The role of plasminogen activators in stroke treatment: fibrinolysis and beyond
Although recent technical advances in thrombectomy have revolutionised acute stroke treatment, prevalence of disability and death related to stroke remain high. Therefore, plasminogen activators—eukaryotic, bacterial, or engineered forms that can promote fibrinolysis by converting plasminogen into a...
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| Veröffentlicht in: | Lancet neurology Jg. 17; H. 12; S. 1121 - 1132 |
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| Sprache: | Englisch |
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England
Elsevier Ltd
01.12.2018
Elsevier Limited |
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| ISSN: | 1474-4422, 1474-4465, 1474-4465 |
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| Abstract | Although recent technical advances in thrombectomy have revolutionised acute stroke treatment, prevalence of disability and death related to stroke remain high. Therefore, plasminogen activators—eukaryotic, bacterial, or engineered forms that can promote fibrinolysis by converting plasminogen into active plasmin and facilitate clot breakdown—are still commonly used in the acute treatment of ischaemic stroke. Hence, plasminogen activators have become a crucial area for clinical investigation for their ability to recanalise occluded arteries in ischaemic stroke and to accelerate haematoma clearance in haemorrhagic stroke. However, inconsistent results, insufficient evidence of efficacy, or reports of side-effects in trial settings might reduce the use of plasminogen activators in clinical practice. Additionally, the mechanism of action for plasminogen activators could extend beyond the vessel lumen and involve plasminogen-independent processes, which would suggest that plasminogen activators have also non-fibrinolytic roles. Understanding the complex mechanisms of action of plasminogen activators can guide future directions for therapeutic interventions in patients with stroke. |
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| AbstractList | Summary Although recent technical advances in thrombectomy have revolutionised acute stroke treatment, prevalence of disability and death related to stroke remain high. Therefore, plasminogen activators—eukaryotic, bacterial, or engineered forms that can promote fibrinolysis by converting plasminogen into active plasmin and facilitate clot breakdown—are still commonly used in the acute treatment of ischaemic stroke. Hence, plasminogen activators have become a crucial area for clinical investigation for their ability to recanalise occluded arteries in ischaemic stroke and to accelerate haematoma clearance in haemorrhagic stroke. However, inconsistent results, insufficient evidence of efficacy, or reports of side-effects in trial settings might reduce the use of plasminogen activators in clinical practice. Additionally, the mechanism of action for plasminogen activators could extend beyond the vessel lumen and involve plasminogen-independent processes, which would suggest that plasminogen activators have also non-fibrinolytic roles. Understanding the complex mechanisms of action of plasminogen activators can guide future directions for therapeutic interventions in patients with stroke. Although recent technical advances in thrombectomy have revolutionised acute stroke treatment, prevalence of disability and death related to stroke remain high. Therefore, plasminogen activators-eukaryotic, bacterial, or engineered forms that can promote fibrinolysis by converting plasminogen into active plasmin and facilitate clot breakdown-are still commonly used in the acute treatment of ischaemic stroke. Hence, plasminogen activators have become a crucial area for clinical investigation for their ability to recanalise occluded arteries in ischaemic stroke and to accelerate haematoma clearance in haemorrhagic stroke. However, inconsistent results, insufficient evidence of efficacy, or reports of side-effects in trial settings might reduce the use of plasminogen activators in clinical practice. Additionally, the mechanism of action for plasminogen activators could extend beyond the vessel lumen and involve plasminogen-independent processes, which would suggest that plasminogen activators have also non-fibrinolytic roles. Understanding the complex mechanisms of action of plasminogen activators can guide future directions for therapeutic interventions in patients with stroke. Although recent technical advances in thrombectomy have revolutionised acute stroke treatment, prevalence of disability and death related to stroke remain high. Therefore, plasminogen activators-eukaryotic, bacterial, or engineered forms that can promote fibrinolysis by converting plasminogen into active plasmin and facilitate clot breakdown-are still commonly used in the acute treatment of ischaemic stroke. Hence, plasminogen activators have become a crucial area for clinical investigation for their ability to recanalise occluded arteries in ischaemic stroke and to accelerate haematoma clearance in haemorrhagic stroke. However, inconsistent results, insufficient evidence of efficacy, or reports of side-effects in trial settings might reduce the use of plasminogen activators in clinical practice. Additionally, the mechanism of action for plasminogen activators could extend beyond the vessel lumen and involve plasminogen-independent processes, which would suggest that plasminogen activators have also non-fibrinolytic roles. Understanding the complex mechanisms of action of plasminogen activators can guide future directions for therapeutic interventions in patients with stroke.Although recent technical advances in thrombectomy have revolutionised acute stroke treatment, prevalence of disability and death related to stroke remain high. Therefore, plasminogen activators-eukaryotic, bacterial, or engineered forms that can promote fibrinolysis by converting plasminogen into active plasmin and facilitate clot breakdown-are still commonly used in the acute treatment of ischaemic stroke. Hence, plasminogen activators have become a crucial area for clinical investigation for their ability to recanalise occluded arteries in ischaemic stroke and to accelerate haematoma clearance in haemorrhagic stroke. However, inconsistent results, insufficient evidence of efficacy, or reports of side-effects in trial settings might reduce the use of plasminogen activators in clinical practice. Additionally, the mechanism of action for plasminogen activators could extend beyond the vessel lumen and involve plasminogen-independent processes, which would suggest that plasminogen activators have also non-fibrinolytic roles. Understanding the complex mechanisms of action of plasminogen activators can guide future directions for therapeutic interventions in patients with stroke. |
| Author | Vivien, Denis Thiebaut, Audrey M Ali, Carine Roussel, Benoit D Gauberti, Maxime Yepes, Manuel Martinez De Lizarrondo, Sara |
| Author_xml | – sequence: 1 givenname: Audrey M surname: Thiebaut fullname: Thiebaut, Audrey M organization: Normandie Université, UNICAEN, INSERM, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, Cyceron, Caen, France – sequence: 2 givenname: Maxime surname: Gauberti fullname: Gauberti, Maxime organization: Normandie Université, UNICAEN, INSERM, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, Cyceron, Caen, France – sequence: 3 givenname: Carine surname: Ali fullname: Ali, Carine organization: Normandie Université, UNICAEN, INSERM, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, Cyceron, Caen, France – sequence: 4 givenname: Sara surname: Martinez De Lizarrondo fullname: Martinez De Lizarrondo, Sara organization: Normandie Université, UNICAEN, INSERM, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, Cyceron, Caen, France – sequence: 5 givenname: Denis surname: Vivien fullname: Vivien, Denis organization: Normandie Université, UNICAEN, INSERM, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, Cyceron, Caen, France – sequence: 6 givenname: Manuel surname: Yepes fullname: Yepes, Manuel organization: Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, and Department of Neurology, Veterans Affairs Medical Center, Atlanta, GA, USA – sequence: 7 givenname: Benoit D surname: Roussel fullname: Roussel, Benoit D email: broussel@cyceron.fr organization: Normandie Université, UNICAEN, INSERM, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, Cyceron, Caen, France |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30507392$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S1474-4422(12)70038-8 10.1182/blood-2016-03-705384 10.1056/NEJMoa0804656 10.1161/STROKEAHA.110.582601 10.1016/S0140-6736(16)32410-2 10.1161/STROKEAHA.110.606293 10.1161/STR.0000000000000152 10.1161/STROKEAHA.110.609693 10.1016/S0140-6736(12)60768-5 10.3389/fmed.2018.00195 10.1016/S0140-6736(10)60491-6 10.1056/NEJMoa1716405 10.1002/neu.20250 10.1007/s12035-013-8511-x 10.1161/STROKEAHA.110.610949 10.1038/cddis.2015.296 10.1002/ana.24834 10.1161/STROKEAHA.116.015164 10.1073/pnas.96.24.14118 10.1016/S1474-4422(17)30253-3 10.1038/83358 10.1111/j.1538-7836.2009.03402.x 10.1080/21655979.2016.1229718 10.1161/STR.0000000000000158 10.1161/STROKEAHA.113.000780 10.1001/jama.2014.3203 10.1016/S0021-9258(19)81052-9 10.1161/STROKEAHA.108.514026 10.1172/JCI41722 10.1038/cdd.2012.86 10.1093/brain/aww172 10.1016/j.ejcb.2016.05.003 10.21873/invivo.11070 10.1111/jth.13849 10.1161/STROKEAHA.107.497115 10.1161/STROKEAHA.111.615724 10.1159/000447722 10.1038/377340a0 10.1056/NEJMoa1411587 10.1182/blood-2016-09-740670 10.3171/jns.2002.97.4.0954 10.1212/WNL.0000000000005162 10.1212/WNL.0000000000004493 10.1016/S0896-6273(00)80597-8 10.1111/j.1538-7836.2009.03663.x 10.1212/WNL.0000000000003399 10.1111/j.1471-4159.2008.05687.x 10.1056/NEJMoa1706442 10.1038/jcbfm.2009.279 