-controlled FREEDOM trial and its extension publication-title: J Bone Miner Res doi: 10.1002/jbmr.3359 – volume: 144 start-page: 753 issue: 10 year: 2006 end-page: 761 ident: CR68 article-title: Systematic review: bisphosphonates and osteonecrosis of the jaws publication-title: Ann Intern Med doi: 10.7326/0003-4819-144-10-200605160-00009 – volume: 296 start-page: 2927 issue: 24 year: 2006 end-page: 2938 ident: CR39 article-title: Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial publication-title: JAMA doi: 10.1001/jama.296.24.2927 – volume: 25 start-page: 41 issue: 1 year: 2010 end-page: 47 ident: CR20 article-title: Risedronate reduces intracortical porosity in women with osteoporosis publication-title: J Bone Miner Res doi: 10.1359/jbmr.090711 – volume: 26 start-page: 339 issue: 1 year: 2015 end-page: 352 ident: CR27 article-title: Effects of long-term alendronate treatment on postmenopausal osteoporosis bone material properties publication-title: Osteoporos Int doi: 10.1007/s00198-014-2929-5 – volume: 25 start-page: 1401 issue: 4 year: 2014 end-page: 1905 ident: CR75 article-title: Factors associated with bisphosphonate treatment failure in postmenopausal women with primary osteoporosis publication-title: Osteoporos Int doi: 10.1007/s00198-014-2619-3 – volume: 364 start-page: 1728 issue: 18 year: 2011 end-page: 1737 ident: CR59 article-title: Bisphosphonate use and atypical fractures of the femoral shaft publication-title: N Engl J Med doi: 10.1056/NEJMoa1010650 – volume: 68 start-page: 243 issue: 2 year: 2010 end-page: 253 ident: CR66 article-title: Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure publication-title: J Oral Maxillofac Surg doi: 10.1016/j.joms.2009.03.050 – volume: 27 start-page: 243 issue: 2 year: 2012 end-page: 254 ident: CR16 article-title: The effect of 3 versus 6 years of Zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT) publication-title: J Bone Miner Res doi: 10.1002/jbmr.1494 – volume: 386 start-page: 1147 issue: 9999 year: 2015 end-page: 1155 ident: CR28 article-title: Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-switch study): extension of a randomised controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(15)61120-5 – ident: CR53 – volume: 26 start-page: 2773 issue: 12 year: 2015 end-page: 2783 ident: CR35 article-title: The effect of 8 or 5 years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM extension study publication-title: Osteoporos Int doi: 10.1007/s00198-015-3234-7 – volume: 26 start-page: 2763 issue: 12 year: 2015 end-page: 2771 ident: CR26 article-title: Further reductions in nonvertebral fracture rate with long-term denosumab treatment in the FREEDOM open-label extension and influence of hip bone mineral density after 3 years publication-title: Osteoporos Int doi: 10.1007/s00198-015-3179-x – volume: 25 start-page: 2267 year: 2010 end-page: 2294 ident: CR9 article-title: A typical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research publication-title: J Bone Miner Res doi: 10.1002/jbmr.253 – volume: 31 start-page: 16 year: 2016 end-page: 35 ident: CR10 article-title: Managing osteoporosis in patients on long-term bisphosphonate