Immunoexpression of matrix metalloproteinase‐2 and matrix metalloproteinase‐9 in the metastasis of squamous cell carcinoma of the human tongue

Background:  Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase‐2 (MMP‐2) and matrix metalloproteinase‐9 (MMP‐9) are reported to degrade basement membrane, facilitating invasion and metastasis. This study determined the expression of...

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Published in:Australian dental journal Vol. 55; no. 4; pp. 385 - 389
Main Authors: Zhou, CX, Gao, Y, Johnson, NW, Gao, J
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01.12.2010
Wiley-Blackwell
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Squamous Cell - enzymology
Carcinoma, Squamous Cell - secondary
Chi-Square Distribution
Dermatology
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Gene Expression
Gene Expression Regulation, Neoplastic
Humans
Immunoenzyme Techniques
Lymph Nodes - enzymology
Lymphatic Metastasis - genetics
Male
Matrix Metalloproteinase 2 - biosynthesis
Matrix Metalloproteinase 2 - genetics
Matrix Metalloproteinase 9 - biosynthesis
Matrix Metalloproteinase 9 - genetics
Matrix metalloproteinase‐2
matrix metalloproteinase‐9
Medical sciences
metastasis
Middle Aged
Neck
Non tumoral diseases
oral squamous cell carcinoma
Otorhinolaryngology. Stomatology
Prognosis
tongue cancer
Tongue Neoplasms - enzymology
Tongue Neoplasms - pathology
Tumors
Tumors of the skin and soft tissue. Premalignant lesions
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Young Adult
Human
Skin disease
Squamous cell carcinoma
Tongue
Basal cell carcinoma
Stomatology
matrix metalloproteinase-9
Tongue cancer
Malignant tumor
Oral squamous cell carcinoma
Dentistry
Metastasis
Matrix metalloproteinase-2
Oral cavity disease
Cancer
ISSN:0045-0421, 1834-7819, 1834-7819
Online Access:Get full text
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Summary:Background:  Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase‐2 (MMP‐2) and matrix metalloproteinase‐9 (MMP‐9) are reported to degrade basement membrane, facilitating invasion and metastasis. This study determined the expression of MMP‐2/MMP‐9 in primary tongue cancer with or without cervical metastases and analysed the significance of such expression in relation to the presence or absence of metastases. Methods:  Expressions of MMP‐2/MMP‐9 were detected by immunohistochemistry in 10 specimens of normal oral mucosa, 20 lymph node‐negative tongue cancers, 41 lymph node‐positive tongue cancers and their metastasized tumours in cervical lymph nodes. Results:  MMP‐2/MMP‐9 expression was seldom found in normal epithelium. In lymph node‐negative tongue cancer, 45% and 40% of these primary tumours were positively stained for MMP‐2/MMP‐9, respectively. Importantly, in lymph node‐positive tongue cancer, 71% and 79% of these primary tumours were positive for MMP‐2/MMP‐9, respectively. Overexpression of MMP‐2/MMP‐9 was present in the metastatic lymph nodes. Conclusions:  Our results imply that MMP‐2 and/or MMP‐9 play an important role in invasion and metastasis in tongue cancer, and that analysis of MMP expression and/or activity in primary tumours may have a predictive value for the actual or potential presence of cervical metastases.
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ISSN:0045-0421
1834-7819
1834-7819
DOI:10.1111/j.1834-7819.2010.01258.x