A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination

The RIG-I-like receptors (RLRs) retinoic acid-inducible gene I protein (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are cytosolic pattern recognition receptors that recognize specific viral RNA products and initiate antiviral innate immunity. Severe fever with thrombocytopenia sy...

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Veröffentlicht in:	The Journal of biological chemistry Jg. 295; H. 28; S. 9691
Hauptverfasser:	Min, Yuan-Qin, Ning, Yun-Jia, Wang, Hualin, Deng, Fei
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 10.07.2020
Schlagworte:	A549 Cells DEAD Box Protein 58 - genetics DEAD Box Protein 58 - immunology HEK293 Cells Humans Immune Evasion Interferon-Induced Helicase, IFIH1 - genetics Interferon-Induced Helicase, IFIH1 - immunology Phlebovirus - genetics Phlebovirus - immunology Receptors, Immunologic Severe Fever with Thrombocytopenia Syndrome - genetics Severe Fever with Thrombocytopenia Syndrome - immunology Severe Fever with Thrombocytopenia Syndrome - pathology Signal Transduction - genetics Signal Transduction - immunology Transcription Factors - genetics Transcription Factors - immunology Tripartite Motif Proteins - genetics Tripartite Motif Proteins - immunology Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - immunology Ubiquitination - genetics Ubiquitination - immunology Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - immunology inclusion body (IB) nonstructural protein (NSs) virulence factor tripartite motif-containing 25 (TRIM25) severe fever with thrombocytopenia syndrome virus (SFTSV) virus-host interaction immune evasion innate immunity viral immunology infectious disease melanoma differentiation–associated protein 5 (MDA5) virology retinoic acid-inducible gene I protein (RIG-I)
ISSN:	1083-351X, 1083-351X
Online-Zugang:	Weitere Angaben
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