treatment: report of a task force of the American Society for Bone and Mineral Research publication-title: J Bone Miner Res doi: 10.1002/jbmr.2708 – volume: 99 start-page: 4094 issue: 11 year: 2014 end-page: 4100 ident: CR30 article-title: A model of BMD changes after alendronate discontinuation to guide postalendronate BMD monitoring publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2014-1193 – volume: 61 start-page: 1115 issue: 9 year: 2003 end-page: 1117 ident: CR65 article-title: Pamidronate and zoledronate induced avascular necrosis of the jaws: a growing epidemic publication-title: J Oral Maxillofac Surg doi: 10.1016/S0278-2391(03)00720-1 – volume: 2 start-page: 11 issue: 2 year: 2009 end-page: 15 ident: CR70 article-title: Oral bisphosphonates and the risk for osteonecrosis of the jaw publication-title: BJMP – volume: 27 start-page: 694 issue: 3 year: 2012 end-page: 701 ident: CR34 article-title: Five years of denosumab exposure in women with postmenopausal osteoporosis: results from the first two years of the FREEDOM extension publication-title: J Bone Miner Res doi: 10.1002/jbmr.1479 – volume: 12 start-page: 43 issue: 1 year: 2017 ident: CR11 article-title: UK clinical guideline for the prevention and treatment of osteoporosis publication-title: Arch Osteoporos doi: 10.1007/s11657-017-0324-5 – volume: 39 start-page: 1 issue: 1 year: 2017 ident: CR72 article-title: Medication-related osteonecrosis of the jaw: a preliminary retrospective study of 130 patients with multiple myeloma publication-title: Maxillofac Plast Reconstr Surg doi: 10.1186/s40902-016-0099-4 – volume: 96 start-page: 394 issue: 2 year: 2011 end-page: 402 ident: CR33 article-title: Effect of denosumab on bone mineral density and biochemical markers of bone turnover: six-year results of a phase 2 clinical trial publication-title: J Clin EndocrinolMetab doi: 10.1210/jc.2010-1805 – volume: 101 start-page: 23 year: 2017 end-page: 30 ident: CR7 article-title: Drug holidays from bisphosphonates and denosumab in postmenopausal osteoporosis: EMAS position statement publication-title: Maturitas doi: 10.1016/j.maturitas.2017.04.008 – volume: 19 start-page: 1259 issue: 8 year: 2004 end-page: 1269 ident: CR38 article-title: Randomized trial of effect of alendronate continuation versus discontinuation in women with low BMD: results from the fracture intervention trial long-term extension publication-title: J Bone Miner Res doi: 10.1359/JBMR.040326 – volume: 105 start-page: 11 year: 2017 end-page: 17 ident: CR40 article-title: Discontinuation of denosumab therapy for osteoporosis: a systematic review and position statement by ECTS publication-title: Bone doi: 10.1016/j.bone.2017.08.003 – volume: 20 start-page: 299 issue: 2 year: 2009 end-page: 307 ident: CR4 article-title: Initiation of antiosteoporotic therapy in patients with recent fractures: a nationwide 606 analysis of prescription rates and persistence publication-title: Osteoporos Int doi: 10.1007/s00198-008-0651-x – volume: 27 start-page: 849 issue: 3 year: 2016 end-page: 852 ident: CR5 article-title: Bisphosphonate drug holidays: we reap what we sow publication-title: Osteoporos Int doi: 