Generalizing polygenic risk scores from Europeans to Hispanics/Latinos

Polygenic risk scores (PRSs) are weighted sums of risk allele counts of single‐nucleotide polymorphisms (SNPs) associated with a disease or trait. PRSs are typically constructed based on published results from Genome‐Wide Association Studies (GWASs), and the majority of which has been performed in l...

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Vydáno v:	Genetic epidemiology Ročník 43; číslo 1; s. 50 - 62
Hlavní autoři:	Grinde, Kelsey E., Qi, Qibin, Thornton, Timothy A., Liu, Simin, Shadyab, Aladdin H., Chan, Kei Hang K., Reiner, Alexander P., Sofer, Tamar
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Wiley Subscription Services, Inc 01.02.2019
Témata:	admixed populations Alleles Blood pressure Computer Simulation Gene frequency genetic diversity Genome-wide association studies Genome-Wide Association Study Genomes Hispanic Americans Hispanic or Latino - genetics Humans Linkage disequilibrium Linkage Disequilibrium - genetics Models, Genetic Multifactorial Inheritance - genetics Polygenic inheritance Polymorphism, Single Nucleotide - genetics Population genetics Risk Factors Single-nucleotide polymorphism Studies White People - genetics genetic diversity admixed populations linkage disequilibrium
ISSN:	0741-0395, 1098-2272, 1098-2272
On-line přístup:	Získat plný text
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