Case Report: Post-Partum SARS-CoV-2 Infection After the First French Uterus Transplantation

Absolute uterus factor infertility, whether congenital or acquired, renders the woman unable to carry a child. Although uterus transplantation (UTx) is being increasingly performed as a non-vital procedure to address this unfortunate condition, the immunosuppression required presents risks that are...

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Veröffentlicht in:Frontiers in surgery Jg. 9; S. 854225
Hauptverfasser: Ayoubi, Jean Marc, Carbonnel, Marie, Kvarnström, Niclas, Revaux, Aurelie, Poulain, Marine, Vanlieferinghen, Sarah, Coatantiec, Yves, Le Marchand, Mathilde, Tourne, Morgan, Pirtea, Paul, Snanoudj, Renaud, Le Guen, Morgan, Dahm-Kähler, Pernilla, Racowsky, Catherine, Brännström, Mats
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Frontiers Media S.A 28.06.2022
Schlagworte:
case report
COVID-19
Gynaecology, Obstetrics and Reproductive Medicine
Gynekologi, obstetrik och reproduktionsmedicin
immunotherapy
Life Sciences
SARS-CoV-2
Surgery
uterus transplantation
uterus transplantation, immunotherapy, COVID-19, SARS-CoV-2, case report
COVID-19
case report
SARS-CoV-2
immunotherapy
uterus transplantation
ISSN:2296-875X, 2296-875X
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Zusammenfassung:Absolute uterus factor infertility, whether congenital or acquired, renders the woman unable to carry a child. Although uterus transplantation (UTx) is being increasingly performed as a non-vital procedure to address this unfortunate condition, the immunosuppression required presents risks that are further compounded by pregnancy and during the puerperium period. These vulnerabilities require avoidance of SARS-CoV-2 infection in pregnant UTx recipients especially during the third trimester, as accumulating evidence reveals increased risks of morbidity and mortality. Here we describe a successful UTx case with delivery of a healthy child, but in which both mother and neonate developed asymptomatic SARS-CoV-2 infection seven days after RNA vaccination, on day 35 post-partum. Although the patient was successfully treated with a combination therapy comprised of two monoclonal antibodies, this case highlights the challenges associated with performing UTx in the era of Covid-19. More broadly, the risks of performing non-vital organ transplantation during a pandemic should be discussed among team members and prospective patients, weighing the risks against the benefits in improving the quality of life, which were considerable for our patient who achieved motherhood with the birth of a healthy child.
Bibliographie:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
Speciality section: This article was submitted to Obstetrics and Gynecological Surgery, a section of the journal Frontiers in Surgery
Edited by: Andrea Tinelli, Xi’an Jiaotong University, China
Reviewed by: Stefan Guenther Tullius, Brigham and Women’s Hospital, Harvard Medical School, United States Heloise Delagreverie, AP-HP, France
ISSN:2296-875X
2296-875X
DOI:10.3389/fsurg.2022.854225