Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia

Animal work implicates chemical carcinogens, such as polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines (HAAs) as contributing to the development of colorectal cancer (CRC). The epidemiologic evidence, however, remains inconsistent possibly due to intra-individual variation in...

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Bibliographic Details
Published in:	Carcinogenesis (New York) Vol. 32; no. 2; p. 203
Main Authors:	Wang, Hansong, Yamamoto, Jennifer F, Caberto, Christian, Saltzman, Barbara, Decker, Robert, Vogt, Thomas M, Yokochi, Lance, Chanock, Stephen, Wilkens, Lynne R, Le Marchand, Loïc
Format:	Journal Article
Language:	English
Published:	England 01.02.2011
Subjects:	Aged Amines - metabolism Amines - toxicity Aryl Hydrocarbon Receptor Nuclear Translocator - genetics Arylamine N-Acetyltransferase - genetics Biotransformation Carcinogens - pharmacokinetics Case-Control Studies Colorectal Neoplasms - etiology Colorectal Neoplasms - genetics Female Genetic Variation Genotype Humans Imidazoles - metabolism Male Middle Aged Polycyclic Aromatic Hydrocarbons - pharmacokinetics Polycyclic Aromatic Hydrocarbons - toxicity Polymorphism, Single Nucleotide Quinoxalines - metabolism Risk Factors
ISSN:	1460-2180, 1460-2180
Online Access:	Get more information
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