Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model

The initiation and progression of breast cancer from the transformation of the normal epithelium to ductal carcinoma in situ (DCIS) and invasive disease is a complex process involving the acquisition of genetic alterations and changes in gene expression, alongside microenvironmental and recognized h...

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Bibliographic Details
Published in:	The Journal of pathology Vol. 240; no. 3; pp. 315 - 328
Main Authors:	Maguire, Sarah L, Peck, Barrie, Wai, Patty T, Campbell, James, Barker, Holly, Gulati, Aditi, Daley, Frances, Vyse, Simon, Huang, Paul, Lord, Christopher J, Farnie, Gillian, Brennan, Keith, Natrajan, Rachael
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01.11.2016 Wiley Subscription Services, Inc
Subjects:	3D spheroid assays breast cancer progression Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - pathology Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - pathology Cell Line, Tumor Cell Transformation, Neoplastic Class I Phosphatidylinositol 3-Kinases Disease Progression DNA, Neoplasm - chemistry DNA, Neoplasm - genetics Exome - genetics Female Gene Expression Regulation, Neoplastic Genome High-Throughput Nucleotide Sequencing Humans Models, Biological Mutation next-generation sequencing Original Paper Original Papers Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Pneumoviridae Sequence Analysis, DNA Spheroids, Cellular Transcriptome Tumor Suppressor Protein p53 - genetics next-generation sequencing breast cancer progression 3D spheroid assays
ISSN:	0022-3417, 1096-9896, 1096-9896
Online Access:	Get full text
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