Plasma Biomarkers of Poor Muscle Quality in Older Men and Women from the Baltimore Longitudinal Study of Aging

Aging is characterized by progressive decline in muscle mass, strength, and quality all of which contribute to functional impairment, falls, mobility disability, and frailty. Circulating factors may provide clues on the mechanisms for decline in muscle quality with aging. Characterizing the metaboli...

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Veröffentlicht in:The journals of gerontology. Series A, Biological sciences and medical sciences Jg. 71; H. 10; S. 1266 - 1272
Hauptverfasser: Moaddel, Ruin, Fabbri, Elisa, Khadeer, Mohammed A, Carlson, Olga D, Gonzalez-Freire, Marta, Zhang, Pingbo, Semba, Richard D, Ferrucci, Luigi
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.10.2016
Schlagworte:
Aged
Aged, 80 and over
Aging - blood
Baltimore
Biomarkers - blood
Blood Chemical Analysis
Case-Control Studies
Female
Humans
Longitudinal Studies
Male
Metabolomics
Middle Aged
Muscle, Skeletal - diagnostic imaging
Sarcopenia - blood
Sarcopenia - diagnostic imaging
Tomography, X-Ray Computed
Muscles
Metabolomics
Sarcopenia
ISSN:1758-535X
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Abstract Aging is characterized by progressive decline in muscle mass, strength, and quality all of which contribute to functional impairment, falls, mobility disability, and frailty. Circulating factors may provide clues on the mechanisms for decline in muscle quality with aging. Characterizing the metabolic profile associated with reduced muscle quality in older persons could have important translational implications for the early identification of subjects at high risk of developing sarcopenia and the identification of targets for new preventive strategies and treatments. In a pilot cross-sectional, case-control study nested in the Baltimore Longitudinal Study on Aging, we compared circulating metabolites between 79 participants with low muscle quality ratio and 79 controls with high muscle quality, matched by age, sex, and height. The concentrations of 180 metabolites were determined by LC MS/MS, using the Biocrates p180 system, a targeted metabolomics approach. Participants with low muscle quality had significantly higher levels of leucine, isoleucine, tryptophan, serotonin, and methionine, while those with high muscle quality had significantly lower levels of putrescine and the selected phophatidylcholine (PCs) and lysoPCs. The results of this study open a new road for future investigations aimed at identifying new metabolic pathways involved in the decline of muscle quality with aging.
AbstractList Aging is characterized by progressive decline in muscle mass, strength, and quality all of which contribute to functional impairment, falls, mobility disability, and frailty. Circulating factors may provide clues on the mechanisms for decline in muscle quality with aging. Characterizing the metabolic profile associated with reduced muscle quality in older persons could have important translational implications for the early identification of subjects at high risk of developing sarcopenia and the identification of targets for new preventive strategies and treatments. In a pilot cross-sectional, case-control study nested in the Baltimore Longitudinal Study on Aging, we compared circulating metabolites between 79 participants with low muscle quality ratio and 79 controls with high muscle quality, matched by age, sex, and height. The concentrations of 180 metabolites were determined by LC MS/MS, using the Biocrates p180 system, a targeted metabolomics approach. Participants with low muscle quality had significantly higher levels of leucine, isoleucine, tryptophan, serotonin, and methionine, while those with high muscle quality had significantly lower levels of putrescine and the selected phophatidylcholine (PCs) and lysoPCs. The results of this study open a new road for future investigations aimed at identifying new metabolic pathways involved in the decline of muscle quality with aging.
Author Carlson, Olga D
Fabbri, Elisa
Khadeer, Mohammed A
Gonzalez-Freire, Marta
Moaddel, Ruin
Zhang, Pingbo
Semba, Richard D
Ferrucci, Luigi
Author_xml – sequence: 1
  givenname: Ruin
  surname: Moaddel
  fullname: Moaddel, Ruin
  email: moaddelru@mail.nih.gov
  organization: Intramural Research Programs, National Institute on Aging, National Institutes of Health, Baltimore, Maryland. moaddelru@mail.nih.gov
– sequence: 2
  givenname: Elisa
  surname: Fabbri
  fullname: Fabbri, Elisa
  organization: Intramural Research Programs, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
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  givenname: Mohammed A
  surname: Khadeer
  fullname: Khadeer, Mohammed A
  organization: Intramural Research Programs, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
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  givenname: Olga D
  surname: Carlson
  fullname: Carlson, Olga D
  organization: Intramural Research Programs, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
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  givenname: Marta
  surname: Gonzalez-Freire
  fullname: Gonzalez-Freire, Marta
  organization: Intramural Research Programs, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
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  givenname: Pingbo
  surname: Zhang
  fullname: Zhang, Pingbo
  organization: Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  givenname: Richard D
  surname: Semba
  fullname: Semba, Richard D
  organization: Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
– sequence: 8
  givenname: Luigi
  surname: Ferrucci
  fullname: Ferrucci, Luigi
  organization: Intramural Research Programs, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
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Keywords Muscles
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Sarcopenia
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SubjectTerms Aged
Aged, 80 and over
Aging - blood
Baltimore
Biomarkers - blood
Blood Chemical Analysis
Case-Control Studies
Female
Humans
Longitudinal Studies
Male
Metabolomics
Middle Aged
Muscle, Skeletal - diagnostic imaging
Sarcopenia - blood
Sarcopenia - diagnostic imaging
Tomography, X-Ray Computed
Title Plasma Biomarkers of Poor Muscle Quality in Older Men and Women from the Baltimore Longitudinal Study of Aging
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