Generalizing polygenic risk scores from Europeans to Hispanics/Latinos

Polygenic risk scores (PRSs) are weighted sums of risk allele counts of single‐nucleotide polymorphisms (SNPs) associated with a disease or trait. PRSs are typically constructed based on published results from Genome‐Wide Association Studies (GWASs), and the majority of which has been performed in l...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genetic epidemiology Jg. 43; H. 1; S. 50 - 62
Hauptverfasser:	Grinde, Kelsey E., Qi, Qibin, Thornton, Timothy A., Liu, Simin, Shadyab, Aladdin H., Chan, Kei Hang K., Reiner, Alexander P., Sofer, Tamar
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Wiley Subscription Services, Inc 01.02.2019
Schlagworte:	admixed populations Alleles Blood pressure Computer Simulation Gene frequency genetic diversity Genome-wide association studies Genome-Wide Association Study Genomes Hispanic Americans Hispanic or Latino - genetics Humans Linkage disequilibrium Linkage Disequilibrium - genetics Models, Genetic Multifactorial Inheritance - genetics Polygenic inheritance Polymorphism, Single Nucleotide - genetics Population genetics Risk Factors Single-nucleotide polymorphism Studies White People - genetics genetic diversity admixed populations linkage disequilibrium
ISSN:	0741-0395, 1098-2272, 1098-2272
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!