Mid‐life and late‐life vascular risk factor burden and neuropathology in old age

Objective To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a community‐based sample. Methods We studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. Ove...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of clinical and translational neurology Jg. 6; H. 12; S. 2403 - 2412
Hauptverfasser:	Conner, Sarah C., Pase, Matthew P., Carneiro, Herman, Raman, Mekala R., McKee, Ann C., Alvarez, Victor E., Walker, Jamie M., Satizabal, Claudia L., Himali, Jayandra J., Stein, Thor D., Beiser, Alexa, Seshadri, Sudha
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States John Wiley & Sons, Inc 01.12.2019 John Wiley and Sons Inc Wiley
Schlagworte:	Age Aged Aged, 80 and over Alzheimer Disease - epidemiology Alzheimer Disease - pathology Alzheimer's disease Arteriosclerosis Atherosclerosis Blood pressure Brain Cardiac arrhythmia Cardiovascular disease Cerebrovascular Disorders - epidemiology Cerebrovascular Disorders - pathology Dementia Diabetes Donations Female Gender Humans Hypertension Longitudinal Studies Male Massachusetts - epidemiology Middle Aged Neuropathology Pathology Prognosis Risk Factors Standard deviation Tissue Banks Massachusetts
ISSN:	2328-9503, 2328-9503
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	Objective To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a community‐based sample. Methods We studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. Overall vascular risk factor burden was calculated using the Framingham Stroke Risk Profile (FSRP). Mid‐life FSRP was measured at 50 to 60 years of age. Following death, brains were autopsied and semi‐quantitatively assessed by board‐certified neuropathologists for cerebrovascular outcomes (cortical infarcts, subcortical infarcts, atherosclerosis, arteriosclerosis) and Alzheimer’s disease pathology (Braak stage, cerebral amyloid angiopathy, and neuritic plaque score). We estimated adjusted odds ratios between vascular risk burden (at mid‐life and before death) and neuropathological outcomes using logistic and proportional‐odds logistic models. Results The median time interval between FSRP and death was 33.4 years for mid‐life FSRP and 4.4 years for final FSRP measurement before death. Higher mid‐life vascular risk burden was associated with increased odds of all cerebrovascular pathology, even with adjustment for vascular risk burden before death. Late‐life vascular risk burden was associated with increased odds of cortical infarcts (OR [95% CI]: 1.04 [1.00, 1.08]) and arteriosclerosis stage (OR [95% CI]: 1.03 [1.00, 1.05]). Mid‐life vascular risk burden was not associated with Alzheimer’s disease pathology, though late‐life vascular risk burden was associated with increased odds of higher Braak stage (OR [95% CI]: 1.03 [1.01, 1.05]). Interpretation Mid‐life vascular risk burden was predictive of cerebrovascular but not Alzheimer’s disease neuropathology, even after adjustment for vascular risk factors before death.
AbstractList	ObjectiveTo determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a community‐based sample.MethodsWe studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. Overall vascular risk factor burden was calculated using the Framingham Stroke Risk Profile (FSRP). Mid‐life FSRP was measured at 50 to 60 years of age. Following death, brains were autopsied and semi‐quantitatively assessed by board‐certified neuropathologists for cerebrovascular outcomes (cortical infarcts, subcortical infarcts, atherosclerosis, arteriosclerosis) and Alzheimer’s disease pathology (Braak stage, cerebral amyloid angiopathy, and neuritic plaque score). We estimated adjusted odds ratios between vascular risk burden (at mid‐life and before death) and neuropathological outcomes using logistic and proportional‐odds logistic models.ResultsThe median time interval between FSRP and death was 33.4 years for mid‐life FSRP and 4.4 years for final FSRP measurement before death. Higher mid‐life vascular risk burden was associated with increased odds of all cerebrovascular pathology, even with adjustment for vascular risk burden before death. Late‐life vascular risk burden was associated with increased odds of cortical infarcts (OR [95% CI]: 1.04 [1.00, 1.08]) and arteriosclerosis stage (OR [95% CI]: 1.03 [1.00, 1.05]). Mid‐life vascular risk burden was not associated with Alzheimer’s disease pathology, though late‐life vascular risk burden was associated with increased odds of higher Braak stage (OR [95% CI]: 1.03 [1.01, 1.05]).InterpretationMid‐life vascular risk burden was predictive of cerebrovascular but not Alzheimer’s disease neuropathology, even after adjustment for vascular risk factors before death. To determine whether vascular risk factor burden in mid- or late-life associates with postmortem vascular and neurodegenerative pathologies in a community-based sample.OBJECTIVETo determine whether vascular risk factor burden in mid- or late-life associates with postmortem vascular and neurodegenerative pathologies in a community-based sample.We studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. Overall vascular risk factor burden was calculated using the Framingham Stroke Risk Profile (FSRP). Mid-life FSRP was measured at 50 to 60 years of age. Following death, brains were autopsied and semi-quantitatively assessed by board-certified neuropathologists for cerebrovascular outcomes (cortical infarcts, subcortical infarcts, atherosclerosis, arteriosclerosis) and Alzheimer's disease pathology (Braak stage, cerebral amyloid angiopathy, and neuritic plaque score). We estimated adjusted odds ratios between vascular risk burden (at mid-life and before death) and neuropathological outcomes using logistic and proportional-odds logistic models.METHODSWe studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. Overall vascular risk factor burden was calculated using the Framingham Stroke Risk Profile (FSRP). Mid-life FSRP was measured at 50 to 60 years of age. Following death, brains were autopsied and semi-quantitatively assessed by board-certified neuropathologists for cerebrovascular outcomes (cortical infarcts, subcortical infarcts, atherosclerosis, arteriosclerosis) and Alzheimer's disease pathology (Braak stage, cerebral amyloid angiopathy, and neuritic plaque score). We estimated adjusted odds ratios between vascular risk burden (at mid-life and before death) and neuropathological outcomes using logistic and proportional-odds logistic models.The median time interval between FSRP and death was 33.4 years for mid-life FSRP and 4.4 years for final FSRP measurement before death. Higher mid-life vascular risk burden was associated with