10.1007/s00198-015-3453-y – volume: 23 start-page: 1769 issue: 6 year: 2012 end-page: 1778 ident: CR14 article-title: Long-term administration of quarterly IV ibandronate is effective and well tolerated in postmenopausal osteoporosis: 5-year data from the DIVA study long-term extension publication-title: Osteoporos Int doi: 10.1007/s00198-011-1793-9 – volume: 24 start-page: 2345 issue: 8 year: 2013 end-page: 2352 ident: CR2 article-title: Effectiveness of risedronate and alendronate on nonvertebral fractures: an observational study through 2 years of therapy publication-title: Osteoporos Int doi: 10.1007/s00198-006-0274-z – volume: 21 start-page: 83 issue: 1 year: 2017 end-page: 91 ident: CR63 article-title: Epidemiology and postoperative outcomes of atypical femoral fractures in older adults: a systematic review publication-title: J Nutr Health Aging doi: 10.1007/s12603-015-0652-3 – volume: 31 start-page: 491 issue: 3 year: 2016 end-page: 497 ident: CR64 article-title: Mortality after hip fracture publication-title: J Bone Miner Res doi: 10.1002/jbmr.2767 – volume: 96 start-page: 3367 issue: 11 year: 2011 end-page: 3373 ident: CR25 article-title: Effect of stopping risedronate after long-term treatment on bone turnover publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2011-0412 – volume: 28 start-page: 1723 issue: 5 year: 2017 end-page: 1732 ident: CR43 article-title: Observations following discontinuation of long-term denosumab therapy publication-title: Osteoporos Int doi: 10.1007/s00198-017-3919-1 – volume: 25 start-page: 48 issue: 1 year: 2010 end-page: 55 ident: CR37 article-title: Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data fromthe fracture intervention trial long-term extension (FLEX) publication-title: J Bone Miner Res doi: 10.1359/jbmr.090702 – volume: 103 start-page: 50 issue: 1 year: 2018 end-page: 54 ident: CR44 article-title: Bone mineral density changes after 1 year of denosumab discontinuation in postmenopausal women with long-term denosumab treatment for osteoporosis publication-title: Calcif Tissue Int doi: 10.1007/s00223-018-0394-4 – volume: 86 start-page: 100 issue: 1 year: 2015 end-page: 107 ident: CR60 article-title: Risk of femoral fracture during and after bisphosphonate therapy publication-title: Acta Orthop doi: 10.3109/17453674.2015.1004149 – volume: 356 start-page: 1809 issue: 18 year: 2007 end-page: 1822 ident: CR71 article-title: Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis publication-title: N Engl J Med doi: 10.1056/NEJMoa067312 – volume: 27 start-page: 1701 issue: 5 year: 2016 end-page: 1708 ident: CR55 article-title: Determinants of change in bone mineral density and fracture risk during bisphosphonate holiday publication-title: Osteoporos Int doi: 10.1007/s00198-015-3447-9 – volume: 174 start-page: 1126 issue: 7 year: 2014 end-page: 1134 ident: CR49 article-title: Fracture prediction after discontinuation of 4 to 5 years of alendronate therapy: the FLEX study publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2014.1232 – volume: 28 start-page: 3431 year: 2017 end-page: 3438 ident: CR56 article-title: Bisphosphonate drug holidays in postmenopausal