PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia

Background Chemotherapy induces a cachectic‐like phenotype, accompanied by skeletal muscle wasting, weakness and mitochondrial dysfunction. Peroxisome proliferator‐activated receptor‐gamma coactivator‐1 alpha (PGC1α), a regulator of mitochondrial biogenesis, is often reduced in cachectic skeletal mu...

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Bibliographic Details
Published in:	Journal of cachexia, sarcopenia and muscle Vol. 13; no. 5; pp. 2480 - 2491
Main Authors:	Huot, Joshua R., Pin, Fabrizio, Chatterjee, Rohit, Bonetto, Andrea
Format:	Journal Article
Language:	English
Published:	Germany John Wiley & Sons, Inc 01.10.2022 John Wiley and Sons Inc Wiley
Subjects:	Age Animals Antineoplastic Agents Body composition cachexia Cachexia - etiology Cancer Chemotherapy Cisplatin Cisplatin - adverse effects Connectivity Cytochromes - metabolism Cytochromes - pharmacology Female Infrared imaging systems Laboratory animals Male Mice Mice, Transgenic Mitochondrial Proteins - metabolism Muscle function Muscle, Skeletal - pathology Muscular Atrophy - etiology Musculoskeletal system Original Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - pharmacology Peroxisome Proliferator-Activated Receptors - metabolism Peroxisome Proliferator-Activated Receptors - pharmacology PGC1α Proteins Skeletal muscle Variance analysis United States > US Chemotherapy PGC1α Cisplatin Skeletal muscle cachexia
ISSN:	2190-5991, 2190-6009, 2190-6009
Online Access:	Get full text
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