increased odds of all cerebrovascular pathology, even with adjustment for vascular risk burden before death. Late-life vascular risk burden was associated with increased odds of cortical infarcts (OR [95% CI]: 1.04 [1.00, 1.08]) and arteriosclerosis stage (OR [95% CI]: 1.03 [1.00, 1.05]). Mid-life vascular risk burden was not associated with Alzheimer's disease pathology, though late-life vascular risk burden was associated with increased odds of higher Braak stage (OR [95% CI]: 1.03 [1.01, 1.05]).RESULTSThe median time interval between FSRP and death was 33.4 years for mid-life FSRP and 4.4 years for final FSRP measurement before death. Higher mid-life vascular risk burden was associated with increased odds of all cerebrovascular pathology, even with adjustment for vascular risk burden before death. Late-life vascular risk burden was associated with increased odds of cortical infarcts (OR [95% CI]: 1.04 [1.00, 1.08]) and arteriosclerosis stage (OR [95% CI]: 1.03 [1.00, 1.05]). Mid-life vascular risk burden was not associated with Alzheimer's disease pathology, though late-life vascular risk burden was associated with increased odds of higher Braak stage (OR [95% CI]: 1.03 [1.01, 1.05]).Mid-life vascular risk burden was predictive of cerebrovascular but not Alzheimer's disease neuropathology, even after adjustment for vascular risk factors before death.INTERPRETATIONMid-life vascular risk burden was predictive of cerebrovascular but not Alzheimer's disease neuropathology, even after adjustment for vascular risk factors before death. Objective To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a community‐based sample. Methods We studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. Overall vascular risk factor burden was calculated using the Framingham Stroke Risk Profile (FSRP). Mid‐life FSRP was measured at 50 to 60 years of age. Following death, brains were autopsied and semi‐quantitatively assessed by board‐certified neuropathologists for cerebrovascular outcomes (cortical infarcts, subcortical infarcts, atherosclerosis, arteriosclerosis) and Alzheimer’s disease pathology (Braak stage, cerebral amyloid angiopathy, and neuritic plaque score). We estimated adjusted odds ratios between vascular risk burden (at mid‐life and before death) and neuropathological outcomes using logistic and proportional‐odds logistic models. Results The median time interval between FSRP and death was 33.4 years for mid‐life FSRP and 4.4 years for final FSRP measurement before death. Higher mid‐life vascular risk burden was associated with increased odds of all cerebrovascular pathology, even with adjustment for vascular risk burden before death. Late‐life vascular risk burden was associated with increased odds of cortical infarcts (OR [95% CI]: 1.04 [1.00, 1.08]) and arteriosclerosis stage (OR [95% CI]: 1.03 [1.00, 1.05]). Mid‐life vascular risk burden was not associated with Alzheimer’s disease pathology, though late‐life vascular risk burden was associated with increased odds of higher Braak stage (OR [95% CI]: 1.03 [1.01, 1.05]). Interpretation Mid‐life vascular risk burden was predictive of cerebrovascular but not Alzheimer’s disease neuropathology, even after adjustment for vascular risk factors before death. To determine whether vascular risk factor burden in mid- or late-life associates with postmortem vascular and neurodegenerative pathologies in a community-based sample. We studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. Overall vascular risk factor burden was calculated using the Framingham Stroke Risk Profile (FSRP). Mid-life FSRP was measured at 50 to 60 years of age. Following death, brains were autopsied and semi-quantitatively assessed by board-certified neuropathologists for cerebrovascular outcomes (cortical infarcts, subcortical infarcts, atherosclerosis, arteriosclerosis) and Alzheimer's disease pathology (Braak stage, cerebral amyloid angiopathy, and neuritic plaque score). We estimated adjusted odds ratios between vascular risk burden (at mid-life and before death) and neuropathological outcomes using logistic and proportional-odds logistic models. The median time interval between FSRP and death was 33.4 years for mid-life FSRP and 4.4 years for final FSRP measurement before death. Higher mid-life vascular risk burden was associated with increased odds of all cerebrovascular pathology, even with adjustment for vascular risk burden before death. Late-life vascular risk burden was associated with increased odds of cortical infarcts (OR [95% CI]: 1.04 [1.00, 1.08]) and arteriosclerosis stage (OR [95% CI]: 1.03 [1.00, 1.05]). Mid-life vascular risk burden was not associated with Alzheimer's disease pathology, though late-life vascular risk burden was associated with increased odds of higher Braak stage (OR [95% CI]: 1.03 [1.01, 1.05]). Mid-life vascular risk burden was predictive of cerebrovascular but not Alzheimer's disease neuropathology, even after adjustment for vascular risk factors before death. Abstract Objective To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a community‐based sample. Methods We studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. Overall vascular risk factor burden was calculated using the Framingham Stroke Risk Profile (FSRP). Mid‐life FSRP was measured at 50 to 60 years of age. Following death, brains were autopsied and semi‐quantitatively assessed by board‐certified neuropathologists for cerebrovascular outcomes (cortical infarcts, subcortical infarcts, atherosclerosis, arteriosclerosis) and Alzheimer’s disease pathology (Braak stage, cerebral amyloid angiopathy, and neuritic plaque score). We estimated adjusted odds ratios between vascular risk burden (at mid‐life and before death) and neuropathological outcomes using logistic and proportional‐odds logistic models. Results The median time interval between FSRP and death was 33.4 years for mid‐life FSRP and 4.4 years for final FSRP measurement before death. Higher mid‐life vascular risk burden was associated with increased odds of all cerebrovascular pathology, even with adjustment for vascular risk burden before death. Late‐life vascular risk burden was associated with increased odds of cortical infarcts (OR [95% CI]: 1.04 [1.00, 1.08]) and arteriosclerosis stage (OR [95% CI]: 1.03 [1.00, 1.05]). Mid‐life vascular risk burden was not associated with Alzheimer’s disease pathology, though late‐life vascular risk burden was associated with increased odds of higher Braak stage (OR [95% CI]: 1.03 [1.01, 1.05]). Interpretation Mid‐life vascular risk burden was predictive of cerebrovascular but not Alzheimer’s disease neuropathology, even after adjustment for vascular risk factors before death.
