Therapeutic application of extracellular vesicles in kidney disease: promises and challenges

Extracellular vesicles (EVs) are nanosized, membrane‐bound vesicles released from different cells. Recent studies have revealed that EVs may participate in renal tissue damage and regeneration through mediating inter‐nephron communication. Thus, the potential use of EVs as therapeutic vector has gai...

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Vydáno v:Journal of cellular and molecular medicine Ročník 22; číslo 2; s. 728 - 737
Hlavní autoři: Lv, Lin‐Li, Wu, Wei‐Jun, Feng, Ye, Li, Zuo‐Lin, Tang, Tao‐Tao, Liu, Bi‐Cheng
Médium: Journal Article
Jazyk:angličtina
Vydáno: England John Wiley & Sons, Inc 01.02.2018
John Wiley and Sons Inc
Témata:
Cell interactions
exosome
extracellular vesicle
Extracellular vesicles
kidney disease
Kidney diseases
Membrane vesicles
Review
Reviews
therapy
kidney disease
exosome
extracellular vesicle
therapy
ISSN:1582-1838, 1582-4934, 1582-4934
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Shrnutí:Extracellular vesicles (EVs) are nanosized, membrane‐bound vesicles released from different cells. Recent studies have revealed that EVs may participate in renal tissue damage and regeneration through mediating inter‐nephron communication. Thus, the potential use of EVs as therapeutic vector has gained considerable interest. In this review, we will discuss the basic characteristics of EVs and its role in nephron cellular communication. Then, the application of EVs as therapeutic vector based on its natural content or as carriers of drug, in acute and chronic kidney injury, was discussed. Finally, perspectives and challenges of EVs in therapy of kidney disease were described.
Bibliografie:ObjectType-Article-1
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ObjectType-Feature-2
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ISSN:1582-1838
1582-4934
1582-4934
DOI:10.1111/jcmm.13407