Strategies to improve the efficiency of mesenchymal stem cell transplantation for reversal of liver fibrosis
End‐stage liver fibrosis frequently progresses to portal vein thrombosis, formation of oesophageal varices, hepatic encephalopathy, ascites, hepatocellular carcinoma and liver failure. Mesenchymal stem cells (MSCs), when transplanted in vivo, migrate into fibrogenic livers and then differentiate int...
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| Published in: | Journal of cellular and molecular medicine Vol. 23; no. 3; pp. 1657 - 1670 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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England
John Wiley & Sons, Inc
01.03.2019
John Wiley and Sons Inc |
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| ISSN: | 1582-1838, 1582-4934, 1582-4934 |
| Online Access: | Get full text |
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| Abstract | End‐stage liver fibrosis frequently progresses to portal vein thrombosis, formation of oesophageal varices, hepatic encephalopathy, ascites, hepatocellular carcinoma and liver failure. Mesenchymal stem cells (MSCs), when transplanted in vivo, migrate into fibrogenic livers and then differentiate into hepatocyte‐like cells or fuse with hepatocytes to protect liver function. Moreover, they can produce various growth factors and cytokines with anti‐inflammatory effects to reverse the fibrotic state of the liver. In addition, only a small number of MSCs migrate to the injured tissue after cell transplantation; consequently, multiple studies have investigated effective strategies to improve the survival rate and activity of MSCs for the treatment of liver fibrosis. In this review, we intend to arrange and analyse the current evidence related to MSC transplantation in liver fibrosis, to summarize the detailed mechanisms of MSC transplantation for the reversal of liver fibrosis and to discuss new strategies for this treatment. Finally, and most importantly, we will identify the current problems with MSC‐based therapies to repair liver fibrosis that must be addressed in order to develop safer and more effective routes for MSC transplantation. In this way, it will soon be possible to significantly improve the therapeutic effects of MSC transplantation for liver regeneration, as well as enhance the quality of life and prolong the survival time of patients with liver fibrosis. |
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| AbstractList | End-stage liver fibrosis frequently progresses to portal vein thrombosis, formation of oesophageal varices, hepatic encephalopathy, ascites, hepatocellular carcinoma and liver failure. Mesenchymal stem cells (MSCs), when transplanted in vivo, migrate into fibrogenic livers and then differentiate into hepatocyte-like cells or fuse with hepatocytes to protect liver function. Moreover, they can produce various growth factors and cytokines with anti-inflammatory effects to reverse the fibrotic state of the liver. In addition, only a small number of MSCs migrate to the injured tissue after cell transplantation; consequently, multiple studies have investigated effective strategies to improve the survival rate and activity of MSCs for the treatment of liver fibrosis. In this review, we intend to arrange and analyse the current evidence related to MSC transplantation in liver fibrosis, to summarize the detailed mechanisms of MSC transplantation for the reversal of liver fibrosis and to discuss new strategies for this treatment. Finally, and most importantly, we will identify the current problems with MSC-based therapies to repair liver fibrosis that must be addressed in order to develop safer and more effective routes for MSC transplantation. In this way, it will soon be possible to significantly improve the therapeutic effects of MSC transplantation for liver regeneration, as well as enhance the quality of life and prolong the survival time of patients with liver fibrosis. End-stage liver fibrosis frequently progresses to portal vein thrombosis, formation of oesophageal varices, hepatic encephalopathy, ascites, hepatocellular carcinoma and liver failure. Mesenchymal stem cells (MSCs), when transplanted in vivo, migrate into fibrogenic livers and then differentiate into hepatocyte-like cells or fuse with hepatocytes to protect liver function. Moreover, they can produce various growth factors and cytokines with anti-inflammatory effects to reverse the fibrotic state of the liver. In addition, only a small number of MSCs migrate to the injured tissue after cell transplantation; consequently, multiple studies have investigated effective strategies to improve the survival rate and activity of MSCs for the treatment of liver fibrosis. In this review, we intend to arrange and analyse the current evidence related to MSC transplantation in liver fibrosis, to summarize the detailed mechanisms of MSC transplantation for the reversal of liver fibrosis and to discuss new strategies for this treatment. Finally, and most importantly, we will identify the current problems with MSC-based therapies to repair liver fibrosis that must be addressed in order to develop safer and more