osteoporosis: effect on clinical fracture risk publication-title: Osteporosis Int doi: 10.1007/s00198-017-4215-9 – volume: 30 start-page: 483 issue: 3 year: 2015 ident: 5002_CR24 publication-title: J Bone Miner Res doi: 10.1002/jbmr.2361 – volume: 101 start-page: 23 year: 2017 ident: 5002_CR7 publication-title: Maturitas doi: 10.1016/j.maturitas.2017.04.008 – volume: 99 start-page: 4546 issue: 12 year: 2014 ident: 5002_CR23 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2014-1971 – ident: 5002_CR12 doi: 10.1136/bmj.e3698 – volume: 29 start-page: 41 issue: 1 year: 2018 ident: 5002_CR45 publication-title: Osteoporos Int doi: 10.1007/s00198-017-4242-6 – volume: 96 start-page: 394 issue: 2 year: 2011 ident: 5002_CR33 publication-title: J Clin EndocrinolMetab doi: 10.1210/jc.2010-1805 – volume: 20 start-page: 299 issue: 2 year: 2009 ident: 5002_CR4 publication-title: Osteoporos Int doi: 10.1007/s00198-008-0651-x – volume: 26 start-page: 2763 issue: 12 year: 2015 ident: 5002_CR26 publication-title: Osteoporos Int doi: 10.1007/s00198-015-3179-x – volume: 28 start-page: 1723 issue: 5 year: 2017 ident: 5002_CR43 publication-title: Osteoporos Int doi: 10.1007/s00198-017-3919-1 – volume: 28 start-page: 3431 year: 2017 ident: 5002_CR56 publication-title: Osteporosis Int doi: 10.1007/s00198-017-4215-9 – volume: 27 start-page: 694 issue: 3 year: 2012 ident: 5002_CR34 publication-title: J Bone Miner Res doi: 10.1002/jbmr.1479 – volume: 39 start-page: 1 issue: 1 year: 2017 ident: 5002_CR72 publication-title: Maxillofac Plast Reconstr Surg doi: 10.1186/s40902-016-0099-4 – volume: 2 start-page: 11 issue: 2 year: 2009 ident: 5002_CR70 publication-title: BJMP – volume: 23 start-page: 1747 issue: 6 year: 2012 ident: 5002_CR32 publication-title: Osteoporos Int doi: 10.1007/s00198-011-1773-0 – volume: 105 start-page: 11 year: 2017 ident: 5002_CR40 publication-title: Bone doi: 10.1016/j.bone.2017.08.003 – volume: 28 start-page: 2997 issue: 10 year: 2017 ident: 5002_CR3 publication-title: Osteoporos Int doi: 10.1007/s00198-017-4144-7 – volume: 29 start-page: 2051 issue: 9 year: 2014 ident: 5002_CR21 publication-title: J Bone Miner Res doi: 10.1002/jbmr.2236 – volume: 27 start-page: 243 issue: 2 year: 2012 ident: 5002_CR16 publication-title: J Bone Miner Res doi: 10.1002/jbmr.1494 – volume: 28 start-page: 1319 issue: 6 year: 2013 ident: 5002_CR31 publication-title: J Bone Miner Res doi: 10.1002/jbmr.1864 – volume: 121 start-page: 1291 issue: 6 year: 2013 ident: 5002_CR36 publication-title: Obstet Gynecol doi: 10.1097/AOG.0b013e318291718c – volume: 366 start-page: 2048 year: 2012 ident: 5002_CR6 publication-title: N Engl J Med doi: 10.1056/NEJMp1202619 – volume: 98 start-page: 4483 issue: 11 year: 2013 ident: 5002_CR19 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2013-1597 – volume: 25 start-page: 48 issue: 1 year: 2010 ident: 5002_CR37 publication-title: J Bone Miner Res doi: 10.1359/jbmr.090702 – volume: 25 start-page: 1401 issue: 4 year: 2014 ident: 5002_CR75 publication-title: Osteoporos Int doi: 10.1007/s00198-014-2619-3 – volume: 174 start-page: 1126 issue: 7 year: 2014 ident: 5002_CR49 publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2014.1232 – volume: 96 start-page: 972 issue: 4 year: 2011 ident: 5002_CR18 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2010-1502 – volume: 296 start-page: 2927 issue: 24 year: 2006 ident: 5002_CR39 publication-title: JAMA doi: 10.1001/jama.296.24.2927 – volume: 33 start-page: 190 issue: 2 year: 2017 ident: 5002_CR41 publication-title: J Bone Miner Res doi: 10.1002/jbmr.3359 – volume: 31 start-page: 16 year: 2016 ident: 5002_CR10 publication-title: J Bone Miner Res doi: 10.1002/jbmr.2708 – volume: 16 start-page: 1016 year: 2010 ident: 5002_CR8 publication-title: Endocr Pract doi: 10.4158/EP.16.6.1016 – volume: 5 start-page: 513 issue: 7 year: 2017 ident: 5002_CR47 publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(17)30138-9 – volume: 27 start-page: 2544 issue: 12 year: 2012 ident: 5002_CR62 publication-title: J Bone Miner Res doi: 10.1002/jbmr.1719 – volume: 33 start-page: 1252 issue: 7 year: 2018 ident: 5002_CR52 publication-title: J Bone Miner Res doi: 10.1002/jbmr.3420 – volume: 33 start-page: 190 issue: 2 year: 2018 ident: 5002_CR50 publication-title: J Bone Miner Res doi: 10.1002/jbmr.3337 – volume: 362 start-page: 1761 issue: 19 year: 2010 ident: 5002_CR58 publication-title: N Engl J Med doi: 10.1056/NEJMoa1001086 – volume: 61 start-page: 1115 issue: 9 year: 2003 ident: 5002_CR65 publication-title: J Oral Maxillofac Surg doi: 10.1016/S0278-2391(03)00720-1 – volume: 31 start-page: 491 issue: 3 year: 2016 ident: 5002_CR64 publication-title: J Bone Miner Res doi: 10.1002/jbmr.2767 – volume: 28 start-page: 2921 issue: 10 year: 2017 ident: 5002_CR73 publication-title: Osteporosis Int doi: 10.1007/s00198-017-4132-y – volume: 17 start-page: 1726 issue: 12 year: 2006 ident: 5002_CR1 publication-title: Osteoporos Int doi: 10.1007/s00198-006-0172-4 – volume: 25 start-page: 976 issue: 5 year: 2010 ident: 5002_CR48 publication-title: J Bone Miner Res doi: 10.1002/jbmr.11 – volume: 63 start-page: 1567 issue: 11 year: 2005 ident: 5002_CR69 publication-title: J Oral Maxillofac Surg doi: 10.1016/j.joms.2005.07.010 – volume: 19 start-page: 1613 year: 2008 ident: 5002_CR57 publication-title: Osteoporos Int doi: 10.1007/s00198-008-0604-4 – volume: 27 start-page: 2612 issue: 12 year: 2012 ident: 5002_CR15 publication-title: J Bone Miner Res doi: 10.1002/jbmr.1494 – volume: 19 start-page: 1259 issue: 8 year: 2004 ident: 5002_CR38 publication-title: J Bone Miner Res doi: 10.1359/JBMR.040326 – volume: 356 start-page: 1809 issue: 18 year: 2007 ident: 5002_CR71 publication-title: N Engl J Med doi: 10.1056/NEJMoa067312 – volume: 32 start-page: 1291 issue: 6 year: 2017 ident: 5002_CR42 publication-title: J Bone Miner Res doi: 10.1002/jbmr.3110 – volume: 18 start-page: 174 year: 2017 ident: 5002_CR46 publication-title: BMC Musculoskelet Disord doi: 10.1186/s12891-017-1520-6 – volume: 68 start-page: 243 issue: 2 year: 2010 ident: 5002_CR66 publication-title: J Oral Maxillofac Surg doi: 10.1016/j.joms.2009.03.050 – volume: 27 start-page: 849 issue: 3 year: 2016 ident: 5002_CR5 publication-title: Osteoporos Int doi: 10.1007/s00198-015-3453-y – volume: 25 start-page: 41 issue: 1 year: 2010 ident: 