Author	Stein, Thor D. Himali, Jayandra J. Raman, Mekala R. Carneiro, Herman Walker, Jamie M. Pase, Matthew P. Beiser, Alexa Seshadri, Sudha Conner, Sarah C. McKee, Ann C. Alvarez, Victor E. Satizabal, Claudia L.
AuthorAffiliation	2 Department of Biostatistics Boston University School of Public Health Boston Massachusetts 8 Boston University Alzheimer's Disease and CTE Center Boston University School of Medicine Boston Massachusetts 9 Department of Veterans Affairs Medical Center Bedford Massachusetts 1 Framingham Heart Study Framingham Massachusetts 6 Department of Medicine Boston University School of Medicine Boston Massachusetts 10 VA Boston Healthcare System Boston Massachusetts 11 Department of Pathology and Laboratory Medicine Boston University School of Medicine Boston Massachusetts 12 Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases UT Health San Antonio San Antonio Texas 4 Centre for Human Psychopharmacology Swinburne University of Technology Melbourne Australia 3 Melbourne Dementia Research Centre The Florey Institute for Neuroscience and Mental Health Melbourne Australia 5 Faculty of Medicine Dentistry and Health Sciences The University of Melbourne Melbourne Australia 7 Department of Neurolo
AuthorAffiliation_xml	– name: 6 Department of Medicine Boston University School of Medicine Boston Massachusetts – name: 4 Centre for Human Psychopharmacology Swinburne University of Technology Melbourne Australia – name: 9 Department of Veterans Affairs Medical Center Bedford Massachusetts – name: 11 Department of Pathology and Laboratory Medicine Boston University School of Medicine Boston Massachusetts – name: 3 Melbourne Dementia Research Centre The Florey Institute for Neuroscience and Mental Health Melbourne Australia – name: 5 Faculty of Medicine Dentistry and Health Sciences The University of Melbourne Melbourne Australia – name: 8 Boston University Alzheimer's Disease and CTE Center Boston University School of Medicine Boston Massachusetts – name: 1 Framingham Heart Study Framingham Massachusetts – name: 2 Department of Biostatistics Boston University School of Public Health Boston Massachusetts – name: 7 Department of Neurology Boston University School of Medicine Boston Massachusetts – name: 10 VA Boston Healthcare System Boston Massachusetts – name: 12 Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases UT Health San Antonio San Antonio Texas
Author_xml	– sequence: 1 givenname: Sarah C. orcidid: 0000-0002-0929-9948 surname: Conner fullname: Conner, Sarah C. organization: Boston University School of Public Health – sequence: 2 givenname: Matthew P. surname: Pase fullname: Pase, Matthew P. organization: The University of Melbourne – sequence: 3 givenname: Herman surname: Carneiro fullname: Carneiro, Herman organization: Boston University School of Medicine – sequence: 4 givenname: Mekala R. surname: Raman fullname: Raman, Mekala R. organization: Boston University School of Medicine – sequence: 5 givenname: Ann C. surname: McKee fullname: McKee, Ann C. organization: Boston University School of Medicine – sequence: 6 givenname: Victor E. surname: Alvarez fullname: Alvarez, Victor E. organization: Boston University School of Medicine – sequence: 7 givenname: Jamie M. surname: Walker fullname: Walker, Jamie M. organization: UT Health San Antonio – sequence: 8 givenname: Claudia L. surname: Satizabal fullname: Satizabal, Claudia L. organization: UT Health San Antonio – sequence: 9 givenname: Jayandra J. surname: Himali fullname: Himali, Jayandra J. organization: UT Health San Antonio – sequence: 10 givenname: Thor D. surname: Stein fullname: Stein, Thor D. organization: Boston University School of Medicine – sequence: 11 givenname: Alexa surname: Beiser fullname: Beiser, Alexa organization: Boston University School of Medicine – sequence: 12 givenname: Sudha surname: Seshadri fullname: Seshadri, Sudha email: suseshad@bu.edu organization: UT Health San Antonio
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31691546$$D View this record in MEDLINE/PubMed
BookMark	eNp9kstuUzEQhi1UREvphgdAR2JTIaX4nnM2SFXEpVKBTVlbE19SB8cO9jlF2fUR-ow8CU5OW7UVYjW-fPPP7_G8RHsxRYvQa4JPCMb0PejITgTumHyGDiij7aQTmO09WO-jo1KWGGNCqGBT-gLtMyI7Irg8QBdfvflzfRO8sw1E0wTo7d3-CooeAuQm-_KzcaD7lJv5kI2NOzbaIac19JcppMWm8bFJwTSwsK_Qcweh2KPbeIh-fPp4MfsyOf_--Wx2ej7RgnA5gdbMqZhaxzAlpjriU8Edd8JY0wpNBFBJWnAYT7XlIGGuJZM1CENAOsMO0dmoaxIs1Tr7FeSNSuDV7iDlhYLcex2sams7MDjRdi3nvHO1NLBaWDvXWdnxqvVh1FoP85U12sY-Q3gk-vgm-ku1SFeq-p4ygqvA8a1ATr8GW3q18kXbECDaNBRFWW0_b4UQFX37BF2mIcfaqkrR2gTGxNbRm4eO7q3cfV4F3o2AzqmUbN09QrDaDofaDofaDUeF8RNY-x56n7av8eHfKWRM-e2D3fxHXJ3OvrEx5y_imMxe
CitedBy_id	crossref_primary_10_1136_bmjopen_2022_069413 crossref_primary_10_1212_WNL_0000000000011772 crossref_primary_10_1113_JP286599 crossref_primary_10_3233_JAD_200412 crossref_primary_10_3233_JAD_220340 crossref_primary_10_1038_s41598_021_98565_w crossref_primary_10_1161_STROKEAHA_120_030226 crossref_primary_10_1161_STROKEAHA_121_032610 crossref_primary_10_3233_JAD_200803 crossref_primary_10_1002_alz_12343 crossref_primary_10_1016_j_jacc_2021_01_059 crossref_primary_10_1038_s41598_023_42071_8 crossref_primary_10_1016_j_nicl_2023_103383 crossref_primary_10_1212_CON_0000000000001508 crossref_primary_10_1212_CPJ_0000000000200271
