Recent advances on the roles of LncRNAs in cardiovascular disease

Cardiovascular diseases are a main cause of mortality whose prevalence continues to increase worldwide. Long non‐coding RNAs (lncRNAs) regulate a variety of biological processes by modifying and regulating transcription of coding genes, directly binding to proteins and even coding proteins themselve...

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Published in:Journal of cellular and molecular medicine Vol. 24; no. 21; pp. 12246 - 12257
Main Authors: Fang, Yexian, Xu, Yuerong, Wang, Runze, Hu, Lang, Guo, Dong, Xue, Feng, Guo, Wangang, Zhang, Dongwei, Hu, Jianqiang, Li, Yan, Zhang, Wei, Zhang, Mingming
Format: Journal Article
Language:English
Published: England John Wiley & Sons, Inc 01.11.2020
John Wiley and Sons Inc
Subjects:
Apoptosis
Atherosclerosis
Autophagy
biological function
Cardiomyocytes
Cardiovascular disease
Cardiovascular diseases
Communication
Congestive heart failure
Deoxyribonucleic acid
DNA
Enzymes
Gene expression
Genomes
Heart
Hypertrophy
Hypoxia
Lipids
Long Non‐coding RNA
Myocardial infarction
Non-coding RNA
Proteins
Review
Reviews
Smooth muscle
Stem cells
Transcription
X chromosomes
Long Non-coding RNA
biological function
cardiovascular diseases
ISSN:1582-1838, 1582-4934, 1582-4934
Online Access:Get full text
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Summary:Cardiovascular diseases are a main cause of mortality whose prevalence continues to increase worldwide. Long non‐coding RNAs (lncRNAs) regulate a variety of biological processes by modifying and regulating transcription of coding genes, directly binding to proteins and even coding proteins themselves. LncRNAs play key roles in the occurrence and development of myocardial infarction, heart failure, myocardial hypertrophy, arrhythmias and other pathological processes that significantly affect the prognosis and survival of patients with cardiovascular diseases. We here review the latest research on lncRNAs in cardiovascular diseases as a basis to formulate future research on prevention and treatment of cardiovascular diseases.
Bibliography:Funding information
This work was supported by the National Natural Science Foundation of China (No. 81900338); Shaanxi Natural Science Basic Research Program (2016JM8062, 2020JQ‐455); Provincial Scientific Foundation of Shaan'Xi (2020TD‐038) and Eagle Program from The Fourth Military Medical University (No. 015210).
Yexian Fang, Yuerong Xu, Runze Wang and Lang Hu contributed equally to this work.
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ISSN:1582-1838
1582-4934
1582-4934
DOI:10.1111/jcmm.15880