5002_CR20 publication-title: J Bone Miner Res doi: 10.1359/jbmr.090711 – volume: 353 year: 2016 ident: 5002_CR74 publication-title: BMJ doi: 10.1136/bmj.i3365 – volume: 24 start-page: 2345 issue: 8 year: 2013 ident: 5002_CR2 publication-title: Osteoporos Int doi: 10.1007/s00198-006-0274-z – volume: 12 start-page: 43 issue: 1 year: 2017 ident: 5002_CR11 publication-title: Arch Osteoporos doi: 10.1007/s11657-017-0324-5 – volume: 30 start-page: 3 issue: 1 year: 2015 ident: 5002_CR67 publication-title: J Bone Miner Res doi: 10.1002/jbmr.2405 – volume: 29 start-page: 1407 issue: 6 year: 2018 ident: 5002_CR51 publication-title: Osteoporos Int doi: 10.1007/s00198-018-4460-6 – volume: 21 start-page: 83 issue: 1 year: 2017 ident: 5002_CR63 publication-title: J Nutr Health Aging doi: 10.1007/s12603-015-0652-3 – volume: 25 start-page: 2267 year: 2010 ident: 5002_CR9 publication-title: J Bone Miner Res doi: 10.1002/jbmr.253 – volume: 26 start-page: 2773 issue: 12 year: 2015 ident: 5002_CR35 publication-title: Osteoporos Int doi: 10.1007/s00198-015-3234-7 – volume: 364 start-page: 1728 issue: 18 year: 2011 ident: 5002_CR59 publication-title: N Engl J Med doi: 10.1056/NEJMoa1010650 – volume: 30 start-page: 934 issue: 5 year: 2015 ident: 5002_CR17 publication-title: J Bone Miner Res doi: 10.1002/jbmr.2442 – volume: 96 start-page: 3367 issue: 11 year: 2011 ident: 5002_CR25 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2011-0412 – ident: 5002_CR53 doi: 10.1136/annrheumdis-2018-eular.4953 – volume: 23 start-page: 1769 issue: 6 year: 2012 ident: 5002_CR14 publication-title: Osteoporos Int doi: 10.1007/s00198-011-1793-9 – volume: 144 start-page: 753 issue: 10 year: 2006 ident: 5002_CR68 publication-title: Ann Intern Med doi: 10.7326/0003-4819-144-10-200605160-00009 – volume: 19 start-page: 365 issue: 3 year: 2008 ident: 5002_CR13 publication-title: Osteoporos Int doi: 10.1007/s00198-007-0460-7 – volume: 26 start-page: 339 issue: 1 year: 2015 ident: 5002_CR27 publication-title: Osteoporos Int doi: 10.1007/s00198-014-2929-5 – volume: 386 start-page: 1147 issue: 9999 year: 2015 ident: 5002_CR28 publication-title: Lancet doi: 10.1016/S0140-6736(15)61120-5 – volume: 26 start-page: 315 issue: 1 year: 2015 ident: 5002_CR54 publication-title: Osteoporos Int doi: 10.1007/s00198-014-2900-5 – volume: 28 start-page: 746 issue: 4 year: 2013 ident: 5002_CR22 publication-title: J Bone Miner Res doi: 10.1002/jbmr.1808 – volume: 103 start-page: 50 issue: 1 year: 2018 ident: 5002_CR44 publication-title: Calcif Tissue Int doi: 10.1007/s00223-018-0394-4 – ident: 5002_CR61 – volume: 86 start-page: 100 issue: 1 year: 2015 ident: 5002_CR60 publication-title: Acta Orthop doi: 10.3109/17453674.2015.1004149 – volume: 99 start-page: 4094 issue: 11 year: 2014 ident: 5002_CR30 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2014-1193 – volume: 24 start-page: 227 issue: 1 year: 2013 ident: 5002_CR29 publication-title: Osteoporos Int doi: 10.1007/s00198-012-2052-4 – volume: 27 start-page: 1701 issue: 5 year: 2016 ident: 5002_CR55 publication-title: Osteoporos Int doi: 10.1007/s00198-015-3447-9 |
| SSID | ssib020737638 ssj0007997 ssib000829773 |
| Score | 2.507291 |
