Thrombin spatial distribution determines protein C activation during hemostasis and thrombosis

Rebalancing the hemostatic system by targeting endogenous anticoagulant pathways, like the protein C (PC) system, is being tested as a means of improving hemostasis in patients with hemophilia. Recent intravital studies of hemostasis demonstrated that, in some vascular contexts, thrombin activity is...

Full description

Bibliographic Details

Published in:	Blood Vol. 139; no. 12; p. 1892
Main Authors:	Marar, Tanya T, Matzko, Chelsea N, Wu, Jie, Esmon, Charles T, Sinno, Talid, Brass, Lawrence F, Stalker, Timothy J, Tomaiuolo, Maurizio
Format:	Journal Article
Language:	English
Published:	United States 24.03.2022
Subjects:	Animals Anticoagulants - pharmacology Endothelial Cells - metabolism Fibrin - metabolism Hemostasis Hemostatics Humans Mice Protein C - pharmacology Thrombin - metabolism Thrombosis - metabolism
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!