Feasibility of monitoring advanced melanoma patients using cell‐free DNA from plasma

Summary To determine the feasibility of liquid biopsy for monitoring of patients with advanced melanoma, cell‐free DNA was extracted from plasma for 25 Stage III/IV patients, most (84.0%) having received previous therapy. DNA concentrations ranged from 0.6 to 390.0 ng/ml (median = 7.8 ng/ml) and wer...

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Bibliographic Details
Published in:	Pigment cell and melanoma research Vol. 31; no. 1; pp. 73 - 81
Main Authors:	Gangadhar, Tara C., Savitch, Samantha L., Yee, Stephanie S., Xu, Wei, Huang, Alexander C., Harmon, Shannon, Lieberman, David B., Soucier, Devon, Fan, Ryan, Black, Taylor A., Morrissette, Jennifer J. D., Salathia, Neeraj, Waters, Jill, Zhang, Shile, Toung, Jonathan, Hummelen, Paul, Fan, Jian‐Bing, Xu, Xiaowei, Amaravadi, Ravi K., Schuchter, Lynn M., Karakousis, Giorgos C., Hwang, Wei‐Ting, Carpenter, Erica L.
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01.01.2018
Subjects:	Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Biopsy Cell-Free Nucleic Acids - blood Cell-Free Nucleic Acids - genetics cell‐free circulating tumor DNA Correlation analysis Deoxyribonucleic acid DNA Feasibility Feasibility Studies Female Gene sequencing High-Throughput Nucleotide Sequencing Humans liquid biopsy Male Melanoma Melanoma - blood Melanoma - diagnosis Melanoma - genetics Middle Aged Monitoring Mutation Patients Pilot Projects precision medicine Skin Neoplasms - blood Skin Neoplasms - diagnosis Skin Neoplasms - genetics Therapy melanoma precision medicine cell-free circulating tumor DNA liquid biopsy
ISSN:	1755-1471, 1755-148X, 1755-148X
Online Access:	Get full text
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