Cites_doi	10.1159/000197389 10.1001/jama.2017.3090 10.1212/01.wnl.0000324925.95210.6d 10.1016/j.jalz.2015.12.006 10.1001/jama.296.24.2939 10.1161/CIRCULATIONAHA.115.021275 10.1016/S0140-6736(14)61774-8 10.1212/WNL.0000000000006360 10.1161/STROKEAHA.115.012608 10.1212/WNL.0000000000004741 10.1212/WNL.41.4.479 10.1016/j.neurobiolaging.2011.10.002 10.2147/VHRM.S1094 10.1161/STROKEAHA.117.013369 10.1161/STROKEAHA.109.573618 10.1161/01.STR.22.3.312 10.2105/AJPH.41.3.279 10.1016/S0140-6736(04)16405-2 10.1161/STROKEAHA.114.007542 10.1007/s00401-011-0910-3 10.1016/j.bbadis.2008.08.005 10.1016/j.jalz.2018.06.3061 10.1371/journal.pone.0018174 10.1212/01.wnl.0000271090.28148.24 10.2174/156720512801322609 10.1161/01.STR.0000181079.42690.bf 10.1161/STROKEAHA.109.570044 10.1093/aje/kwn164 10.3233/JAD-170179 10.1093/aje/kwm021 10.1016/j.neurobiolaging.2015.05.021 10.1007/BF00308809 10.1093/eurheartj/ehy288 10.1212/WNL.0000000000004228
ContentType	Journal Article
Copyright	2019 The Authors. published by Wiley Periodicals, Inc on behalf of American Neurological Association. 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: 2019 The Authors. published by Wiley Periodicals, Inc on behalf of American Neurological Association. – notice: 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. – notice: 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID	24P AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88G 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ K9. M0S M2M PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 5PM DOA
DOI	10.1002/acn3.50936
DatabaseName	Wiley Online Library Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Psychology Database (Alumni) ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Psychology Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Central (New) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Publicly Available Content Database MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
DocumentTitleAlternate	Vascular Risk Factor Burden and Neuropathology
EISSN	2328-9503
EndPage	2412
ExternalDocumentID	oai_doaj_org_article_82320af58984449f8dba3f30cff9e694 PMC6917310 31691546 10_1002_acn3_50936 ACN350936
Genre	article Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GeographicLocations	Massachusetts
GeographicLocations_xml	– name: Massachusetts
GrantInformation_xml	– fundername: National Heart, Lung, and Blood Institute (NHLBI) funderid: F31HL145904‐01; T32HL125232‐01A1; N01‐HC‐25195; HHSN268201500001I; 75N92019D00031 – fundername: National Institute on Aging funderid: R01 AG054076; R01 AG049607; R01 AG033193; U01 AG049505; U01 AG052409; RF1 AG054156 – fundername: National Institute of Neurological Disorders and Stroke funderid: NS017950; UH2 NS100605 – fundername: National Institute of General Medical Sciences (NIGMS) funderid: T32GM74905‐14 – fundername: National Heart Foundation of Australia Future Leader Fellowship funderid: 102052 – fundername: Alzheimer’s Association funderid: AARGD‐16‐443384 – fundername: NHLBI NIH HHS grantid: F31 HL145904 – fundername: NHLBI NIH HHS grantid: 75N92019D00031 – fundername: NIA NIH HHS grantid: U01 AG049505 – fundername: Alzheimer's Association grantid: AARGD-16-443384 – fundername: NINDS NIH HHS grantid: R01 NS017950 – fundername: NHLBI NIH HHS grantid: HHSN268201500001I – fundername: NHLBI NIH HHS grantid: T32 HL125232 – fundername: NIA NIH HHS grantid: RF1 AG057768 – fundername: NIA NIH HHS grantid: R01 AG049607 – fundername: NIA NIH HHS grantid: R01 AG033193 – fundername: ; grantid: AARGD‐16‐443384 – fundername: ; grantid: F31HL145904‐01; T32HL125232‐01A1; N01‐HC‐25195; HHSN268201500001I; 75N92019D00031 – fundername: National Heart Foundation of Australia Future Leader Fellowship grantid: 102052 – fundername: ; grantid: NS017950; UH2 NS100605 – fundername: ; grantid: R01 AG054076; R01 AG049607; R01 AG033193; U01 AG049505; U01 AG052409; RF1 AG054156 – fundername: ; grantid: T32GM74905‐14
GroupedDBID	0R~ 1OC 24P 53G 5VS 7X7 8FI 8FJ AAHHS ABDBF ABUWG ACCFJ ACCMX ACGFS ACUHS ACXQS ADBBV ADKYN ADRAZ ADZMN ADZOD AEEZP AEQDE AFKRA AIWBW AJBDE ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AOIJS AVUZU AZQEC BAWUL BCNDV BENPR BPHCQ BVXVI CCPQU DIK DWQXO EBS EJD FYUFA GNUQQ GODZA GROUPED_DOAJ HMCUK HYE IAO IHR INH ITC KQ8 M2M M48 OK1 PIMPY PQQKQ PROAC PSYQQ RPM SUPJJ UKHRP WIN AAMMB AAYXX AEFGJ AFFHD AGXDD AIDQK AIDYY CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM 3V. 7XB 8FK K9. PJZUB PKEHL PPXIY PQEST PQUKI PRINS Q9U 7X8 5PM M~E
ID	FETCH-LOGICAL-c5146-a8db257ef3021d6914754f4f5ded85c15a2618af007ce4a6abc6366ab5d1a6fd3
IEDL.DBID	DOA
ISICitedReferencesCount	17
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000494347600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2328-9503
IngestDate	Tue Oct 14 19:03:18 EDT 2025 Tue Nov 04 02:01:12 EST 2025 Sun Nov 09 12:49:46 EST 2025 Sat Nov 29 15:06:49 EST 2025 Mon Jul 21 05:55:12 EDT 2025 Sat Nov 29 02:47:04 EST 2025 Tue Nov 18 22:14:45 EST 2025 Wed Jan 22 16:40:39 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	12
Language	English
License	Attribution 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c5146-a8db257ef3021d6914754f4f5ded85c15a2618af007ce4a6abc6366ab5d1a6fd3
