Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction

The interrupted Fischer indole synthesis of arylhydrazines and biocatalytically generated chiral bicyclic imines selectively affords either tetracyclic pyrroloindolines or tricyclic tryptamine analogues depending on the reaction conditions. We demonstrate that the reaction is compatible with a varie...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 54; no. 47; pp. 14133 - 14136
Main Authors:	de Graaff, Corien, Bensch, Lisa, Boersma, Sjoerd J., Cioc, Răzvan C., van Lint, Matthijs J., Janssen, Elwin, Turner, Nicholas J., Orru, Romano V. A., Ruijter, Eelco
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 16.11.2015 WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	asymmetric synthesis bioactive compounds cascade reactions Chemistry Chemistry, Multidisciplinary Cholinesterase Cholinesterase inhibitors Indoles - chemical synthesis Indoles - chemistry Molecular Structure Physical Sciences Pyrroles - chemical synthesis Pyrroles - chemistry Science & Technology synthetic methods tryptamines Tryptamines - chemical synthesis Tryptamines - chemistry cascade reactions asymmetric synthesis ENANTIOSELECTIVE SYNTHESIS tryptamines bioactive compounds DERIVATIVES synthetic methods ARYLBORONIC ACIDS DESYMMETRIZATION
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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