| SecondaryResourceType | review_article |
| Snippet | Summary
Given the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis... Given the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis therapies... SummaryGiven the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis... |
| SourceID | liege proquest pubmed crossref springer nii |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1733 |
| SubjectTerms | Age Factors Atypical fracture Bisphosphonate-Associated Osteonecrosis of the Jaw Bisphosphonate-Associated Osteonecrosis of the Jaw - epidemiology Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology Bisphosphonates Bone Density Bone Density - physiology Bone Density Conservation Agents Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - therapeutic use Bone loss Bone mineral density Bone strength Clinical Decision-Making Clinical Decision-Making - methods Decision making Denosumab Denosumab - administration & dosage Denosumab - therapeutic use Diphosphonates Diphosphonates - administration & dosage Diphosphonates - therapeutic use Drug Administration Schedule Drug holiday Endocrinology Femur Fractures Geriatrics Gériatrie Human health sciences Humans Immunotherapy info:eu-repo/classification/ddc/616 Medicine Medicine & Public Health Monoclonal antibodies Original Article Orthopedics Osteoporosis Osteoporosis, Postmenopausal Osteoporosis, Postmenopausal - drug therapy Osteoporosis, Postmenopausal - physiopathology Osteoporotic Fractures Osteoporotic Fractures - epidemiology Osteoporotic Fractures - prevention & control Pharmacokinetics Postmenopausal/drug therapy Public health, health care sciences & services Rheumatology Rhumatologie Risk Assessment Risk Assessment - methods Risk Factors Santé publique, services médicaux & soins de santé Sciences de la santé humaine Vertebrae Withholding Treatment |
| SummonAdditionalLinks | – databaseName: Nursing & Allied Health Database dbid: 7RV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3di9QwEB_0TsQXz2-rd1LBNy02H20SEOQ4XHzQQ0Rl30KTpkdhac_t7i3-985kuz1E7158KSVJyyQzmfySycwAvGLeS-WFyQInlxyFe1ajqjzTDAtZnTeijo7Cn9TpqZ7PzZfxwG0Yr1XudGJU1HXv6Yz8LS5jJUINXuj35z8zyhpF1tUxhcZN2GeEjVGe1dcfkyZWJiZXwU27yoxk89FpJrrOEbaha1wmywvSCps_Fqb9BZmscb3p2vZf2PMvu2lcjmYH_9uRe3B3BKLp8VZy7sON0D2A259HU_tDeDcj_6n1MqR0-zxtUF76DZKSUoAJkg46Zkv7JiUvkR5RfD-0Q7p15_r1CL7PPnw7-ZiNqRYyj4hpleki1Jw7ZrzmQtaN4Vo72owx3ugSMRkWVVI50QjhdJA6YHkdnKpM2TSIQh7DXtd34SmkkofSY40oaylFxVzpvcbGqBpr54RKgO3G2foxDjmlw1jYKYJy5I3Fh428sZsEXk_fnG-jcFzb-k1kn-2XrrUX3FII7fi-XpzZylsXLKJObblE7SMSOEIuIy30ZFqhIBUIzAolCwpPqBM43DHSjhN8sJdcTODlVI2DT_aWqgv9mtpQFjejWZ7Ak63cTNQLCpEqc4m07gTp8udXd-3Z9bQ8hzs8ijTdgTuEvdVyHY7glr9YtcPyRZwcvwFoXA-q priority: 102 providerName: ProQuest |
| Title | Fracture risk following intermission of osteoporosis therapy |
| URI | https://cir.nii.ac.jp/crid/1872555065574545408 https://link.springer.com/article/10.1007/s00198-019-05002-w https://www.ncbi.nlm.nih.gov/pubmed/31175404 https://www.proquest.com/docview/2236326258 https://www.proquest.com/docview/2283109810 https://orbi.uliege.be/handle/2268/246383 |
| Volume | 30 |