Notes	Funding information Ms. Conner reports funding from the National Institute of General Medical Sciences (NIGMS) Interdisciplinary Training Grant for Biostatisticians (T32GM74905‐14) and the National Heart, Lung, and Blood Institute (NHLBI) (F31HL145904‐01). Dr. Raman reports funding from NHLBI (T32HL125232‐01A1). Dr. Satizabal is supported by the Alzheimer’s Association (AARGD‐16‐443384). Dr. Pase is funded by a National Heart Foundation of Australia Future Leader Fellowship (ID, 102052). This study was also supported by grants from the National Institute on Aging (R01 AG054076, R01 AG049607, R01 AG033193, U01 AG049505, U01 AG052409, RF1 AG054156) and the National Institute of Neurological Disorders and Stroke (NS017950 and UH2 NS100605), and the NHLBI contract for the Framingham Heart Study (contract no. N01‐HC‐25195, HHSN268201500001I, and 75N92019D00031). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0002-0929-9948
OpenAccessLink	https://doaj.org/article/82320af58984449f8dba3f30cff9e694
PMID	31691546
PQID	2327543354
PQPubID	2034580
PageCount	10
ParticipantIDs	doaj_primary_oai_doaj_org_article_82320af58984449f8dba3f30cff9e694 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6917310 proquest_miscellaneous_2312548555 proquest_journals_2327543354 pubmed_primary_31691546 crossref_primary_10_1002_acn3_50936 crossref_citationtrail_10_1002_acn3_50936 wiley_primary_10_1002_acn3_50936_ACN350936
PublicationCentury	2000
PublicationDate	December 2019
PublicationDateYYYYMMDD	2019-12-01
PublicationDate_xml	– month: 12 year: 2019 text: December 2019
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: Bognor Regis – name: Hoboken
PublicationTitle	Annals of clinical and translational neurology
PublicationTitleAlternate	Ann Clin Transl Neurol
PublicationYear	2019
Publisher	John Wiley & Sons, Inc John Wiley and Sons Inc Wiley
Publisher_xml	– name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley
References	2017; 317 2004; 363 2015; 36 2012; 123 2017; 60 2017; 48 2007; 165 2015; 386 2017; 89 1991; 82 2006; 296 2008; 168 2008; 4 2017; 135 2011; 6 2008; 71 2012; 33 2010; 41 1951; 41 2016; 12 2015; 46 2018; 39 2009; 32 1991; 22 1991; 41 2018; 91 1975; 2 2009; 1792 2016; 47 2007; 69 2018; 14 2012; 9 2005; 36 e_1_2_8_28_1 e_1_2_8_29_1 e_1_2_8_24_1 e_1_2_8_25_1 e_1_2_8_26_1 e_1_2_8_27_1 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_21_1 e_1_2_8_22_1 e_1_2_8_23_1 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_14_1 e_1_2_8_35_1 Sharrett AR (e_1_2_8_6_1) 1975; 2 e_1_2_8_15_1 e_1_2_8_16_1 e_1_2_8_32_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_30_1
References_xml	– volume: 6 year: 2011 article-title: Weight trimming and propensity score weighting publication-title: PLoS ONE ONE – volume: 47 start-page: 1201 year: 2016 end-page: 1206 article-title: Association of ideal cardiovascular health with vascular brain injury and incident dementia publication-title: Stroke – volume: 33 start-page: 1979 year: 2012 end-page: 1987 article-title: Coronary risk correlates with cerebral amyloid deposition publication-title: Neurobiol Aging – volume: 296 start-page: 2939 year: 2006 end-page: 2946 article-title: Trends in incidence, lifetime risk, severity, and 30‐day mortality of stroke over the past 50 years publication-title: JAMA – volume: 48 start-page: 2013 year: 2017 end-page: 2020 article-title: Role of improved vascular health in the declining incidence of dementia publication-title: Stroke – volume: 9 start-page: 673 year: 2012 end-page: 686 article-title: The Framingham brain donation program: neuropathology along the cognitive continuum publication-title: Curr Alzheimer Res – volume: 41 start-page: 1508 year: 2010 end-page: 1513 article-title: Recent nationwide trends in discharge statin treatment of hospitalized patients with stroke publication-title: Stroke – volume: 69 start-page: 2197 year: 2007 end-page: 2204 article-title: Mixed brain pathologies account for most dementia cases in community‐dwelling older persons publication-title: Neurology – volume: 89 start-page: 2447 year: 2017 end-page: 2454 article-title: Blood pressure from mid‐ to late life and risk of incident dementia publication-title: Neurology – volume: 36 start-page: 2087 year: 2005 end-page: 2093 article-title: Trends in stroke incidence in Auckland, New Zealand, during 1981 to 2003 publication-title: Stroke – volume: 135 start-page: 1145 year: 2017 end-page: 1159 article-title: Revised Framingham stroke risk profile to reflect temporal trends publication-title: Circulation – volume: 12 start-page: 882 year: 2016 end-page: 889 article-title: Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology publication-title: Alzheimers Dement – volume: 317 start-page: 1443 year: 2017 end-page: 1450 article-title: Association between midlife vascular risk factors and estimated brain amyloid deposition publication-title: JAMA – volume: 4 start-page: 547 year: 2008 end-page: 552 article-title: Early vascular aging (EVA): consequences and prevention publication-title: Vasc Health Risk Manag – volume: 91 start-page: e1479 year: 2018 end-page: e1486 article-title: Vascular risk at younger ages most strongly associates with current and future brain volume publication-title: Neurology – volume: 386 start-page: 154 year: 2015 end-page: 162 article-title: 50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study publication-title: Lancet – volume: 60 start-page: 1035 year: 2017 end-page: 1043 article-title: Diabetes is not associated with Alzheimer's disease neuropathology publication-title: J Alzheimers Dis – volume: 168 start-page: 656 year: 2008 end-page: 664 article-title: Constructing inverse probability weights for marginal structural models publication-title: Am J Epidemiol – volume: 41 start-page: 600 year: 2010 end-page: 606 article-title: Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study publication-title: Stroke – volume: 1792 