Activated protein C has a regulatory role in factor VIII function

Mechanisms thought to regulate activated factor VIII (FVIIIa) cofactor function include A2-domain dissociation and activated protein C (APC) cleavage. Unlike A2-domain dissociation, there is no known phenotype associated with altered APC cleavage of FVIII, and biochemical studies have suggested APC...

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Bibliographic Details
Published in:Blood Vol. 137; no. 18; p. 2532
Main Authors: Wilhelm, Amelia R, Parsons, Nicole A, Samelson-Jones, Benjamin J, Davidson, Robert J, Esmon, Charles T, Camire, Rodney M, George, Lindsey A
Format: Journal Article
Language:English
Published: United States 06.05.2021
ISSN:1528-0020, 1528-0020
Online Access:Get more information
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