10.1056/NEJM199308053290602 10.1186/1742-2094-11-96 10.1001/jamaneurol.2016.5374 10.1016/S0021-9258(18)61211-6 10.1161/STROKEAHA.109.577288 10.1182/blood-2013-12-543074 10.1126/science.1100135 10.1056/NEJMoa1214300 10.1111/j.1538-7836.2007.02665.x 10.1016/S0140-6736(12)60949-0 10.1177/1747493017729239 10.1007/s00415-012-6583-6 10.1111/joim.12576 10.1111/ijs.12097 10.1161/STROKEAHA.117.019896 10.1016/j.mcn.2016.03.005 10.1038/nm1787 10.1038/jcbfm.2014.208 10.3171/jns.2007.106.2.314 10.1182/blood-2015-08-662650 10.1056/NEJMoa1804355 10.1016/j.atherosclerosis.2012.10.072 10.1523/JNEUROSCI.1241-12.2012 10.1038/cdd.2017.35 10.3389/fneur.2017.00371 10.1172/JCI200319212 10.1038/nm0403-371 10.1161/STROKEAHA.117.019138 10.1016/j.neulet.2007.12.004 10.1111/j.1460-9568.1993.tb00529.x 10.1161/STROKEAHA.110.592535 10.1074/jbc.M113.509133 10.1161/STROKEAHA.113.003305 10.1038/jcbfm.2015.47 10.1007/s12035-015-9432-7 10.1016/j.neuropharm.2014.05.001 10.1161/STROKEAHA.116.014091 10.1016/j.mcn.2012.10.001 10.3389/fnmol.2016.00121 10.1161/STROKEAHA.111.000411 10.1111/j.1460-9568.2006.05062.x 10.1161/STROKEAHA.117.016720 10.1177/0271678X18764495 10.1074/jbc.RA118.002534 10.1182/blood-2012-11-464545 10.1161/STROKEAHA.113.001790 10.1084/jem.20101880 10.1523/JNEUROSCI.5296-11.2012 10.1016/S1474-4422(16)30234-4 10.1523/JNEUROSCI.1630-17.2017 10.1212/WNL.57.suppl_2.S69 10.1182/blood-2008-02-141630 10.1182/blood-2014-07-588319 10.1161/STROKEAHA.111.671966 10.1161/STROKEAHA.106.476648 10.1161/CIRCULATIONAHA.117.027290 10.1007/s00415-015-7850-0 10.1182/blood.V66.4.913.913 10.1056/NEJM199512143332401 10.1038/nn998 10.1177/0271678X17719180 10.1161/STROKEAHA.111.630624 10.1056/NEJMoa1515510 10.1056/NEJMoa1503780 10.1007/s11936-013-0277-y 10.1523/JNEUROSCI.5309-13.2014 10.1227/01.NEU.0000103488.94855.4F 10.1056/NEJMoa1213701 10.1007/s12975-012-0188-3 |
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| References | Yaghi, Willey, Cucchiara (bib85) 2017; 48 Tsirka, Gualandris, Amaral, Strickland (bib42) 1995; 377 Pang, Teng, Zaitsev (bib32) 2004; 306 dela Peña, Yoo, Tajiri (bib97) 2015; 35 Nagai, Okada, Kawao (bib15) 2008; 432 Wyseure, Rubio, Denorme (bib67) 2015; 125 (bib17) 1995; 333 Gauberti, Potzeha, Vivien, Martinez de Lizarrondo (bib104) 2018; 5 Mould, Carhuapoma, Muschelli (bib112) 2013; 44 Su, Fredriksson, Schielke, Eriksson, Lawrence (bib33) 2009; 7 Lekoubou, Awoumou, Kengne (bib51) 2017; 12 Leys, Hommet, Jacquet (bib52) 2016; 87 Prasad, Mendelow, Gregson (bib106) 2008 Nicole, Docagne, Ali (bib30) 2001; 7 Dent, Sumi, Morris, Seeley (bib7) 1993; 5 Jeanneret, Wu, Merino (bib4) 2016; 9 Ziai, Tuhrim, Lane (bib5) 2014; 9 Keller, Hobohm, Zeynalova, Classen, Baum (bib50) 2015; 262 Wu, Catano, Echeverry (bib16) 2014; 34 Le Behot, Gauberti, Martinez De Lizarrondo (bib78) 2014; 123 Adams, Effron, Torner (bib77) 2008; 39 Gautier, Ouk, Tagzirt (bib98) 2014; 11 Adivitiya, Khasa (bib18) 2017; 8 Yepes, Sandkvist, Moore, Bugge, Strickland, Lawrence (bib3) 2003; 112 Appella, Robinson, Ullrich (bib6) 1987; 262 Louessard, Lacroix, Martineau (bib24) 2016; 53 Martinez de Lizarrondo, Gakuba, Herbig (bib81) 2017; 136 Lees, Bluhmki, von Kummer (bib100) 2010; 375 Fam, Zeineddine, Eliyas (bib119) 2017; 89 Vaughan (bib72) 2011; 122 Denorme, Wyseure, Peeters (bib71) 2016; 47 Persson, Östling, Smith (bib13) 2014; 45 Onatsu, Taina, Mustonen (bib14) 2017; 31 Sonni, Lioutas, Selim (bib105) 2014; 16 Powers, Rabinstein, Ackerson (bib1) 2018; 49 Pawlak, Magarinos, Melchor, McEwen, Strickland (bib34) 2003; 6 Alvarez, Rossetti, Papavasileiou, Michel (bib49) 2013; 260 Seeds, Basham, Haffke (bib28) 1999; 96 Li, Yang, Li (bib113) 2017; 8 Lee, Ko, Kwon (bib29) 2014; 49 Correa, Gauberti, Parcq (bib25) 2011; 208 Wardlaw (bib84) 2001; 57 Echeverry, Wu, Haile, Guzman, Yepes (bib40) 2010; 120 Staykov, Kuramatsu, Bardutzky (bib118) 2017; 81 Angles-Cano, Balaton, Le Bonniec, Genot, Elion, Sultan (bib23) 1985; 66 Keric, Maier, Samadani (bib110) 2012; 3 Fonarow, Zhao, Smith (bib89) 2014; 311 Brouns, Heylen, Willemse (bib68) 2010; 8 Demchuk, Dowlatshahi, Rodriguez-Luna (bib88) 2012; 11 Cassé, Bardou, Danglot (bib27) 2012; 32 Kramer, Jenne, Zygun (bib122) 2015; 35 Baranes, Lederfein, Huang, Chen, Bailey, Kandel (bib31) 1998; 21 Medcalf (bib20) 2017; 15 Anderson, Robinson, Lindley (bib86) 2016; 374 Hanley, Lane, McBee (bib117) 2017; 389 Samson, Nevin, Croucher (bib38) 2008; 107 Schmitt, Goretzki, Jänicke (bib9) 1991; 50 Coutinho, Liebeskind, Slater (bib58) 2017; 74 Wardlaw, Murray, Berge, del Zoppo (bib60) 2014; 7 Sandercock, Wardlaw, Lindley (bib99) 2012; 379 An, Zhang, Polavarapu, Zhang, Zhang, Yepes (bib90) 2008; 112 Simão, Ustunkaya, Clermont, Feener (bib102) 2017; 129 Rijken, Hoylaerts, Collen (bib21) 1982; 257 Alessi, Gaudin, Grosjean (bib69) 2016; 42 Lochner, Honigman, Grant (bib26) 2006; 66 Matys, Strickland (bib43) 2003; 9 Rohde, Rohde, Thiex (bib108) 2002; 97 Gaberel, Montagne, Lesept (bib114) 2014; 85 Fagan, Waller, Nichols (bib95) 2010; 41 Amin-Hanjani, Ogilvy, Barker (bib120) 2004; 54 Logallo, Novotny, Assmus (bib65) 2017; 16 Campbell, Mitchell, Churilov (bib66) 2018; 378 Gaberel, Magheru, Parienti, Huttner, Vivien, Emery (bib115) 2011; 42 (bib19) 1993; 329 Ciccone, Valvassori (bib56) 2013; 368 Riedel, Zimmermann, Jensen-Kondering, Stingele, Deuschl, Jansen (bib64) 2011; 42 Smith, Sung, Saver (bib54) 2008; 39 Hacke, Kaste, Bluhmki (bib61) 2008; 359 Jeanneret, Ospina, Diaz (bib44) 2018 Berkhemer, Fransen, Beumer (bib53) 2015; 372 Etminan, Beseoglu, Eicker, Turowski, Steiger, Hänggi (bib121) 2013; 44 Merino, Diaz, Manrique, Cheng, Yepes (bib12) 2018; 293 Mantuano, Lam, Gonias (bib37) 2013; 288 Louessard, Bardou, Lemarchand (bib41) 2017; 24 Kohler, Prentice, Bates (bib96) 2013; 44 Barreto, Ford, Shen (bib83) 2017; 48 Naff, Williams, Keyl (bib116) 2011; 42 Messé, Pervez, Smith (bib87) 2013; 44 Zhang, Zhang, Buller (bib45) 2010; 41 Nogueira, Jadhav, Haussen (bib59) 2018; 378 Bustamante, Ning, García-Berrocoso (bib82) 2018; 90 Jovin, Chamorro, Cobo (bib57) 2015; 372 Wu, Echeverry, Wu (bib36) 2013; 52 Parcq, Bertrand, Montagne (bib22) 2012; 19 Thomalla, Simonsen, Boutitie (bib2) 2018; 379 Fernandez-Cadenas, Alvarez-Sabin, Ribo (bib70) 2007; 5 Lahtinen, Lukasiuk, Pitkänen (bib8) 2006; 24 Zhu, Fan, Yu (bib73) 2010; 30 Bhatia, Hill, Shobha (bib62) 2010; 41 Choi, Park, Lee (bib74) 2018; 49 Macrez, Ortega, Bardou (bib48) 2016; 139 Paciaroni, Balucani, Agnelli (bib101) 2012; 43 Denorme, Langhauser, Desender (bib80) 2016; 127 Murata, Rosell, Scannevin, Rhodes, Wang, Lo (bib94) 2008; 39 Thiex, Weis, Krings (bib109) 2007; 106 Diaz, Merino, Manrique (bib11) 2017; 37 Zinkstok, Roos (bib76) 2012; 380 Hanley, Thompson, Muschelli (bib107) 2016; 15 Semina, Rubina, Sysoeva (bib10) 2016; 95 Wahlgren, Thorén, Höjeberg (bib93) 2017; 281 Goulay, Naveau, Gaberel, Vivien, Parcq (bib111) 2018; 38 Grummisch, Jadavji, Smith (bib46) 2016; 74 Macrez, Obiang, Gauberti (bib47) 2011; 42 Marcos-Contreras, Martinez de Lizarrondo, Bardou (bib103) 2016; 128 Su, Fredriksson, Geyer (bib91) 2008; 14 Momi, Tantucci, Van Roy, Ulrichts, Ricci, Gresele (bib79) 2013; 121 Rodríguez-González, Blanco, Rodríguez-Yáñez, Moldes, Castillo, Sobrino (bib92) 2013; 226 Bertrand, Lesept, Chevilley (bib39) 2015; 6 Wu, Wu, Nicholson (bib35) 2012; 32 Mair, von Kummer, Adami (bib63) 2017; 48 Broderick, Palesch, Demchuk (bib55) 2013; 368 Ducroux, Di Meglio, Loyau (bib75) 2018; 49 Louessard (10.1016/S1474-4422(18)30323-5_bib41) 2017; 24 Leys (10.1016/S1474-4422(18)30323-5_bib52) 2016; 87 Li (10.1016/S1474-4422(18)30323-5_bib113) 2017; 8 Persson (10.1016/S1474-4422(18)30323-5_bib13) 2014; 45 Matys (10.1016/S1474-4422(18)30323-5_bib43) 2003; 9 Hanley (10.1016/S1474-4422(18)30323-5_bib107) 2016; 15 Onatsu (10.1016/S1474-4422(18)30323-5_bib14) 2017; 31 Macrez (10.1016/S1474-4422(18)30323-5_bib47) 2011; 42 Zhang (10.1016/S1474-4422(18)30323-5_bib45) 2010; 41 Wyseure (10.1016/S1474-4422(18)30323-5_bib67) 2015; 125 Yaghi (10.1016/S1474-4422(18)30323-5_bib85) 2017; 48 Bustamante (10.1016/S1474-4422(18)30323-5_bib82) 2018; 90 Baranes (10.1016/S1474-4422(18)30323-5_bib31) 1998; 21 Su (10.1016/S1474-4422(18)30323-5_bib33) 2009; 7 Amin-Hanjani (10.1016/S1474-4422(18)30323-5_bib120) 2004; 54 Denorme (10.1016/S1474-4422(18)30323-5_bib71) 2016; 47 Momi (10.1016/S1474-4422(18)30323-5_bib79) 2013; 121 Sonni (10.1016/S1474-4422(18)30323-5_bib105) 2014; 16 Kohler (10.1016/S1474-4422(18)30323-5_bib96) 2013; 44 Campbell (10.1016/S1474-4422(18)30323-5_bib66) 2018; 378 Prasad (10.1016/S1474-4422(18)30323-5_bib106) 2008 Alessi (10.1016/S1474-4422(18)30323-5_bib69) 2016; 42 Martinez de Lizarrondo (10.1016/S1474-4422(18)30323-5_bib81) 2017; 136 Wahlgren (10.1016/S1474-4422(18)30323-5_bib93) 2017; 281 (10.1016/S1474-4422(18)30323-5_bib17) 1995; 333 Wu (10.1016/S1474-4422(18)30323-5_bib35) 2012; 32 Merino (10.1016/S1474-4422(18)30323-5_bib12) 2018; 293 Murata (10.1016/S1474-4422(18)30323-5_bib94) 2008; 39 Berkhemer (10.1016/S1474-4422(18)30323-5_bib53) 2015; 372 Zhu (10.1016/S1474-4422(18)30323-5_bib73) 2010; 30 Thomalla (10.1016/S1474-4422(18)30323-5_bib2) 2018; 379 Adams (10.1016/S1474-4422(18)30323-5_bib77) 2008; 39 Riedel (10.1016/S1474-4422(18)30323-5_bib64) 2011; 42 Powers (10.1016/S1474-4422(18)30323-5_bib1) 2018; 49 Jeanneret (10.1016/S1474-4422(18)30323-5_bib44) 2018 Wu (10.1016/S1474-4422(18)30323-5_bib16) 2014; 34 Logallo (10.1016/S1474-4422(18)30323-5_bib65) 2017; 16 Gaberel (10.1016/S1474-4422(18)30323-5_bib114) 2014; 85 Denorme (10.1016/S1474-4422(18)30323-5_bib80) 2016; 127 Lees (10.1016/S1474-4422(18)30323-5_bib100) 2010; 375 Paciaroni (10.1016/S1474-4422(18)30323-5_bib101) 2012; 43 Fonarow (10.1016/S1474-4422(18)30323-5_bib89) 2014; 311 Echeverry (10.1016/S1474-4422(18)30323-5_bib40) 2010; 120 Adivitiya (10.1016/S1474-4422(18)30323-5_bib18) 2017; 8 Seeds (10.1016/S1474-4422(18)30323-5_bib28) 1999; 96 Nagai (10.1016/S1474-4422(18)30323-5_bib15) 2008; 432 Louessard (10.1016/S1474-4422(18)30323-5_bib24) 