start-page: 454 year: 2009 end-page: 469 article-title: Human cerebral neuropathology of Type 2 diabetes mellitus publication-title: Biochim Biophys Acta – volume: 2 start-page: 76 year: 1975 article-title: Letter: possible toxic water factor in coronary heart‐disease publication-title: Lancet – volume: 41 start-page: 279 year: 1951 end-page: 281 article-title: Epidemiological approaches to heart disease: the Framingham Study publication-title: Am J Public Health Nations Health – volume: 89 start-page: 697 year: 2017 end-page: 704 article-title: Florbetapir imaging in cerebral amyloid angiopathy‐related hemorrhages publication-title: Neurology – volume: 123 start-page: 1 year: 2012 end-page: 11 article-title: National Institute on Aging‐Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach publication-title: Acta Neuropathol – volume: 22 start-page: 312 year: 1991 end-page: 318 article-title: Probability of stroke: a risk profile from the Framingham Study publication-title: Stroke – volume: 41 start-page: 479 year: 1991 end-page: 486 article-title: The Consortium to establish a registry for alzheimer's disease (CERAD). Part II. standardization of the neuropathologic assessment of alzheimer's disease publication-title: Neurology – volume: 363 start-page: 1925 year: 2004 end-page: 1933 article-title: Change in stroke incidence, mortality, case‐fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study) publication-title: Lancet – volume: 82 start-page: 239 year: 1991 end-page: 259 article-title: Neuropathological stageing of Alzheimer‐related changes publication-title: Acta Neuropathol – volume: 165 start-page: 1328 year: 2007 end-page: 1335 article-title: The third generation cohort of the national heart, lung, and blood institute's Framingham Heart Study: design, recruitment, and initial examination publication-title: Am J Epidemiol – volume: 14 start-page: 1416 year: 2018 end-page: 1426 article-title: Stroke and dementia risk: A systematic review and meta‐analysis publication-title: Alzheimers Dement – volume: 32 start-page: 229 year: 2009 end-page: 239 article-title: Adjustment for selection bias in observational studies with application to the analysis of autopsy data publication-title: Neuroepidemiology – volume: 39 start-page: 3119 year: 2018 end-page: 3125 article-title: Association between systolic blood pressure and dementia in the Whitehall II cohort study: role of age, duration, and threshold used to define hypertension publication-title: Eur Heart J – volume: 71 start-page: 750 year: 2008 end-page: 757 article-title: Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology publication-title: Neurology – volume: 46 start-page: 989 year: 2015 end-page: 995 article-title: Trends in endovascular therapy and clinical outcomes within the nationwide get with the guidelines‐stroke registry publication-title: Stroke – volume: 36 start-page: 2501 year: 2015 end-page: 2508 article-title: Stroke risk interacts with Alzheimer's disease biomarkers on brain aging outcomes publication-title: Neurobiol Aging – ident: e_1_2_8_20_1 doi: 10.1159/000197389 – ident: e_1_2_8_32_1 doi: 10.1001/jama.2017.3090 – ident: e_1_2_8_31_1 doi: 10.1212/01.wnl.0000324925.95210.6d – ident: e_1_2_8_28_1 doi: 10.1016/j.jalz.2015.12.006 – volume: 2 start-page: 76 year: 1975 ident: e_1_2_8_6_1 article-title: Letter: possible toxic water factor in coronary heart‐disease publication-title: Lancet – ident: e_1_2_8_10_1 doi: 10.1001/jama.296.24.2939 – ident: e_1_2_8_12_1 doi: 10.1161/CIRCULATIONAHA.115.021275 – ident: e_1_2_8_16_1 doi: 10.1016/S0140-6736(14)61774-8 – ident: e_1_2_8_2_1 doi: 10.1212/WNL.0000000000006360 – ident: e_1_2_8_24_1 doi: 10.1161/STROKEAHA.115.012608 – ident: e_1_2_8_3_1 doi: 10.1212/WNL.0000000000004741 – ident: e_1_2_8_18_1 doi: 10.1212/WNL.41.4.479 – ident: e_1_2_8_34_1 doi: 10.1016/j.neurobiolaging.2011.10.002 – ident: e_1_2_8_23_1 doi: 10.2147/VHRM.S1094 – ident: e_1_2_8_27_1 doi: 10.1161/STROKEAHA.117.013369 – ident: e_1_2_8_15_1 doi: 10.1161/STROKEAHA.109.573618 – ident: e_1_2_8_13_1 doi: 10.1161/01.STR.22.3.312 – ident: e_1_2_8_5_1 doi: 10.2105/AJPH.41.3.279 – ident: e_1_2_8_11_1 doi: 10.1016/S0140-6736(04)16405-2 – ident: e_1_2_8_14_1 doi: 10.1161/STROKEAHA.114.007542 – ident: e_1_2_8_17_1 doi: 10.1007/s00401-011-0910-3 – ident: e_1_2_8_30_1 doi: 10.1016/j.bbadis.2008.08.005 – ident: e_1_2_8_26_1 doi: 10.1016/j.jalz.2018.06.3061 – ident: e_1_2_8_22_1 doi: 10.1371/journal.pone.0018174 – ident: e_1_2_8_36_1 doi: 10.1212/01.wnl.0000271090.28148.24 – ident: e_1_2_8_8_1 doi: 10.2174/156720512801322609 – ident: e_1_2_8_9_1 doi: 10.1161/01.STR.0000181079.42690.bf – ident: e_1_2_8_25_1 doi: 10.1161/STROKEAHA.109.570044 – ident: e_1_2_8_21_1 doi: 10.1093/aje/kwn164 – ident: e_1_2_8_29_1 doi: 10.3233/JAD-170179 – ident: e_1_2_8_7_1 doi: 10.1093/aje/kwm021 – ident: e_1_2_8_35_1 doi: 10.1016/j.neurobiolaging.2015.05.021 – ident: e_1_2_8_19_1 doi: 10.1007/BF00308809 – ident: e_1_2_8_4_1 doi: 10.1093/eurheartj/ehy288 – ident: e_1_2_8_33_1 doi: 10.1212/WNL.0000000000004228
SSID	ssj0001125372
Score	2.2043095
Snippet	Objective To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a... To determine whether vascular risk factor burden in mid- or late-life associates with postmortem vascular and neurodegenerative pathologies in a... ObjectiveTo determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a... Abstract Objective To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies...
