Stretchable Electrochemical Sensor for Real-Time Monitoring of Cells and Tissues

Stretchable electrochemical sensors are conceivably a powerful technique that provides important chemical information to unravel elastic and curvilinear living body. However, no breakthrough was made in stretchable electrochemical device for biological detection. Herein, we synthesized Au nanotubes...

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Veröffentlicht in:Angewandte Chemie International Edition Jg. 55; H. 14; S. 4537 - 4541
Hauptverfasser: Liu, Yan-Ling, Jin, Zi-He, Liu, Yan-Hong, Hu, Xue-Bo, Qin, Yu, Xu, Jia-Quan, Fan, Cui-Fang, Huang, Wei-Hua
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Germany Blackwell Publishing Ltd 24.03.2016
Wiley Subscription Services, Inc
Ausgabe:International ed. in English
Schlagworte:
Biosensing Techniques
Dimethylpolysiloxanes - chemistry
electrochemical detection
Electrochemical Techniques - instrumentation
Electrochemistry
endothelial cells
gold nanotubes
Human Umbilical Vein Endothelial Cells
Humans
Microscopy, Electron, Scanning
Nanotechnology
Sensors
stretchable sensor
vascular tissue
electrochemical detection
endothelial cells
stretchable sensor
vascular tissue
gold nanotubes
ISSN:1433-7851, 1521-3773, 1521-3773
Online-Zugang:Volltext
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Zusammenfassung:Stretchable electrochemical sensors are conceivably a powerful technique that provides important chemical information to unravel elastic and curvilinear living body. However, no breakthrough was made in stretchable electrochemical device for biological detection. Herein, we synthesized Au nanotubes (NTs) with large aspect ratio to construct an effective stretchable electrochemical sensor. Interlacing network of Au NTs endows the sensor with desirable stability against mechanical deformation, and Au nanostructure provides excellent electrochemical performance and biocompatibility. This allows for the first time, real‐time electrochemical monitoring of mechanically sensitive cells on the sensor both in their stretching‐free and stretching states as well as sensing of the inner lining of blood vessels. The results demonstrate the great potential of this sensor in electrochemical detection of living body, opening a new window for stretchable electrochemical sensor in biological exploration. Biomedical sensor: A highly controllable strategy has been developed for synthesizing Au nanotubes with a large aspect ratio. The nanotubes were used to construct an effective stretchable electrochemical sensor and to realize real‐time monitoring of mechanically sensitive cells and tissues.
Bibliographie:National Natural Science Foundation of China - No. 21375099; No. 21575110
Ministry of Education of China - No. 20120141110031
ArticleID:ANIE201601276
Fundamental Research Funds for the Central Universities - No. 2042014kf0192
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istex:57F97C9A9D9757BDA78EF2055467DDFBEF972944
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SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201601276