2016; 53 Rodríguez-González (10.1016/S1474-4422(18)30323-5_bib92) 2013; 226 Rohde (10.1016/S1474-4422(18)30323-5_bib108) 2002; 97 Lochner (10.1016/S1474-4422(18)30323-5_bib26) 2006; 66 Alvarez (10.1016/S1474-4422(18)30323-5_bib49) 2013; 260 Kramer (10.1016/S1474-4422(18)30323-5_bib122) 2015; 35 Zinkstok (10.1016/S1474-4422(18)30323-5_bib76) 2012; 380 Barreto (10.1016/S1474-4422(18)30323-5_bib83) 2017; 48 Demchuk (10.1016/S1474-4422(18)30323-5_bib88) 2012; 11 An (10.1016/S1474-4422(18)30323-5_bib90) 2008; 112 Staykov (10.1016/S1474-4422(18)30323-5_bib118) 2017; 81 Simão (10.1016/S1474-4422(18)30323-5_bib102) 2017; 129 Keller (10.1016/S1474-4422(18)30323-5_bib50) 2015; 262 Ciccone (10.1016/S1474-4422(18)30323-5_bib56) 2013; 368 Cassé (10.1016/S1474-4422(18)30323-5_bib27) 2012; 32 Vaughan (10.1016/S1474-4422(18)30323-5_bib72) 2011; 122 Ducroux (10.1016/S1474-4422(18)30323-5_bib75) 2018; 49 Gautier (10.1016/S1474-4422(18)30323-5_bib98) 2014; 11 Rijken (10.1016/S1474-4422(18)30323-5_bib21) 1982; 257 Choi (10.1016/S1474-4422(18)30323-5_bib74) 2018; 49 Dent (10.1016/S1474-4422(18)30323-5_bib7) 1993; 5 Gauberti (10.1016/S1474-4422(18)30323-5_bib104) 2018; 5 Wardlaw (10.1016/S1474-4422(18)30323-5_bib60) 2014; 7 Fagan (10.1016/S1474-4422(18)30323-5_bib95) 2010; 41 Grummisch (10.1016/S1474-4422(18)30323-5_bib46) 2016; 74 Coutinho (10.1016/S1474-4422(18)30323-5_bib58) 2017; 74 dela Peña (10.1016/S1474-4422(18)30323-5_bib97) 2015; 35 Keric (10.1016/S1474-4422(18)30323-5_bib110) 2012; 3 Wu (10.1016/S1474-4422(18)30323-5_bib36) 2013; 52 Fernandez-Cadenas (10.1016/S1474-4422(18)30323-5_bib70) 2007; 5 Nicole (10.1016/S1474-4422(18)30323-5_bib30) 2001; 7 Bhatia (10.1016/S1474-4422(18)30323-5_bib62) 2010; 41 Schmitt (10.1016/S1474-4422(18)30323-5_bib9) 1991; 50 Correa (10.1016/S1474-4422(18)30323-5_bib25) 2011; 208 Hacke (10.1016/S1474-4422(18)30323-5_bib61) 2008; 359 Mair (10.1016/S1474-4422(18)30323-5_bib63) 2017; 48 Ziai (10.1016/S1474-4422(18)30323-5_bib5) 2014; 9 Tsirka (10.1016/S1474-4422(18)30323-5_bib42) 1995; 377 Medcalf (10.1016/S1474-4422(18)30323-5_bib20) 2017; 15 Yepes (10.1016/S1474-4422(18)30323-5_bib3) 2003; 112 Samson (10.1016/S1474-4422(18)30323-5_bib38) 2008; 107 Pang (10.1016/S1474-4422(18)30323-5_bib32) 2004; 306 Naff (10.1016/S1474-4422(18)30323-5_bib116) 2011; 42 Gaberel (10.1016/S1474-4422(18)30323-5_bib115) 2011; 42 Mantuano (10.1016/S1474-4422(18)30323-5_bib37) 2013; 288 Jovin (10.1016/S1474-4422(18)30323-5_bib57) 2015; 372 Smith (10.1016/S1474-4422(18)30323-5_bib54) 2008; 39 Lee (10.1016/S1474-4422(18)30323-5_bib29) 2014; 49 Broderick (10.1016/S1474-4422(18)30323-5_bib55) 2013; 368 Marcos-Contreras (10.1016/S1474-4422(18)30323-5_bib103) 2016; 128 Thiex (10.1016/S1474-4422(18)30323-5_bib109) 2007; 106 Messé (10.1016/S1474-4422(18)30323-5_bib87) 2013; 44 Lekoubou (10.1016/S1474-4422(18)30323-5_bib51) 2017; 12 Parcq (10.1016/S1474-4422(18)30323-5_bib22) 2012; 19 Wardlaw (10.1016/S1474-4422(18)30323-5_bib84) 2001; 57 Bertrand (10.1016/S1474-4422(18)30323-5_bib39) 2015; 6 Brouns (10.1016/S1474-4422(18)30323-5_bib68) 2010; 8 Su (10.1016/S1474-4422(18)30323-5_bib91) 2008; 14 Jeanneret (10.1016/S1474-4422(18)30323-5_bib4) 2016; 9 Macrez (10.1016/S1474-4422(18)30323-5_bib48) 2016; 139 Fam (10.1016/S1474-4422(18)30323-5_bib119) 2017; 89 Hanley (10.1016/S1474-4422(18)30323-5_bib117) 2017; 389 Angles-Cano (10.1016/S1474-4422(18)30323-5_bib23) 1985; 66 Lahtinen (10.1016/S1474-4422(18)30323-5_bib8) 2006; 24 (10.1016/S1474-4422(18)30323-5_bib19) 1993; 329 Nogueira (10.1016/S1474-4422(18)30323-5_bib59) 2018; 378 Pawlak (10.1016/S1474-4422(18)30323-5_bib34) 2003; 6 Sandercock (10.1016/S1474-4422(18)30323-5_bib99) 2012; 379 Etminan (10.1016/S1474-4422(18)30323-5_bib121) 2013; 44 Diaz (10.1016/S1474-4422(18)30323-5_bib11) 2017; 37 Goulay (10.1016/S1474-4422(18)30323-5_bib111) 2018; 38 Mould (10.1016/S1474-4422(18)30323-5_bib112) 2013; 44 Anderson (10.1016/S1474-4422(18)30323-5_bib86) 2016; 374 Appella (10.1016/S1474-4422(18)30323-5_bib6) 1987; 262 Semina (10.1016/S1474-4422(18)30323-5_bib10) 2016; 95 Le Behot (10.1016/S1474-4422(18)30323-5_bib78) 2014; 123 |
| References_xml | – volume: 32 start-page: 9848 year: 2012 end-page: 9858 ident: bib35 article-title: Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain publication-title: J Neurosci – volume: 38 start-page: 1180 year: 2018 end-page: 1189 ident: bib111 article-title: Optimised tPA: a non-neurotoxic fibrinolytic agent for the drainage of intracerebral hemorrhages publication-title: J Cereb Blood Flow Metab – volume: 288 start-page: 34009 year: 2013 end-page: 34018 ident: bib37 article-title: LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein publication-title: J Biol Chem – volume: 85 start-page: 158 year: 2014 end-page: 165 ident: bib114 article-title: Urokinase versus for intraventricular hemorrhage fibrinolysis publication-title: Neuropharmacology – volume: 14 start-page: 731 year: 2008 end-page: 737 ident: bib91 article-title: Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke publication-title: Nat Med – volume: 24 start-page: 1518 year: 2017 end-page: 1529 ident: bib41 article-title: Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death publication-title: Cell Death Differ – volume: 112 start-page: 2787 year: 2008 end-page: 2794 ident: bib90 article-title: Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain publication-title: Blood – volume: 112 start-page: 1533 year: 2003 end-page: 1540 ident: bib3 article-title: Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein publication-title: J Clin Invest – volume: 37 start-page: 10310 year: 2017 end-page: 10322 ident: bib11 article-title: A cross talk between neuronal urokinase-type plasminogen activator (uPA) and astrocytic uPA receptor (uPAR) promotes astrocytic activation and synaptic recovery in the ischemic brain publication-title: J Neurosci – volume: 12 start-page: 923 year: 2017 end-page: 931 ident: bib51 article-title: Incidence of seizure in stroke patients treated with recombinant tissue plasminogen activator: a systematic review and meta-analysis publication-title: Int J Stroke – volume: 42 start-page: 2776 year: 2011 end-page: 2781 ident: bib115 article-title: Intraventricular fibrinolysis versus external ventricular drainage alone in intraventricular hemorrhage: a meta-analysis publication-title: Stroke – volume: 129 start-page: 2280 year: 2017 end-page: 2290 ident: bib102 article-title: Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke publication-title: Blood – volume: 81 start-page: 93 year: 2017 end-page: 103 ident: bib118 article-title: Efficacy and safety of combined intraventricular fibrinolysis with lumbar drainage for prevention of permanent shunt dependency after intracerebral hemorrhage with severe ventricular involvement: a randomized trial and individual patient data meta-analysis publication-title: Ann Neurol – volume: 329 start-page: 383 year: 1993 end-page: 389 ident: bib19 article-title: Prehospital thrombolytic therapy in patients with suspected acute myocardial infarction publication-title: N Engl J Med – volume: 139 start-page: 2406 year: 2016 end-page: 2419 ident: bib48 article-title: Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis publication-title: Brain – volume: 226 start-page: 165 year: 2013 end-page: 171 ident: bib92 article-title: Platelet derived growth factor-CC isoform is associated with hemorrhagic transformation in ischemic stroke patients treated with tissue plasminogen activator publication-title: Atherosclerosis – volume: 42 start-page: 2315 year: 2011 end-page: 2322 ident: bib47 article-title: Antibodies preventing the interaction of tissue-type plasminogen activator with N-methyl-D-aspartate receptors reduce stroke damages and extend the therapeutic window of thrombolysis publication-title: Stroke – volume: 5 start-page: 633 year: 1993 end-page: 647 ident: bib7 article-title: Urokinase-type plasminogen activator expression by neurons and oligodendrocytes during process outgrowth in developing rat brain publication-title: Eur J Neurosci – volume: 368 start-page: 2433 year: 2013 end-page: 2434 ident: bib56 article-title: Endovascular treatment for acute ischemic stroke publication-title: N Engl J Med – volume: 6 start-page: 168 year: 2003 end-page: 174 ident: bib34 article-title: Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior publication-title: Nat Neurosci – volume: 66 start-page: 564 year: 2006 end-page: 577 ident: bib26 article-title: Activity-dependent release of tissue plasminogen activator from the dendritic spines of hippocampal neurons revealed by live-cell imaging publication-title: J Neurobiol – volume: 41 start-page: 1001 year: 2010 end-page: 1007 ident: bib45 article-title: Combination treatment with VELCADE and low-dose tissue plasminogen activator provides potent neuroprotection in aged rats after embolic focal ischemia publication-title: Stroke – volume: 9 start-page: 536 year: 2014 end-page: 542 ident: bib5 article-title: A multicenter, randomized, double-blinded, placebo-controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III) publication-title: Int J Stroke – volume: 125 start-page: 1325 year: 2015 end-page: 1332 ident: bib67 article-title: Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke publication-title: Blood – volume: 47 start-page: 2419 year: 2016 end-page: 2422 ident: bib71 article-title: Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice publication-title: Stroke – volume: 123 start-page: 3354 year: 2014 end-page: 3363 ident: bib78 article-title: GpIbα-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice publication-title: Blood – volume: 262 start-page: 2364 year: 2015 end-page: 2372 ident: bib50 article-title: Does treatment with t-PA increase the risk of developing epilepsy after stroke? publication-title: J Neurol – volume: 293 start-page: 9234 year: 2018 end-page: 9247 ident: bib12 article-title: Urokinase-type plasminogen activator (uPA) promotes ezrin-mediated reorganization of the synaptic cytoskeleton in the ischemic brain publication-title: J Biol Chem – volume: 281 start-page: 273 year: 2017 end-page: 283 ident: bib93 article-title: Randomized assessment of imatinib in patients with acute ischaemic stroke treated with intravenous thrombolysis publication-title: J Intern Med – volume: 41 start-page: 2254 year: 2010 end-page: 2258 ident: bib62 article-title: Low rates of acute recanalization with intravenous recombinant tissue plasminogen activator in ischemic stroke: real-world experience and a call for action publication-title: Stroke – volume: 50 start-page: 731 year: 1991 end-page: 741 ident: bib9 article-title: Biological and clinical relevance of the urokinase-type plasminogen activator (uPA) in breast cancer publication-title: Biomed Biochim Acta – volume: 90 start-page: e995 year: 2018 end-page: e1004 ident: bib82 article-title: Usefulness of ADAMTS13 to predict response to recanalization therapies in acute ischemic stroke publication-title: Neurology – volume: 15 start-page: 1228 year: 2016 end-page: 1237 ident: bib107 article-title: Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial publication-title: Lancet Neurol – volume: 42 start-page: 1775 year: 2011 end-page: 1777 ident: bib64 article-title: The importance of size: successful recanalization by intravenous thrombolysis in acute anterior stroke depends on thrombus length publication-title: Stroke – volume: 7 start-page: 59 year: 2001 end-page: 64 ident: bib30 article-title: The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling publication-title: Nat Med – volume: 74 start-page: 25 year: 2016 end-page: 33 ident: bib46 article-title: tPA promotes cortical neuron survival via mTOR-dependent mechanisms publication-title: Mol Cell Neurosci – volume: 49 start-page: 754 year: 2018 end-page: 757 ident: bib75 article-title: Thrombus neutrophil extracellular traps content impair tPA-Induced thrombolysis in acute ischemic stroke publication-title: Stroke – volume: 31 start-page: 381 year: 2017 end-page: 386 ident: bib14 article-title: Soluble urokinase-type plasminogen activator receptor predicts all-cause 5-year mortality in ischemic stroke and TIA publication-title: In Vivo – volume: 372 start-page: 11 year: 2015 end-page: 20 ident: bib53 article-title: A randomized trial of intraarterial treatment for acute ischemic stroke publication-title: N Engl J Med – volume: 39 start-page: 87 year: 2008 end-page: 99 ident: bib77 article-title: Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial: Abciximab in Emergency Treatment of Stroke Trial (AbESTT-II) publication-title: Stroke – volume: 128 start-page: 2423 year: 2016 end-page: 2434 ident: bib103 article-title: Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism publication-title: Blood – volume: 44 start-page: 2162 year: 2013 end-page: 2168 ident: bib121 article-title: Prospective, randomized, open-label phase II trial on concomitant intraventricular fibrinolysis and low-frequency rotation after severe subarachnoid hemorrhage publication-title: Stroke – volume: 16 start-page: 277 year: 2014 ident: bib105 article-title: New avenues for treatment of intracranial hemorrhage publication-title: Curr Treat Options Cardiovasc Med – volume: 32 start-page: 5186 year: 2012 end-page: 5199 ident: bib27 article-title: Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals publication-title: J Neurosci – volume: 375 start-page: 1695 year: 2010 end-page: 1703 ident: bib100 article-title: Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials publication-title: Lancet – volume: 87 start-page: 2416 year: 2016 end-page: 2426 ident: bib52 article-title: Proportion of single-chain recombinant tissue plasminogen activator and outcome after stroke publication-title: Neurology – volume: 24 start-page: 1935 year: 2006 end-page: 1945 ident: bib8 article-title: Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis publication-title: Eur J Neurosci – year: 2008 ident: bib106 article-title: Surgery for primary supratentorial intracerebral haemorrhage publication-title: Cochrane Database Syst Rev – volume: 53 start-page: 5000 year: 2016 end-page: 5012 ident: bib24 article-title: Tissue plasminogen activator expression is restricted to subsets of excitatory pyramidal glutamatergic neurons publication-title: Mol Neurobiol – volume: 432 start-page: 46 year: 2008 end-page: 49 ident: bib15 article-title: Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke publication-title: Neurosci Lett – volume: 8 start-page: 331 year: 2017 end-page: 358 ident: bib18 article-title: The evolution of recombinant thrombolytics: current status and future directions publication-title: Bioengineered – volume: 372 start-page: 2296 year: 2015 end-page: 2306 ident: bib57 article-title: Thrombectomy within 8 hours after symptom onset in ischemic stroke publication-title: N Engl J Med – volume: 74 start-page: 268 year: 2017 end-page: 274 ident: bib58 article-title: Combined intravenous thrombolysis and thrombectomy vs thrombectomy alone for acute ischemic stroke: a pooled analysis of the SWIFT and STAR studies publication-title: JAMA Neurol – volume: 106 start-page: 314 year: 2007 end-page: 320 ident: bib109 article-title: Addition of intravenous N-methyl-D-aspartate receptor antagonists to local fibrinolytic therapy for the optimal treatment of experimental intracerebral hemorrhages publication-title: J Neurosurg – volume: 378 start-page: 11 year: 2018 end-page: 21 ident: bib59 article-title: Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct publication-title: N Engl J Med – volume: 260 start-page: 55 year: 2013 end-page: 61 ident: bib49 article-title: Acute seizures in acute ischemic stroke: does thrombolysis have a role to play? publication-title: J Neurol – volume: 66 start-page: 913 year: 1985 end-page: 920 ident: bib23 article-title: Production of monoclonal antibodies to the high fibrin-affinity, tissue-type plasminogen activator of human plasma. Demonstration of its endothelial origin by immunolocalization publication-title: Blood – volume: 127 start-page: 2337 year: 2016 end-page: 2345 ident: bib80 article-title: ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice publication-title: Blood – volume: 48 start-page: e343 year: 2017 end-page: e361 ident: bib85 article-title: Treatment and outcome of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association publication-title: Stroke – volume: 257 start-page: 2920 year: 1982 end-page: 2925 ident: bib21 article-title: Fibrinolytic properties of one-chain and two-chain human extrinsic (tissue-type) plasminogen activator publication-title: J Biol Chem – volume: 136 start-page: 646 year: 2017 end-page: 660 ident: bib81 article-title: Potent thrombolytic effect of publication-title: Circulation – volume: 262 start-page: 4437 year: 1987 end-page: 4440 ident: bib6 article-title: The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases publication-title: J Biol Chem – volume: 379 start-page: 611 year: 2018 end-page: 622 ident: bib2 article-title: MRI-guided thrombolysis for stroke with unknown time of onset publication-title: N Engl J Med – volume: 45 start-page: 18 year: 2014 end-page: 23 ident: bib13 article-title: Soluble urokinase plasminogen activator receptor: a risk factor for carotid plaque, stroke, and coronary artery disease publication-title: Stroke – volume: 35 start-page: 1241 year: 2015 end-page: 1248 ident: bib122 article-title: Intraventricular fibrinolysis with tissue plasminogen activator is associated with transient cerebrospinal fluid inflammation: a randomized controlled trial publication-title: J Cereb Blood Flow Metab – volume: 5 start-page: 1862 year: 2007 end-page: 1868 ident: bib70 article-title: Influence of thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 gene polymorphisms on tissue-type plasminogen activator-induced recanalization in ischemic stroke patients publication-title: J Thromb Haemost – volume: 43 start-page: 125 year: 2012 end-page: 130 ident: bib101 article-title: Systemic thrombolysis in patients with acute ischemic stroke and Internal Carotid ARtery Occlusion: the ICARO study publication-title: Stroke – volume: 6 start-page: e1924 year: 2015 ident: bib39 article-title: Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR publication-title: Cell Death Dis – volume: 359 start-page: 1317 year: 2008 end-page: 1329 ident: bib61 article-title: Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke publication-title: N Engl J Med – volume: 97 start-page: 954 year: 2002 end-page: 962 ident: bib108 article-title: Fibrinolysis therapy achieved with tissue plasminogen activator and aspiration of the liquefied clot after experimental intracerebral hemorrhage: rapid reduction in hematoma volume but intensification of delayed edema formation publication-title: J Neurosurg – volume: 95 start-page: 295 year: 2016 end-page: 310 ident: bib10 article-title: Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching publication-title: Eur J Cell Biol – volume: 16 start-page: 781 year: 2017 end-page: 788 ident: bib65 article-title: Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial publication-title: Lancet Neurol – volume: 52 start-page: 9 year: 2013 end-page: 19 ident: bib36 article-title: Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK1/2-CREB-ATF3 signaling pathway publication-title: Mol Cell Neurosci – volume: 121 start-page: 5088 year: 2013 end-page: 5097 ident: bib79 article-title: Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs publication-title: Blood – volume: 44 start-page: 2493 year: 2013 end-page: 2499 ident: bib96 article-title: Intravenous minocycline in acute stroke: a randomized, controlled pilot study and meta-analysis publication-title: Stroke – volume: 35 start-page: 338 year: 2015 end-page: 346 ident: bib97 article-title: Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis publication-title: J Cereb Blood Flow Metab – volume: 34 start-page: 14219 year: 2014 end-page: 14232 ident: bib16 article-title: Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke publication-title: J Neurosci – volume: 5 start-page: 195 year: 2018 ident: bib104 article-title: Impact of Bradykinin Generation During Thrombolysis in Ischemic Stroke publication-title: Front Med (Lausanne) – volume: 333 start-page: 1581 year: 1995 end-page: 1587 ident: bib17 article-title: Tissue plasminogen activator for acute ischemic stroke publication-title: N Engl J Med – volume: 380 start-page: 731 year: 2012 end-page: 737 ident: bib76 article-title: Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial publication-title: Lancet – volume: 49 start-page: 199 year: 2014 end-page: 215 ident: bib29 article-title: tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells publication-title: Mol Neurobiol – volume: 48 start-page: 1608 year: 2017 end-page: 1616 ident: bib83 article-title: Randomized, multicenter trial of ARTSS-2 (argatroban with recombinant tissue plasminogen activator for acute stroke) publication-title: Stroke – volume: 39 start-page: 3372 year: 2008 end-page: 3377 ident: bib94 article-title: Extension of the thrombolytic time window with minocycline in experimental stroke publication-title: Stroke – volume: 3 start-page: 88 year: 2012 end-page: 93 ident: bib110 article-title: Tissue plasminogen activator induced delayed edema in experimental porcine intracranial hemorrhage: reduction with plasminogen activator inhibitor-1 administration publication-title: Transl Stroke Res – volume: 42 start-page: 404 year: 2016 end-page: 414 ident: bib69 article-title: Changes in activated thrombin-activatable fibrinolysis inhibitor levels following thrombolytic therapy in ischemic stroke patients correlate with clinical outcome publication-title: Cerebrovasc Dis – volume: 9 start-page: 371 year: 2003 end-page: 372 ident: bib43 article-title: Tissue plasminogen activator and NMDA receptor cleavage publication-title: Nat Med – volume: 7 year: 2014 ident: bib60 article-title: Thrombolysis for acute ischaemic stroke publication-title: Cochrane Database Syst Rev – volume: 15 start-page: 2089 year: 2017 end-page: 2098 ident: bib20 article-title: Fibrinolysis: from blood to the brain publication-title: J Thromb Haemost – volume: 96 start-page: 14118 year: 1999 end-page: 14123 ident: bib28 article-title: Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene publication-title: Proc Natl Acad Sci USA – volume: 311 start-page: 1632 year: 2014 end-page: 1640 ident: bib89 article-title: Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative publication-title: JAMA – volume: 44 start-page: 1354 year: 2013 end-page: 1359 ident: bib87 article-title: Lipid profile, lipid-lowering medications, and intracerebral hemorrhage after tPA in get with the guidelines-stroke publication-title: Stroke – volume: 11 start-page: 307 year: 2012 end-page: 314 ident: bib88 article-title: Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study publication-title: Lancet Neurol – volume: 8 start-page: 75 year: 2010 end-page: 80 ident: bib68 article-title: The decrease in procarboxypeptidase U (TAFI) concentration in acute ischemic stroke correlates with stroke severity, evolution and outcome publication-title: J Thromb Haemost – volume: 30 start-page: 1137 year: 2010 end-page: 1146 ident: bib73 article-title: Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke publication-title: J Cereb Blood Flow Metab – volume: 7 start-page: 155 year: 2009 end-page: 158 ident: bib33 article-title: Tissue plasminogen activator-mediated PDGF signaling and neurovascular coupling in stroke publication-title: J Thromb Haemost – volume: 120 start-page: 2194 year: 2010 end-page: 2205 ident: bib40 article-title: Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus publication-title: J Clin Invest – volume: 21 start-page: 813 year: 1998 end-page: 825 ident: bib31 article-title: Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway publication-title: Neuron – volume: 377 start-page: 340 year: 1995 end-page: 344 ident: bib42 article-title: Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator publication-title: Nature – volume: 49 start-page: 652 year: 2018 end-page: 659 ident: bib74 article-title: Erythrocyte fraction within retrieved thrombi contributes to thrombolytic response in acute ischemic stroke publication-title: Stroke – volume: 107 start-page: 1091 year: 2008 end-page: 1101 ident: bib38 article-title: Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function publication-title: J Neurochem – volume: 368 start-page: 893 year: 2013 end-page: 903 ident: bib55 article-title: Endovascular therapy after intravenous t-PA versus t-PA alone for stroke publication-title: N Engl J Med – volume: 122 start-page: 312 year: 2011 end-page: 325 ident: bib72 article-title: PAI-1 antagonists: the promise and the peril publication-title: Trans Am Clin Climatol Assoc – volume: 208 start-page: 1229 year: 2011 end-page: 1242 ident: bib25 article-title: Tissue plasminogen activator prevents white matter damage following stroke publication-title: J Exp Med – volume: 54 start-page: 326 year: 2004 end-page: 334 ident: bib120 article-title: Does intracisternal thrombolysis prevent vasospasm after aneurysmal subarachnoid hemorrhage? A meta-analysis publication-title: Neurosurgery – volume: 378 start-page: 1573 year: 2018 end-page: 1582 ident: bib66 article-title: Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke publication-title: N Engl J Med – volume: 49 start-page: e46 year: 2018 end-page: e110 ident: bib1 article-title: 2018 guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association publication-title: Stroke – volume: 41 start-page: 2283 year: 2010 end-page: 2287 ident: bib95 article-title: Minocycline to improve neurologic outcome in stroke (MINOS): a dose-finding study publication-title: Stroke – volume: 19 start-page: 1983 year: 2012 end-page: 1991 ident: bib22 article-title: Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity publication-title: Cell Death Differ – volume: 8 start-page: 371 year: 2017 ident: bib113 article-title: Urokinase vs Tissue-Type Plasminogen Activator for Thrombolytic Evacuation of Spontaneous Intracerebral Hemorrhage in Basal Ganglia publication-title: Front Neurol – volume: 39 start-page: 1205 year: 2008 end-page: 1212 ident: bib54 article-title: Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial publication-title: Stroke – volume: 389 start-page: 603 year: 2017 end-page: 611 ident: bib117 article-title: Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial publication-title: Lancet – volume: 57 start-page: S69 year: 2001 end-page: S76 ident: bib84 article-title: Overview of Cochrane thrombolysis meta-analysis publication-title: Neurology – volume: 9 start-page: 121 year: 2016 ident: bib4 article-title: Tissue-type plasminogen activator (tPA) modulates the postsynaptic response of cerebral cortical neurons to the presynaptic release of glutamate publication-title: Front Mol Neurosci – volume: 374 start-page: 2313 year: 2016 end-page: 2323 ident: bib86 article-title: Low-dose versus standard-dose intravenous alteplase in acute ischemic stroke publication-title: N Engl J Med – year: 2018 ident: bib44 article-title: Tissue-type plasminogen activator protects the postsynaptic density in the ischemic brain publication-title: J Cereb Blood Flow Metab – volume: 11 start-page: 96 year: 2014 ident: bib98 article-title: Impact of the neutrophil response to granulocyte colony-stimulating factor on the risk of hemorrhage when used in combination with tissue plasminogen activator during the acute phase of experimental stroke publication-title: J Neuroinflammation – volume: 379 start-page: 2352 year: 2012 end-page: 2363 ident: bib99 article-title: The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial publication-title: Lancet – volume: 48 start-page: 353 year: 2017 end-page: 360 ident: bib63 article-title: Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke publication-title: Stroke – volume: 306 start-page: 487 year: 2004 end-page: 491 ident: bib32 article-title: Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity publication-title: Science – volume: 42 start-page: 3009 year: 2011 end-page: 3016 ident: bib116 article-title: Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial publication-title: Stroke – volume: 44 start-page: 627 year: 2013 end-page: 634 ident: bib112 article-title: Minimally invasive surgery plus recombinant tissue-type plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema publication-title: Stroke – volume: 89 start-page: 1553 year: 2017 end-page: 1560 ident: bib119 article-title: CSF inflammatory response after intraventricular hemorrhage publication-title: Neurology – volume: 11 start-page: 307 year: 2012 ident: 10.1016/S1474-4422(18)30323-5_bib88 article-title: Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study publication-title: Lancet Neurol doi: 10.1016/S1474-4422(12)70038-8 – volume: 128 start-page: 2423 year: 2016 ident: 10.1016/S1474-4422(18)30323-5_bib103 article-title: Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism publication-title: Blood doi: 10.1182/blood-2016-03-705384 – volume: 359 start-page: 1317 year: 2008 ident: 10.1016/S1474-4422(18)30323-5_bib61 article-title: Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke publication-title: N Engl J Med doi: 10.1056/NEJMoa0804656 – volume: 41 start-page: 2283 year: 2010 ident: 10.1016/S1474-4422(18)30323-5_bib95 article-title: Minocycline to improve neurologic outcome in stroke (MINOS): a dose-finding study publication-title: Stroke doi: 10.1161/STROKEAHA.110.582601 – volume: 389 start-page: 603 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib117 article-title: Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial publication-title: Lancet doi: 10.1016/S0140-6736(16)32410-2 – volume: 42 start-page: 2315 year: 2011 ident: 10.1016/S1474-4422(18)30323-5_bib47 article-title: Antibodies preventing the interaction of tissue-type plasminogen activator with N-methyl-D-aspartate receptors reduce stroke damages and extend the therapeutic window of thrombolysis publication-title: Stroke doi: 10.1161/STROKEAHA.110.606293 – volume: 48 start-page: e343 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib85 article-title: Treatment and outcome of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association publication-title: Stroke doi: 10.1161/STR.0000000000000152 – volume: 42 start-page: 1775 year: 2011 ident: 10.1016/S1474-4422(18)30323-5_bib64 article-title: The importance of size: successful recanalization by intravenous thrombolysis in acute anterior stroke depends on thrombus length publication-title: Stroke doi: 10.1161/STROKEAHA.110.609693 – volume: 379 start-page: 2352 year: 2012 ident: 10.1016/S1474-4422(18)30323-5_bib99 article-title: The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(12)60768-5 – volume: 5 start-page: 195 year: 2018 ident: 10.1016/S1474-4422(18)30323-5_bib104 article-title: Impact of Bradykinin Generation During Thrombolysis in Ischemic Stroke publication-title: Front Med (Lausanne) doi: 10.3389/fmed.2018.00195 – volume: 375 start-page: 1695 year: 2010 ident: 10.1016/S1474-4422(18)30323-5_bib100 article-title: Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials publication-title: Lancet doi: 10.1016/S0140-6736(10)60491-6 – volume: 378 start-page: 1573 year: 2018 ident: 10.1016/S1474-4422(18)30323-5_bib66 article-title: Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke publication-title: N Engl J Med doi: 10.1056/NEJMoa1716405 – volume: 66 start-page: 564 year: 2006 ident: 10.1016/S1474-4422(18)30323-5_bib26 article-title: Activity-dependent release of tissue plasminogen activator from the dendritic spines of hippocampal neurons revealed by live-cell imaging publication-title: J Neurobiol doi: 10.1002/neu.20250 – volume: 49 start-page: 199 year: 2014 ident: 10.1016/S1474-4422(18)30323-5_bib29 article-title: tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells publication-title: Mol Neurobiol doi: 10.1007/s12035-013-8511-x – volume: 42 start-page: 3009 year: 2011 ident: 10.1016/S1474-4422(18)30323-5_bib116 article-title: Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial publication-title: Stroke doi: 10.1161/STROKEAHA.110.610949 – volume: 6 start-page: e1924 year: 2015 ident: 10.1016/S1474-4422(18)30323-5_bib39 article-title: Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR publication-title: Cell Death Dis doi: 10.1038/cddis.2015.296 – volume: 81 start-page: 93 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib118 article-title: Efficacy and safety of combined intraventricular fibrinolysis with lumbar drainage for prevention of permanent shunt dependency after intracerebral hemorrhage with severe ventricular involvement: a randomized trial and individual patient data meta-analysis publication-title: Ann Neurol doi: 10.1002/ana.24834 – volume: 48 start-page: 353 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib63 article-title: Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke publication-title: Stroke doi: 10.1161/STROKEAHA.116.015164 – volume: 96 start-page: 14118 year: 1999 ident: 10.1016/S1474-4422(18)30323-5_bib28 article-title: Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.96.24.14118 – volume: 16 start-page: 781 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib65 article-title: Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial publication-title: Lancet Neurol doi: 10.1016/S1474-4422(17)30253-3 – volume: 7 start-page: 59 year: 2001 ident: 10.1016/S1474-4422(18)30323-5_bib30 article-title: The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling publication-title: Nat Med doi: 10.1038/83358 – volume: 7 start-page: 155 issue: suppl 1 year: 2009 ident: 10.1016/S1474-4422(18)30323-5_bib33 article-title: Tissue plasminogen activator-mediated PDGF signaling and neurovascular coupling in stroke publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2009.03402.x – volume: 8 start-page: 331 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib18 article-title: The evolution of recombinant thrombolytics: current status and future directions publication-title: Bioengineered doi: 10.1080/21655979.2016.1229718 – volume: 49 start-page: e46 year: 2018 ident: 10.1016/S1474-4422(18)30323-5_bib1 article-title: 2018 guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association publication-title: Stroke doi: 10.1161/STR.0000000000000158 – volume: 44 start-page: 2493 year: 2013 ident: 10.1016/S1474-4422(18)30323-5_bib96 article-title: Intravenous minocycline in acute stroke: a randomized, controlled pilot study and meta-analysis publication-title: Stroke doi: 10.1161/STROKEAHA.113.000780 – volume: 311 start-page: 1632 year: 2014 ident: 10.1016/S1474-4422(18)30323-5_bib89 article-title: Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative publication-title: JAMA doi: 10.1001/jama.2014.3203 – volume: 257 start-page: 2920 year: 1982 ident: 10.1016/S1474-4422(18)30323-5_bib21 article-title: Fibrinolytic properties of one-chain and two-chain human extrinsic (tissue-type) plasminogen activator publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)81052-9 – volume: 39 start-page: 3372 year: 2008 ident: 10.1016/S1474-4422(18)30323-5_bib94 article-title: Extension of the thrombolytic time window with minocycline in experimental stroke publication-title: Stroke doi: 10.1161/STROKEAHA.108.514026 – volume: 120 start-page: 2194 year: 2010 ident: 10.1016/S1474-4422(18)30323-5_bib40 article-title: Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus publication-title: J Clin Invest doi: 10.1172/JCI41722 – volume: 50 start-page: 731 year: 1991 ident: 10.1016/S1474-4422(18)30323-5_bib9 article-title: Biological and clinical relevance of the urokinase-type plasminogen activator (uPA) in breast cancer publication-title: Biomed Biochim Acta – volume: 19 start-page: 1983 year: 2012 ident: 10.1016/S1474-4422(18)30323-5_bib22 article-title: Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity publication-title: Cell Death Differ doi: 10.1038/cdd.2012.86 – volume: 139 start-page: 2406 year: 2016 ident: 10.1016/S1474-4422(18)30323-5_bib48 article-title: Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis publication-title: Brain doi: 10.1093/brain/aww172 – volume: 7 year: 2014 ident: 10.1016/S1474-4422(18)30323-5_bib60 article-title: Thrombolysis for acute ischaemic stroke publication-title: Cochrane Database Syst Rev – volume: 95 start-page: 295 year: 2016 ident: 10.1016/S1474-4422(18)30323-5_bib10 article-title: Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching publication-title: Eur J Cell Biol doi: 10.1016/j.ejcb.2016.05.003 – volume: 31 start-page: 381 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib14 article-title: Soluble urokinase-type plasminogen activator receptor predicts all-cause 5-year mortality in ischemic stroke and TIA publication-title: In Vivo doi: 10.21873/invivo.11070 – volume: 15 start-page: 2089 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib20 article-title: Fibrinolysis: from blood to the brain publication-title: J Thromb Haemost doi: 10.1111/jth.13849 – volume: 39 start-page: 1205 year: 2008 ident: 10.1016/S1474-4422(18)30323-5_bib54 article-title: Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial publication-title: Stroke doi: 10.1161/STROKEAHA.107.497115 – volume: 42 start-page: 2776 year: 2011 ident: 10.1016/S1474-4422(18)30323-5_bib115 article-title: Intraventricular fibrinolysis versus external ventricular drainage alone in intraventricular hemorrhage: a meta-analysis publication-title: Stroke doi: 10.1161/STROKEAHA.111.615724 – volume: 42 start-page: 404 year: 2016 ident: 10.1016/S1474-4422(18)30323-5_bib69 article-title: Changes in activated thrombin-activatable fibrinolysis inhibitor levels following thrombolytic therapy in ischemic stroke patients correlate with clinical outcome publication-title: Cerebrovasc Dis doi: 10.1159/000447722 – volume: 377 start-page: 340 year: 1995 ident: 10.1016/S1474-4422(18)30323-5_bib42 article-title: Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator publication-title: Nature doi: 10.1038/377340a0 – volume: 372 start-page: 11 year: 2015 ident: 10.1016/S1474-4422(18)30323-5_bib53 article-title: A randomized trial of intraarterial treatment for acute ischemic stroke publication-title: N Engl J Med doi: 10.1056/NEJMoa1411587 – volume: 129 start-page: 2280 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib102 article-title: Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke publication-title: Blood doi: 10.1182/blood-2016-09-740670 – volume: 97 start-page: 954 year: 2002 ident: 10.1016/S1474-4422(18)30323-5_bib108 article-title: Fibrinolysis therapy achieved with tissue plasminogen activator and aspiration of the liquefied clot after experimental intracerebral hemorrhage: rapid reduction in hematoma volume but intensification of delayed edema formation publication-title: J Neurosurg doi: 10.3171/jns.2002.97.4.0954 – volume: 90 start-page: e995 year: 2018 ident: 10.1016/S1474-4422(18)30323-5_bib82 article-title: Usefulness of ADAMTS13 to predict response to recanalization therapies in acute ischemic stroke publication-title: Neurology doi: 10.1212/WNL.0000000000005162 – volume: 89 start-page: 1553 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib119 article-title: CSF inflammatory response after intraventricular hemorrhage publication-title: Neurology doi: 10.1212/WNL.0000000000004493 – volume: 21 start-page: 813 year: 1998 ident: 10.1016/S1474-4422(18)30323-5_bib31 article-title: Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway publication-title: Neuron doi: 