SourceID	doaj pubmedcentral proquest pubmed crossref wiley
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	2403
SubjectTerms	Age Aged Aged, 80 and over Alzheimer Disease - epidemiology Alzheimer Disease - pathology Alzheimer's disease Arteriosclerosis Atherosclerosis Blood pressure Brain Cardiac arrhythmia Cardiovascular disease Cerebrovascular Disorders - epidemiology Cerebrovascular Disorders - pathology Dementia Diabetes Donations Female Gender Humans Hypertension Longitudinal Studies Male Massachusetts - epidemiology Middle Aged Neuropathology Pathology Prognosis Risk Factors Standard deviation Tissue Banks
SummonAdditionalLinks	– databaseName: ProQuest Central dbid: BENPR link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7BFiEuvKGBgozgAlJos37EPqG2asWBripUUG-R4wdEWiXtbsuZn8Bv5JcwdpwsK6pekFbazWYijTUzns_25BuAN6L2mAgQuQnML7hAUQ5jrnA581JyXaKTxTfkvn4qZzN5eqqO04bbMpVVDnNinKhtZ8Ie-TZm_pIzSjn7cHaeh65R4XQ1tdC4CRuBqYxNYGPvYHb8ebXLgvmbltORl3S6rU1L32OWjJzMq0wUCfuvQpn_Fkv-DWJjFjq897_634e7CX-S3d5hHsAN1z6E20fphP0RnBw19vfPX_PGO6JbS-aIRYfroWqVhHp00nfqIXV8DyLKRm7M0OI4btWTpiXd3BKcsB7Dl8ODk_2Peeq8kBsEUCLX0tYYy85ThABWqIKh7p55bp2V3BRc48JLao8Awzimha6NoAK_uC208JY-gUnbtW4TCBpb7qgaP4Vh3tealU65qaeaal5rl8HbwQqVSbTkoTvGvOoJladVsFgVLZbB61H2rCfjuFJqLxhzlAgE2vGPbvGtSvFYSbTHjvZcKskYUx4HrCkO13ivnFAsg63BjFWK6mW1smEGr8bbGI_hkEW3rrsMMuhygXGHZ_C095xRExqYiThDDcs1n1pTdf1O23yPnN_4YIlIPIN30fuuGX61uz-j8dez68fwHO4g-lN9bc4WTC4Wl-4F3DI_Lprl4mWKpD-pUylt priority: 102 providerName: ProQuest – databaseName: Wiley Online Library Open Access dbid: 24P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bSxwxFD5YLcWX1t6nVUlpX1pY3dlcJgFfrCh9qIsPtvgWMrnowDIru9pnf4K_sb-kJ5nLulQKUljYnc0J5HK-Od9kku8AfBJlwECAzE1gfMEHFOURc7kfsCAlNwU6WToh9_N7MR7LszN1sgJ73VmYRh-iX3CLyEj36whwU853F6KhxtZ0B8MdFY9gLc-pjIkbRuxkscKCsZum7E3IGhDVfEh7fdLR7qL6UkRKwv33sc2_N03eJbMpGh09-79-bMDTloWS_cZtnsOKr1_Ak-P2PftLOD2u3O-b20kVPDG1IxNkpN11t3eVxF3ppMnXQ8p0GiLZJoXMmOg4LdiTqibTiSN423oFP44OTw--Ddr8CwOLNEoMjHQlItoHikTACZWzgrPAAnfeSW5zbvDxS5qANMN6ZoQpraACv7jLjQiOvobVelr7t0BwyuVQlfjJLQuhNKzwyo8CNdTw0vgMPndzoG0rTh5zZEx0I6s80nGYdBqmDD72tpeNJMe9Vl_jVPYWUUY7_TGdnesWlVqiZwxN4FJJxpgK2GFDsbs2BOWFYhlsdo6gW2zPNdbBcaCUY_GHvhhRGV-1mNpPr6MNOl_U3eEZvGn8pm8JjfpEnGELiyWPWmrqckldXSTlb6xYIB_P4EvyqH90X-8fjGn69e4hxu9hHRmhavbrbMLq1ezab8Fj--uqms-2E77-ANPpJ9g priority: 102 providerName: Wiley-Blackwell
Title	Mid‐life and late‐life vascular risk factor burden and neuropathology in old age
URI	https://onlinelibrary.wiley.com/doi/abs/10.1002%2Facn3.50936 https://www.ncbi.nlm.nih.gov/pubmed/31691546 https://www.proquest.com/docview/2327543354 https://www.proquest.com/docview/2312548555 https://pubmed.ncbi.nlm.nih.gov/PMC6917310 https://doaj.org/article/82320af58984449f8dba3f30cff9e694
Volume	6
WOSCitedRecordID	wos000494347600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: DOA dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: 7X7 dateStart: 20140101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: BENPR dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: M2M dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: PIMPY dateStart: 20140101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: WIN dateStart: 20140101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Open Access customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: 24P dateStart: 20140101 isFulltext: true titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html providerName: Wiley-Blackwell