| WOSCitedRecordID | wos000483690500003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1433-2965 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0007997 issn: 1433-2965 databaseCode: RSV dateStart: 19970101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3di9QwEB-8WxFf_P6o3i0VfNPC5qNNCr7ocYsPuhyrHvsWmjSVwtLKdvcW_3tnsm1FPAV9GUoyDelkkvzSycwAvGTOSeVEnnhOLjkKz6y5KmaJZljIylklyuAo_EEtFnq1yi96p7BuuO0-mCTDSj06uxEaoYtXeTJLaR7vj2CC252mhA3LT5fj-qvykFIFj-oqySVb9a4y17fxy3Y0WZOhGneZpq6vQ5y_WUvDJjS_-3_dvwd3etAZvz1oyX244ZsHcOtjb1Z_CG_m5Cu12_iYbprHFepGu8fGYwomQZpAv9TitorJI6RFxN52dRcfXLe-P4Iv8_PPZ--TPq1C4hAdbROd-pJzy3KnuZBllXOtLR28GK90hvgLiwqprKiEsNpL7bG89FYVeVZViDgew3HTNv4pxJL7zGGNyEopRcFs5pxGZlwGS2uFioAN0jWujzlOqS_WZoyWHMRikJggFrOP4NX4zrdDxI2_cr8Og2baja3NFTcULjs879ZfTeGM9QYRpjZc4kojIjjFscW-EGVa4YEqRRCWKplSKEIdwckw6qafzB2-LzJEuTzF6hdjNQqfbCtF49sd8VDGtlyzWQRPDtoy9l5QOFQ5k9jXQTV-Nv7nT3v2b-zP4TYP2kX3307geLvZ-VO46a62dbeZwpFaXhJdqUA1Un3GpjB5d764WE7DFPoBhxQLfQ |
| linkProvider | Springer Nature |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VFgEX3o9AC0GCE0QkthM7EgghYNWq2xWHIu3NJI6DIq2Sstntqn-K38iM86gQ0FsPXKLIcaKJ_Xke9jwAXkTGCGl4GlhGITkSbdZUZmGgImyMirDkhQsUnsrZTM3n6Zct-DnEwpBb5cATHaMuGkN75G9QjCWoarBYvT_5EVDVKDpdHUpodLA4tGcbNNnadwefcH5fMjb5fPxxP-irCgQGlYNVoGJbMJZHqVGMi6JMmVI52R0RK1WC6gc2ZULmvOQ8V1Yoi-2FzWWWJmWJAhe_ewV2kI9LMvbkfDTwQpm6Yi4hivwgFdG8D9JxoXqkS5HbWBqEMXGhzW-CcGdBR-Qo3-qq-puu-8c5rRN_k1v_28Ddhpu9ou1_6FbGHdiy9V24dtS7EtyDtxOKD1svrU_e9X6J66HZ4K_7lECD0E_biH5T-hQF06CV0rRV63fhamf34eul0P4Atuumto_AF8wmBp_wpBCCZ1GeGKOwM7L-Is-59CAa5lWbPs86lftY6DFDtMOCxot2WNAbD16N75x0WUYu7P3awUU3y7zSp0xTinB3v15815nRudWoVSvNBHJX7sEeogppoWukJBqRMSqesRQxpV9UHuwOwNE9A2v1OWo8eD4-xsGn86Ssts2a-lCVulRFoQcPO5yO1HNKAStCgbQOwD3_-L9_7fHFtDyD6_vHR1M9PZgdPoEbzC0n8vfbhe3Vcm334Ko5XVXt8qlbmD58u2xA_wIDGGwD |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3Nb5RAFH-prWl68bsWbRUTPSkpzAzMkGiMad3YtG560GRvIwyDIdlAXXa76b_mX-d7A-zGqL314IWQYSCP4fe-mPcB8DIyRkjD08AySsmR6LOmMgsDFeFgVIQlL1yi8Jkcj9Vkkp5vwM8hF4bCKgeZ6AR10Rj6R36IaixBU4PF6rDswyLOj0fvL34E1EGKdlqHdhodRE7t1RLdt_bdyTF-61eMjT5-OfoU9B0GAoOGwjxQsS0Yy6PUKMZFUaZMqZx8kIiVKkFTBIcyIXNecp4rK5TF8cLmMkuTskTli8-9BVsSSSPHTx2tw0tk6hq7hKj-g1REkz5hx6XtkV1FIWRpEMYkkZa_KcWtKW2Xo66rq-pvdu8fe7ZOFY7u_s-LeA_u9Aa4_6HjmPuwYesHsP25DzF4CG9HlDe2mFmfou79EvmkWeIy-FRYg7iCfi_6TelTdkyD3kvTVq3fpbFdPYKvN0L7LmzWTW33wBfMJgav8KQQgmdRnhijcDKqhCLPufQgGr6xNn39dWoDMtWrytEOFxoP2uFCLz14vbrnoqs-cu3sNw46upnllb5kmkqHu_PF9LvOjM6tRmtbaSZQ6nIPDhBhSAsdIyXRuYzRII2liKkso_JgfwCR7gVbq9cI8uDF6jIuPu0zZbVtFjSHutelKgo9eNxhdkU9p9KwIhRI6wDi9cP__WpPrqflOWwjjvXZyfj0Kewwx1kUBrgPm_PZwh7AbXM5r9rZM8ejPny7aTz_AtmodIo |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fracture+risk+following+intermission+of+osteoporosis+therapy&rft.jtitle=Osteoporosis+international&rft.au=Dennison%2C+E+M&rft.au=Cooper%2C+C&rft.au=Kanis%2C+J+A&rft.au=Bruy%C3%A8re%2C+O&rft.date=2019-09-01&rft.eissn=1433-2965&rft.volume=30&rft.issue=9&rft.spage=1733&rft_id=info:doi/10.1007%2Fs00198-019-05002-w&rft_id=info%3Apmid%2F31175404&rft.externalDocID=31175404 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0937-941X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0937-941X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0937-941X&client=summon |