Immunoexpression of matrix metalloproteinase‐2 and matrix metalloproteinase‐9 in the metastasis of squamous cell carcinoma of the human tongue

Background: Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase‐2 (MMP‐2) and matrix metalloproteinase‐9 (MMP‐9) are reported to degrade basement membrane, facilitating invasion and metastasis. This study determined the expression of...

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Vydáno v:	Australian dental journal Ročník 55; číslo 4; s. 385 - 389
Hlavní autoři:	Zhou, CX, Gao, Y, Johnson, NW, Gao, J
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Oxford, UK Blackwell Publishing Ltd 01.12.2010 Wiley-Blackwell
Témata:	Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - secondary Chi-Square Distribution Dermatology Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Gene Expression Gene Expression Regulation, Neoplastic Humans Immunoenzyme Techniques Lymph Nodes - enzymology Lymphatic Metastasis - genetics Male Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Matrix metalloproteinase‐2 matrix metalloproteinase‐9 Medical sciences metastasis Middle Aged Neck Non tumoral diseases oral squamous cell carcinoma Otorhinolaryngology. Stomatology Prognosis tongue cancer Tongue Neoplasms - enzymology Tongue Neoplasms - pathology Tumors Tumors of the skin and soft tissue. Premalignant lesions Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Young Adult Human Skin disease Squamous cell carcinoma Tongue Basal cell carcinoma Stomatology matrix metalloproteinase-9 Tongue cancer Malignant tumor Oral squamous cell carcinoma Dentistry Metastasis Matrix metalloproteinase-2 Oral cavity disease Cancer
ISSN:	0045-0421, 1834-7819, 1834-7819
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Shrnutí:	Background: Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase‐2 (MMP‐2) and matrix metalloproteinase‐9 (MMP‐9) are reported to degrade basement membrane, facilitating invasion and metastasis. This study determined the expression of MMP‐2/MMP‐9 in primary tongue cancer with or without cervical metastases and analysed the significance of such expression in relation to the presence or absence of metastases. Methods: Expressions of MMP‐2/MMP‐9 were detected by immunohistochemistry in 10 specimens of normal oral mucosa, 20 lymph node‐negative tongue cancers, 41 lymph node‐positive tongue cancers and their metastasized tumours in cervical lymph nodes. Results: MMP‐2/MMP‐9 expression was seldom found in normal epithelium. In lymph node‐negative tongue cancer, 45% and 40% of these primary tumours were positively stained for MMP‐2/MMP‐9, respectively. Importantly, in lymph node‐positive tongue cancer, 71% and 79% of these primary tumours were positive for MMP‐2/MMP‐9, respectively. Overexpression of MMP‐2/MMP‐9 was present in the metastatic lymph nodes. Conclusions: Our results imply that MMP‐2 and/or MMP‐9 play an important role in invasion and metastasis in tongue cancer, and that analysis of MMP expression and/or activity in primary tumours may have a predictive value for the actual or potential presence of cervical metastases.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0045-0421 1834-7819 1834-7819
DOI:	10.1111/j.1834-7819.2010.01258.x