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9RAEB-0ivRF_KzReqzoi8LZS_b7sS0tFkwIUvV8CpvNLgaOXOmHz_4J_o3-Jc5ucvEOi74IYXPJTmBvdibz22TyG4BXovYYCBC5CYwvuEDRDn0udVPmleJGopHFL-Q-vZdFoeZzXa6V-go5YT09cK-4PYUhf2Y8V1oxxrRXTW2opzPrvXZCRyZQRD1ri6n4dAXjNpXZyEea7Rnb0bcYHSMX8-8IFIn6r0OXfyZJroPXGH2O78HdATaS_X649-GG6x7AnXx4Mf4QTvO2-fn9x6L1jpiuIQuEkKvjVbIpCWnkpC-wQ-r4-UKUjZSWoTJxfMJO2o4sFw3B-8wj-Hh8dHr4bjoUTJhaxD1ialA56IIO1ZOljdApk5x55nnjGsVtyg2ul5TxiAusY0aY2goqcMeb1Ajf0Mew1S079wQIzpGa6Rq31DLva8Ok0y7z1FDDa-MSeL1SYmUHNvFQ1GJR9TzIWRUUXkWFJ_BylD3rOTSulToIczFKBN7reAKtoRqsofqXNSSwu5rJanDGiwqvQT1QyrH7xdiNbhTejZjOLa-CDFpMIMrhCez0Ez-OhAZCIc5whHLDJDaGutnTtV8jVTdeKBFAJ_AmGs9f_n61f1jQ-Ovp_1DEM9hGaKf7xJtd2Lo8v3LP4bb9dtlenE_gZsZKbOVcxlZN4NbBUVF-mEQ3wjbPcjxXnuTlFzz6fFL8An-fIec
linkProvider	Directory of Open Access Journals
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3NbtQwEB6VgoAL_z-BAkbAAaTQJrYT-4BQKVStullxWKrejJPYEGmVlN0WxI1H4El4KJ6EsfOzrKh66wFppexuJpEn_jwzjsffADxNcouOACO3BP0LTlCkwTEXmZBZIbhOEWR-h9z-KB2PxcGBfL8Cv_q9MC6tsreJ3lCXTeHeka-j5085o5Sz14dfQlc1yq2u9iU0Wljsme_fcMo2f7X7Fvv3WRxvv5ts7YRdVYGwwOAgCbUoc8SpsRTdW5nIiOF9LbO8NKXgRcQ1TiqEtug8C8N0ovMioQkeeBnpxJYU73sOzjOcCblSEVmcLd7pYLRA03hgQY3XdVHTl-iTPQP0wu_58gAnxbT_pmb-HTJ7n7d99X97WtfgShddk812OFyHFVPfgItZlz9wEyZZVf7-8XNaWUN0XZIpRtr97z4nl7hse9LWISK53-XhZT3zpyvg7BciSFWTZloSNMe34MOZ6HQbVuumNneBIJTFhszxExXM2lyz1EgTW6qp5rk2ATzve10VHem6q_0xVS1ddKwcQpRHSABPBtnDlmrkRKk3DjyDhKMH9380s0-qszZKYP9vaMuFFIwxaVFhTVHdwlppEskCWOthozqbNVcLzATweDiN1sYtIenaNMdOBiHu-IR4AHdapA4toY53iTNsYbqE4aWmLp-pq8-e0RwvTHGeEcALj_ZT1FebW2Pqv907XYdHcGlnko3UaHe8dx8uY5wr2yykNVg9mh2bB3Ch-HpUzWcP_Rgm8PGsh8Ef03SFeQ
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3NbtQwEB6Vgiou_P8EChgBB5DCNrGdxAeESsuKqt1VDwX1Zhz_QKRVUnZbEDcegefhcXgSxk6yy4qqtx6QIiWbTLKe3c8z43j8DcDTrHToCDByy9C_4ABFWOxziY2ZKwqucgRZWCH3YS8fj4vDQ7G_Ar_6tTA-rbK3icFQm0b7d-QD9Pw5Z5RyNnBdWsT-9vD10ZfYV5DyM619OY0WIrv2-zccvs1e7Wzjf_0sTYdvD7bexV2FgVhjoJDFqjAlYtY6iq7OZCJh-B2OOW6sKbhOuMIBRqEcOlJtmcpUqTOa4Y6bRGXOUHzuBbiYM8599YRROlq838HIgebpnBE1HShd05fonwMb9MIHhlIBp8W3_6Zp_h0-B_83vPo__3LX4EoXdZPNtptchxVb34C1UZdXcBMORpX5_ePnpHKWqNqQCUbg_ec-V5f4LHzS1iciZVj9EWQDI6gv7BwmKEhVk2ZiCJrpW_D-XHS6Dat1U9u7QBDixYYocUs0c65ULLfCpo4qqnipbATPewRI3ZGx-5ogE9nSSKfSo0UGtETwZC571FKQnCr1xgNpLuFpw8OJZvpJdlZIFoiFDeV4IQrGmHCosKKornZO2EywCNZ7CMnOls3kAj8RPJ5fRivkp5ZUbZsTL4Nw9zxDPII7LWrnLaGej4kzbGG-hOelpi5fqavPgekcb8xx_BHBi4D8M9SXm1tjGo7una3DI1hD9Mu9nfHufbiM4a9ok5PWYfV4emIfwCX99biaTR-G7kzg43n3gj_Z544_
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mid-life+and+late-life+vascular+risk+factor+burden+and+neuropathology+in+old+age&rft.jtitle=Annals+of+clinical+and+translational+neurology&rft.au=Conner%2C+Sarah+C&rft.au=Pase%2C+Matthew+P&rft.au=Carneiro%2C+Herman&rft.au=Raman%2C+Mekala+R&rft.date=2019-12-01&rft.eissn=2328-9503&rft.volume=6&rft.issue=12&rft.spage=2403&rft_id=info:doi/10.1002%2Facn3.50936&rft_id=info%3Apmid%2F31691546&rft.externalDocID=31691546
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2328-9503&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2328-9503&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2328-9503&client=summon