Immunoexpression of matrix metalloproteinase‐2 and matrix metalloproteinase‐9 in the metastasis of squamous cell carcinoma of the human tongue
Background: Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase‐2 (MMP‐2) and matrix metalloproteinase‐9 (MMP‐9) are reported to degrade basement membrane, facilitating invasion and metastasis. This study determined the expression of...
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| Published in: | Australian dental journal Vol. 55; no. 4; pp. 385 - 389 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Oxford, UK
Blackwell Publishing Ltd
01.12.2010
Wiley-Blackwell |
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| ISSN: | 0045-0421, 1834-7819, 1834-7819 |
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| Abstract | Background: Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase‐2 (MMP‐2) and matrix metalloproteinase‐9 (MMP‐9) are reported to degrade basement membrane, facilitating invasion and metastasis. This study determined the expression of MMP‐2/MMP‐9 in primary tongue cancer with or without cervical metastases and analysed the significance of such expression in relation to the presence or absence of metastases.
Methods: Expressions of MMP‐2/MMP‐9 were detected by immunohistochemistry in 10 specimens of normal oral mucosa, 20 lymph node‐negative tongue cancers, 41 lymph node‐positive tongue cancers and their metastasized tumours in cervical lymph nodes.
Results: MMP‐2/MMP‐9 expression was seldom found in normal epithelium. In lymph node‐negative tongue cancer, 45% and 40% of these primary tumours were positively stained for MMP‐2/MMP‐9, respectively. Importantly, in lymph node‐positive tongue cancer, 71% and 79% of these primary tumours were positive for MMP‐2/MMP‐9, respectively. Overexpression of MMP‐2/MMP‐9 was present in the metastatic lymph nodes.
Conclusions: Our results imply that MMP‐2 and/or MMP‐9 play an important role in invasion and metastasis in tongue cancer, and that analysis of MMP expression and/or activity in primary tumours may have a predictive value for the actual or potential presence of cervical metastases. |
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| AbstractList | Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are reported to degrade basement membrane,facilitating invasion and metastasis. This study determined the expression of MMP-2/MMP-9 in primary tongue cancer with or without cervical metastases and analysed the significance of such expression in relation to the presence or absence of metastases.
Expressions of MMP-2⁄MMP-9 were detected by immunohistochemistry in 10 specimens of normal oral mucosa, 20 lymph node-negative tongue cancers, 41 lymph node-positive tongue cancers and their metastasized tumours in cervical lymph nodes.
MMP-2⁄MMP-9 expression was seldom found in normal epithelium. In lymph node-negative tongue cancer, 45% and 40% of these primary tumours were positively stained for MMP-2⁄MMP-9, respectively. Importantly, in lymph node-positive tongue cancer, 71% and 79% of these primary tumours were positive for MMP-2⁄MMP-9, respectively. Overexpression of MMP-2⁄MMP-9 was present in the metastatic lymph nodes.
Our results imply that MMP-2 and/or MMP-9 play an important role in invasion and metastasis in tongue cancer, and that analysis of MMP expression and/or activity in primary tumours may have a predictive value for the actual or potential presence of cervical metastases. Background: Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase‐2 (MMP‐2) and matrix metalloproteinase‐9 (MMP‐9) are reported to degrade basement membrane, facilitating invasion and metastasis. This study determined the expression of MMP‐2/MMP‐9 in primary tongue cancer with or without cervical metastases and analysed the significance of such expression in relation to the presence or absence of metastases. Methods: Expressions of MMP‐2/MMP‐9 were detected by immunohistochemistry in 10 specimens of normal oral mucosa, 20 lymph node‐negative tongue cancers, 41 lymph node‐positive tongue cancers and their metastasized tumours in cervical lymph nodes. Results: MMP‐2/MMP‐9 expression was seldom found in normal epithelium. In lymph node‐negative tongue cancer, 45% and 40% of these primary tumours were positively stained for MMP‐2/MMP‐9, respectively. Importantly, in lymph node‐positive tongue cancer, 71% and 79% of these primary tumours were positive for MMP‐2/MMP‐9, respectively. Overexpression of MMP‐2/MMP‐9 was present in the metastatic lymph nodes. Conclusions: Our results imply that MMP‐2 and/or MMP‐9 play an important role in invasion and metastasis in tongue cancer, and that analysis of MMP expression and/or activity in primary tumours may have a predictive value for the actual or potential presence of cervical metastases. Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are reported to degrade basement membrane,facilitating invasion and metastasis. This study determined the expression of MMP-2/MMP-9 in primary tongue cancer with or without cervical metastases and analysed the significance of such expression in relation to the presence or absence of metastases.BACKGROUNDSquamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are reported to degrade basement membrane,facilitating invasion and metastasis. This study determined the expression of MMP-2/MMP-9 in primary tongue cancer with or without cervical metastases and analysed the significance of such expression in relation to the presence or absence of metastases.Expressions of MMP-2⁄MMP-9 were detected by immunohistochemistry in 10 specimens of normal oral mucosa, 20 lymph node-negative tongue cancers, 41 lymph node-positive tongue cancers and their metastasized tumours in cervical lymph nodes.METHODSExpressions of MMP-2⁄MMP-9 were detected by immunohistochemistry in 10 specimens of normal oral mucosa, 20 lymph node-negative tongue cancers, 41 lymph node-positive tongue cancers and their metastasized tumours in cervical lymph nodes.MMP-2⁄MMP-9 expression was seldom found in normal epithelium. In lymph node-negative tongue cancer, 45% and 40% of these primary tumours were positively stained for MMP-2⁄MMP-9, respectively. Importantly, in lymph node-positive tongue cancer, 71% and 79% of these primary tumours were positive for MMP-2⁄MMP-9, respectively. Overexpression of MMP-2⁄MMP-9 was present in the metastatic lymph nodes.RESULTSMMP-2⁄MMP-9 expression was seldom found in normal epithelium. In lymph node-negative tongue cancer, 45% and 40% of these primary tumours were positively stained for MMP-2⁄MMP-9, respectively. Importantly, in lymph node-positive tongue cancer, 71% and 79% of these primary tumours were positive for MMP-2⁄MMP-9, respectively. Overexpression of MMP-2⁄MMP-9 was present in the metastatic lymph nodes.Our results imply that MMP-2 and/or MMP-9 play an important role in invasion and metastasis in tongue cancer, and that analysis of MMP expression and/or activity in primary tumours may have a predictive value for the actual or potential presence of cervical metastases.CONCLUSIONSOur results imply that MMP-2 and/or MMP-9 play an important role in invasion and metastasis in tongue cancer, and that analysis of MMP expression and/or activity in primary tumours may have a predictive value for the actual or potential presence of cervical metastases. Background: Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase‐2 (MMP‐2) and matrix metalloproteinase‐9 (MMP‐9) are reported to degrade basement membrane, facilitating invasion and metastasis. This study determined the expression of MMP‐2/MMP‐9 in primary tongue cancer with or without cervical metastases and analysed the significance of such expression in relation to the presence or absence of metastases. Methods: Expressions of MMP‐2/MMP‐9 were detected by immunohistochemistry in 10 specimens of normal oral mucosa, 20 lymph node‐negative tongue cancers, 41 lymph node‐positive tongue cancers and their metastasized tumours in cervical lymph nodes. Results: MMP‐2/MMP‐9 expression was seldom found in normal epithelium. In lymph node‐negative tongue cancer, 45% and 40% of these primary tumours were positively stained for MMP‐2/MMP‐9, respectively. Importantly, in lymph node‐positive tongue cancer, 71% and 79% of these primary tumours were positive for MMP‐2/MMP‐9, respectively. Overexpression of MMP‐2/MMP‐9 was present in the metastatic lymph nodes. Conclusions: Our results imply that MMP‐2 and/or MMP‐9 play an important role in invasion and metastasis in tongue cancer, and that analysis of MMP expression and/or activity in primary tumours may have a predictive value for the actual or potential presence of cervical metastases. |
| Author | Gao, Y Gao, J Zhou, CX Johnson, NW |
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| Cites_doi | 10.1002/(SICI)1097-0347(199910)21:7<627::AID-HED7>3.0.CO;2-2 10.1016/S1368-8375(99)00004-4 10.1002/jcp.20948 10.1016/j.ijom.2008.07.014 10.1016/j.bjoms.2008.06.001 10.1126/science.1067100 10.1016/j.bbrc.2006.02.068 10.1021/bi8020789 10.1038/modpathol.3800506 10.1158/0008-5472.CAN-08-2635 10.1007/s10549-004-1200-8 10.1002/(SICI)1097-0347(199705)19:3<205::AID-HED7>3.0.CO;2-6 10.1016/j.oraloncology.2004.08.013 10.1016/j.juro.2009.01.012 10.1097/00029330-200810010-00004 10.1002/j.0022-0337.2001.65.4.tb03403.x 10.1002/(SICI)1096-9098(200002)73:2<95::AID-JSO7>3.0.CO;2-R 10.1093/jnci/89.17.1260 10.1002/hed.20869 10.1002/path.1466 10.1016/S0959-8049(00)00156-8 10.1016/j.oraloncology.2008.06.002 10.1002/pro.5560040502 |
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| Keywords | Human Skin disease Squamous cell carcinoma Tongue Basal cell carcinoma Stomatology matrix metalloproteinase-9 Tongue cancer Malignant tumor Oral squamous cell carcinoma Dentistry Metastasis Matrix metalloproteinase-2 Oral cavity disease Cancer |
| Language | English |
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| Snippet | Background: Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase‐2 (MMP‐2) and matrix... Background: Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase‐2 (MMP‐2) and matrix... Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9... |
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| SubjectTerms | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - secondary Chi-Square Distribution Dermatology Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Gene Expression Gene Expression Regulation, Neoplastic Humans Immunoenzyme Techniques Lymph Nodes - enzymology Lymphatic Metastasis - genetics Male Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Matrix metalloproteinase‐2 matrix metalloproteinase‐9 Medical sciences metastasis Middle Aged Neck Non tumoral diseases oral squamous cell carcinoma Otorhinolaryngology. Stomatology Prognosis tongue cancer Tongue Neoplasms - enzymology Tongue Neoplasms - pathology Tumors Tumors of the skin and soft tissue. Premalignant lesions Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Young Adult |
| Title | Immunoexpression of matrix metalloproteinase‐2 and matrix metalloproteinase‐9 in the metastasis of squamous cell carcinoma of the human tongue |
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