LncRNA FAF attenuates hypoxia/ischaemia‐induced pyroptosis via the miR‐185‐5p/PAK2 axis in cardiomyocytes

Pyroptosis is associated with various cardiovascular diseases. Increasing evidence suggests that long noncoding RNAs (lncRNAs) have been implicated in gene regulation, but how lncRNAs participate in the regulation of pyroptosis in the heart remains largely unknown. In this study, we aimed to explore...

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Veröffentlicht in:	Journal of cellular and molecular medicine Jg. 26; H. 10; S. 2895 - 2907
Hauptverfasser:	Gu, Jie, Shi, Jian‐Zhou, Wang, Ya‐Xing, Liu, Liu, Wang, Si‐Bo, Sun, Jia‐Teng, Shan, Tian‐Kai, Wang, Hao, Wang, Qi‐Ming, Wang, Lian‐Sheng
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England John Wiley & Sons, Inc 01.05.2022 John Wiley and Sons Inc
Schlagworte:	Adenoviruses Apoptosis Bioinformatics Cardiomyocytes Cardiovascular disease Cardiovascular diseases Cell viability Coronary vessels Cytokines Experiments Fibroblast growth factor receptor 9 Gene expression Gene regulation Heart attacks Heart failure Humans Hypoxia Hypoxia - metabolism hypoxia/ischaemia Immunofluorescence Ischemia L-Lactate dehydrogenase Laboratory animals Lactic acid lncRNA FAF MicroRNAs - genetics MicroRNAs - metabolism miR‐185‐5p Mortality Myocardial infarction Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocytes, Cardiac - metabolism Non-coding RNA Original p21-activated kinase p21-Activated Kinases - genetics p21-Activated Kinases - metabolism PAK2 Pathogens Polymerase chain reaction Proteins Pyroptosis Pyroptosis - genetics RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Rodents Therapeutic targets Western blotting United States > US China pyroptosis hypoxia/ischaemia lncRNA FAF miR-185-5p PAK2
ISSN:	1582-1838, 1582-4934, 1582-4934
Online-Zugang:	Volltext
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