10.1016/S0896-6273(00)80597-8 – volume: 8 start-page: 75 year: 2010 ident: 10.1016/S1474-4422(18)30323-5_bib68 article-title: The decrease in procarboxypeptidase U (TAFI) concentration in acute ischemic stroke correlates with stroke severity, evolution and outcome publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2009.03663.x – volume: 87 start-page: 2416 year: 2016 ident: 10.1016/S1474-4422(18)30323-5_bib52 article-title: Proportion of single-chain recombinant tissue plasminogen activator and outcome after stroke publication-title: Neurology doi: 10.1212/WNL.0000000000003399 – volume: 107 start-page: 1091 year: 2008 ident: 10.1016/S1474-4422(18)30323-5_bib38 article-title: Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function publication-title: J Neurochem doi: 10.1111/j.1471-4159.2008.05687.x – volume: 378 start-page: 11 year: 2018 ident: 10.1016/S1474-4422(18)30323-5_bib59 article-title: Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct publication-title: N Engl J Med doi: 10.1056/NEJMoa1706442 – volume: 30 start-page: 1137 year: 2010 ident: 10.1016/S1474-4422(18)30323-5_bib73 article-title: Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke publication-title: J Cereb Blood Flow Metab doi: 10.1038/jcbfm.2009.279 – volume: 329 start-page: 383 year: 1993 ident: 10.1016/S1474-4422(18)30323-5_bib19 article-title: Prehospital thrombolytic therapy in patients with suspected acute myocardial infarction publication-title: N Engl J Med doi: 10.1056/NEJM199308053290602 – volume: 11 start-page: 96 year: 2014 ident: 10.1016/S1474-4422(18)30323-5_bib98 article-title: Impact of the neutrophil response to granulocyte colony-stimulating factor on the risk of hemorrhage when used in combination with tissue plasminogen activator during the acute phase of experimental stroke publication-title: J Neuroinflammation doi: 10.1186/1742-2094-11-96 – volume: 74 start-page: 268 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib58 article-title: Combined intravenous thrombolysis and thrombectomy vs thrombectomy alone for acute ischemic stroke: a pooled analysis of the SWIFT and STAR studies publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2016.5374 – volume: 262 start-page: 4437 year: 1987 ident: 10.1016/S1474-4422(18)30323-5_bib6 article-title: The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)61211-6 – volume: 41 start-page: 1001 year: 2010 ident: 10.1016/S1474-4422(18)30323-5_bib45 article-title: Combination treatment with VELCADE and low-dose tissue plasminogen activator provides potent neuroprotection in aged rats after embolic focal ischemia publication-title: Stroke doi: 10.1161/STROKEAHA.109.577288 – volume: 123 start-page: 3354 year: 2014 ident: 10.1016/S1474-4422(18)30323-5_bib78 article-title: GpIbα-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice publication-title: Blood doi: 10.1182/blood-2013-12-543074 – volume: 306 start-page: 487 year: 2004 ident: 10.1016/S1474-4422(18)30323-5_bib32 article-title: Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity publication-title: Science doi: 10.1126/science.1100135 – volume: 368 start-page: 893 year: 2013 ident: 10.1016/S1474-4422(18)30323-5_bib55 article-title: Endovascular therapy after intravenous t-PA versus t-PA alone for stroke publication-title: N Engl J Med doi: 10.1056/NEJMoa1214300 – volume: 5 start-page: 1862 year: 2007 ident: 10.1016/S1474-4422(18)30323-5_bib70 article-title: Influence of thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 gene polymorphisms on tissue-type plasminogen activator-induced recanalization in ischemic stroke patients publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2007.02665.x – volume: 380 start-page: 731 year: 2012 ident: 10.1016/S1474-4422(18)30323-5_bib76 article-title: Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(12)60949-0 – volume: 12 start-page: 923 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib51 article-title: Incidence of seizure in stroke patients treated with recombinant tissue plasminogen activator: a systematic review and meta-analysis publication-title: Int J Stroke doi: 10.1177/1747493017729239 – volume: 260 start-page: 55 year: 2013 ident: 10.1016/S1474-4422(18)30323-5_bib49 article-title: Acute seizures in acute ischemic stroke: does thrombolysis have a role to play? publication-title: J Neurol doi: 10.1007/s00415-012-6583-6 – volume: 281 start-page: 273 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib93 article-title: Randomized assessment of imatinib in patients with acute ischaemic stroke treated with intravenous thrombolysis publication-title: J Intern Med doi: 10.1111/joim.12576 – volume: 9 start-page: 536 year: 2014 ident: 10.1016/S1474-4422(18)30323-5_bib5 article-title: A multicenter, randomized, double-blinded, placebo-controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III) publication-title: Int J Stroke doi: 10.1111/ijs.12097 – volume: 49 start-page: 754 year: 2018 ident: 10.1016/S1474-4422(18)30323-5_bib75 article-title: Thrombus neutrophil extracellular traps content impair tPA-Induced thrombolysis in acute ischemic stroke publication-title: Stroke doi: 10.1161/STROKEAHA.117.019896 – volume: 74 start-page: 25 year: 2016 ident: 10.1016/S1474-4422(18)30323-5_bib46 article-title: tPA promotes cortical neuron survival via mTOR-dependent mechanisms publication-title: Mol Cell Neurosci doi: 10.1016/j.mcn.2016.03.005 – volume: 14 start-page: 731 year: 2008 ident: 10.1016/S1474-4422(18)30323-5_bib91 article-title: Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke publication-title: Nat Med doi: 10.1038/nm1787 – volume: 35 start-page: 338 year: 2015 ident: 10.1016/S1474-4422(18)30323-5_bib97 article-title: Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis publication-title: J Cereb Blood Flow Metab doi: 10.1038/jcbfm.2014.208 – volume: 106 start-page: 314 year: 2007 ident: 10.1016/S1474-4422(18)30323-5_bib109 article-title: Addition of intravenous N-methyl-D-aspartate receptor antagonists to local fibrinolytic therapy for the optimal treatment of experimental intracerebral hemorrhages publication-title: J Neurosurg doi: 10.3171/jns.2007.106.2.314 – volume: 127 start-page: 2337 year: 2016 ident: 10.1016/S1474-4422(18)30323-5_bib80 article-title: ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice publication-title: Blood doi: 10.1182/blood-2015-08-662650 – volume: 379 start-page: 611 year: 2018 ident: 10.1016/S1474-4422(18)30323-5_bib2 article-title: MRI-guided thrombolysis for stroke with unknown time of onset publication-title: N Engl J Med doi: 10.1056/NEJMoa1804355 – volume: 226 start-page: 165 year: 2013 ident: 10.1016/S1474-4422(18)30323-5_bib92 article-title: Platelet derived growth factor-CC isoform is associated with hemorrhagic transformation in ischemic stroke patients treated with tissue plasminogen activator publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2012.10.072 – volume: 32 start-page: 9848 year: 2012 ident: 10.1016/S1474-4422(18)30323-5_bib35 article-title: Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1241-12.2012 – volume: 24 start-page: 1518 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib41 article-title: Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death publication-title: Cell Death Differ doi: 10.1038/cdd.2017.35 – volume: 8 start-page: 371 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib113 article-title: Urokinase vs Tissue-Type Plasminogen Activator for Thrombolytic Evacuation of Spontaneous Intracerebral Hemorrhage in Basal Ganglia publication-title: Front Neurol doi: 10.3389/fneur.2017.00371 – volume: 112 start-page: 1533 year: 2003 ident: 10.1016/S1474-4422(18)30323-5_bib3 article-title: Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein publication-title: J Clin Invest doi: 10.1172/JCI200319212 – volume: 9 start-page: 371 year: 2003 ident: 10.1016/S1474-4422(18)30323-5_bib43 article-title: Tissue plasminogen activator and NMDA receptor cleavage publication-title: Nat Med doi: 10.1038/nm0403-371 – volume: 49 start-page: 652 year: 2018 ident: 10.1016/S1474-4422(18)30323-5_bib74 article-title: Erythrocyte fraction within retrieved thrombi contributes to thrombolytic response in acute ischemic stroke publication-title: Stroke doi: 10.1161/STROKEAHA.117.019138 – volume: 432 start-page: 46 year: 2008 ident: 10.1016/S1474-4422(18)30323-5_bib15 article-title: Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke publication-title: Neurosci Lett doi: 10.1016/j.neulet.2007.12.004 – issue: 4 year: 2008 ident: 10.1016/S1474-4422(18)30323-5_bib106 article-title: Surgery for primary supratentorial intracerebral haemorrhage publication-title: Cochrane Database Syst Rev – volume: 5 start-page: 633 year: 1993 ident: 10.1016/S1474-4422(18)30323-5_bib7 article-title: Urokinase-type plasminogen activator expression by neurons and oligodendrocytes during process outgrowth in developing rat brain publication-title: Eur J Neurosci doi: 10.1111/j.1460-9568.1993.tb00529.x – volume: 41 start-page: 2254 year: 2010 ident: 10.1016/S1474-4422(18)30323-5_bib62 article-title: Low rates of acute recanalization with intravenous recombinant tissue plasminogen activator in ischemic stroke: real-world experience and a call for action publication-title: Stroke doi: 10.1161/STROKEAHA.110.592535 – volume: 288 start-page: 34009 year: 2013 ident: 10.1016/S1474-4422(18)30323-5_bib37 article-title: LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein publication-title: J Biol Chem doi: 10.1074/jbc.M113.509133 – volume: 45 start-page: 18 year: 2014 ident: 10.1016/S1474-4422(18)30323-5_bib13 article-title: Soluble urokinase plasminogen activator receptor: a risk factor for carotid plaque, stroke, and coronary artery disease publication-title: Stroke doi: 10.1161/STROKEAHA.113.003305 – volume: 35 start-page: 1241 year: 2015 ident: 10.1016/S1474-4422(18)30323-5_bib122 article-title: Intraventricular fibrinolysis with tissue