effective routes for MSC transplantation. In this way, it will soon be possible to significantly improve the therapeutic effects of MSC transplantation for liver regeneration, as well as enhance the quality of life and prolong the survival time of patients with liver fibrosis.End-stage liver fibrosis frequently progresses to portal vein thrombosis, formation of oesophageal varices, hepatic encephalopathy, ascites, hepatocellular carcinoma and liver failure. Mesenchymal stem cells (MSCs), when transplanted in vivo, migrate into fibrogenic livers and then differentiate into hepatocyte-like cells or fuse with hepatocytes to protect liver function. Moreover, they can produce various growth factors and cytokines with anti-inflammatory effects to reverse the fibrotic state of the liver. In addition, only a small number of MSCs migrate to the injured tissue after cell transplantation; consequently, multiple studies have investigated effective strategies to improve the survival rate and activity of MSCs for the treatment of liver fibrosis. In this review, we intend to arrange and analyse the current evidence related to MSC transplantation in liver fibrosis, to summarize the detailed mechanisms of MSC transplantation for the reversal of liver fibrosis and to discuss new strategies for this treatment. Finally, and most importantly, we will identify the current problems with MSC-based therapies to repair liver fibrosis that must be addressed in order to develop safer and more effective routes for MSC transplantation. In this way, it will soon be possible to significantly improve the therapeutic effects of MSC transplantation for liver regeneration, as well as enhance the quality of life and prolong the survival time of patients with liver fibrosis. |
| Author | Duan, Jinfeng Hu, Chenxia Zhao, Lingfei Li, Lanjuan |
| AuthorAffiliation | 5 The Key Laboratory of Mental Disorder Management of Zhejiang Province, Department of Psychiatry, First Affiliated Hospital Zhejiang University Hangzhou Zhejiang PR China 4 Institute of Nephrology Zhejiang University Hangzhou Zhejiang PR China 1 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital Zhejiang University Hangzhou Zhejiang PR China 3 Key Laboratory of Kidney Disease Prevention and Control Technology Hangzhou Zhejiang PR China 2 Kidney Disease Center, First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou Zhejiang PR China |
| AuthorAffiliation_xml | – name: 2 Kidney Disease Center, First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou Zhejiang PR China – name: 5 The Key Laboratory of Mental Disorder Management of Zhejiang Province, Department of Psychiatry, First Affiliated Hospital Zhejiang University Hangzhou Zhejiang PR China – name: 1 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital Zhejiang University Hangzhou Zhejiang PR China – name: 4 Institute of Nephrology Zhejiang University Hangzhou Zhejiang PR China – name: 3 Key Laboratory of Kidney Disease Prevention and Control Technology Hangzhou Zhejiang PR China |
| Author_xml | – sequence: 1 givenname: Chenxia surname: Hu fullname: Hu, Chenxia organization: Zhejiang University – sequence: 2 givenname: Lingfei surname: Zhao fullname: Zhao, Lingfei organization: Zhejiang University – sequence: 3 givenname: Jinfeng surname: Duan fullname: Duan, Jinfeng organization: Zhejiang University – sequence: 4 givenname: Lanjuan orcidid: 0000-0001-7106-128X surname: Li fullname: Li, Lanjuan email: ljli@zju.edu.cn organization: Zhejiang University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30635966$$D View this record in MEDLINE/PubMed |
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| Copyright | 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | mesenchymal stem cell liver fibrosis improvement mechanism regression |
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| License | Attribution 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Chenxia Hu and Lingfei Zhao contributed equally to this work. |
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| Snippet | End‐stage liver fibrosis frequently progresses to portal vein thrombosis, formation of oesophageal varices, hepatic encephalopathy, ascites, hepatocellular... End-stage liver fibrosis frequently progresses to portal vein thrombosis, formation of oesophageal varices, hepatic encephalopathy, ascites, hepatocellular... |
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| SubjectTerms | Animals Ascites Bile Cell Differentiation Cytokines Esophagus Fibrosis Growth factors Hepatic encephalopathy Hepatocellular carcinoma Hepatocytes Humans improvement Inflammation Liver Liver cancer Liver Cirrhosis - pathology Liver Cirrhosis - therapy Liver diseases Liver failure liver fibrosis Liver Regeneration mechanism mesenchymal stem cell Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stem Cells - cytology Mesenchyme Portal vein Quality of life regression Review Reviews Stem cell transplantation Thrombosis |
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| Title | Strategies to improve the efficiency of mesenchymal stem cell transplantation for reversal of liver fibrosis |
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