plasminogen activator is associated with transient cerebrospinal fluid inflammation: a randomized controlled trial publication-title: J Cereb Blood Flow Metab doi: 10.1038/jcbfm.2015.47 – volume: 53 start-page: 5000 year: 2016 ident: 10.1016/S1474-4422(18)30323-5_bib24 article-title: Tissue plasminogen activator expression is restricted to subsets of excitatory pyramidal glutamatergic neurons publication-title: Mol Neurobiol doi: 10.1007/s12035-015-9432-7 – volume: 85 start-page: 158 year: 2014 ident: 10.1016/S1474-4422(18)30323-5_bib114 article-title: Urokinase versus for intraventricular hemorrhage fibrinolysis publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2014.05.001 – volume: 47 start-page: 2419 year: 2016 ident: 10.1016/S1474-4422(18)30323-5_bib71 article-title: Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice publication-title: Stroke doi: 10.1161/STROKEAHA.116.014091 – volume: 52 start-page: 9 year: 2013 ident: 10.1016/S1474-4422(18)30323-5_bib36 article-title: Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK1/2-CREB-ATF3 signaling pathway publication-title: Mol Cell Neurosci doi: 10.1016/j.mcn.2012.10.001 – volume: 122 start-page: 312 year: 2011 ident: 10.1016/S1474-4422(18)30323-5_bib72 article-title: PAI-1 antagonists: the promise and the peril publication-title: Trans Am Clin Climatol Assoc – volume: 9 start-page: 121 year: 2016 ident: 10.1016/S1474-4422(18)30323-5_bib4 article-title: Tissue-type plasminogen activator (tPA) modulates the postsynaptic response of cerebral cortical neurons to the presynaptic release of glutamate publication-title: Front Mol Neurosci doi: 10.3389/fnmol.2016.00121 – volume: 44 start-page: 627 year: 2013 ident: 10.1016/S1474-4422(18)30323-5_bib112 article-title: Minimally invasive surgery plus recombinant tissue-type plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema publication-title: Stroke doi: 10.1161/STROKEAHA.111.000411 – volume: 24 start-page: 1935 year: 2006 ident: 10.1016/S1474-4422(18)30323-5_bib8 article-title: Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis publication-title: Eur J Neurosci doi: 10.1111/j.1460-9568.2006.05062.x – volume: 48 start-page: 1608 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib83 article-title: Randomized, multicenter trial of ARTSS-2 (argatroban with recombinant tissue plasminogen activator for acute stroke) publication-title: Stroke doi: 10.1161/STROKEAHA.117.016720 – year: 2018 ident: 10.1016/S1474-4422(18)30323-5_bib44 article-title: Tissue-type plasminogen activator protects the postsynaptic density in the ischemic brain publication-title: J Cereb Blood Flow Metab doi: 10.1177/0271678X18764495 – volume: 293 start-page: 9234 year: 2018 ident: 10.1016/S1474-4422(18)30323-5_bib12 article-title: Urokinase-type plasminogen activator (uPA) promotes ezrin-mediated reorganization of the synaptic cytoskeleton in the ischemic brain publication-title: J Biol Chem doi: 10.1074/jbc.RA118.002534 – volume: 121 start-page: 5088 year: 2013 ident: 10.1016/S1474-4422(18)30323-5_bib79 article-title: Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs publication-title: Blood doi: 10.1182/blood-2012-11-464545 – volume: 44 start-page: 2162 year: 2013 ident: 10.1016/S1474-4422(18)30323-5_bib121 article-title: Prospective, randomized, open-label phase II trial on concomitant intraventricular fibrinolysis and low-frequency rotation after severe subarachnoid hemorrhage publication-title: Stroke doi: 10.1161/STROKEAHA.113.001790 – volume: 208 start-page: 1229 year: 2011 ident: 10.1016/S1474-4422(18)30323-5_bib25 article-title: Tissue plasminogen activator prevents white matter damage following stroke publication-title: J Exp Med doi: 10.1084/jem.20101880 – volume: 32 start-page: 5186 year: 2012 ident: 10.1016/S1474-4422(18)30323-5_bib27 article-title: Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals publication-title: J Neurosci doi: 10.1523/JNEUROSCI.5296-11.2012 – volume: 15 start-page: 1228 year: 2016 ident: 10.1016/S1474-4422(18)30323-5_bib107 article-title: Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial publication-title: Lancet Neurol doi: 10.1016/S1474-4422(16)30234-4 – volume: 37 start-page: 10310 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib11 article-title: A cross talk between neuronal urokinase-type plasminogen activator (uPA) and astrocytic uPA receptor (uPAR) promotes astrocytic activation and synaptic recovery in the ischemic brain publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1630-17.2017 – volume: 57 start-page: S69 year: 2001 ident: 10.1016/S1474-4422(18)30323-5_bib84 article-title: Overview of Cochrane thrombolysis meta-analysis publication-title: Neurology doi: 10.1212/WNL.57.suppl_2.S69 – volume: 112 start-page: 2787 year: 2008 ident: 10.1016/S1474-4422(18)30323-5_bib90 article-title: Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain publication-title: Blood doi: 10.1182/blood-2008-02-141630 – volume: 125 start-page: 1325 year: 2015 ident: 10.1016/S1474-4422(18)30323-5_bib67 article-title: Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke publication-title: Blood doi: 10.1182/blood-2014-07-588319 – volume: 44 start-page: 1354 year: 2013 ident: 10.1016/S1474-4422(18)30323-5_bib87 article-title: Lipid profile, lipid-lowering medications, and intracerebral hemorrhage after tPA in get with the guidelines-stroke publication-title: Stroke doi: 10.1161/STROKEAHA.111.671966 – volume: 39 start-page: 87 year: 2008 ident: 10.1016/S1474-4422(18)30323-5_bib77 article-title: Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial: Abciximab in Emergency Treatment of Stroke Trial (AbESTT-II) publication-title: Stroke doi: 10.1161/STROKEAHA.106.476648 – volume: 136 start-page: 646 year: 2017 ident: 10.1016/S1474-4422(18)30323-5_bib81 article-title: Potent thrombolytic effect of N-Acetylcysteine on arterial thrombi publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.027290 – volume: 262 start-page: 2364 year: 2015 ident: 10.1016/S1474-4422(18)30323-5_bib50 article-title: Does treatment with t-PA increase the risk of developing epilepsy after stroke? publication-title: J Neurol doi: 10.1007/s00415-015-7850-0 – volume: 66 start-page: 913 year: 1985 ident: 10.1016/S1474-4422(18)30323-5_bib23 article-title: Production of monoclonal antibodies to the high fibrin-affinity, tissue-type plasminogen activator of human plasma. Demonstration of its endothelial origin by immunolocalization publication-title: Blood doi: 10.1182/blood.V66.4.913.913 – volume: 333 start-page: 1581 year: 1995 ident: 10.1016/S1474-4422(18)30323-5_bib17 article-title: Tissue plasminogen activator for acute ischemic stroke publication-title: N Engl J Med doi: 10.1056/NEJM199512143332401 – volume: 6 start-page: 168 year: 2003 ident: 10.1016/S1474-4422(18)30323-5_bib34 article-title: Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior publication-title: Nat Neurosci doi: 10.1038/nn998 – volume: 38 start-page: 1180 year: 2018 ident: 10.1016/S1474-4422(18)30323-5_bib111 article-title: Optimised tPA: a non-neurotoxic fibrinolytic agent for the drainage of intracerebral hemorrhages publication-title: J Cereb Blood Flow Metab doi: 10.1177/0271678X17719180 – volume: 43 start-page: 125 year: 2012 ident: 10.1016/S1474-4422(18)30323-5_bib101 article-title: Systemic thrombolysis in patients with acute ischemic stroke and Internal Carotid ARtery Occlusion: the ICARO study publication-title: Stroke doi: 10.1161/STROKEAHA.111.630624 – volume: 374 start-page: 2313 year: 2016 ident: 10.1016/S1474-4422(18)30323-5_bib86 article-title: Low-dose versus standard-dose intravenous alteplase in acute ischemic stroke publication-title: N Engl J Med doi: 10.1056/NEJMoa1515510 – volume: 372 start-page: 2296 year: 2015 ident: 10.1016/S1474-4422(18)30323-5_bib57 article-title: Thrombectomy within 8 hours after symptom onset in ischemic stroke publication-title: N Engl J Med doi: 10.1056/NEJMoa1503780 – volume: 16 start-page: 277 year: 2014 ident: 10.1016/S1474-4422(18)30323-5_bib105 article-title: New avenues for treatment of intracranial hemorrhage publication-title: Curr Treat Options Cardiovasc Med doi: 10.1007/s11936-013-0277-y – volume: 34 start-page: 14219 year: 2014 ident: 10.1016/S1474-4422(18)30323-5_bib16 article-title: Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke publication-title: J Neurosci doi: 10.1523/JNEUROSCI.5309-13.2014 – volume: 54 start-page: 326 year: 2004 ident: 10.1016/S1474-4422(18)30323-5_bib120 article-title: Does intracisternal thrombolysis prevent vasospasm after aneurysmal subarachnoid hemorrhage? A meta-analysis publication-title: Neurosurgery doi: 10.1227/01.NEU.0000103488.94855.4F – volume: 368 start-page: 2433 year: 2013 ident: 10.1016/S1474-4422(18)30323-5_bib56 article-title: Endovascular treatment for acute ischemic stroke publication-title: N Engl J Med doi: 10.1056/NEJMoa1213701 – volume: 3 start-page: 88 year: 2012 ident: 10.1016/S1474-4422(18)30323-5_bib110 article-title: Tissue plasminogen activator induced delayed edema in experimental porcine intracranial hemorrhage: reduction with plasminogen activator inhibitor-1 administration publication-title: Transl Stroke Res doi: 10.1007/s12975-012-0188-3 |
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| Snippet | Although recent technical advances in thrombectomy have revolutionised acute stroke treatment, prevalence of disability and death related to stroke remain... Summary Although recent technical advances in thrombectomy have revolutionised acute stroke treatment, prevalence of disability and death related to stroke... |
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| SubjectTerms | Arteries Brain Fibrin Fibrinolysis Hematoma Neurotoxicity Physiology Plasmin Proteins Stroke Therapeutic applications |
| Title | The role of plasminogen activators in stroke treatment: fibrinolysis and beyond |
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